Selective CXCR4 antagonism by Tat: implications for in vivo expansion of coreceptor use by HIV-1

scientific article

Selective CXCR4 antagonism by Tat: implications for in vivo expansion of coreceptor use by HIV-1 is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2000PNAS...9711466X
P356DOI10.1073/PNAS.97.21.11466
P3181OpenCitations bibliographic resource ID336710
P932PMC publication ID17223
P698PubMed publication ID11027346
P5875ResearchGate publication ID12297719

P2093author name stringH Xiao
K T Jeang
H L Tiffany
P M Murphy
M Benkirane
E A Rich
C Neuveut
P2860cites workCXCR4 expression during lymphopoiesis: implications for human immunodeficiency virus type 1 infection of the thymusQ35892412
Tat as one key to HIV-induced immune pathogenesis and Tat (correction of Pat) toxoid as an important component of a vaccineQ35993736
Change in coreceptor use correlates with disease progression in HIV-1--infected individualsQ36376800
The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infectionQ38949380
Extracellular HIV-1 tat protein up-regulates the expression of surface CXC-chemokine receptor 4 in resting CD4+ T cells.Q39443021
CCR5 coreceptor usage of non-syncytium-inducing primary HIV-1 is independent of phylogenetically distinct global HIV-1 isolates: delineation of consensus motif in the V3 domain that predicts CCR-5 usage.Q39607422
Differential syncytium-inducing capacity of human immunodeficiency virus isolates: frequent detection of syncytium-inducing isolates in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complexQ40128160
Indicator cell lines for detection of primary strains of human and simian immunodeficiency virusesQ41104028
Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120.Q41335848
Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patientsQ41734588
Macrophage inflammatory protein-1beta induces migration and activation of human thymocytes.Q42830305
Similarity of chemokines charge and the V3 domain of HIV-1 env proteinQ43183430
CXCR4 and CCR5 expression delineates targets for HIV-1 disruption of T cell differentiation.Q52532093
Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis.Q53421778
Control of SHIV-89.6P-infection of cynomolgus monkeys by HIV-1 Tat protein vaccineQ59511395
The neglected role of type I interferon in the T-cell response: implications for its clinical useQ71475326
Transplantation of discordant xenografts: a challenge revisitedQ71475332
HIV-1 entry inhibitors: evading the issueQ95817407
Genotypic and phenotypic characterization of HIV-1 patients with primary infectionQ22242245
HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled ReceptorQ22242268
Identification of a major co-receptor for primary isolates of HIV-1Q22251282
A new classification for HIV-1Q22251292
Inhibition of CXCR4-dependent HIV-1 infection by extracellular HIV-1 TatQ22253931
Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTESQ24310697
Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309Q24653253
A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactorsQ28118386
Epithelin/granulin growth factors: extracellular cofactors for HIV-1 and HIV-2 Tat proteinsQ28138821
Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cellsQ28270680
The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolatesQ28282895
Activity of different bicyclam derivatives against human immunodeficiency virus depends on their interaction with the CXCR4 chemokine receptorQ28293420
Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4Q28379182
A small molecule CXCR4 inhibitor that blocks T cell line-tropic HIV-1 infectionQ28379184
A small-molecule inhibitor directed against the chemokine receptor CXCR4 prevents its use as an HIV-1 coreceptorQ28379187
The impact of the syncytium-inducing phenotype of human immunodeficiency virus on disease progressionQ28507706
CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1Q28646859
HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation timeQ29547822
HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5Q29616094
Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and diseaseQ29616432
Conditional reduction of human immunodeficiency virus type 1 replication by a gain-of-herpes simplex virus 1 thymidine kinase functionQ30424775
Multifaceted activities of the HIV-1 transactivator of transcription, Tat.Q33743566
Analysis of the temporal relationship between human immunodeficiency virus type 1 quasispecies in sequential blood samples and various organs obtained at autopsyQ33782045
CXCR-4 is expressed by primary macrophages and supports CCR5-independent infection by dual-tropic but not T-tropic isolates of human immunodeficiency virus type 1Q33782165
Tat protein induces human immunodeficiency virus type 1 (HIV-1) coreceptors and promotes infection with both macrophage-tropic and T-lymphotropic HIV-1 strainsQ33785321
Angiogenic properties of human immunodeficiency virus type 1 Tat proteinQ34267637
Vaccination with tat toxoid attenuates disease in simian/HIV-challenged macaquesQ35114827
Pronounced acute immunosuppression in vivo mediated by HIV Tat challengeQ35633540
Recombinant human immunodeficiency virus type 1 genomes with tat unconstrained by overlapping reading frames reveal residues in Tat important for replication in tissue culture.Q35866513
Mapping of independent V3 envelope determinants of human immunodeficiency virus type 1 macrophage tropism and syncytium formation in lymphocytes.Q35874433
Genetically divergent strains of simian immunodeficiency virus use CCR5 as a coreceptor for entryQ35880381
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectHIVQ15787
P304page(s)11466-71
P577publication date2000-10-10
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleSelective CXCR4 antagonism by Tat: implications for in vivo expansion of coreceptor use by HIV-1
P478volume97

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cites work (P2860)
Q46698274"cART intensification by the HIV-1 Tat B clade vaccine: progress to phase III efficacy studies".
Q37054470A HIV-Tat/C4-binding protein chimera encoded by a DNA vaccine is highly immunogenic and contains acute EcoHIV infection in mice
Q33931214A cell-penetrating antibody fragment against HIV-1 Rev has high antiviral activity: characterization of the paratope
Q34666037Activation of Egr-1 expression in astrocytes by HIV-1 Tat: new insights into astrocyte-mediated Tat neurotoxicity
Q92906228Anti-Tat Immunity in HIV-1 Infection: Effects of Naturally Occurring and Vaccine-Induced Antibodies Against Tat on the Course of the Disease
Q73138904Antibodies to Tat and Vpr in the GRIV cohort: differential association with maintenance of long-term non-progression status in HIV-1 infection
Q30410538Anxiety-like behavior of mice produced by conditional central expression of the HIV-1 regulatory protein, Tat.
Q55315393Apolipoprotein E isoform dependently affects Tat-mediated HIV-1 LTR transactivation.
Q35114694Breaking down the barrier: the effects of HIV-1 on the blood-brain barrier.
Q42255378Breaking in and busting out: cell-penetrating peptides and the endosomal escape problem.
Q36599919CD44-mediated monocyte transmigration across Cryptococcus neoformans-infected brain microvascular endothelial cells is enhanced by HIV-1 gp41-I90 ectodomain
Q41930612Canonical and Non-Canonical Autophagy in HIV-1 Replication Cycle
Q39955713Caveolin-1 regulates human immunodeficiency virus-1 Tat-induced alterations of tight junction protein expression via modulation of the Ras signaling
Q35126422Changing patterns in the neuropathogenesis of HIV during the HAART era.
Q40720095Characterization of the anti-HIV effects of native lactoferrin and other milk proteins and protein-derived peptides
Q35050395Chemokine receptors: emerging opportunities for new anti-HIV therapies
Q35198110Chemokines and viruses: friends or foes?
Q35945472Cocaine self-administration enhances excitatory responses of pyramidal neurons in the rat medial prefrontal cortex to human immunodeficiency virus-1 Tat.
Q37348901Codon optimization of the tat antigen of human immunodeficiency virus type 1 generates strong immune responses in mice following genetic immunization
Q27013928Cortical consequences of HIV-1 Tat exposure in rats are enhanced by chronic cocaine
Q55365547Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells.
Q40182651D1/NMDA receptors and concurrent methamphetamine+ HIV-1 Tat neurotoxicity
Q61799358Didehydro-Cortistatin A Inhibits HIV-1 by Specifically Binding to the Unstructured Basic Region of Tat
Q35559749Didehydro-cortistatin A inhibits HIV-1 Tat mediated neuroinflammation and prevents potentiation of cocaine reward in Tat transgenic mice
Q33897742Differential induction of interleukin-10 in monocytes by HIV-1 clade B and clade C Tat proteins.
Q35003533Differential induction of rat neuronal excitotoxic cell death by human immunodeficiency virus type 1 clade B and C tat proteins.
Q34017924Direct effects of HIV-1 Tat on excitability and survival of primary dorsal root ganglion neurons: possible contribution to HIV-1-associated pain
Q47397529Doxycycline-inducible and astrocyte-specific HIV-1 Tat transgenic mice (iTat) as an HIV/neuroAIDS model.
Q36445102Dual role of autophagy in HIV-1 replication and pathogenesis
Q42683735Dynamic plasticity of NMDA receptor-mediated calcium entry in neurons exposed to HIV-tat.
Q41620362E5564 inhibits immunosuppressive cytokine IL-10 induction promoted by HIV-1 Tat protein
Q40052643Effects of HIV-1 Tat and Methamphetamine on Blood-Brain Barrier Integrity and Function In Vitro
Q36997333Endolysosome involvement in HIV-1 transactivator protein-induced neuronal amyloid beta production
Q36563605Endothelial cells and cathepsins: Biochemical and biomechanical regulation
Q59360928Epigenetic Promoter DNA Methylation of miR-124 Promotes HIV-1 Tat-Mediated Microglial Activation via MECP2-STAT3 Axis
Q34517239Excess soluble CD40L contributes to blood brain barrier permeability in vivo: implications for HIV-associated neurocognitive disorders
Q40676905Exosome-associated release, uptake, and neurotoxicity of HIV-1 Tat protein.
Q37988482Exploring transduction mechanisms of protein transduction domains (PTDs) in living cells utilizing single-quantum dot tracking (SQT) technology
Q39616924Expressed cell-penetrating peptides can induce a bystander effect, but passage through the secretory pathway reduces protein transduction activity.
Q38790617Fate of microglia during HIV-1 infection: From activation to senescence?
Q38617624Functional roles of HIV-1 Tat protein in the nucleus.
Q24795458Gene expression profile of HIV-1 Tat expressing cells: a close interplay between proliferative and differentiation signals
Q37010956Generation and characterization of neutralizing human monoclonal antibodies against human immunodeficiency virus type 1 Tat antigen
Q33819189Genetic variation and HIV-associated neurologic disease.
Q92135927Genetic variation and function of the HIV-1 Tat protein
Q36242915HIV Infects Bronchial Epithelium and Suppresses Components of the Mucociliary Clearance Apparatus
Q37490454HIV Tat Impairs Neurogenesis through Functioning As a Notch Ligand and Activation of Notch Signaling Pathway
Q40271342HIV Tat induces a prolonged MYC relocalization next to IGH in circulating B-cells.
Q39494342HIV Tat protein inhibits hERG K+ channels: a potential mechanism of HIV infection induced LQTs
Q35088029HIV Tat, its TARgets and the control of viral gene expression
Q36675927HIV Tat-Mediated Induction of Human Brain Microvascular Endothelial Cell Apoptosis Involves Endoplasmic Reticulum Stress and Mitochondrial Dysfunction.
Q39641516HIV Type 1 Nef is released from infected cells in CD45(+) microvesicles and is present in the plasma of HIV-infected individuals
Q38824376HIV and viral protein effects on the blood brain barrier
Q59361093HIV-1 Protein Tat Impairs Neuronal Dendrites via Activation of PP1 and Regulation of the CREB/BDNF Pathway
Q59357751HIV-1 TAT-mediated microglial activation: role of mitochondrial dysfunction and defective mitophagy
Q95326529HIV-1 Tat - TLR4/MD2 interaction drives the expression of IDO-1 in monocytes derived dendritic cells through NF-κB dependent pathway
Q27487322HIV-1 Tat Activates Neuronal Ryanodine Receptors with Rapid Induction of the Unfolded Protein Response and Mitochondrial Hyperpolarization
Q38963813HIV-1 Tat C modulates NOX2 and NOX4 expressions through miR-17 in a human microglial cell line
Q43598814HIV-1 Tat C modulates expression of miRNA-101 to suppress VE-cadherin in human brain microvascular endothelial cells.
Q37002574HIV-1 Tat Protein Activates both the MyD88 and TRIF Pathways To Induce Tumor Necrosis Factor Alpha and Interleukin-10 in Human Monocytes.
Q35668299HIV-1 Tat Protein Induces Production of Proinflammatory Cytokines by Human Dendritic Cells and Monocytes/Macrophages through Engagement of TLR4-MD2-CD14 Complex and Activation of NF-κB Pathway.
Q37176830HIV-1 Tat Regulates Occludin and Aβ Transfer Receptor Expression in Brain Endothelial Cells via Rho/ROCK Signaling Pathway
Q24564896HIV-1 Tat enters T cells using coated pits before translocating from acidified endosomes and eliciting biological responses
Q41505540HIV-1 Tat inhibits phagocytosis by preventing the recruitment of Cdc42 to the phagocytic cup.
Q34508575HIV-1 Tat protein binds to TLR4-MD2 and signals to induce TNF-α and IL-10.
Q34758981HIV-1 Tat protein increases microglial outward K(+) current and resultant neurotoxic activity
Q46245165HIV-1 Tat protein induces DNA damage in human peripheral blood B-lymphocytes via mitochondrial ROS production.
Q40606349HIV-1 Tat protein induces PD-L1 (B7-H1) expression on dendritic cells through tumor necrosis factor alpha- and toll-like receptor 4-mediated mechanisms
Q35000687HIV-1 Tat protein induces the production of IDO in human monocyte derived-dendritic cells through a direct mechanism: effect on T cells proliferation.
Q37313544HIV-1 Tat protein perturbs diacylglycerol production at the plasma membrane of neurosecretory cells during exocytosis
Q30436450HIV-1 Tat protein suppresses cholangiocyte toll-like receptor 4 expression and defense against Cryptosporidium parvum
Q46437339HIV-1 Tat protein-induced alterations of ZO-1 expression are mediated by redox-regulated ERK 1/2 activation
Q46830857HIV-1 Tat raises an adjuvant-free humoral immune response controlled by its core region and its ability to form cysteine-mediated oligomers
Q34903986HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: implication for HIV-associated neurocognitive disorder (HAND).
Q24556641HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?
Q30638542HIV-1 Tat-induced changes in synaptically-driven network activity adapt during prolonged exposure
Q36185385HIV-1 Tat-induced microglial activation and neuronal damage is inhibited via CD45 modulation: A potential new treatment target for HAND.
Q33393202HIV-1 Tat-induced platelet activation and release of CD154 contribute to HIV-1-associated autoimmune thrombocytopenia
Q90221085HIV-1 Tat: Role in Bystander Toxicity
Q33581852HIV-1 clade B Tat, but not clade C Tat, increases X4 HIV-1 entry into resting but not activated CD4+ T cells
Q33641330HIV-1 inhibits autophagy in bystander macrophage/monocytic cells through Src-Akt and STAT3.
Q42229248HIV-1 protein Tat produces biphasic changes in NMDA-evoked increases in intracellular Ca2+ concentration via activation of Src kinase and nitric oxide signaling pathways
Q92205468HIV-1 proteins gp120 and tat induce the epithelial-mesenchymal transition in oral and genital mucosal epithelial cells
Q34768563HIV-1 regulatory proteins: targets for novel drug development
Q34477471HIV-1 tat promotes integrin-mediated HIV transmission to dendritic cells by binding Env spikes and competes neutralization by anti-HIV antibodies
Q40551410HIV-1 tat protein recruits CIS to the cytoplasmic tail of CD127 to induce receptor ubiquitination and proteasomal degradation
Q36040759HIV-1, reactive oxygen species, and vascular complications
Q39515527HIV-1-induced alterations of claudin-5 expression at the blood-brain barrier level
Q82182169HIV-TAT protein upregulates expression of multidrug resistance protein 1 in the blood-brain barrier
Q41578290HIV-Tat Protein Forms Phosphoinositide-dependent Membrane Pores Implicated in Unconventional Protein Secretion
Q37257571HIV-associated disruption of mucosal epithelium facilitates paracellular penetration by human papillomavirus
Q35106306HIV-associated disruption of tight and adherens junctions of oral epithelial cells facilitates HSV-1 infection and spread
Q40142273Heparin-mimicking sulfonic acid polymers as multitarget inhibitors of human immunodeficiency virus type 1 Tat and gp120 proteins
Q33797753High-performance capillary electrophoresis for determining HIV-1 Tat protein in neurons
Q45382212Homeostatic chemokines CCL19 and CCL21 promote inflammation in human immunodeficiency virus-infected patients with ongoing viral replication
Q27637986Homonuclear (1)H-NMR assignment and structural characterization of human immunodeficiency virus type 1 Tat Mal protein
Q59353651Human Immunodeficiency Virus Type 1 gp120 and Tat Induce Mitochondrial Fragmentation and Incomplete Mitophagy in Human Neurons
Q58766255Human immunodeficiency virus Tat-TIP30 interaction promotes metastasis by enhancing the nuclear translocation of Snail in lung cancer cell lines
Q40462487Human immunodeficiency virus protein Tat induces oligodendrocyte injury by enhancing outward K+ current conducted by KV1.3.
Q44775961Human immunodeficiency virus type 1 Tat and methamphetamine affect the release and activation of matrix-degrading proteinases
Q38331655Human immunodeficiency virus type 1 Tat protein induces an intracellular calcium increase in human monocytes that requires DHP receptors: involvement in TNF-alpha production
Q36203752Human immunodeficiency virus type 1 genetic diversity in the nervous system: evolutionary epiphenomenon or disease determinant?
Q35857699Human immunodeficiency virus type 1 subtype C Tat fails to induce intracellular calcium flux and induces reduced tumor necrosis factor production from monocytes
Q34234127Human immunodeficiency virus type-1 and chemokines: beyond competition for common cellular receptors
Q36148402Human immunodeficiency virus type-1 protein Tat induces tumor necrosis factor-alpha-mediated neurotoxicity
Q30497248Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.
Q36754429Human immunodeficiency virus-1 protein Tat induces excitotoxic loss of presynaptic terminals in hippocampal cultures
Q37194615Human immunodeficiency virus-associated disruption of mucosal barriers and its role in HIV transmission and pathogenesis of HIV/AIDS disease
Q35208314IL-7 receptor recovery on CD8 T-cells isolated from HIV+ patients is inhibited by the HIV Tat protein
Q34988973Ibudilast (AV411), and its AV1013 analog, reduce HIV-1 replication and neuronal death induced by HIV-1 and morphine
Q33873538Ibudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency virus-1 Tat-mediated activation of microglial cells
Q81034939Increasing the humoral immunogenic properties of the HIV-1 Tat protein using a ligand-stabilizing strategy
Q24305565Induction of C chemokine XCL1 (lymphotactin/single C motif-1 alpha/activation-induced, T cell-derived and chemokine-related cytokine) expression by HIV-1 Tat protein
Q39128871Infection by CXCR4-Tropic Human Immunodeficiency Virus Type 1 Is Inhibited by the Cationic Cell-Penetrating Peptide Derived from HIV-1 Tat.
Q41419929Inhibition of connexin hemichannels alleviates non-alcoholic steatohepatitis in mice
Q37273867Insight into the mechanisms of aminoglycoside derivatives interaction with HIV-1 entry steps and viral gene transcription
Q34170914Intact lipid rafts regulate HIV-1 Tat protein-induced activation of the Rho signaling and upregulation of P-glycoprotein in brain endothelial cells
Q21245111Interaction of human dipeptidyl peptidase IV and human immunodeficiency virus type-1 transcription transactivator in Sf9 cells
Q42972738Interactive role of human immunodeficiency virus type 1 (HIV-1) clade-specific Tat protein and cocaine in blood-brain barrier dysfunction: implications for HIV-1-associated neurocognitive disorder
Q41925734Intracellular HIV-1 Tat protein represses constitutive LMP2 transcription increasing proteasome activity by interfering with the binding of IRF-1 to STAT1.
Q38310502Intracellular HIV-Tat expression induces IL-10 synthesis by the CREB-1 transcription factor through Ser133 phosphorylation and its regulation by the ERK1/2 MAPK in human monocytic cells.
Q35220407Investigating the role of ankyrin-rich membrane spanning protein in human immunodeficiency virus type-1 Tat-induced microglia activation
Q28239006JM4 is a four-transmembrane protein binding to the CCR5 receptor
Q36166231Ketone bodies protection against HIV-1 Tat-induced neurotoxicity
Q40537332Local delivery of recombinant vaccinia virus expressing secondary lymphoid chemokine (SLC) results in a CD4 T-cell dependent antitumor response
Q40056807Lytic EBV infection investigated by detection of Soluble Epstein-Barr virus ZEBRA in the serum of patients with PTLD.
Q37728093Macrophage signaling in HIV-1 infection
Q39834242Mechanism for HIV-1 Tat insertion into the endosome membrane
Q33770575Mechanism of HIV-1-TAT induction of interleukin-1beta from human monocytes: Involvement of the phospholipase C/protein kinase C signaling cascade
Q34516015Mesenchymal stem cell derived hematopoietic cells are permissive to HIV-1 infection
Q36950000Mitogen-activated protein kinase p38 in HIV infection and associated brain injury
Q35921136Modeling HIV-associated neurocognitive disorders in mice: new approaches in the changing face of HIV neuropathogenesis
Q33889326Modifications in host cell cytoskeleton structure and function mediated by intracellular HIV-1 Tat protein are greatly dependent on the second coding exon
Q40903523Modulation of microtubule assembly by the HIV-1 Tat protein is strongly dependent on zinc binding to Tat.
Q37501478Molecular mechanism: the human dopamine transporter histidine 547 regulates basal and HIV-1 Tat protein-inhibited dopamine transport
Q36157637Morphine modulation of toll-like receptors in microglial cells potentiates neuropathogenesis in a HIV-1 model of coinfection with pneumococcal pneumoniae
Q34343025Mutation of tyrosine 470 of human dopamine transporter is critical for HIV-1 Tat-induced inhibition of dopamine transport and transporter conformational transitions.
Q41863627Neuronal survival and resistance to HIV-1 Tat toxicity in the primary culture of rat fetal neurons.
Q35749130Neuropathologies in Transgenic Mice Expressing Human Immunodeficiency Virus Type 1 Tat Protein under the Regulation of the Astrocyte-Specific Glial Fibrillary Acidic Protein Promoter and Doxycycline
Q38815332New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model.
Q36710889Nonmuscle myosin light-chain kinase mediates microglial migration induced by HIV Tat: involvement of β1 integrins.
Q34691351Novel multi-component nanopharmaceuticals derived from poly(ethylene) glycol, retro-inverso-Tat nonapeptide and saquinavir demonstrate combined anti-HIV effects
Q37547409Novel neuroprotective GSK-3β inhibitor restricts Tat-mediated HIV-1 replication
Q38344102Nox4-derived H2O2 mediates endoplasmic reticulum signaling through local Ras activation
Q33649838Nuclear factor-kappa B family member RelB inhibits human immunodeficiency virus-1 Tat-induced tumor necrosis factor-alpha production
Q35941437Oligodendrocytes Are Targets of HIV-1 Tat: NMDA and AMPA Receptor-Mediated Effects on Survival and Development.
Q37002797PPARalpha and PPARgamma effectively protect against HIV-induced inflammatory responses in brain endothelial cells
Q40508633Phosphatidylinositol-(4,5)-bisphosphate enables efficient secretion of HIV-1 Tat by infected T-cells
Q34281340Platelet-derived growth factor-BB restores HIV Tat -mediated impairment of neurogenesis: role of GSK-3β/β-catenin.
Q35009483Preferential vulnerability of astroglia and glial precursors to combined opioid and HIV-1 Tat exposure in vitro.
Q79869481Preventing HIV-1 Tat-induced neuronal apoptosis using antioxidant enzymes: mechanistic and therapeutic implications
Q24799564Proliferative activity of extracellular HIV-1 Tat protein in human epithelial cells: expression profile of pathogenetically relevant genes
Q36253322Proteoglycans in host-pathogen interactions: molecular mechanisms and therapeutic implications
Q26853681Proteomics, biomarkers, and HIV-1: A current perspective
Q40852719Protocol for Detection of HIV-Tat Protein in Cerebrospinal Fluid by a Sandwich Enzyme-Linked Immunosorbent Assay
Q55315288Reduced intraepidermal nerve fibre density, glial activation, and sensory changes in HIV type-1 Tat-expressing female mice: involvement of Tat during early stages of HIV-associated painful sensory neuropathy.
Q33605370Repeated cocaine treatment enhances HIV-1 Tat-induced cortical excitability via over-activation of L-type calcium channels
Q34378293RhoA/Rho-kinase and vascular diseases: what is the link?
Q37519397Role of Tat protein in HIV neuropathogenesis
Q36045347Role of endolysosomes in HIV-1 Tat-induced neurotoxicity
Q26996314Roles and functions of HIV-1 Tat protein in the CNS: an overview
Q34645645Selection in context: patterns of natural selection in the glycoprotein 120 region of human immunodeficiency virus 1 within infected individuals
Q39023036Selective up-regulation of functional CXCR4 expression in erythroid cells by HIV-1 Tat protein
Q48939388Signaling mechanisms of HIV-1 Tat-induced alterations of claudin-5 expression in brain endothelial cells
Q33640033Similarity in viral and host promoters couples viral reactivation with host cell migration
Q39797374Single particle tracking confirms that multivalent Tat protein transduction domain-induced heparan sulfate proteoglycan cross-linkage activates Rac1 for internalization
Q39197203Small HIV-1-Tat peptides inhibit HIV replication in cultured T-cells
Q92912382Strong In Vivo Inhibition of HIV-1 Replication by Nullbasic, a Tat Mutant
Q40613424Structure-activity relationship of neomycin, paromomycin, and neamine-arginine conjugates, targeting HIV-1 gp120-CXCR4 binding step.
Q35613792T-cell and neuronal apoptosis in HIV infection: implications for therapeutic intervention
Q36868552Targeting the glutamatergic system for the treatment of HIV-associated neurocognitive disorders
Q34091216Tat 101-mediated enhancement of brain pericyte migration involves platelet-derived growth factor subunit B homodimer: implications for human immunodeficiency virus-associated neurocognitive disorders.
Q28214887Tat acetyl-acceptor lysines are important for human immunodeficiency virus type-1 replication
Q38877236Tat mutations in an African cohort that do not prevent transactivation but change its immunogenic properties
Q22248066The C Terminus of HIV-1 Tat Modulates the Extent of CD178-mediated Apoptosis of T Cells
Q97525253The Glutamate System as a Crucial Regulator of CNS Toxicity and Survival of HIV Reservoirs
Q22248069The Glutamine-rich Region of the HIV-1 Tat Protein Is Involved in T-cell Apoptosis
Q40369884The HIV-1 Tat protein selectively enhances CXCR4 and inhibits CCR5 expression in megakaryocytic K562 cells
Q28085435The Startling Properties of Fibroblast Growth Factor 2: How to Exit Mammalian Cells without a Signal Peptide at Hand
Q40213471The ability of chloroquine to prevent tat-induced cytokine secretion by monocytes is implicated in its in vivo anti-human immunodeficiency virus type 1 activity.
Q33974601The basic domain of HIV-tat transactivating protein is essential for its targeting to lipid rafts and regulating fibroblast growth factor-2 signaling in podocytes isolated from children with HIV-1-associated nephropathy
Q26777952The cross-talk of HIV-1 Tat and methamphetamine in HIV-associated neurocognitive disorders
Q35689260The human immunodeficiency virus type 1 tat protein enhances Cryptosporidium parvum-induced apoptosis in cholangiocytes via a Fas ligand-dependent mechanism
Q38292349The human immunodeficiency virus-1 Tat protein activates human umbilical vein endothelial cell E-selectin expression via an NF-kappa B-dependent mechanism
Q48485626The immunophilin ligand GPI1046 protects neurons from the lethal effects of the HIV-1 proteins gp120 and Tat by modulating endoplasmic reticulum calcium load
Q34219706The ins and outs of HIV-1 Tat.
Q35917148The next generation of HIV/AIDS drugs: novel and developmental antiHIV drugs and targets
Q35047224The oral commensal, Streptococcus gordonii, synergizes with Tat protein to induce HIV-1 promoter activation in monocytes/macrophages
Q40833190The possible involvement of CXCR4 in the inhibition of HIV-1 infection mediated by DP178/gp41.
Q41922188The role of human dopamine transporter in NeuroAIDS.
Q37876485The unconventional secretory machinery of fibroblast growth factor 2.
Q33734695Time-Dependent, HIV-Tat-Induced Perturbation of Human Neurons In Vitro: Towards a Model for the Molecular Pathology of HIV-Associated Neurocognitive Disorders
Q37825906Tits and bits of HIV Tat protein.
Q35024694Transactivation and signaling functions of Tat are not correlated: biological and immunological characterization of HIV-1 subtype-C Tat protein
Q33933260Viral exploitation and subversion of the immune system through chemokine mimicry
Q37220038What does the structure-function relationship of the HIV-1 Tat protein teach us about developing an AIDS vaccine?
Q54415847[HIV-associated cognitive disorders: tat perturbs neurosecretion].

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