Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism.

scientific article published in September 2002

Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1523/JNEUROSCI.22-17-07650.2002
P932PMC publication ID6757968
P698PubMed publication ID12196588

P50authorRu-Rong JiQ42386007
P2093author name stringJianren Mao
Grewo Lim
Backil Sung
P2860cites workDNA fragmentation in granular cells of human cerebellum following global ischemiaQ70983125
A caspase-3-like protease is involved in NF-kappaB activation induced by stimulation of N-methyl-D-aspartate receptors in rat striatumQ73093466
NMDA and opioid receptors: their interactions in antinociception, tolerance and neuroplasticityQ73196404
Involvement of activated caspase-3-like proteases in N-methyl-D-aspartate-induced apoptosis in cerebrocortical neuronsQ73315891
Differential activities of intrathecal MK-801 or morphine to alter responses to thermal and mechanical stimuli in normal or nerve-injured ratsQ73452402
Enzymatic degradation protects neurons from glutamate excitotoxicityQ74146341
N -methyl- D -aspartate (NMDA) induced apoptosis in adult rabbit retinasQ74338259
Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injuryQ78060140
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentationQ24642901
Progressive enhancement of delayed hyperalgesia induced by repeated heroin administration: a sensitization processQ28189431
Opioids induce while nicotine suppresses apoptosis in human lung cancer cellsQ28306814
Chronic morphine induces up-regulation of the pro-apoptotic Fas receptor and down-regulation of the anti-apoptotic Bcl-2 oncoprotein in rat brainQ28363748
A role for nucleus accumbens glutamate transmission in the relapse to cocaine-seeking behaviorQ28373340
Morphine promotes apoptosis in Jurkat cellsQ28374975
NeuN, a neuronal specific nuclear protein in vertebratesQ28510657
Neuronal plasticity: increasing the gain in painQ29615421
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesiaQ29620385
Caspase inhibitors promote the survival of avulsed spinal motoneurons in neonatal rats.Q32106420
Cell death in the superficial dorsal horn in a model of neuropathic painQ33181857
Cellular mechanisms of neuropathic pain, morphine tolerance, and their interactionsQ33679560
Riluzole increases high-affinity glutamate uptake in rat spinal cord synaptosomesQ33909931
Characterization of striatal lesions produced by glutamate uptake alteration: cell death, reactive gliosis, and changes in GLT1 and GADD45 mRNA expressionQ34506808
Role of protein kinase C in desensitization of spinal delta-opioid-mediated antinociception in the mouseQ35874052
Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neuronsQ36605145
Acute decrease in net glutamate uptake during energy deprivation.Q36985138
Glutamate and the pathophysiology of hypoxic--ischemic brain damageQ38161694
Depression of retinal glutamate transporter function leads to elevated intravitreal glutamate levels and ganglion cell deathQ38308058
Opioid analgesic-induced apoptosis and caspase-independent cell death in human lung carcinoma A549 cells.Q39427768
Apoptosis in the Nervous System: Morphological Features, Methods, Pathology, and PreventionQ40423446
kappa-Opioid receptor potentiates apoptosis via a phospholipase C pathway in the CNE2 human epithelial tumor cell lineQ40837210
Mechanisms of hyperalgesia and morphine tolerance: a current view of their possible interactions.Q41002806
Heterogeneity and functional properties of subtypes of sodium-dependent glutamate transporters in the mammalian central nervous system.Q41188027
The pharmacology and mechanism of action of riluzoleQ41263084
Experimental mononeuropathy reduces the antinociceptive effects of morphine: implications for common intracellular mechanisms involved in morphine tolerance and neuropathic pain.Q41652154
Spinal PKC activity and expression: role in tolerance produced by continuous spinal morphine infusionQ41732395
Hyperalgesia and myoclonus in terminal cancer patients treated with continuous intravenous morphineQ42287163
The inhibition of nitric oxide-activated poly(ADP-ribose) synthetase attenuates transsynaptic alteration of spinal cord dorsal horn neurons and neuropathic pain in the rat.Q42547439
Hyperalgesia induced by high-dose intrathecal sufentanil in neuropathic pain.Q42550229
Effect of NO synthase inhibition on NMDA- and ischaemia-induced hippocampal lesionsQ43429365
Protection by NMDA antagonists against selective cell loss following transient ischaemiaQ43530761
Differential roles of NMDA and non-NMDA receptor activation in induction and maintenance of thermal hyperalgesia in rats with painful peripheral mononeuropathyQ43547058
Protein kinase C modulates NMDA receptor trafficking and gatingQ43558099
Interleukin-10 prevents glutamate-mediated cerebellar granule cell death by blocking caspase-3-like activity.Q43581713
Inhibition of morphine tolerance and dependence by MS-153, a glutamate transporter activatorQ43604538
Involvement of spinal protein kinase Cgamma in the attenuation of opioid mu-receptor-mediated G-protein activation after chronic intrathecal administration of [D-Ala2,N-MePhe4,Gly-Ol(5)]enkephalin.Q43610828
Changes in the expression of glial glutamate transporters in the rat brain accompanied with morphine dependence and naloxone-precipitated withdrawalQ43651505
The role of NMDA receptors in neonatal cocaine-induced neurotoxicityQ43709804
Reduced development of tolerance to the analgesic effects of morphine and clonidine in PKC gamma mutant miceQ43814056
NMDA receptor inhibition prevents tolerance to cocaineQ43945488
The NMDA receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioidsQ44332822
Dynorphin promotes abnormal pain and spinal opioid antinociceptive tolerance.Q44333127
Sustained potentiation of NMDA receptor-mediated glutamate responses through activation of protein kinase C by a μ opioidQ44335232
Expression of mu-, delta-, and kappa-opioid receptor-like immunoreactivities in rat dorsal root ganglia after carrageenan-induced inflammationQ44341541
Dual ultrastructural localization of mu-opioid receptors and NMDA-type glutamate receptors in the shell of the rat nucleus accumbensQ44345874
Repetitive opioid abstinence causes progressive hyperalgesia sensitive to N-methyl-D-aspartate receptor blockade in the rat.Q44347824
Regulation of the glial glutamate transporter GLT-1 by glutamate and delta-opioid receptor stimulationQ44348434
Frequent colocalization of mu opioid and NMDA-type glutamate receptors at postsynaptic sites in periaqueductal gray neurons.Q44352087
Mu-opioid and NMDA-type glutamate receptors are often colocalized in spiny neurons within patches of the caudate-putamen nucleus.Q44352563
Pain-related increases in spinal cord membrane-bound protein kinase C following peripheral nerve injuryQ44896954
The development of morphine tolerance and dependence is associated with translocation of protein kinase C.Q45080390
Increases in protein kinase C gamma immunoreactivity in the spinal cord of rats associated with tolerance to the analgesic effects of morphineQ45081186
Thermal hyperalgesia in association with the development of morphine tolerance in rats: roles of excitatory amino acid receptors and protein kinase C.Q45085836
Spatial patterns of increased spinal cord membrane-bound protein kinase C and their relation to increases in 14C-2-deoxyglucose metabolic activity in rats with painful peripheral mononeuropathyQ45093137
Spinal amino acid release and precipitated withdrawal in rats chronically infused with spinal morphineQ46086009
Effect of transient naloxone antagonism on tolerance development in rats receiving continuous spinal morphine infusionQ46823137
Excitatory amino acid antagonists (kynurenic acid and MK-801) attenuate the development of morphine tolerance in the ratQ46904809
Delayed application of MK-801 attenuates development of morphine tolerance in ratsQ46956859
Regional differences in the effects of glutamate uptake inhibitor L-trans-pyrrolidine-2,4-dicarboxylic acid on extracellular amino acids and dopamine in rat brain: an in vivo microdialysis studyQ47691289
Protective effect of apoptosis-inhibitory agent, N-tosyl-L-phenylalanyl chloromethyl ketone against ischemia-induced hippocampal neuronal damageQ47696892
Combined mechanical trauma and metabolic impairment in vitro induces NMDA receptor-dependent neuronal cell death and caspase-3-dependent apoptosisQ48100781
Repeated cocaine alters glutamate receptor subunit levels in the nucleus accumbens and ventral tegmental area of rats that develop behavioral sensitizationQ48198206
Reciprocal changes in the expression of Bcl-2 and Bax in hypoglossal nucleus after axotomy in adult rats: possible involvement in the induction of neuronal cell deathQ48215639
Chronic catheterization of the spinal subarachnoid spaceQ48344815
Phospholipase A2 modulates different subtypes of excitatory amino acid receptors: autoradiographic evidenceQ48392729
Riluzole inhibits the release of glutamate in the caudate nucleus of the cat in vivoQ48396095
Role of caspases in N-methyl-D-aspartate-induced apoptosis in cerebrocortical neuronsQ48403884
Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulationQ48493712
Cocaine induces apoptosis in cortical neurons of fetal miceQ48701879
Antagonism of stimulation-produced analgesia by p-CPA, a serotonin synthesis inhibitorQ48726529
Substrate turnover by transporters curtails synaptic glutamate transientsQ48906935
Enhancement of NMDA-induced functional responses without concomitant NMDA receptor changes following chronic ethanol exposure in cerebellar granule cells.Q50514865
Prostaglandin E1 prevents apoptotic cell death in superficial dorsal horn of rat spinal cord.Q50527322
The cytoarchitectonic organization of the spinal cord in the rat. I. The lower thoracic and lumbosacral cord.Q50919908
Cocaine induces cell death within the primate fetal cerebral wall.Q51423377
The loss of antinociceptive efficacy of spinal morphine in rats with nerve ligation injury is prevented by reducing spinal afferent drive.Q51591862
Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801Q52052445
Effects of bombesin on methadone-induced apoptosis of human lung cancer cells.Q52277165
Apoptosis of NG108-15 cells induced by buprenorphine hydrochloride occurs via the caspase-3 pathway.Q55475246
NMDA blockade attenuates caspase-3 activation and DNA fragmentation after neonatal hypoxia-ischemiaQ56880509
Activation of apoptosis-linked caspase(s) in NMDA-injured brains in neonatal ratsQ58115481
P433issue17
P407language of work or nameEnglishQ1860
P921main subjectmorphineQ81225
neurotoxicityQ3338704
apoptotic processQ14599311
opioidQ427523
P304page(s)7650-7661
P577publication date2002-09-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleNeuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism
P478volume22

Reverse relations

cites work (P2860)
Q37531862A new pharmacological role for donepezil: attenuation of morphine-induced tolerance and apoptosis in rat central nervous system
Q88162637Adjunctive therapy for neonatal abstinence syndrome: why not personalize it for each infant based on their in-utero exposure?
Q44396263Altered expression and uptake activity of spinal glutamate transporters after nerve injury contribute to the pathogenesis of neuropathic pain in rats.
Q46294271An intriguing association between dental and mental pathology in addicted and control subjects: a cross-sectional survey
Q35149088Biphasic effect of curcumin on morphine tolerance: a preliminary evidence from cytokine/chemokine protein array analysis
Q92857202Carbonyl-protein content increases in brain and blood of female rats after chronic oxycodone treatment
Q86441455Changes of GTP cyclohydrolase I and neuronal apoptosis in rat spinal dorsal cord induced by sciatic nerve injury
Q35764822Chronic Opium Treatment Can Differentially Induce Brain and Liver Cells Apoptosis in Diabetic and Non-diabetic Male and Female Rats
Q37155946Chronic daily headache: transformational migraine, chronic migraine, and related disorders
Q52297206Chronic immune stimulation as a contributing cause of chronic disease in opiate addiction including multi-system ageing
Q48228685Chronic methadone treatment and repeated withdrawal impair cognition and increase the expression of apoptosis-related proteins in mouse brain.
Q51735904Chronic oxycodone induces axonal degeneration in rat brain.
Q41774030Cocaine-Mediated Autophagy in Astrocytes Involves Sigma 1 Receptor, PI3K, mTOR, Atg5/7, Beclin-1 and Induces Type II Programed Cell Death
Q35943702Deficit of circulating stem--progenitor cells in opiate addiction: a pilot study
Q64075887Dexmedetomidine for the Management of Postoperative Pain and Sedation in Newborns
Q42422393Dexmedetomidine versus standard therapy with fentanyl for sedation in mechanically ventilated premature neonates
Q34624598Do opioids induce hyperalgesia?
Q39787535Down-regulation of c-Cbl by morphine accounts for persistent ERK1/2 signaling in delta-opioid receptor-expressing HEK293 cells
Q46024266Effect of chronic administration of morphine on the gene expression level of sodium-dependent vitamin C transporters in rat hippocampus and lumbar spinal cord.
Q28660034Effects of opiates and HIV proteins on neurons: the role of ferritin heavy chain and a potential for synergism
Q37629247Effects of psychostimulants on neurotrophins implications for psychostimulant-induced neurotoxicity
Q89909001Electroacupuncture Alleviates Experimental Chronic Inflammatory Pain by Inhibiting Calcium Voltage-Gated Channel-Mediated Inflammation
Q35581558Endogenous opiates and behavior: 2002
Q33231309Escalating management of progressive neuropathic cancer pain
Q37227174Evaluation of the effects of specific opioid receptor agonists in a rodent model of spinal cord injury
Q36092170Evidence of accelerated ageing in clinical drug addiction from immune, hepatic and metabolic biomarkers
Q36389131Exacerbated mechanical hyperalgesia in rats with genetically predisposed depressive behavior: role of melatonin and NMDA receptors
Q26740384From Drug-Induced Developmental Neuroapoptosis to Pediatric Anesthetic Neurotoxicity-Where Are We Now?
Q46491990GLT-1 expression and Glu uptake in rat cerebral cortex are increased by phencyclidine.
Q80852989Gaps and junctions between clinical experience and theoretical framework in the use of opioids
Q34231164General anesthetics in pediatric anesthesia: influences on the developing brain
Q28484293Global changes in the rat heart proteome induced by prolonged morphine treatment and withdrawal
Q24806575Glutamate transporter: an unexpected target for some antibiotics
Q24806246Glutamate-induced apoptosis in primary cortical neurons is inhibited by equine estrogens via down-regulation of caspase-3 and prevention of mitochondrial cytochrome c release
Q80130959Impact of chronic nicotine on the development and maintenance of neuropathic hypersensitivity in the rat
Q36590742In vivo morphine treatment synergistically increases LPS-induced caspase activity in immune organs
Q26768068Interactions of Opioids and HIV Infection in the Pathogenesis of Chronic Pain
Q39279068Intracerebroventricular administration of riluzole prevents morphine-induced apoptosis in the lumbar region of the rat spinal cord.
Q80367537Loss of neurons from laminas I-III of the spinal dorsal horn is not required for development of tactile allodynia in the spared nerve injury model of neuropathic pain
Q43236166Maternal oral consumption of morphine increases Bax/Bcl-2 ratio and caspase 3 activity during early neural system development in rat embryos
Q37198850Mesenchymal Stem Cells Reversed Morphine Tolerance and Opioid-induced Hyperalgesia
Q42936784Minocycline prevents morphine-induced apoptosis in rat cerebral cortex and lumbar spinal cord: a possible mechanism for attenuating morphine tolerance.
Q35579655Molecular mechanisms of excitatory signaling upon chronic opioid agonist treatment
Q40037212Morphine Inhibited the Rat Neural Stem Cell Proliferation Rate by Increasing Neuro Steroid Genesis.
Q64261647Morphine biotransformation genes and neonatal clinical factors predicted behaviour problems in very preterm children at 18 months
Q36798747Morphine induces ubiquitin-proteasome activity and glutamate transporter degradation
Q41530211Morphine pre- and post-conditioning exacerbates apoptosis in rat hippocampus cells in a model of homocysteine-induced oxidative stress.
Q48629661Morphine preconditioning protects against LPS-induced neuroinflammation and memory deficit
Q36428066Morphine, a potential antagonist of cisplatin cytotoxicity, inhibits cisplatin-induced apoptosis and suppression of tumor growth in nasopharyngeal carcinoma xenografts
Q52592793Morphine-alcohol treatment impairs cognitive functions and increases neuro-inflammatory responses in the medial prefrontal cortex of juvenile male rats.
Q36807732Morphine-enhanced apoptosis in selective brain regions of neonatal rats
Q48842409Morphine-induced apoptosis in the ventral tegmental area and hippocampus after the development but not extinction of reward-related behaviors in rats.
Q39267599Neurobiological Effects of Morphine after Spinal Cord Injury
Q42475582Neuropathological alterations in drug abusers : The involvement of neurons, glial, and vascular systems
Q24681779Neuropsychological functioning in opiate-dependent subjects receiving and following methadone maintenance treatment
Q49270407Opiate Drugs with Abuse Liability Hijack the Endogenous Opioid System to Disrupt Neuronal and Glial Maturation in the Central Nervous System
Q35582306Opioid Therapy for Chronic Pain
Q38090368Opioid administration following spinal cord injury: implications for pain and locomotor recovery
Q34613490Opioid induced hyperalgesia in anesthetic settings
Q35044048Opioid resistance in chronic daily headache: a synthesis of ideas from the bench and bedside
Q36405690Opioid-induced abnormal pain sensitivity
Q44807834Opioid-induced hyperalgesia. Pathophysiology and clinical relevance
Q37328701Peroxynitrite and opiate antinociceptive tolerance: a painful reality
Q44341348Postnatal development of mu-opioid receptors in the rat caudate-putamen nucleus parallels asymmetric synapse formation
Q43811430Pre-operative opioid analgesia reduces clinical success of laparoscopic gastric electrical stimulation placement in patients with gastroparesis.
Q33593295Prenatal morphine exposure reduces pyramidal neurons in CA1, CA2 and CA3 subfields of mice hippocampus
Q39536727Protective role of taurine against morphine-induced neurotoxicity in C6 cells via inhibition of oxidative stress
Q91790243Protein Kinase A Is Involved in Neuropathic Pain by Activating the p38MAPK Pathway to Mediate Spinal Cord Cell Apoptosis
Q36398092Psychosocial and treatment correlates of opiate free success in a clinical review of a naltrexone implant program
Q36098677Purkinje cells loss in off spring due to maternal morphine sulfate exposure: a morphometric study
Q42049607Recombinant human growth hormone improves cognitive capacity in a pain patient exposed to chronic opioids
Q36734759Reversal of opiate-induced apoptosis by human recombinant growth hormone in murine foetus primary hippocampal neuronal cell cultures
Q28568562Riluzole prevents morphine-induced apoptosis in rat cerebral cortex
Q37293705Spinal expression of Hippo signaling components YAP and TAZ following peripheral nerve injury in rats
Q42077528Stereological study of the effects of morphine consumption and abstinence on the number of the neurons and oligodendrocytes in medial prefrontal cortex of rats
Q37849424Tetracyclines and pain
Q59797210The Protective and Restorative Effects of Growth Hormone and Insulin-Like Growth Factor-1 on Methadone-Induced Toxicity In Vitro
Q41977639The impact of morphine after a spinal cord injury
Q93113089The mitochondrial calcium uniporter contributes to morphine tolerance through pCREB and CPEB1 in rat spinal cord dorsal horn
Q37907914The role of morphine in regulation of cancer cell growth
Q37629272The role of the somatotrophic axis in neuroprotection and neuroregeneration of the addictive brain
Q42639183Therapeutic manipulation of peroxynitrite attenuates the development of opiate-induced antinociceptive tolerance in mice
Q90299756Topical Ketamine with Other Adjuvants: Underutilized for Refractory Cancer Pain? A Case Series and Suggested Revision of the World Health Organization Stepladder for Cancer Pain
Q62086883Update of the Scientific Opinion on opium alkaloids in poppy seeds
Q33987944Validation of a preclinical spinal safety model: effects of intrathecal morphine in the neonatal rat
Q36310086X Chromosome Inactivation in Opioid Addicted Women

Search more.