The motivational valence of nicotine in the rat ventral tegmental area is switched from rewarding to aversive following blockade of the alpha7-subunit-containing nicotinic acetylcholine receptor

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The motivational valence of nicotine in the rat ventral tegmental area is switched from rewarding to aversive following blockade of the alpha7-subunit-containing nicotinic acetylcholine receptor is …
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scholarly articleQ13442814

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P356DOI10.1007/S00213-002-1317-6
P698PubMed publication ID12569428

P50authorDerek van der KooyQ5262492
P2093author name stringSteven R Laviolette
P2860cites workEvidence that nicotinic alpha(7) receptors are not involved in the hyperlocomotor and rewarding effects of nicotine.Q27863674
Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytesQ28301363
The role of nicotinic receptor beta-2 subunits in nicotine discrimination and conditioned taste aversionQ28511348
Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nucleiQ28564628
Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotineQ28589593
Nicotinic receptors in the brain: correlating physiology with functionQ33763401
GABA(A) receptors in the ventral tegmental area control bidirectional reward signalling between dopaminergic and non-dopaminergic neural motivational systemsQ33939402
Nicotine-induced enhancement of glutamatergic and GABAergic synaptic transmission in the mouse amygdala.Q38299405
Nicotine self-administration in animals and humans: similarities and differencesQ40902634
The nicotinic antagonist methyllycaconitine has differential effects on nicotine self-administration and nicotine withdrawal in the rat.Q43788914
Blockade of mesolimbic dopamine transmission dramatically increases sensitivity to the rewarding effects of nicotine in the ventral tegmental areaQ44295864
Response of nicotine self-administration in the rat to manipulations of mu-opioid and gamma-aminobutyric acid receptors in the ventral tegmental areaQ44331544
Aversion instead of preference learning indicated by nicotine place conditioning in ratsQ44918479
The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotineQ45122619
Two pharmacologically distinct components of nicotinic receptor-mediated rubidium efflux in mouse brain require the beta2 subunitQ48228603
Nicotine modifies the activity of ventral tegmental area dopaminergic neurons and hippocampal GABAergic neuronsQ48366302
N-methyl-D-aspartate receptor antagonism in the ventral tegmental area diminishes the systemic nicotine-induced dopamine release in the nucleus accumbensQ48522936
Deprivation state switches the neurobiological substrates mediating opiate reward in the ventral tegmental area.Q48823459
Methyl lycaconitine: A novel nicotinic antagonist.Q50792110
Mecamylamine blockade of both positive and negative effects of IV nicotine in human volunteers.Q51079328
Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area.Q51627333
Antagonism of the discriminative and aversive stimulus properties of nicotine in C57BL/6J mice.Q52583578
Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptorsQ71768164
Putative role of presynaptic alpha7* nicotinic receptors in nicotine stimulated increases of extracellular levels of glutamate and aspartate in the ventral tegmental areaQ73109938
A comparison of the effects of nicotine on dopamine and non-dopamine neurons in the rat ventral tegmental area: an in vitro electrophysiological studyQ73661239
P433issue3
P921main subjectnicotineQ12144
P304page(s)306-313
P577publication date2003-02-05
P1433published inPsychopharmacologyQ1422802
P1476titleThe motivational valence of nicotine in the rat ventral tegmental area is switched from rewarding to aversive following blockade of the alpha7-subunit-containing nicotinic acetylcholine receptor
P478volume166

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cites work (P2860)
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