Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction

scientific article

Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NI1515
P698PubMed publication ID17906628
P5875ResearchGate publication ID5937587

P50authorJohn CoffinQ6226532
Bruce D. WalkerQ23770361
Gordon J. FreemanQ27088375
Sylvie Le GallQ37376422
Florencia PereyraQ72530851
Eric S RosenbergQ89548046
Alicja Piechocka-TrochaQ89549631
John ZaundersQ95422081
Anthony KelleherQ96053206
Kristin L MossQ114434956
Almas RathodQ114434963
Toshiyuki MiuraQ114434971
Mark A. BrockmanQ30389078
P2093author name stringDaniel E Kaufmann
Sarah Palmer
Baogong Zhu
Daniel G Kavanagh
Brett Baker
Michael T Waring
Ryan Ahern
Elizabeth W Mackey
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Human immunodeficiency virus type 1 (HIV-1)-specific CD4+ T cells that proliferate in vitro detected in samples from most viremic subjects and inversely associated with plasma HIV-1 levelsQ37596842
Murine malaria is exacerbated by CTLA-4 blockadeQ39098212
Immunotherapy with OX40L-Fc or anti-CTLA-4 enhances local tissue responses and killing of Leishmania donovani.Q39634065
Lack of intrinsic CTLA-4 expression has minimal effect on regulation of antiviral T-cell immunity.Q40721856
Progress in defining CD4 helper cell responses in chronic viral infectionsQ42109893
Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphomaQ42821039
CTLA-4 regulates the murine immune response to Trypanosoma cruzi infection.Q44005882
Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1-infected subjects with progressive disease: changes after antiretroviral therapyQ45721932
Effects of sustained HIV-1 plasma viremia on HIV-1 Gag-specific CD4+ T cell maturation and function.Q51024682
Induction of CTLA-4-mediated anergy contributes to persistent colonization in the murine model of gastric Helicobacter pylori infectionQ56902208
TGF-beta mediates CTLA-4 suppression of cellular immunity in murine kalaazarQ56906232
Foxp3 programs the development and function of CD4+CD25+ regulatory T cellsQ27860714
TNF/TNFR family members in costimulation of T cell responsesQ28240053
The B7 family revisitedQ28240070
Enhancement of antitumor immunity by CTLA-4 blockadeQ28275730
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4Q28284177
Restoring function in exhausted CD8 T cells during chronic viral infectionQ28289222
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cellsQ29618394
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progressionQ29618956
Fully differentiated HIV-1 specific CD8+ T effector cells are more frequently detectable in controlled than in progressive HIV-1 infectionQ30830619
Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infectionQ33869806
CTLA-4 upregulation during HIV infection: association with anergy and possible target for therapeutic interventionQ34521402
Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunctionQ34570127
PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infectionQ34570624
Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infectionQ34571341
CTLA-4: new insights into its biological function and use in tumor immunotherapyQ34711491
Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patientsQ34959906
Suppression of HIV-specific T cell activity by lymph node CD25+ regulatory T cells from HIV-infected individualsQ35652583
Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunityQ35762422
Changes in paracrine interleukin-2 requirement, CCR7 expression, frequency, and cytokine secretion of human immunodeficiency virus-specific CD4+ T cells are a consequence of antigen loadQ35784804
CTLA-4 blockade decreases TGF-beta, IDO, and viral RNA expression in tissues of SIVmac251-infected macaquesQ35848881
HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS.Q35848896
Mechanisms of suppression by suppressor T cellsQ36078047
Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cellsQ36228688
CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cellsQ36366857
Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responsesQ36376333
CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease statusQ36399748
A molecular perspective of CTLA-4 functionQ36427322
Diminished Proliferation of Human Immunodeficiency Virus-Specific CD4+T Cells Is Associated with Diminished Interleukin-2 (IL-2) Production and Is Recovered by Exogenous IL-2Q36474240
New real-time reverse transcriptase-initiated PCR assay with single-copy sensitivity for human immunodeficiency virus type 1 RNA in plasmaQ36891848
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)1246-1254
P577publication date2007-09-30
P1433published inNature ImmunologyQ1071725
P1476titleUpregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction
P478volume8

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Q24634293Role of PD-1 in HIV pathogenesis and as target for therapy
Q34612821Role of the Fas/FasL pathway in HIV or SIV disease
Q45368686Role of the coinhibitory receptor cytotoxic T lymphocyte antigen-4 on apoptosis-Prone CD8 T cells in persistent hepatitis B virus infection
Q35871953Selective Loss of Early Differentiated, Highly Functional PD1high CD4 T Cells with HIV Progression
Q36937145Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade
Q37055402Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication
Q36269639Silymarin suppresses basal and stimulus-induced activation, exhaustion, differentiation, and inflammatory markers in primary human immune cells
Q36108518Single-Cell Characterization of Viral Translation-Competent Reservoirs in HIV-Infected Individuals
Q35587218Site-specific differences in T cell frequencies and phenotypes in the blood and gut of HIV-uninfected and ART-treated HIV+ adults
Q92404807Striking a Balance-Cellular and Molecular Drivers of Memory T Cell Development and Responses to Chronic Stimulation
Q38491191Success and failure of the cellular immune response against HIV-1.
Q27487939Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade
Q35842352Systemic inhibition of myeloid dendritic cells by circulating HLA class I molecules in HIV-1 infection
Q29620463T cell exhaustion
Q35582265T cell exhaustion during persistent viral infections
Q27022690T cell replicative senescence in human aging
Q39026157T-Cell Receptor (TCR) Clonotype-Specific Differences in Inhibitory Activity of HIV-1 Cytotoxic T-Cell Clones Is Not Mediated by TCR Alone.
Q35666026T-Cell Subsets Predict Mortality in Malnourished Zambian Adults Initiating Antiretroviral Therapy
Q92291598T-cell exhaustion in HIV infection
Q37139996T-cell exhaustion in HIV infection.
Q28083810T-cell exhaustion in chronic hepatitis B infection: current knowledge and clinical significance
Q34102010T-cell exhaustion: characteristics, causes and conversion
Q36513955TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection
Q33519047TGF-beta and IL-10 production by HIV-specific CD8+ T cells is regulated by CTLA-4 signaling on CD4+ T cells
Q56897131TIM-3, a Possible Target for Immunotherapy in Cancer and Chronic Viral Infections
Q26745923Targeting the latent reservoir to achieve functional HIV cure
Q50131761The Biology of Monocytes and Dendritic Cells: Contribution to HIV Pathogenesis
Q35728956The CTLA-4 and PD-1/PD-L1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology
Q47975503The Foxo and the hound: chasing the in vivo regulation of T cell populations during infection
Q97883485The Role of Immunomodulatory Receptors in the Pathogenesis of HIV Infection: A Therapeutic Opportunity for HIV Cure?
Q59806975The Roles of Coinhibitory Receptors in Pathogenesis of Human Retroviral Infections
Q45324456The Significance of Type-I Interferons in the Pathogenesis and Therapy of Human Immunodeficiency Virus 1 Infection
Q98504318The T cell differentiation landscape is shaped by tumour mutations in lung cancer
Q40481911The Vast Universe of T Cell Diversity: Subsets of Memory Cells and Their Differentiation.
Q37287296The diversity of costimulatory and inhibitory receptor pathways and the regulation of antiviral T cell responses.
Q92476068The forces driving clonal expansion of the HIV-1 latent reservoir
Q37027166The growth and potential of human antiviral monoclonal antibody therapeutics.
Q27002959The immunological synapse: the gateway to the HIV reservoir
Q38037339The impact of differential antiviral immunity in children and adults
Q52430553The latest evidence for possible HIV-1 curative strategies.
Q37451618The presence of programmed death 1 (PD-1)-positive tumor-infiltrating lymphocytes is associated with poor prognosis in human breast cancer.
Q36380567The role of IL-10 in regulating immunity to persistent viral infections
Q34629141The third signal cytokine IL-12 rescues the anti-viral function of exhausted HBV-specific CD8 T cells
Q36155524Therapeutic blockade of transforming growth factor beta fails to promote clearance of a persistent viral infection
Q36010933Thirty Years with HIV Infection-Nonprogression Is Still Puzzling: Lessons to Be Learned from Controllers and Long-Term Nonprogressors
Q36384423Tim-3-expressing CD4+ and CD8+ T cells in human tuberculosis (TB) exhibit polarized effector memory phenotypes and stronger anti-TB effector functions
Q33614649Tissue-specific differences in PD-1 and PD-L1 expression during chronic viral infection: implications for CD8 T-cell exhaustion
Q26797214Tryptophan Catabolism in Chronic Viral Infections: Handling Uninvited Guests
Q36065998Tuberculosis Therapy Modifies the Cytokine Profile, Maturation State, and Expression of Inhibitory Molecules on Mycobacterium tuberculosis-Specific CD4+ T-Cells
Q37426844Understanding B cell activation: from single molecule tracking, through Tolls, to stalking memory in malaria
Q34525050Unique human immune signature of Ebola virus disease in Guinea
Q35839496Update on hepatitis C virus-specific immunity
Q38223279Viral (hepatitis C virus, hepatitis B virus, HIV) persistence and immune homeostasis
Q36434375p38 Mitogen-activated protein kinase/signal transducer and activator of transcription-3 pathway signaling regulates expression of inhibitory molecules in T cells activated by HIV-1-exposed dendritic cells
Q33475710siRNA knockdown of PD-L1 and PD-L2 in monocyte-derived dendritic cells only modestly improves proliferative responses to Gag by CD8(+) T cells from HIV-1-infected individuals

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