Modulation of brain alpha 2-adrenoceptor and mu-opioid receptor densities during morphine dependence and spontaneous withdrawal in rats

scientific article

Modulation of brain alpha 2-adrenoceptor and mu-opioid receptor densities during morphine dependence and spontaneous withdrawal in rats is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/BF00169310
P698PubMed publication ID2830545

P2093author name stringJ A García-Sevilla
L Ugedo
I Ulibarri
P2860cites workProtein measurement with the Folin phenol reagentQ20900776
Chronic morphine administration increases the apparent number of α2-adrenergic receptors in rat brainQ34252422
Production of tolerance and physical dependence in the rat by simple administration of morphine in drinking waterQ39925995
Biochemical Characteristics and Regulation of Brain ?2-AdrenoceptorsQ40094669
Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidineQ40205667
Effects of alpha 2-agonists on morphine withdrawal behaviour: potentiation of jumping mediated by alpha 2-receptorsQ41340252
Naltrexone precipitated opiate withdrawal in methadone addicted human subjects: evidence for noradrenergic hyperactivityQ41577420
Dorsal noradrenergic bundle lesions fail to alter opiate withdrawal or suppression of opiate withdrawal by clonidineQ41582231
Alpha 2-adrenoceptor-mediated inhibition of platelet adenylate cyclase activity in heroin addicts in abstinence.Q42500836
Biochemical characterization of high-affinity 3H-opioid binding. Further evidence for Mu1 sitesQ44330210
Modulation of opioid system in C57 mice after repeated treatment with morphine and naloxone: biochemical and behavioral correlatesQ44330295
Morphine-induced opioid receptor down-regulation detected in intact adult rat brain cellsQ44346967
Activation of presynaptic alpha 2-adrenoceptors attenuates the inhibitory effect of mu-opioid receptor agonists on noradrenaline release from brain slicesQ44347314
Mutual interaction between presynaptic alpha 2-adrenoceptors and opioid kappa-receptors at the noradrenergic axons of rabbit brain cortexQ44347387
The addiction cycle to narcotics in the rat and its relation to catecholaminesQ44490556
Labelling of human platelet alpha 2-adrenoceptors with the full agonist [3H](-)adrenalineQ46178530
Opiate and alpha 2-adrenoceptor responses of rat amygdaloid neurons: co-localization and interactions during withdrawal.Q48442788
Effects of clonidine on morphine withdrawal signs in the ratQ48486020
Biochemical correlates of morphine withdrawal. 1. Characterization in the adrenal medulla and locus ceruleusQ48494726
Morphine dependence and withdrawal without alterations in cerebral β-adrenergic receptor densityQ48645014
Chronic opiate treatment does not modify alpha 2-adrenergic receptors in rat cerebral cortex, kidney and in the neurotumor cell line NCB20.Q48713731
Changes in alpha2 adrenoreceptors in various areas of the rat brain after long-term administration of "mu" and "kappa" opiate agonistsQ48840680
Brain catecholamine metabolites and behavior in morphine withdrawalQ48858694
Naltrexone-induced opiate receptor supersensitivityQ48911058
Suppression of physical dependence and induction of hypersensitivity to morphine by stereotaxic hypothalamic lesions in addicted rats. A new theory of addiction.Q51120389
A pharmacokinetic analysis program (multi) for microcomputerQ52732710
Biochemical correlates of morphine withdrawal. 2. Effects of clonidine.Q54492308
Platelet α-adrenoceptors in heroin addicts during withdrawal and after treatment with clonidineQ62082742
Development of physical dependence on morphine in respect to time and dosage and quantification of the precipitated withdrawal syndrome in ratsQ69702618
alpha 2-Adrenoreceptors in rat brain are decreased after long-term tricyclic antidepressant drug treatmentQ72890174
Alteration in beta-adrenergic receptor binding in brain, lung and heart during morphine and alcohol dependence and withdrawalQ72899736
P433issue5
P921main subjectmorphineQ81225
morphine dependenceQ240975
opioidQ427523
P304page(s)530-537
P577publication date1987-11-01
P1433published inNaunyn-Schmiedeberg's Archives of PharmacologyQ1468251
P1476titleModulation of brain alpha 2-adrenoceptor and mu-opioid receptor densities during morphine dependence and spontaneous withdrawal in rats
P478volume336

Reverse relations

cites work (P2860)
Q44341503Alpha-2-adrenoceptor hyporesponsiveness in isolated tissues of cholestatic animals: involvement of opioid and nitric oxide systems
Q48409868Attenuation of withdrawal-induced hyperactivity of locus coeruleus neurones by inhibitors of nitric oxide synthase in morphine-dependent rats.
Q28361194Brain alpha(2)-adrenoceptors in monoamine-depleted rats: increased receptor density, G coupling proteins, receptor turnover and receptor mRNA
Q28298326Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors
Q67521018Chronic infusion of clonidine does not alleviate spontaneous morphine withdrawal symptoms in rats
Q28363748Chronic morphine induces up-regulation of the pro-apoptotic Fas receptor and down-regulation of the anti-apoptotic Bcl-2 oncoprotein in rat brain
Q48151665Effect of morphine and abstinence syndrome on [3H]bromoxidine binding to alpha 2-adrenoceptors in rat brain
Q44306512Effects of morphine administration and its withdrawal on rat brain aminopeptidase activities
Q44332520Effects of opioid and alpha 2-adrenoceptor agonists on the isolated ileum of morphine-dependent guinea-pigs during withdrawal and after clonidine treatment
Q30009384Functional characterization of G-protein-coupled receptors: a bioinformatics approach
Q24630645Heteromerization of G protein-coupled receptors: relevance to neurological disorders and neurotherapeutics
Q48747696Naloxone-precipitated withdrawal in morphine-dependent rats increases the expression of alpha 2a-adrenoceptor mRNA in brain
Q40887933Opiate addiction and the locus coeruleus. The clinical utility of clonidine, naltrexone, methadone, and buprenorphine.
Q42544065Quantitative evaluation of opioid withdrawal signs in rats repeatedly treated with morphine and injected with naloxone, in the absence or presence of the antiabstinence agent clonidine
Q44345799Regulation of immunolabelled mu-opioid receptors and protein kinase C-alpha and zeta isoforms in the frontal cortex of human opiate addicts
Q43563188Subcellular localization of alpha-2A-adrenergic receptors in the rat medial nucleus tractus solitarius: regional targeting and relationship with catecholamine neurons
Q36389121Tolerance and sensitization to chronic escalating dose heroin following extended withdrawal in Fischer rats: possible role of mu-opioid receptors
Q44335902mu-Opioid receptor and alpha 2-adrenoceptor agonist binding sites in the postmortem brain of heroin addicts
Q44332220mu-opioid receptor and alpha2-adrenoceptor agonist stimulation of [35S]GTPgammaS binding to G-proteins in postmortem brains of opioid addicts