Chronic morphine induces up-regulation of the pro-apoptotic Fas receptor and down-regulation of the anti-apoptotic Bcl-2 oncoprotein in rat brain

scientific article

Chronic morphine induces up-regulation of the pro-apoptotic Fas receptor and down-regulation of the anti-apoptotic Bcl-2 oncoprotein in rat brain is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SJ.BJP.0704364
P932PMC publication ID1573055
P698PubMed publication ID11704646
P5875ResearchGate publication ID11649551

P2093author name stringJ A García-Sevilla
M A Boronat
M J García-Fuster
P2860cites workMu opioid receptor phosphorylation, desensitization, and ligand efficacyQ44347204
Agonist induced homologous desensitization of mu-opioid receptors mediated by G protein-coupled receptor kinases is dependent on agonist efficacy.Q44350174
Cerebral CT findings in male opioid-dependent patients: stereological, planimetric and linear measurementsQ44350802
Alterations of immune functions in heroin addicts and heroin withdrawal subjectsQ47723420
Increased density of guanine nucleotide-binding proteins in the postmortem brains of heroin addictsQ48109089
Morphine alters the structure of neurons in the nucleus accumbens and neocortex of ratsQ48167146
Disclosing apoptosis in the CNS.Q48198798
Neurofilament proteins and the mesolimbic dopamine system: common regulation by chronic morphine and chronic cocaine in the rat ventral tegmental areaQ48476698
Chronic morphine alters calbindin D-28k immunostaining patterns in mouse forebrainQ48492925
Marked decrease of immunolabelled 68 kDa neurofilament (NF-L) proteins in brains of opiate addictsQ48708352
Increase in bax expression in substantia nigra following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment of miceQ49121100
Fas-mediated cell death promoted by opioidsQ59098772
Leydig cell apoptosis after the administration of ethane dimethanesulfonate to the adult male rat is a Fas-mediated processQ78086532
Protein measurement with the Folin phenol reagentQ20900776
CD95's deadly mission in the immune systemQ28142072
Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosisQ28250587
Morphine promotes apoptosis in Jurkat cellsQ28374975
Cocaine induces apoptosis in fetal myocardial cells through a mitochondria-dependent pathwayQ28377860
The Bcl-2 protein family: arbiters of cell survivalQ29618158
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell deathQ29620000
The Fas death factorQ29620461
The pharmacology of apoptosis.Q33547883
Apoptosis and the nervous systemQ33806940
Structure and function of Fas/Fas ligandQ33811723
Fas ligand-induced apoptosisQ33847658
Apoptosis in the nervous systemQ34068965
Attenuation of tolerance to opioid-induced antinociception and protection against morphine-induced decrease of neurofilament proteins by idazoxan and other I2-imidazoline ligands.Q35027984
Opiates inhibit neurogenesis in the adult rat hippocampusQ35163722
Regulation of neuronal Bcl2 protein expression and calcium homeostasis by transforming growth factor type beta confers wide-ranging protection on rat hippocampal neuronsQ35993899
Chronic restraint stress promotes lymphocyte apoptosis by modulating CD95 expressionQ36368408
Chronic morphine induces visible changes in the morphology of mesolimbic dopamine neuronsQ37316191
Regional calpain and caspase-3 proteolysis of alpha-spectrin after traumatic brain injuryQ40844816
Under siege: The brain on opiatesQ40986699
Cyclic AMP protects against staurosporine and wortmannin-induced apoptosis and opioid-enhanced apoptosis in both embryonic and immortalized (F-11kappa7) neuronsQ41055527
Etorphine inhibits cell growth and induces apoptosis in SK-N-SH cells: involvement of pertussis toxin-sensitive G proteinsQ41080829
Chronic exposure to kappa-opioids enhances the susceptibility of immortalized neurons (F-11kappa 7) to apoptosis-inducing drugs by a mechanism that may involve ceramide.Q41108497
Morphine enhances macrophage apoptosis.Q42450969
Acute and chronic effects of morphine and naloxone on the phosphorylation of neurofilament-H proteins in the rat brainQ43596545
Regulation of nonphosphorylated and phosphorylated forms of neurofilament proteins in the prefrontal cortex of human opioid addictsQ44332350
Modulation of brain alpha 2-adrenoceptor and mu-opioid receptor densities during morphine dependence and spontaneous withdrawal in ratsQ44342691
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectbrainQ1073
morphineQ81225
apoptotic processQ14599311
P304page(s)1263-70
P577publication date2001-11-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titleChronic morphine induces up-regulation of the pro-apoptotic Fas receptor and down-regulation of the anti-apoptotic Bcl-2 oncoprotein in rat brain
P478volume134

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