CXCR4 expression during lymphopoiesis: implications for human immunodeficiency virus type 1 infection of the thymus

scientific article published in September 1997

CXCR4 expression during lymphopoiesis: implications for human immunodeficiency virus type 1 infection of the thymus is …
instance of (P31):
scholarly articleQ13442814

External links are
P932PMC publication ID191976
P698PubMed publication ID9261420

P2093author name stringJ A Zack
S G Kitchen
P2860cites workHIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled ReceptorQ22242268
Identification of a major co-receptor for primary isolates of HIV-1Q22251282
The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entryQ24315492
Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytesQ24324518
The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycleQ24685965
A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactorsQ28118386
Molecular cloning of the cDNA and chromosomal localization of the gene for a putative seven-transmembrane segment (7-TMS) receptor isolated from human spleenQ28260321
The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolatesQ28282895
HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structureQ28283258
CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1Q28646859
Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular cloneQ29547734
The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1Q29616093
HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5Q29616094
Interleukin-8 and related chemotactic cytokines--CXC and CC chemokinesQ34662656
A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus type 1 strains.Q35868457
Mechanism of human immunodeficiency virus type 1 localization in CD4-negative thymocytes: differentiation from a CD4-positive precursor allows productive infectionQ35889286
The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytesQ36028490
Differentiation of CD3-4-8- human fetal thymocytes in vivo: characterization of a CD3-4+8- intermediateQ36361993
Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicityQ36633938
Incompletely reverse-transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retroviral life cycleQ36693174
Differential regulation of HIV-1 fusion cofactor expression by CD28 costimulation of CD4+ T cellsQ38933102
Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entryQ39464591
In vivo pathogenic properties of two clonal human immunodeficiency virus type 1 isolates.Q39872035
Rapid-high, syncytium-inducing isolates of human immunodeficiency virus type 1 induce cytopathicity in the human thymus of the SCID-hu mouse.Q40043073
Chemokines, leukocyte trafficking, and inflammationQ40502969
Evidence for cell-surface association between fusin and the CD4-gp120 complex in human cell linesQ41157521
A new reporter system for detection of retroviral infectionQ41320562
The SCID-hu mouse as a model for HIV-1 infectionQ41546977
CD4-independent infection by HIV-2 is mediated by fusin/CXCR4.Q42813563
In vitro studies of HIV-1 expression in thymocytes from infants and childrenQ43462469
Differential tropism of HIV-1 isolates for distinct thymocyte subsets in vitro.Q43759128
The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and functionQ44322674
HIV induces thymus depletion in vivoQ45305157
Divergent effects of chronic HIV-1 infection on human thymocyte maturation in SCID-hu miceQ58663588
Flow cytometric assessment of human T-cell differentiation in thymus and bone marrowQ67894937
Human T cells in the SCID-hu mouse are phenotypically normal and functionally competentQ67899463
Infection of the SCID-hu mouse by HIV-1Q67985380
Human thymocytes do not respond to interleukin-2 after removal of mature "bright" CD5 positive cellsQ69113982
Selective stimulation of human thymocyte subpopulations by recombinant IL-4 and IL-3Q69735055
Delimitation of the proliferative stages in the human thymus indicates that cell expansion occurs before the expression of CD3 (T cell receptor)Q70522097
Effects of cytokines on HIV-1 production by thymocytesQ70796776
Selective thymocyte depletion in neonatal HIV-1 thymic infectionQ72719149
P433issue9
P407language of work or nameEnglishQ1860
P1104number of pages7
P304page(s)6928-6934
P577publication date1997-09-01
P1433published inJournal of VirologyQ1251128
P1476titleCXCR4 expression during lymphopoiesis: implications for human immunodeficiency virus type 1 infection of the thymus
P478volume71

Reverse relations

cites work (P2860)
Q33849878Activated peripheral CD8 lymphocytes express CD4 in vivo and are targets for infection by human immunodeficiency virus type 1.
Q28343930Antiviral activity of 2'-deoxy-3'-oxa-4'-thiocytidine (BCH-10652) against lamivudine-resistant human immunodeficiency virus type 1 in SCID-hu Thy/Liv mice
Q39583317CCR5- and CXCR4-utilizing strains of human immunodeficiency virus type 1 exhibit differential tropism and pathogenesis in vivo.
Q24525316CCR8 on human thymocytes functions as a human immunodeficiency virus type 1 coreceptor
Q39525705Conserved arginine residue in the membrane-spanning domain of HIV-1 gp41 is required for efficient membrane fusion
Q39167289Coreceptor competition for association with CD4 may change the susceptibility of human cells to infection with T-tropic and macrophagetropic isolates of human immunodeficiency virus type 1
Q33785363Costimulation of naive CD8(+) lymphocytes induces CD4 expression and allows human immunodeficiency virus type 1 infection.
Q36132255Developmental regulation of P-glycoprotein activity within thymocytes results in increased anti-HIV protease inhibitor activity
Q33558676Different tempo and anatomic location of dual-tropic and X4 virus emergence in a model of R5 simian-human immunodeficiency virus infection
Q33785876Differential tropism and replication kinetics of human immunodeficiency virus type 1 isolates in thymocytes: coreceptor expression allows viral entry, but productive infection of distinct subsets is determined at the postentry level.
Q29622903Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1.
Q39590030Functional reconstitution of thymopoiesis after human immunodeficiency virus infection.
Q33943870Glucose transporter 1 expression identifies a population of cycling CD4+ CD8+ human thymocytes with high CXCR4-induced chemotaxis.
Q35787190Glut1-mediated glucose transport regulates HIV infection
Q35557244HIV reservoirs in vivo and new strategies for possible eradication of HIV from the reservoir sites
Q35716711HIV-1 replication and pathogenesis in the human thymus
Q35160655Human immunodeficiency virus persistence and production in T-cell development
Q37574658Human immunodeficiency virus type 1 Vpr-mediated G2 arrest requires Rad17 and Hus1 and induces nuclear BRCA1 and gamma-H2AX focus formation.
Q34014536IFN-α is constitutively expressed in the human thymus, but not in peripheral lymphoid organs
Q34342452Impact of cytokines on replication in the thymus of primary human immunodeficiency virus type 1 isolates from infants
Q24681021Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice
Q35015256In vivo HIV-1 infection of CD45RA(+)CD4(+) T cells is established primarily by syncytium-inducing variants and correlates with the rate of CD4(+) T cell decline
Q33784206In vivo distribution of the human immunodeficiency virus/simian immunodeficiency virus coreceptors: CXCR4, CCR3, and CCR5.
Q39100446In vivo pathogenesis of a human immunodeficiency virus type 1 reporter virus
Q36958820Induction of simian AIDS in infant rhesus macaques infected with CCR5- or CXCR4-utilizing simian-human immunodeficiency viruses is associated with distinct lesions of the thymus
Q33818582Late-emerging strains of HIV induce T-cell homeostasis failure by promoting bystander cell death and immune exhaustion in naïve CD4 and all CD8 T-cells
Q30305455Pathogenesis of primary R5 human immunodeficiency virus type 1 clones in SCID-hu mice
Q30834495Phylodynamics of HIV-1 in lymphoid and non-lymphoid tissues reveals a central role for the thymus in emergence of CXCR4-using quasispecies
Q36469775Prediction of R5, X4, and R5X4 HIV-1 coreceptor usage with evolved neural networks
Q39630648Preferential cytolysis of peripheral memory CD4+ T cells by in vitro X4-tropic human immunodeficiency virus type 1 infection before the completion of reverse transcription
Q33650466R5 strains of human immunodeficiency virus type 1 from rapid progressors lacking X4 strains do not possess X4-type pathogenicity in human thymus.
Q28366094Rapid and irreversible CD4+ T-cell depletion induced by the highly pathogenic simian/human immunodeficiency virus SHIV(DH12R) is systemic and synchronous
Q39595155Reconstitution of human thymic implants is limited by human immunodeficiency virus breakthrough during antiretroviral therapy
Q36050101Relevance of early detection of HIV type 1 SI/CXCR4-using viruses in vertically infected children
Q24673389Selective CXCR4 antagonism by Tat: implications for in vivo expansion of coreceptor use by HIV-1
Q52018818T cell signaling mechanisms that regulate HIV-1 infection.
Q33785321Tat protein induces human immunodeficiency virus type 1 (HIV-1) coreceptors and promotes infection with both macrophage-tropic and T-lymphotropic HIV-1 strains
Q37888712The bone marrow microenvironment and leukemia: biology and therapeutic targeting
Q53622930Thymic volume is associated independently with the magnitude of short- and long-term repopulation of CD4+ T cells in HIV-infected adults after highly active antiretroviral therapy (HAART).
Q33649854Thymocyte-thymic epithelial cell interaction leads to high-level replication of human immunodeficiency virus exclusively in mature CD4(+) CD8(-) CD3(+) thymocytes: a critical role for tumor necrosis factor and interleukin-7.
Q34640562Towards an HIV cure: a global scientific strategy
Q38200520Tracking migration during human T cell development
Q28469262Validation of the SCID-hu Thy/Liv mouse model with four classes of licensed antiretrovirals

Search more.