The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function

scientific article

The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode1988Sci...241.1632M
P356DOI10.1126/SCIENCE.2971269
P698PubMed publication ID2971269

P2093author name stringWeissman IL
Lieberman M
Kaneshima H
Namikawa R
McCune JM
Shultz LD
P433issue4873
P407language of work or nameEnglishQ1860
P921main subjectmurine modelQ122890741
P1104number of pages8
P304page(s)1632-1639
P577publication date1988-09-01
P1433published inScienceQ192864
P1476titleThe SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function
P478volume241

Reverse relations

cites work (P2860)
Q352522153'-Azido-3'-deoxythymidine prevents induction of murine acquired immunodeficiency syndrome in C57BL/10 mice infected with LP-BM5 murine leukemia viruses, a possible animal model for antiretroviral drug screening
Q367900587 Development of Mouse Hematopoietic Lineages
Q42742542A SCID-hu in vivo model of human Waldenström macroglobulinemia
Q36601933A Simple Mouse Model for the Study of Human Immunodeficiency Virus
Q40437300A clinically relevant SCID-hu in vivo model of human multiple myeloma
Q61443625A framework for the ethical assessment of chimeric animal research involving human neural tissue
Q35556088A human monoclonal antibody which inhibits the coaggregation activity of Porphyromonas gingivalis.
Q45038124A humanized mouse model of anaphylactic peanut allergy.
Q37070130A metastatic nude-mouse model of human pancreatic cancer constructed orthotopically with histologically intact patient specimens
Q47399665A mightier mouse with human adaptive immunity
Q36969230A model for personalized in vivo analysis of human immune responsiveness
Q53630555A novel SCID mouse model for studying spontaneous metastasis of human lung cancer to human tissue.
Q28371858A novel peptide aldehyde with activity against human cytomegalovirus in two different in vivo models
Q92667638A pathogenic role of plasmacytoid dendritic cells in autoimmunity and chronic viral infection
Q52046893A promising model of primary human immunization in human-scid mouse.
Q45230747A rat monoclonal anti-(human CD2) and L-leucine methyl ester impacts on human/SCID mouse graft and B lymphoproliferative syndrome
Q33750950A recombinant bcl-x s adenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells
Q40113593Abnormal isoform of prion protein accumulates in follicular dendritic cells in mice with Creutzfeldt-Jakob disease
Q38353724Activation of the signal transducer and activator of transcription 1 signaling pathway in thymocytes from HIV-1-infected human thymus
Q67726985Acute humanvs. mouse graftvs. host disease in normal and immunodeficient mice
Q74462279Adoptive transfer of genetically modified human hematopoietic stem cells into preimmune canine fetuses
Q37512281Adoptive transfer of human lymphoid cells to severely immunodeficient mice: models for normal human immune function, autoimmunity, lymphomagenesis, and AIDS.
Q59126043Advanced model systems and tools for basic and translational human immunology
Q27008307Advancing animal models of human type 1 diabetes by engraftment of functional human tissues in immunodeficient mice
Q38831338Allograft Cancer Cell Transplantation in Zebrafish
Q79125739Alloimmune Injury and Rejection of Human Skin Grafts on Human Peripheral Blood Lymphocyte–Reconstituted Non-Obese Diabetic Severe Combined Immunodeficient β2-Microglobulin-Null Mice
Q33559066An albumin-conjugated peptide exhibits potent anti-HIV activity and long in vivo half-life
Q44006786An assay for long-term engrafting human hematopoietic cells based on newborn NOD/SCID/beta2-microglobulin(null) mice
Q37418688An improved model to study tumor cell autonomous metastasis programs using MTLn3 cells and the Rag2(-/-) gammac (-/-) mouse
Q43788979Analysis of autoantibody production in SCID-systemic lupus erythematosus (SLE) chimeras
Q26767476Animal Models for HIV Cure Research
Q26777022Animal and human mucosal tissue models to study HIV biomedical interventions: can we predict success?
Q33957283Animal model for the therapy of acquired immunodeficiency syndrome with reverse transcriptase inhibitors
Q34050742Animal models for AIDS pathogenesis
Q30423656Animal models for HIV/AIDS research
Q37844065Animal models for development of an AIDS vaccine
Q36066980Animal models of acute myelogenous leukaemia - development, application and future perspectives.
Q84251637Anti-CD47 antibodies promote phagocytosis and inhibit the growth of human myeloma cells
Q36364071Anti-SCID mouse reactivity shapes the human CD4+ T cell repertoire in hu-PBL-SCID chimeras
Q58648259Antibody-Conjugated Nanoparticles for Biomedical Applications
Q36528798Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model
Q52056534Antigen-specific human immunoglobulin production in SCID mice transplanted with human peripheral lymphocytes is dependent on CD4+ CD45RO+ T cells.
Q21144657Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice
Q35650970Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells.
Q33905476Antitumor effects of interleukin-7 and adoptive immunotherapy on human colon carcinoma xenografts
Q28343930Antiviral activity of 2'-deoxy-3'-oxa-4'-thiocytidine (BCH-10652) against lamivudine-resistant human immunodeficiency virus type 1 in SCID-hu Thy/Liv mice
Q40487963Antiviral therapy in human immunodeficiency virus infections. Current status (Part II).
Q92620214Application of Highly Immunocompromised Mice for the Establishment of Patient-Derived Xenograft (PDX) Models
Q35892241Application of xenogeneic stem cells for induction of transplantation tolerance: present state and future directions
Q34372087Are natural killer cells the key to treating Epstein-Barr virus-associated lymphoproliferative disorders?
Q53120483Assessment of human platelet survival in the NOD/SCID mouse model: technical considerations.
Q71997950Attenuation of lpr-graft-versus-host disease (GVHD) in MRL/lpr spleen cell-injected SCID mice by in vivo treatment with anti-V beta 8.1,2 monoclonal antibody
Q40560708Autoimmunity versus allo- and xeno-reactivity in SCID mice
Q37390234BLT-humanized C57BL/6 Rag2-/-γc-/-CD47-/- mice are resistant to GVHD and develop B- and T-cell immunity to HIV infection
Q36361653Bacterial superantigens mediate T cell deletions in the mouse severe combined immunodeficiency-human liver/thymus model
Q90594756Barriers for HIV Cure: The Latent Reservoir
Q91607012Benefits and limitations of humanized mice in HIV persistence studies
Q41905059Biological half-life of normal and truncated human IgG3 in scid mice
Q40078135Biological pathways and in vivo antitumor activity induced by Atiprimod in myeloma
Q30651272Bone marrow stem cell protection from chemotherapy by low--molecular-weight compounds
Q36948581Broad influenza-specific CD8+ T-cell responses in humanized mice vaccinated with influenza virus vaccines
Q39583317CCR5- and CXCR4-utilizing strains of human immunodeficiency virus type 1 exhibit differential tropism and pathogenesis in vivo.
Q53370464CD19-CD45 low/- CD38 high/CD138+ plasma cells enrich for human tumorigenic myeloma cells.
Q41047206CD34+Thy-1+Lin- stem cells from mobilized peripheral blood
Q40401338CD34-positive early stages of human T-cell differentiation
Q72686894CD4+ T cells from collagen-induced arthritic mice are essential to transfer arthritis into severe combined immunodeficient mice
Q35892412CXCR4 expression during lymphopoiesis: implications for human immunodeficiency virus type 1 infection of the thymus
Q38945956CXCR4 tropic human immunodeficiency virus type 1 induces an apoptotic cascade in immature infected thymocytes that resembles thymocyte negative selection
Q37195155Can humanized mice reflect the complex pathobiology of HIV-associated neurocognitive disorders?
Q37602302Cancer stem cells and the cellular hierarchy in haematological malignancies
Q37398584Cancer stem cells: relevance to SCT
Q33801683Chapter 12. Placental remodeling of the uterine vasculature
Q35598496Characterization of a thymus-tropic HIV-1 isolate from a rapid progressor: role of the envelope
Q35832063Characterization of hu-PBL-SCID mice with high human immunoglobulin serum levels and graft-versus-host disease
Q83133198Characterization of human B cells in umbilical cord blood-transplanted NOD/SCID mice
Q33736043Characterization of the human antiporcine immune response: a prerequisite to xenotransplantation
Q63363252Characterization of γ/δ T cell clones isolated from human fetal liverand thymus
Q38666256Chimeric antigen receptor T cells for the treatment of cancer and the future of preclinical models for predicting their toxicities.
Q84040857Co-transplantation of fetal bone tissue facilitates the development and reconstitution in human B cells in humanized NOD/SCID/IL-2Rγnull (NSG) mice
Q37055410Common themes in microbial pathogenicity
Q36194697Comparative animal models for the study of lymphohematopoietic tumors: strengths and limitations of present approaches
Q39971262Comparison of human fetal liver, umbilical cord blood, and adult blood hematopoietic stem cell engraftment in NOD-scid/gammac-/-, Balb/c-Rag1-/-gammac-/-, and C.B-17-scid/bg immunodeficient mice
Q46097971Comparison of strategies to detect and quantitate uniquely marked cells in intra- and inter-species hemopoietic chimeras
Q50788309Competitive repopulation assay of two gene-marked cord blood units in NOD/SCID/gammac(null) mice.
Q40656354Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/γcnull mice model
Q27022477Concise review: humanized models of tumor immunology in the 21st century: convergence of cancer research and tissue engineering
Q30664978Conserved and divergent aspects of human T-cell development and migration in humanized mice
Q36671440Cord blood stem and progenitor cells
Q45869865Cotransplantation of third-party mesenchymal stromal cells can alleviate single-donor predominance and increase engraftment from double cord transplantation
Q47606345Current Progress in EBV-Associated B-Cell Lymphomas
Q33577361Current advances in humanized mouse models
Q34474320Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis
Q36042986Current status review: the severe combined immunodeficient (SCID) mouse: xenogeneic-SCID chimeras in the investigation of human autoimmune disease
Q41013991Cytokine dependent growth of human TF-1 leukemic cell line in human GM-CSF and IL-3 producing transgenic SCID mice
Q36355613Cytomegalovirus impairs cytotrophoblast-induced lymphangiogenesis and vascular remodeling in an in vivo human placentation model
Q33854835Cytopathicity of human immunodeficiency virus type 1 primary isolates depends on coreceptor usage and not patient disease status
Q35039896Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation
Q41322386Deficiency in T cell responses of human fetal lymph node cells: a lack of accessory cells
Q38749141Defining the optimal murine models to investigate immune checkpoint blockers and their combination with other immunotherapies
Q34994838Detection of human hematopoietic stem cell engraftment in the livers of adult immunodeficient mice by an optimized flow cytometric method
Q38884521Development of Humanized Mice in the Age of Genome Editing.
Q60048505Development of Severe Combined Immunodeficient (SCID) Pig Models for Translational Cancer Modeling: Future Insights on How Humanized SCID Pigs Can Improve Preclinical Cancer Research
Q70527007Development of T cell receptor alpha beta-bearing T cells in the submersion organ culture of murine fetal thymus at high oxygen concentration
Q35159582Development of a vaccine for the prevention of AIDS, a critical appraisal
Q34931908Development of alphabeta T cells in the human thymus
Q24669724Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice
Q36016352Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rγKO mice
Q33908298Development of pemphigus vulgaris-like lesions in severe combined immunodeficiency disease mice reconstituted with lymphocytes from patients
Q52179231Differential effects of CD4+ and CD8+ cells on lymphocyte development from human cord blood cells in murine fetal thymus explants.
Q67993236Differential sensitivity of renal cell carcinoma xenografts towards therapy with interferon-alpha, interferon-gamma, tumor necrosis factor and their combinations
Q36361993Differentiation of CD3-4-8- human fetal thymocytes in vivo: characterization of a CD3-4+8- intermediate
Q48276056Distinct in vivo engraftment and growth patterns of t(1;19)+/E2A-PBX1+ and t(9;22)+/BCR-ABL+ human leukemia cells in SCID mice
Q39796195Diverse T-cell differentiation potentials of human fetal thymus, fetal liver, cord blood and adult bone marrow CD34 cells on lentiviral Delta-like-1-modified mouse stromal cells
Q36816122Ectopic lymphokine gene expression in human peripheral blood lymphocytes in vivo
Q40146856Effect of donor and recipient immunization protocols on primary and secondary human antibody responses in SCID mice reconstituted with human peripheral blood mononuclear cells
Q41493097Effectiveness of HB2 (anti-CD7)--saporin immunotoxin in an in vivo model of human T-cell leukaemia developed in severe combined immunodeficient mice
Q72097885Efficacy of an anti-CD5-ricin a chain immunoconjugate in an improved human peripheral blood lymphocyte-reconstituted severe combined immunodeficient mouse model
Q71617657Efficient production of IgG human monoclonal antibodies by lymphocytes stimulated by lipopolysaccharide, pokeweed mitogen, and interleukin 4
Q51167248End-stage organ failure: will regenerative medicine keep its promise?
Q30974719Engineering antigen-specific T cells from genetically modified human hematopoietic stem cells in immunodeficient mice
Q26745978Engineering approaches for regeneration of T lymphopoiesis
Q33844310Engineering humanized mice for improved hematopoietic reconstitution
Q34066833Engineering the human thymic microenvironment to support thymopoiesis in vivo
Q67898702Engraftment and Development of Human T and B Cells in Mice After Bone Marrow Transplantation
Q35600543Engraftment and long-term expression of human fetal hemopoietic stem cells in sheep following transplantation in utero
Q35891607Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2rγ null mice is enhanced by transgenic expression of membrane-bound human SCF.
Q40979773Engraftment of myasthenia gravis thymocytes into severe combined immunodeficiency (SCID) mice
Q37273984Enhanced Reconstitution of Human Erythropoiesis and Thrombopoiesis in an Immunodeficient Mouse Model with Kit(Wv) Mutations
Q54707671Enhancement of specific immunoglobulin production in SCID-hu-PBL mice after in vitro priming of human B cells with superantigen.
Q41704288Epstein-Barr virus (EBV)-associated lymphoproliferative disease in the SCID mouse model: implications for the pathogenesis of EBV-positive lymphomas in man
Q37147232Establishing humanized mice using stem cells: maximizing the potential
Q39783316Establishment and maintenance of HIV latency: model systems and opportunities for intervention
Q41736124Establishment of Theileria-infected bovine cell lines in scid mice
Q40706072Establishment of a primary effusion lymphoma cell line (RM-P1) and in vivo growth system using SCID mice
Q72412152Establishment of human IgE system in severe combined immunodeficient mice with peripheral blood mononuclear cells from asthmatic children
Q33581952Ethics of fetal tissue transplantation
Q41820518Evaluation of the tolerogenic effects of donor bone marrow cells using a severe combined immunodeficient mouse-human islet transplant model
Q27318356Ex vivo expanded human regulatory T cells delay islet allograft rejection via inhibiting islet-derived monocyte chemoattractant protein-1 production in CD34+ stem cells-reconstituted NOD-scid IL2rγnull mice
Q36708954Experimental approaches to the study of HIV-1 latency
Q54121855Experimental studies on immunosuppression: how do they predict for man?
Q36375588Experimental transmission of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) to SCID-hu Thy/Liv mice
Q24529578Expression and function of chemokine receptors on human thymocytes: implications for infection by human immunodeficiency virus type 1.
Q33911359Expression of HLA class II molecules in humanized NOD.Rag1KO.IL2RgcKO mice is critical for development and function of human T and B cells
Q33350230Failure of blood mononuclear cells from human donors with autoimmune haemolytic anaemia to reconstitute severe combined immunodeficient mice
Q33742501Feline immunodeficiency virus, a model for reverse transcriptase-targeted chemotherapy for acquired immune deficiency syndrome
Q37634024Fetal regulatory T cells and peripheral immune tolerance in utero: implications for development and disease
Q36915916FoxP3+CD4+ regulatory T cells play an important role in acute HIV-1 infection in humanized Rag2-/-gammaC-/- mice in vivo
Q38572329Foxp3 and Treg cells in HIV-1 infection and immuno-pathogenesis
Q26864024From Beta cell replacement to beta cell regeneration: implications for antidiabetic therapy
Q34527769Frontier of therapeutic antibody discovery: The challenges and how to face them
Q74180150Functional analysis of initial cell divisions defines the subsequent fate of individual human CD34(+)CD38(-) cells
Q39590030Functional reconstitution of thymopoiesis after human immunodeficiency virus infection.
Q74471526Furry flasks?
Q40497122Future prospects for animal models created by transplanting human haematopoietic cells into immune-deficient mice.
Q27022347Gene therapy strategies for HIV/AIDS: preclinical modeling in humanized mice
Q46361829Generation and use of a humanized bone-marrow-ossicle niche for hematopoietic xenotransplantation into mice
Q34023762Generation of Rat Pancreas in Mouse by Interspecific Blastocyst Injection of Pluripotent Stem Cells
Q39923037Generation of T lineage cells from human embryonic stem cells in a feeder free system
Q36357115Generation of biliary lesions after transfer of human lymphocytes into severe combined immunodeficient (SCID) mice
Q39997497Generation of human monoclonal antibodies recognising membranous antigens of the lung adenocarcinoma cell line A549 using an AMeX immunohistostaining method
Q34135605Generation of improved humanized mouse models for human infectious diseases
Q73308236Generation of primary antigen-specific human T- and B-cell responses in immunocompetent SCID-hu mice
Q36437963Giant cell vasculitis is a T cell-dependent disease
Q37969755Granuloma transplantation: an approach to study mycobacterium-host interactions
Q41689649Growth factors and hematopoietic stem cells
Q41647307Growth of MCF-7 human breast carcinoma in severe combined immunodeficient mice: growth suppression by recombinant interleukin-2 treatment and role of lymphokine-activated killer cells
Q72110976Growth of Primary Human Acute Lymphoblastic and Myeloblastic Leukemia in SCID Mice
Q58990568HIV and Kaposi's sarcoma in mice
Q45305157HIV induces thymus depletion in vivo
Q40321405HIV latency in the humanized BLT mouse
Q38270498HIV latency is influenced by regions of the viral genome outside of the long terminal repeats and regulatory genes
Q37676228HIV-1 immunopathogenesis in humanized mouse models
Q38905274HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-gamma c-/- (RAG-hu) mouse model
Q35750948HIV-1 infection and pathogenesis in a novel humanized mouse model
Q33682963HIV-1 pathogenesis and therapeutic intervention in the SCID-hu Thy/Liv mouse: a model for primary HIV-1 infection in the human thymus
Q35716711HIV-1 replication and pathogenesis in the human thymus
Q34875979HIV-1 replication cycle
Q46062714HIV-1-induced thymocyte depletion is associated with indirect cytopathicity and infection of progenitor cells in vivo
Q37254475HIV-specific CD8⁺ T-cell immunity in humanized bone marrow-liver-thymus mice
Q39014236HTLV-I hu-SCID mouse in the study of HTLV-I neurotropism
Q35161714Harnessing the immune system's arsenal: producing human monoclonal antibodies for therapeutics and investigating immune responses
Q35831685Hemagglutination and graft-versus-host disease in the severe combined immunodeficiency mouse lymphoproliferative disease model
Q40841674Hematology Testing in Mice
Q40907374Hematopoietic Growth Factors and Blast Progenitors in Acute Leukemia
Q36637556Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes
Q29396498Hematopoietic stem cell: self-renewal versus differentiation
Q34293470Hematopoietic stem cells can be CD34+ or CD34-.
Q27023434Hematopoietic-stem-cell-based gene therapy for HIV disease
Q55334102High human IgG levels in severe combined immunodeficient mouse reconstituted with human splenic tissues from patients with gastric cancer
Q35898011High viral burden and rapid CD4+ cell depletion in human immunodeficiency virus type 1-infected SCID-hu mice suggest direct viral killing of thymocytes in vivo
Q38808207High-Throughput Humanized Mouse Models for Evaluation of HIV-1 Therapeutics and Pathogenesis.
Q35877342High-efficiency transduction of human lymphoid progenitor cells and expression in differentiated T cells
Q34914050Homeostatic expansion and phenotypic conversion of human T cells depend on peripheral interactions with APCs
Q33681388Human Cytomegalovirus Induces Cellular and Humoral Virus-specific Immune Responses in Humanized BLT Mice
Q36365868Human Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes home preferentially to and induce selective regressions of autologous EBV-induced B cell lymphoproliferations in xenografted C.B-17 scid/scid mice
Q71639865Human RANTES induces the migration of human T lymphocytes into the peripheral tissues of mice with severe combined immune deficiency
Q72344503Human T cells in hu-PBL-SCID mice proliferate in response to Daudi lymphoma and confer anti-tumour immunity
Q39003768Human T-cell leukemia virus infection of human hematopoietic progenitor cells: maintenance of virus infection during differentiation in vitro and in vivo
Q40698897Human T-cell lineage development in foetal thymus-engrafted SCID mice
Q36164542Human adaptive immune system Rag2-/-gamma(c)-/- mice
Q33577374Human allograft rejection in humanized mice: a historical perspective
Q35647543Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age.
Q40977104Human cytomegalovirus genes in the 15-kilobase region are required for viral replication in implanted human tissues in SCID mice
Q36030112Human cytomegalovirus in a SCID-hu mouse: thymic epithelial cells are prominent targets of viral replication
Q45190392Human cytomegalovirus infection leads to elevated levels of transplant arteriosclerosis in a humanized mouse aortic xenograft model
Q73379512Human fetal liver cells induce colonies in spleen of lethally irradiated mice
Q37012122Human growth hormone promotes engraftment of murine or human T cells in severe combined immunodeficient mice
Q38662832Human haematopoietic stem cell development: from the embryo to the dish
Q33995307Human hemato-lymphoid system mice: current use and future potential for medicine
Q41823203Human hematopoietic cells and thymic epithelial cells induce tolerance via different mechanisms in the SCID-hu mouse thymus
Q34941696Human hematopoietic lineage commitment
Q36351925Human hematopoietic precursors in long-term culture: single CD34+ cells that lack detectable T cell, B cell, and myeloid cell antigens produce multiple colony-forming cells when cultured with marrow stromal cells
Q42254467Human immune system development and survival of non-obese diabetic (NOD)-scid IL2rγ(null) (NSG) mice engrafted with human thymus and autologous haematopoietic stem cells
Q36688402Human immunodeficiency virus (HIV)-infected tumor xenografts as an in vivo model for antiviral therapy: role of alpha/beta interferon in restriction of tumor growth in nude mice injected with HIV-infected U937 tumor cells
Q36773289Human immunodeficiency virus bearing a disrupted central DNA flap is pathogenic in vivo
Q41096686Human immunodeficiency virus infection of human cells transplanted to severe combined immunodeficient mice.
Q37517923Human immunodeficiency virus infection of human lymph nodes in the SCID-hu mouse
Q36362448Human immunodeficiency virus infection of the human thymus and disruption of the thymic microenvironment in the SCID-hu mouse
Q33784571Human immunodeficiency virus inhibits multilineage hematopoiesis in vivo
Q33854319Human immunodeficiency virus type 1 IIIB selected for replication in vivo exhibits increased envelope glycoproteins in virions without alteration in coreceptor usage: separation of in vivo replication from macrophage tropism
Q37047050Human immunodeficiency virus type 1 infection of neural xenografts
Q30305454Human immunodeficiency virus type 1 pathogenesis in SCID-hu mice correlates with syncytium-inducing phenotype and viral replication
Q33816889Human immunodeficiency virus type 1 strains R5 and X4 induce different pathogenic effects in hu-PBL-SCID mice, depending on the state of activation/differentiation of human target cells at the time of primary infection.
Q33822674Human immunodeficiency virus type 1-induced hematopoietic inhibition is independent of productive infection of progenitor cells in vivo
Q43929735Human immunoglobulin production in immunodeficient mice: enhancement by immunosuppression of host and in vitro activation of human mononuclear cells
Q43233892Human interleukin-15 improves engraftment of human T cells in NOD-SCID mice
Q37299847Human intrathymic development: a selective approach.
Q33786418Human lymphoblastoid CD4(+) T cells become permissive to macrophage-tropic strains of human immunodeficiency virus type 1 after passage into severe combined immunodeficient mice through in vivo upregulation of CCR5: in vivo dynamics of CD4(+) [...]
Q37981545Human lymphohematopoietic reconstitution and immune function in immunodeficient mice receiving cotransplantation of human thymic tissue and CD34(+) cells
Q36230932Human mature T cells that are anergic in vivo prevail in SCID mice reconstituted with human peripheral blood
Q35446761Human natural regulatory T cell development, suppressive function, and postthymic maturation in a humanized mouse model
Q57599053Human peripheral blood leukocytes transplanted on CB17 scid-scid mice are transferred to their offspring
Q73438385Human renal allograft rejection in the SCID/rat radiation chimera
Q41831183Human skin cells support thymus-independent T cell development
Q34572945Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo
Q34159789Human villous adenomas engrafted into scid mice survive for prolonged period without malignant transformation
Q45126833Human-mouse lymphoid chimeras: host-vs.-graft and graft-vs.-host reactions
Q52932628Humanised mouse models in drug discovery for skin inflammation.
Q89755936Humanization of Immunodeficient Animals for the Modeling of Transplantation, Graft Versus Host Disease and Regenerative Medicine
Q92327815Humanized Mice as an Effective Evaluation System for Peptide Vaccines and Immune Checkpoint Inhibitors
Q92881586Humanized Mice for Live-Attenuated Vaccine Research: From Unmet Potential to New Promises
Q40211555Humanized Mice with Subcutaneous Human Solid Tumors for Immune Response Analysis of Vaccinia Virus-Mediated Oncolysis
Q96690458Humanized Mouse Models for Evaluation of PSC Immunogenicity
Q39459609Humanized Mouse Models for Human Immunodeficiency Virus Infection.
Q38640208Humanized Mouse Models for Transplant Immunology
Q64228779Humanized Mouse Models of Rheumatoid Arthritis for Studies on Immunopathogenesis and Preclinical Testing of Cell-Based Therapies
Q53568179Humanized NOD/LtSz-scid IL2 receptor common gamma chain knockout mice in diabetes research.
Q33939330Humanized Rag1-/- γc-/- mice support multilineage hematopoiesis and are susceptible to HIV-1 infection via systemic and vaginal routes
Q36756422Humanized Rag2(-/-)gammac(-/-) (RAG-hu) mice can sustain long-term chronic HIV-1 infection lasting more than a year
Q26771440Humanized hemato-lymphoid system mice
Q92503390Humanized immune system mouse models: progress, challenges and opportunities
Q38838864Humanized mice for HIV and AIDS research
Q35027512Humanized mice for studying human leukocyte integrins in vivo
Q37179146Humanized mice for the study of infectious diseases
Q37049736Humanized mice for the study of type 1 diabetes and beta cell function
Q34607151Humanized mice in translational biomedical research
Q53592113Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1.
Q28728527Humanized mice recapitulate key features of HIV-1 infection: a novel concept using long-acting anti-retroviral drugs for treating HIV-1
Q39329450Humanized mice: A brief overview on their diverse applications in biomedical research.
Q26996648Humanized mice: novel model for studying mechanisms of human immune-based therapies
Q38196608Humanized mouse models in transplantation research
Q37089865Humanized mouse models of HIV infection
Q34533579Humanized mouse models of epstein-barr virus infection and associated diseases
Q36142747Humanized mouse models of human cytomegalovirus infection
Q92153241Humanized mouse models reveal an immunologic classification of idiopathic CD4 lymphocytopenia subtypes
Q33941638Humanized mouse models to study human diseases
Q37019267Humoral Immunity in scid Mice Reconstituted with Cells from Immunoglobulin-Deficient or Normal Humans
Q37254488Humoral immunity in humanized mice: a work in progress
Q36972070IL-2 receptor γ-chain molecule is critical for intestinal T-cell reconstitution in humanized mice
Q36690000Identification of T cell-signaling pathways that stimulate latent HIV in primary cells
Q24656265Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood
Q21559618Identification of an astrovirus commonly infecting laboratory mice in the US and Japan
Q37289792Identification of newly isolated Babesia parasites from cattle in Korea by using the Bo-RBC-SCID mice
Q34308700Immature human thymocytes can be driven to differentiate into nonlymphoid lineages by cytokines from thymic epithelial cells
Q41180599Immune deficiency in SCID mice
Q48556537Immune privilege and immunogenicity reside among different layers of the mouse cornea. 2000.
Q36553607Immune-Deficient Mice as Models for Human Hematopoietic Disease
Q33274792Immunization of hu-PBL–SCID mice and the rescue of human monoclonal Fab fragments through combinatorial libraries
Q35846092Immunodeficient mice as hosts for hemoparasitic infections
Q37600286Immunodeficient mice xenografted with human lymphoid cells: new models for in vivo studies of human immunobiology and infectious diseases
Q35765555Immunodeficient mouse model for human hematopoietic stem cell engraftment and immune system development
Q43639080Immunoglobulin production in severe combined immunodeficient (SCID) mice reconstituted with human peripheral blood mononuclear cells.
Q33814477Immunohistochemical analysis, human papillomavirus DNA detection, hormonal manipulation, and exogenous gene expression of normal and dysplastic human cervical epithelium in severe combined immunodeficiency mice.
Q38675619Immunologic and pharmacologic concepts of monoclonal antibodies.
Q41505435Immunotoxin studies in a model of human T-cell acute lymphoblastic leukemia developed in severe combined immune-deficient mice
Q35426801Impaired human responses to tetanus toxoid in vitamin A-deficient SCID mice reconstituted with human peripheral blood lymphocytes
Q36397429Impaired surfactant production by alveolar epithelial cells in a SCID-hu lung mouse model of congenital human cytomegalovirus infection
Q36365582Improved engraftment of human hematopoietic cells in severe combined immunodeficient (SCID) mice carrying human cytokine transgenes
Q35795065Improved engraftment of human spleen cells in NOD/LtSz-scid/scid mice as compared with C.B-17-scid/scid mice.
Q36601983Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary
Q39315707In Vivo Models of Human Immunodeficiency Virus Persistence and Cure Strategies
Q44001900In vitro preactivated human T cells engraft in SCID mice and migrate to murine lymphoid tissues
Q41932886In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication.
Q46069567In vivo evaluation of human hematopoiesis through xenotransplantation of purified hematopoietic stem cells from umbilical cord blood
Q35270138In vivo models of human lymphopoiesis and autoimmunity in severe combined immune deficient mice
Q39100446In vivo pathogenesis of a human immunodeficiency virus type 1 reporter virus
Q39872035In vivo pathogenic properties of two clonal human immunodeficiency virus type 1 isolates.
Q36515119In vivo platforms for analysis of HIV persistence and eradication
Q37340763In vivo treatment of human leukemia in a scid mouse model with c-myb antisense oligodeoxynucleotides
Q35619845Induction of MHC class I expression on immature thymocytes in HIV-1-infected SCID-hu Thy/Liv mice: evidence of indirect mechanisms.
Q43598504Induction of experimental systemic lupus erythematosus (SLE) in mice with severe combined immunodeficiency (SCID)
Q41404314Induction of primary antigen-specific immune reponses in SCID-hu-PBL by coupled T-B epitopes
Q37247943Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice
Q40736018Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function
Q45970875Infection by porcine endogenous retrovirus after islet xenotransplantation in SCID mice.
Q35394786Infection of SCID mice with Mycobacterium leprae and control with antigen-activated "immune" human peripheral blood mononuclear cells
Q35100976Infection of human cytomegalovirus in cultured human gingival tissue
Q35788681Inflammation, immune reactivity, and angiogenesis in a severe combined immunodeficiency model of rheumatoid arthritis
Q39134077Influence of human myasthenia gravis thymus on the differentiation of human cord blood stem cells in SCID mice
Q31115718Inhibition of Tat-mediated transactivation and HIV-1 replication by human anti-hCyclinT1 intrabodies
Q28368330Inhibition of human immunodeficiency virus type 1 infection in SCID-hu Thy/Liv mice by the G-quartet-forming oligonucleotide, ISIS 5320
Q36229284Intrarectal transmission, systemic infection, and CD4+ T cell depletion in humanized mice infected with HIV-1
Q74261294Islet xenograft destruction in the hu-PBL-severe combined immunodeficient (SCID) mouse necessitates anti-CD3 preactivation of human immune cells
Q36922569Isolation of a candidate human hematopoietic stem-cell population
Q42541770Kidney transplant revisited (1990)
Q38263295Latest animal models for anti-HIV drug discovery
Q27322228Lentiviral vector delivery of human interleukin-7 (hIL-7) to human immune system (HIS) mice expands T lymphocyte populations
Q53302987Leukaemia stem cells and the evolution of cancer-stem-cell research.
Q73397027Limitation of Hu-PBL-scid mouse model in direct application to immunotoxicity assessment
Q34237806Limited B cell repertoire in severe combined immunodeficient mice engrafted with peripheral blood mononuclear cells derived from immunodeficient or normal humans
Q35981519Limited role for the thymus in SIV pathogenesis
Q73043963Long term substitution and specific immune responses after transfer of bovine peripheral blood lymphocytes into severe combined immunodeficient mice
Q42092076Long-term human hematopoiesis in the SCID-hu mouse
Q34131709Long-term repopulating ability of xenogeneic transplanted human fetal liver hematopoietic stem cells in sheep
Q92366030Long-term survival and differentiation of human thymocytes in human thymus-grafted immunodeficient mice
Q44245848Long-term survival of human spermatogonial stem cells in mouse testes
Q35494359Low-dose interleukin 2 prevents the development of Epstein-Barr virus (EBV)-associated lymphoproliferative disease in scid/scid mice reconstituted i.p. with EBV-seropositive human peripheral blood lymphocytes
Q73415909Lupus manifestations in severe combined immunodeficient (SCID) mice and in human/mouse radiation chimeras
Q42768290Lymphoid reconstitution of the human fetal thymus in SCID mice with CD34+ precursor cells
Q36232070Lymphoproliferative disease in human peripheral blood mononuclear cell-injected SCID mice. I. T lymphocyte requirement for B cell tumor generation
Q36436908Lymphotropic Viruses as Etiologic Agents of Lymphoma
Q67599021MRL/lpr-->severe combined immunodeficiency mouse allografts produce autoantibodies, acute graft-versus-host disease or a wasting syndrome depending on the source of cells
Q35585979Macrophages prevent human red blood cell reconstitution in immunodeficient mice
Q37624015Man-made antibodies
Q38167666Manipulation of hematopoietic stem cells for regenerative medicine
Q33793274Marking and gene expression by a lentivirus vector in transplanted human and nonhuman primate CD34(+) cells
Q72769524Mature helper T cell requirement for immunoglobulin production by neonatal native B cells injected intraperitoneally into severe combined immunodeficient (SCID) mice
Q39874671Measles virus infection of thymic epithelium in the SCID-hu mouse leads to thymocyte apoptosis.
Q35889286Mechanism of human immunodeficiency virus type 1 localization in CD4-negative thymocytes: differentiation from a CD4-positive precursor allows productive infection
Q37853939Mechanisms controlling hematopoietic stem cell functions during normal hematopoiesis and hematological malignancies
Q35891603Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation
Q37126312Mice engrafted with human fetal thymic tissue and hematopoietic stem cells develop pathology resembling chronic graft-versus-host disease.
Q36299357Mice in the world of stem cell biology
Q34730602Mice transgenic for CD4-specific human CD4, CCR5 and cyclin T1 expression: a new model for investigating HIV-1 transmission and treatment efficacy
Q21146658Mice transgenic for equine cyclin T1 and ELR1 are susceptible to equine infectious anemia virus infection
Q34920166Mice with human immune system components as in vivo models for infections with human pathogens
Q92511043Modeling Varicella Zoster Virus Persistence and Reactivation - Closer to Resolving a Perplexing Persistent State
Q40497129Modeling human retroviral pathogenesis and antiretroviral gene therapy in the SCID mouse
Q38164593Modeling normal and malignant human hematopoiesis in vivo through newborn NSG xenotransplantation
Q49914671Modeling the human bone marrow niche in mice: From host bone marrow engraftment to bioengineering approaches
Q34263657Molecular Characterization, Reactivation, and Depletion of Latent HIV
Q39820667Molecular biology and pathogenesis of animal lentivirus infections.
Q35173841Molecular biology of hematopoietic stem cells
Q24313183Molecular cloning and characterization of WP34, a phosphorylated human lymphocyte differentiation and activation antigen
Q37755851Monoclonal antibodies in diagnosis and therapy
Q38798188Mouse Models for Assessing Protein Immunogenicity: Lessons and Challenges
Q38016511Mouse models as a translational platform for the development of new therapeutic agents in multiple myeloma
Q38937610Mouse models for pre-clinical drug testing in leukemia
Q37737987Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease
Q34590684Mouse models with human immunity and their application in biomedical research
Q59478476Multiple genetically engineered humanized microenvironments in a single mouse
Q38795321Murine Models of Epstein-Barr Virus-Associated Lymphomagenesis
Q37077665Murine models for HIV vaccination and challenge.
Q40946526Myelin basic protein-specific T lymphocytes induce chronic relapsing experimental autoimmune encephalomyelitis in lymphocyte-deficient (SCID) mice
Q73086701NOD/SCID mice transplanted with marrow from patients with myelodysplastic syndrome (MDS) show long-term propagation of normal but not clonal human precursors
Q36622723Neoplastic stem cells: a novel therapeutic target in clinical oncology
Q38004015New approaches to expand hematopoietic stem and progenitor cells
Q37337138No irradiation required: The future of humanized immune system modeling in murine hosts
Q37034635Nonprimate models of HIV-1 infection and pathogenesis
Q89965644Novel Engraftment and T Cell Differentiation of Human Hematopoietic Cells in ART -/- IL2RG -/Y SCID Pigs
Q58987031Novel HIV systems
Q37084504Novel humanized murine models for HIV research
Q43496456Obtention of a human primary humoral response against schistosome protective antigens in severe combined immunodeficiency mice after the transfer of human peripheral blood mononuclear cells
Q36931065Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine
Q35749938Origins of mammalian hematopoiesis: in vivo paradigms and in vitro models
Q37254483Overcoming current limitations in humanized mouse research
Q35035610PD-1 blockade in chronically HIV-1-infected humanized mice suppresses viral loads
Q33863465Paradigm shifts in stem-cell biology
Q33492216Paradoxical enhancement of tumor growth in mice with severe combined immunodeficiency which produce a human immunoglobulin G reactive against tumor cells
Q33716675Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation.
Q30305455Pathogenesis of primary R5 human immunodeficiency virus type 1 clones in SCID-hu mice
Q80031735Perforin-independent rejection of transplanted human stem cells
Q73550868Perinatal induction of immunotolerance to cardiac and pulmonary allografts
Q45874365Peritoneal sanctuary for human lymphopoiesis in SCID mice injected with human peripheral blood lymphocytes from Epstein-Barr virus-negative donors
Q40064566Persistent infection of normal mice with human immunodeficiency virus
Q102144611Pharmacological Activation of Non-canonical NF-κB Signaling Activates Latent HIV-1 Reservoirs In Vivo
Q53495266Phenotypic and Functional Studies of Human Peripheral Blood Lymphocytes Engrafted in scid Mice
Q38502873Positive regulatory gamma delta T cells in contact sensitivity: augmented responses by in vivo treatment with anti-gamma delta monoclonal antibody, or anti-V gamma 5 or V delta 4.
Q35128255Potent activity of 2'-beta-fluoro-2',3'-dideoxyadenosine against human immunodeficiency virus type 1 infection in hu-PBL-SCID mice.
Q35605784Potential of embryonic and adult stem cells in vitro.
Q36890224Potential of the scid mouse as a host for human tumors
Q37019281Preclinical Evaluation of Human Hematolymphoid Function in the SCID-hu Mouse
Q39339749Primary HIV-1 infection of human CD4+ T cells passaged into SCID mice leads to selection of chronically infected cells through a massive fas-mediated autocrine suicide of uninfected cells
Q54127314Primary blasts from infants with acute lymphoblastic leukemia cause overt leukemia in SCID mice.
Q39878783Primary human immunodeficiency virus type 1 viremia and central nervous system invasion in a novel hu-PBL-immunodeficient mouse strain
Q41756541Production of a diverse repertoire of human antibodies in genetically engineered mice
Q41610889Production of human immunoglobulin G reactive against human cancer in tumor-bearing mice with severe combined immunodeficiency reconstituted with human splenic tissues
Q32103173Production of human monoclonal antibodies in SCID mouse
Q44563926Prognostic significance of T-lineage leukemic cell growth in SCID mice: a Children's Cancer Group study
Q38409791Propagating Humanized BLT Mice for the Study of Human Immunology and Immunotherapy
Q33795512Protective immune responses induced by secretion of a chimeric soluble protein from a recombinant Mycobacterium bovis bacillus Calmette-Guérin vector candidate vaccine for human immunodeficiency virus type 1 in small animals
Q30448634R5 human immunodeficiency virus type 1 infection of fetal thymic organ culture induces cytokine and CCR5 expression
Q33650466R5 strains of human immunodeficiency virus type 1 from rapid progressors lacking X4 strains do not possess X4-type pathogenicity in human thymus.
Q28592133RAG-1-deficient mice have no mature B and T lymphocytes
Q84068289Rag2-/- gamma-chain-/- mice as hosts for human vessel transplantation and allogeneic human leukocyte reconstitution
Q34975395Rapid Tumor Formation of Human T-Cell Leukemia Virus Type 1-Infected Cell Lines in Novel NOD-SCID/γcnullMice: Suppression by an Inhibitor against NF-κB
Q40329064Rapid expression of human immunodeficiency virus following activation of latently infected cells
Q54936296Rapid growth and spontaneous metastasis of human germinal tumors ectopically transplanted into scid (severe combined immunodeficiency) and scid-nudestreaker mice.
Q40043073Rapid-high, syncytium-inducing isolates of human immunodeficiency virus type 1 induce cytopathicity in the human thymus of the SCID-hu mouse.
Q35025116Rats produced by interspecies spermatogonial transplantation in mice and in vitro microinsemination.
Q51410352Rebooting Human Immunology.
Q34195247Recapitulation of normal and abnormal BB rat immune system development in scid mouse/rat lymphohemopoietic chimeras
Q92543466Recent Advances in Allergy Research Using Humanized Mice
Q37254480Recent advances in humanized mice: accelerating the development of an HIV vaccine
Q36375811Recent advances in the growth and isolation of primitive human haemopoietic progenitor cells
Q55343646Receptor-targeted aptamer-siRNA conjugate-directed transcriptional regulation of HIV-1.
Q58178129Reconstitution of Immunological Imbalance in SCID Mice Given Tonsillar Mononuclear Cells from Patients with IgA Nephropathy
Q38498361Reconstitution of human lymphocytes following ex vivo expansion of human umbilical cord blood CD34+ cells and transplantation in Rag2-/- gamma c-/- mice model.
Q39595155Reconstitution of human thymic implants is limited by human immunodeficiency virus breakthrough during antiretroviral therapy
Q28488527Rectal transmission of transmitted/founder HIV-1 is efficiently prevented by topical 1% tenofovir in BLT humanized mice
Q45885467Reduced tumorigenicity of human gastric carcinoma cells engineered to produce IL-2 in SCID mice reconstituted with peripheral blood cells from cancer patients
Q30176097Regions of human immunodeficiency virus type 1 nef required for function in vivo
Q44378836Regulation of Maternal–Fetal Virus Transmission in Immunologically Reconstituted SCID Mice Infected with Lactate Dehydrogenase-Elevating Virus
Q37600607Renaissance for mouse models of human hematopoiesis and immunobiology
Q35856279Replication and pathogenicity of human immunodeficiency virus type 1 accessory gene mutants in SCID-hu mice
Q36633938Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity
Q36175538Resistance to human immunodeficiency virus 1 infection of SCID mice reconstituted with peripheral blood leukocytes from donors vaccinated with vaccinia gp160 and recombinant gp160.
Q54272403Responses to larval Taenia taeniaeformis in mice with severe combined immunodeficiency (scid).
Q31909374Retroviral marking of human bone marrow fibroblasts: in vitro expansion and localization in calvarial sites after subcutaneous transplantation in vivo
Q35604723Retroviral-mediated transfer of the human glucocerebrosidase gene into cultured Gaucher bone marrow
Q45866942RevM10-Mediated Inhibition of HIV-1 Replication in Chronically Infected T Cells
Q39879985RevM10-expressing T cells derived in vivo from transduced human hematopoietic stem-progenitor cells inhibit human immunodeficiency virus replication
Q39820681SCID mice and the study of parasitic disease
Q35646248SCID mice in the study of human autoimmune diseases
Q73584258SCID mouse models: more than furry flasks
Q36951729SCID-Hu mice immunized with a pneumococcal vaccine produce specific human antibodies and show increased resistance to infection
Q33851415Separation of human immunodeficiency virus type 1 replication from nef-mediated pathogenesis in the human thymus
Q24669589Sequence-based identification of microbial pathogens: a reconsideration of Koch's postulates
Q36651958Serological, biological, and molecular characterization of New Zealand white rabbits infected by intraperitoneal inoculation with cell-free human immunodeficiency virus
Q34255262Severe combined immunodeficiency mouse-human skin chimeras: a unique animal model for the study of psoriasis and cutaneous inflammation
Q40129737Simultaneous detection of multiple pathogens by multiplex PCR coupled with DNA biochip hybridization
Q34356549Species-specific metastasis of human tumor cells in the severe combined immunodeficiency mouse engrafted with human tissue
Q84696524Specific human IgE response after immunization with birch pollen in scid mice transplanted with human peripheral blood mononuclear cells—A model for human allergy?
Q47683086Specificity of Hematopoietic Stem and Progenitor Cell Homing to Bone Marrow: A Perspective
Q35811283Spontaneous Pneumocystis carinii pneumonia in immunodeficient mutant scid mice. Natural history and pathobiology
Q34344216Stem cell gene transfer--efficacy and safety in large animal studies.
Q36362598Stem cell research: future implications for internal medicine
Q41689634Stem cells in chronic myelogenous leukemia
Q34565274Stem cells in regenerative biology and medicine
Q40438232Stem cells, clonal progenitors, and commitment to the three lymphocyte linages: T, B, and NK Cells
Q26849806Studies of retroviral infection in humanized mice
Q42338715Studying human immunology and immunopathology in humanized mice transplanted with human lymphoid tissues and immune cells
Q36229754Successful engraftment of human postnatal thymus in severe combined immune deficient (SCID) mice: differential engraftment of thymic components with irradiation versus anti-asialo GM-1 immunosuppressive regimens
Q41632290Successful graft of HTLV-I-transformed human T-cells (MT-2) in severe combined immunodeficiency mice treated with anti-asialo GM-1 antibody
Q40654989Successful multilineage engraftment of human cord blood cells in pigs after in utero transplantation
Q36511820Summary of presentations at the NIH/NIAID New Humanized Rodent Models 2007 Workshop
Q77212598Surgical technique for vascularized thymus transplantation in mice
Q41670554Syncytium Formation in Cultured Human Lymphoid Tissue: Fusion of Implanted HIV Glycoprotein 120/41-Expressing Cells with Native CD4+Cells
Q72873376Synergetic effect of interleukin-2 and cellular cytotoxicity against a novel tumor-associated carbohydrate antigen Le(a)/Le(a) (dimeric Le(a)) mediated by monoclonal antibody NCC-ST-421 in adoptive immunization using SCID mice
Q35830294Syphilis superinfection activates expression of human immunodeficiency virus I in latently infected rabbits
Q28472590Systemic administration of antiretrovirals prior to exposure prevents rectal and intravenous HIV-1 transmission in humanized BLT mice
Q92008485T Lymphocyte Development and Activation in Humanized Mouse Model
Q45789448T cells or active Epstein-Barr virus infection in the development of lymphoproliferative disease in human B cell-injected severe combined immunodeficient mice
Q34984536T lineage differentiation from human embryonic stem cells
Q36361803T lymphocyte differentiation in vitro from adult human prethymic CD34+ bone marrow cells
Q35872456T-cell dysfunctions in hu-PBL-SCID mice infected with human immunodeficiency virus (HIV) shortly after reconstitution: in vivo effects of HIV on highly activated human immune cells.
Q37867570T-cell receptor and autoimmune disease
Q37567989Targeting c-Mpl for revival of human immunodeficiency virus type 1-induced hematopoietic inhibition when CD34+ progenitor cells are re-engrafted into a fresh stromal microenvironment in vivo
Q77977537The CD4 Loss in AIDS Patients is not Immunopathologically Mediated
Q33650192The E. Donnall Thomas lecture: normal and neoplastic stem cells
Q35112331The NOD/SCID chimeric mouse model of human B cell development: studies on the VH4 family immunoglobulin repertoire and implications for SLE
Q46121365The Response to Burn Injury in Mice With Human Hematolymphoid Systems
Q40788237The SCID mouse: relevance as an animal model system for studying human disease.
Q41546977The SCID-hu mouse as a model for HIV-1 infection
Q41521953The SCID-hu mouse: an in vivo model for HIV-1 infection in humans
Q47888689The Trimera mouse: generating human monoclonal antibodies and an animal model for human diseases
Q55078034The Use of the Humanized Mouse Model in Gene Therapy and Immunotherapy for HIV and Cancer.
Q36361449The concurrent maturation of mouse and human thymocytes in human fetal thymus implanted in NIH-beige-nude-xid mice is associated with the reconstitution of the murine immune system
Q34012447The development of the immune system during pregnancy and early life
Q34134909The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche.
Q39036388The envelope gp120 gene of human immunodeficiency virus type 1 determines the rate of CD4-positive T-cell depletion in SCID mice engrafted with human peripheral blood leukocytes
Q34926717The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and NOD/SCID/B2m(null) mice
Q44582551The fate of human peripheral blood lymphocytes after transplantation into SCID mice
Q36229985The immunodeficient scid mouse as a model for human lymphatic filariasis
Q38366893The immunopathogenesis of HIV infection
Q49062938The intraspleen huPBL NOD/SCID model to study the human HIV-specific antibody response selected in the course of natural infection
Q37900419The mouse is out of the bag: insights and perspectives on HIV-1-infected humanized mouse models
Q40876696The new antibody technologies.
Q36951804The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases
Q35276631The pathogenesis of AIDS lymphomas: a foundation for addressing the challenges of therapy and prevention
Q48504672The road ended up at stem cells
Q70527020The role of natural antibodies and ABO (H) blood groups in transplantation of human lymphoid cells into mice
Q25257167The thrombopoietin receptor, c-Mpl, is a selective surface marker for human hematopoietic stem cells.
Q41233084The use of SCID mice in biotechnology and as a model for human disease
Q40712126The use of fetal tissue for therapeutic applications
Q54244413The use of humanized mice for studies of viral pathogenesis and immunity.
Q35206268The utility of the new generation of humanized mice to study HIV-1 infection: transmission, prevention, pathogenesis, and treatment
Q37346027The utilization of humanized mouse models for the study of human retroviral infections
Q41102652Therapeutic Human Antibodies Derived from PCR Amplification of B‐Cell Variable Regions
Q42001743Thymic selection of the human T cell receptor V beta repertoire in SCID-hu mice
Q45854426Tissue distribution of mucosal antibody-producing cells specific for respiratory syncytial virus in severe combined immune deficiency (SCID) mice engrafted with human tonsils
Q33956786Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation
Q46546302Today's SCID-hu mouse
Q104617072Tracking HIV Rebound following Latency Reversal Using Barcoded HIV
Q34565309Traditional and molecular techniques for the study of emerging bacterial diseases: one laboratory's perspective
Q36353439Transfer of human systemic lupus erythematosus in severe combined immunodeficient (SCID) mice
Q29398132Transfer of multiple sclerosis into severe combined immunodeficiency mice by mononuclear cells from cerebrospinal fluid of the patients
Q35764161Transfer of rheumatoid arthritis into severe combined immunodeficient mice. The pathogenetic implications of T cell populations oligoclonally expanding in the rheumatoid joints
Q72840889Transfer of type 1 (insulin-dependent) diabetes mellitus associated autoimmunity to mice with severe combined immunodeficiency (SCID)
Q45883782Transient renewal of thymopoiesis in HIV-infected human thymic implants following antiviral therapy
Q26772335Translating Treg Therapy in Humanized Mice
Q73109454Transplantation and chimera as extended self
Q47587003Transplantation and growth characteristics of human fetal lymph node in immunodeficient mice
Q37019276Transplantation of Normal and Leukemic Human Bone Marrow into Immune-Deficient Mice: Development of Animal Models for Human Hematopoiesis
Q41020244Transplantation of thymic autoimmune microenvironment to severe combined immunodeficiency mice. A new model of myasthenia gravis
Q28326886Treatment of murine cytomegalovirus infections in severe combined immunodeficient mice with ganciclovir, (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine, interferon, and bropirimine
Q35845405Tropism of varicella-zoster virus for human CD4+ and CD8+ T lymphocytes and epidermal cells in SCID-hu mice
Q40465763T‐Cell Repertoires in Health and Diseasea
Q60267505U937-SCID mouse xenografts: a new model for acute in vivo HIV-1 infection suitable to test antiviral strategies
Q36231592Unexpected effects of the severe combined immunodeficiency mutation on murine lymphomagenesis
Q35738486Use of Humanized Mice to Study the Pathogenesis of Autoimmune and Inflammatory Diseases
Q95841651Use of Humanized Mouse Models for Studying HIV-1 Infection, Pathogenesis and Persistence
Q34582987Use of a SCID mouse/human lymphoma model to evaluate cytokine-induced killer cells with potent antitumor cell activity
Q35783479Use of a novel chimeric mouse model with a functionally active human immune system to study human immunodeficiency virus type 1 infection
Q37354186Use of humanized severe combined immunodeficient mice for human vaccine development
Q40497058Use of severe combined immunodeficient mice to measure developmental potential of B-cell precursors.
Q35123273Use of standardized SCID-hu Thy/Liv mouse model for preclinical efficacy testing of anti-human immunodeficiency virus type 1 compounds
Q37374872Use of the in vivo hollow fiber assay in natural products anticancer drug discovery.
Q36621632Using the BLT humanized mouse as a stem cell based gene therapy tumor model
Q28469262Validation of the SCID-hu Thy/Liv mouse model with four classes of licensed antiretrovirals
Q41710742Viral pathogenesis and immunity within the thymus
Q36201405What we are learning on HTLV-1 pathogenesis from animal models
Q74072877Xenogeneic (bovine) peripheral blood leukocytes engrafted into severe combined immunodeficient mice retain primary immune function
Q40928493Xenograft model systems for human melanoma
Q36799846Xenograft models for the preclinical evaluation of new therapies in acute leukemia
Q77070950Xenotransplantation
Q27013024Xenotransplantation models to study the effects of toxicants on human fetal tissues
Q86848619[Development of immunodeficient mice/humanized mouse models and their applications in hematology research]
Q53447499[Transgenic human thymopoiesis from retrovirally transduced umbilical cord blood hematopoietic stem cells: experimental studies in the SCID-hu mouse]
Q36466103hu-PBL-SCID Mice: A Model for Human Immune Function, AIDS, and Lymphomagenesis

Search more.