Differential effects of phospholipase inhibitors on free fatty acid efflux in rat cerebral cortex during ischemia-reperfusion injury

scientific article published in September 2002

Differential effects of phospholipase inhibitors on free fatty acid efflux in rat cerebral cortex during ischemia-reperfusion injury is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0006-8993(02)03142-6
P698PubMed publication ID12231462

P2093author name stringJ W Phillis
F G Diaz
J G Pilitsis
M H O'Regan
P2860cites workThe mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagyQ28280478
Docosahexaenoic acid improves long-term potentiation attenuated by phospholipase A(2) inhibitor in rat hippocampal slicesQ28361180
Regulated formation of eicosanoidsQ28366333
Oxidant, mitochondria and calcium: an overviewQ33537010
Regulation and inhibition of phospholipase A2.Q33636666
Inhibitors of intracellular phospholipase A2 activity: their neurochemical effects and therapeutical importance for neurological disordersQ33704434
Functional coupling between secretory phospholipase A2 and cyclooxygenase-2 and its regulation by cytosolic group IV phospholipase A2Q36164895
Deacylation-reacylation of arachidonoyl groups in cerebral phospholipidsQ38686457
Mammalian calcium-independent phospholipase A2.Q40375569
Free arachidonic acid and other lipids in the nervous system during early ischemia and after electroshockQ40767815
The growing phospholipase A2 superfamily of signal transduction enzymesQ41341078
Phospholipase A2 and its role in brain tissue.Q41584381
Modification of ion homeostasis by lipid peroxidation: roles in neuronal degeneration and adaptive plasticityQ41719465
Action of phospholipases A2 and C on free fatty acid release during complete ischemia in rat neocortex. Effect of phospholipase C inhibitor and N-methyl-D-aspartate antagonistQ43502389
Arachidonic acid causes cell death through the mitochondrial permeability transition. Implications for tumor necrosis factor-alpha aopototic signalingQ43514127
Differential effects of calcium-dependent and calcium-independent phospholipase A(2) inhibitors on kainate-induced neuronal injury in rat hippocampal slicesQ43614730
A possible mechanism of mitochondrial dysfunction during cerebral ischemia: inhibition of mitochondrial respiration activity by arachidonic acidQ43621520
Phospholipase A2 mediates ischemic injury in the hippocampus: a regional difference of neuronal vulnerabilityQ43674642
Inhibition of Na(+)/H(+) exchange by SM-20220 attenuates free fatty acid efflux in rat cerebral cortex during ischemia-reperfusion injuryQ43732149
Inhibition of Na(+)/Ca(2+) exchange by KB-R7943, a novel selective antagonist, attenuates phosphoethanolamine and free fatty acid efflux in rat cerebral cortex during ischemia-reperfusion injuryQ43764349
Human group IIA secretory phospholipase A2 induces neuronal cell death via apoptosisQ43830222
Inhibition of mitochondrial Na(+)/Ca(2+) exchange by 7-chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one attenuates free fatty acid efflux in rat cerebral cortex during ischemia-reperfusion injuryQ43901260
Quantification of free fatty acids in human cerebrospinal fluidQ43910155
Free fatty acids in human cerebrospinal fluid following subarachnoid hemorrhage and their potential role in vasospasm: a preliminary observationQ44108161
Distinct roles in signal transduction for each of the phospholipase A2 enzymes present in P388D1 macrophages.Q44816682
The phospholipase A2 inhibitor, quinacrine, reduces infarct size in rats after transient middle cerebral artery occlusionQ47311935
Expression of group II phospholipase A2 in rat brain after severe forebrain ischemia and in endotoxic shockQ48088212
Ischemia-induced changes in cerebral mitochondrial free fatty acids, phospholipids, and respiration in the rat.Q48127817
Localization of cytosolic phospholipase A2 messenger RNA mainly in neurons in the rat brainQ48149755
Cytosolic phospholipase A2 is induced in reactive glia following different forms of neurodegenerationQ48154082
Severity of experimental brain injury on lactate and free fatty acid accumulation and Evans blue extravasation in the rat cortex and hippocampusQ48172802
Brain edema: induction in cortical slices by polyunsaturated fatty acidsQ48173284
Activation of cPLA2, PKC, and ERKs in the rat cerebral cortex during ischemia/reperfusionQ48200172
Cytosolic Ca2+ changes during in vitro ischemia in rat hippocampal slices: major roles for glutamate and Na+-dependent Ca2+ release from mitochondria.Q48230980
Early metabolic inhibition-induced intracellular sodium and calcium increase in rat cerebellar granule cellsQ48296463
Genes encoding multiple forms of phospholipase A2 are expressed in rat brain.Q48308153
Manoalide, a phospholipase A2 inhibitor, inhibits arachidonate incorporation and turnover in brain phospholipids of the awake rat.Q48358027
Cyclosporin A, but not FK 506, protects mitochondria and neurons against hypoglycemic damage and implicates the mitochondrial permeability transition in cell death.Q48436702
A light and electron microscopic study of cytoplasmic phospholipase A2 and cyclooxygenase-2 in the hippocampus after kainate lesionsQ48466882
Mild hypothermia reduces the rate of metabolism of arachidonic acid following postischemic reperfusionQ48528489
Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2.Q48580352
Effect of Oleate on Neurotransmitter Transport and Other Plasma Membrane Functions in Rat Brain SynaptosomesQ48666763
Time course of changes in lactate and free fatty acids after experimental brain injury and relationship to morphologic damageQ48670829
Mitochondria accumulate Ca2+ following intense glutamate stimulation of cultured rat forebrain neuronesQ48811571
Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain.Q48890665
Translocation of phospholipase A2 from cytosol to membranes in rat brain induced by calcium ionsQ48931123
Mechanisms of glutamate and aspartate release in the ischemic rat cerebral cortexQ48941184
Enhanced accumulation of free fatty acids in experimental focal cerebral ischemiaQ49074164
Reactive glia express cytosolic phospholipase A2 after transient global forebrain ischemia in the rat.Q49105101
Long-chain fatty acids promote opening of the reconstituted mitochondrial permeability transition pore.Q53902212
Fatty acid-induced uncoupling of oxidative phosphorylation is partly due to opening of the mitochondrial permeability transition pore.Q53957729
Fatty acid-promoted mitochondrial permeability transition by membrane depolarization and binding to the ADP/ATP carrier.Q53959848
Regional Differences in Arachidonic Acid Release in Rat Hippocampal CA1 and CA3 Regions during Cerebral IschemiaQ60597329
Arachidonic acid and other fatty acids directly activate potassium channels in smooth muscle cellsQ69073424
Calcium-mediated translocation of cytosolic phospholipase A2 to the nuclear envelope and endoplasmic reticulumQ70808889
Long-term potentiation requires activation of calcium-independent phospholipase A2Q70869030
Cerebroprotective action of the phospholipase inhibitor quinacrine in the ischemia/reperfused gerbil hippocampusQ70919454
Relation between accumulation of phospholipase A2 reaction products and Ca2+ release in isolated liver mitochondriaQ71857959
Selectivity of Inhibition of Na+-Ca2+ Exchange of Heart Mitochondria by Benzothiazepine CGP-37157Q72075722
A possible role for phospholipases in the release of neurotransmitter amino acids from ischemic rat cerebral cortexQ72244935
Differential modulation of human glutamate transporter subtypes by arachidonic acidQ72645544
Melittin enhances amino acid and free fatty acid release from the in vivo cerebral cortexQ73212365
Cortical impact injury in rats promotes a rapid and sustained increase in polyunsaturated free fatty acids and diacylglycerolsQ73726168
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectfatty acidQ61476
reperfusion injuryQ1413991
P304page(s)96-106
P577publication date2002-09-01
P1433published inBrain ResearchQ4955782
P1476titleDifferential effects of phospholipase inhibitors on free fatty acid efflux in rat cerebral cortex during ischemia-reperfusion injury
P478volume951

Reverse relations

cites work (P2860)
Q35125588Characterization of modes of release of amino acids in the ischemic/reperfused rat cerebral cortex
Q33252112Chronic intracerebroventricular delivery of the secretory phospholipase A2 inhibitor, 12-epi-scalaradial, does not improve outcome after focal cerebral ischemia-reperfusion in rats
Q34363951Docosahexaenoic acid: brain accretion and roles in neuroprotection after brain hypoxia and ischemia
Q44223718Effects of immunosuppressants, calcineurin inhibition, and blockade of endoplasmic reticulum calcium channels on free fatty acid efflux from the ischemic/reperfused rat cerebral cortex
Q61439995Lipotoxic Effects of Palmitic Acid on Astrocytes Are Associated with Autophagy Impairment
Q37711265Low molecular weight phospholipases A2 in mammalian brain and neural cells: roles in functions and dysfunctions
Q37340856Molecular mechanisms and cell signaling of 20-hydroxyeicosatetraenoic acid in vascular pathophysiology
Q35600801Phospholipase A2 in the central nervous system: implications for neurodegenerative diseases
Q48428206Post-sampling release of free fatty acids - effects of heat stabilization and methods of euthanasia
Q37336053Reduction of lipoxidative load by secretory phospholipase A2 inhibition protects against neurovascular injury following experimental stroke in rat.
Q47579436Sex differences in the phagocytic and migratory activity of microglia and their impairment by palmitic acid

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