Ketone bodies protection against HIV-1 Tat-induced neurotoxicity

scientific article

Ketone bodies protection against HIV-1 Tat-induced neurotoxicity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1471-4159.2012.07764.X
P932PMC publication ID3419790
P698PubMed publication ID22524563
P5875ResearchGate publication ID224823255

P2093author name stringNorman J Haughey
Susan A Masino
Thad A Rosenberger
Jonathan D Geiger
Liang Hui
Xuesong Chen
Dhaval Bhatt
Nicholas H Geiger
P2860cites workMCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosisQ24301992
The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodiesQ24646616
Selective CXCR4 antagonism by Tat: implications for in vivo expansion of coreceptor use by HIV-1Q24673389
HIV-1 associated dementia: symptoms and causesQ27473387
HIV-1 Tat Activates Neuronal Ryanodine Receptors with Rapid Induction of the Unfolded Protein Response and Mitochondrial HyperpolarizationQ27487322
Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondriaQ72593109
In situ detection of PCR-amplified HIV-1 nucleic acids in lymph nodes and peripheral blood in patients with asymptomatic HIV-1 infection and advanced-stage AIDSQ72687052
Tat mediates apoptosis in vivo in the rat central nervous systemQ73330035
Interaction of HIV Tat and matrix metalloproteinase in HIV neuropathogenesis: a new host defense mechanismQ79810628
Preventing HIV-1 Tat-induced neuronal apoptosis using antioxidant enzymes: mechanistic and therapeutic implicationsQ79869481
Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tatQ28145171
Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophagesQ28145895
Mitochondrial control of cell death induced by HIV-1-encoded proteinsQ28200272
HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicityQ28210557
HIV tat and neurotoxicityQ28239973
Tat protein from HIV-1 activates MAP kinase in granular neurons and glial cells from rat cerebellumQ28250735
HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cellsQ28252348
Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cellsQ28289237
Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicityQ28298642
Synergistic neurotoxicity by human immunodeficiency virus proteins Tat and gp120: protection by memantineQ28369859
A growth factor attenuates HIV-1 Tat and morphine induced damage to human neurons: implication in HIV/AIDS-drug abuse casesQ28477511
Control of glucose utilization in working perfused rat heartQ28579696
The role of host genetics in the susceptibility for HIV-associated neurocognitive disordersQ30411844
Molecular pathway involved in HIV-1-induced CNS pathology: role of viral regulatory protein, Tat.Q33594713
Mitochondria and neuronal survivalQ33807218
Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetesQ33817233
HIV-associated neurocognitive disorder: pathogenesis and therapeutic opportunitiesQ34037622
Ketone bodies, potential therapeutic usesQ34092390
HIV-1 Tat causes apoptotic death and calcium homeostasis alterations in rat neurons.Q34095509
Neuroprotection by acetoacetate and β-hydroxybutyrate against NMDA-induced RGC damage in rat--possible involvement of kynurenic acidQ34280603
HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER StudyQ34370880
The efficacy of the ketogenic diet-1998: a prospective evaluation of intervention in 150 childrenQ34481820
Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic dietQ34542879
Dementia and neurocognitive disorders due to HIV-1 infectionQ34602429
Modification of brain aging and neurodegenerative disorders by genes, diet, and behaviorQ34711201
HIV neurotoxicity: potential therapeutic interventionsQ34795283
Calcium dysregulation and neuronal apoptosis by the HIV-1 proteins Tat and gp120.Q34978071
Human immunodeficiency virus (HIV) proteins in neuropathogenesis of HIV dementiaQ34993084
A ketogenic diet suppresses seizures in mice through adenosine A₁ receptorsQ35572467
HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytesQ35652521
Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxicQ35856188
D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson diseaseQ35919815
HIV dementia: an evolving diseaseQ35972797
Neuronal apoptosis induced by HIV-1 Tat protein and TNF-alpha: potentiation of neurotoxicity mediated by oxidative stress and implications for HIV-1 dementia.Q47931417
D-beta-hydroxybutyrate inhibits the apoptosis of PC12 cells induced by 6-OHDA in relation to up-regulating the ratio of Bcl-2/Bax mRNA.Q48236505
HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stressQ48313745
HIV-1 trans activator of transcription protein elicits mitochondrial hyperpolarization and respiratory deficit, with dysregulation of complex IV and nicotinamide adenine dinucleotide homeostasis in cortical neurons.Q48319980
The immunophilin ligand GPI1046 protects neurons from the lethal effects of the HIV-1 proteins gp120 and Tat by modulating endoplasmic reticulum calcium loadQ48485626
Effects of ketogenic diet on electroconvulsive threshold and brain contents of adenosine nucleotidesQ48824185
Oxidative damage induced by the injection of HIV-1 Tat protein in the rat striatumQ48877809
Permeability of the blood-brain barrier to HIV-1 Tat.Q48938059
The ketogenic diet and epilepsyQ56431461
[HIV-1 neuropathogenesis: therapeutic strategies against neuronal loss induced by gp120/Tat glycoprotein in the central nervous system]Q58000811
Extraction and measurement of myocardial nucleotides, nucleosides, and purine bases by high-performance liquid chromatographyQ68404881
Cell death in HIV dementiaQ36068289
Cerebral ketone body metabolismQ36118288
Human immunodeficiency virus type-1 protein Tat induces tumor necrosis factor-alpha-mediated neurotoxicityQ36148402
Protection against human immunodeficiency virus type 1 Tat neurotoxicity by Ginkgo biloba extract EGb 761 involving glial fibrillary acidic proteinQ36202870
Secrets of the lac operon. Glucose hysteresis as a mechanism in dietary restriction, aging and diseaseQ36633918
Insulin, ketone bodies, and mitochondrial energy transduction.Q36706028
Bioenergetics of mitochondria in cultured neurons and their role in glutamate excitotoxicityQ36800065
D-beta-hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's diseaseQ36976707
Calcium in cell injury and deathQ37014795
Estradiol and lithium chloride specifically alter NMDA receptor subunit NR1 mRNA and excitotoxicity in primary culturesQ37189865
The comorbidity of HIV-associated neurocognitive disorders and Alzheimer's disease: a foreseeable medical challenge in post-HAART eraQ37193610
PDGF-mediated protection of SH-SY5Y cells against Tat toxin involves regulation of extracellular glutamate and intracellular calciumQ37366558
Continued high prevalence and adverse clinical impact of human immunodeficiency virus-associated sensory neuropathy in the era of combination antiretroviral therapy: the CHARTER StudyQ37584886
A coat of many colors: neuroimmune crosstalk in human immunodeficiency virus infectionQ37617639
Acetoacetate protects neuronal cells from oxidative glutamate toxicityQ40325330
Delta opioid agonists attenuate TAT(1-72)-induced oxidative stress in SK-N-SH cells.Q40372338
The role of mitochondrial alterations in the combined toxic effects of human immunodeficiency virus Tat protein and methamphetamine on calbindin positive-neurons.Q40447137
Adenosine receptors control HIV-1 Tat-induced inflammatory responses through protein phosphataseQ40518676
Intracellular human immunodeficiency virus Tat expression in astrocytes promotes astrocyte survival but induces potent neurotoxicity at distant sites via axonal transportQ40674779
The role of monoamine metabolism in oxidative glutamate toxicity.Q41158837
Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120.Q41335848
Cerebrospinal fluid HIV RNA originates from both local CNS and systemic sourcesQ41721709
Differential involvement of p38 and JNK MAP kinases in HIV-1 Tat and gp120-induced apoptosis and neurite degeneration in striatal neuronsQ41869742
Ketones inhibit mitochondrial production of reactive oxygen species production following glutamate excitotoxicity by increasing NADH oxidationQ42085329
Ketones prevent synaptic dysfunction induced by mitochondrial respiratory complex inhibitorsQ42177440
Variable progression of HIV-associated dementiaQ42456961
Ketone bodies are protective against oxidative stress in neocortical neuronsQ42510499
Human immunodeficiency virus-1 Tat protein and methamphetamine interact synergistically to impair striatal dopaminergic functionQ42527671
Acetoacetate as regulator of palmitic acid-induced uncoupling involving liver mitochondrial ADP/ATP antiporter and aspartate/glutamate antiporter.Q42969628
D-beta-hydroxybutyrate prevents MPP+-induced neurotoxicity in PC12 cellsQ43256162
Effect of beta-hydroxybutyrate, a cerebral function improving agent, on cerebral hypoxia, anoxia and ischemia in mice and ratsQ43793315
HIV-1 Tat-mediated apoptosis in human brain microvascular endothelial cellsQ44320785
Human immunodeficiency virus type 1 Tat protein directly activates neuronal N-methyl-D-aspartate receptors at an allosteric zinc-sensitive siteQ44459049
Acetoacetate protects hippocampal neurons against glutamate-mediated neuronal damage during glycolysis inhibition.Q44532198
The human immunodeficiency virus type-1 transcription factor Tat produces elevations in intracellular Ca2+ that require function of an N-methyl-D-aspartate receptor polyamine-sensitive siteQ44673435
Excitotoxic calcium overload in a subpopulation of mitochondria triggers delayed death in hippocampal neurons.Q44939763
Cytotoxic effects of exposure to the human immunodeficiency virus type 1 protein Tat in the hippocampus are enhanced by prior ethanol treatmentQ45194007
Ceftriaxone protects against the neurotoxicity of human immunodeficiency virus proteinsQ45403949
Molecular interactions of the type 1 human immunodeficiency virus transregulatory protein Tat with N-methyl-d-aspartate receptor subunitsQ45445627
Neuronal excitatory properties of human immunodeficiency virus type 1 Tat protein.Q45757726
Human immunodeficiency virus type 1 Tat protein induces death by apoptosis in primary human neuron cultures.Q45763749
Antioxidant capacity contributes to protection of ketone bodies against oxidative damage induced during hypoglycemic conditions.Q45995997
Availability of neurotransmitter glutamate is diminished when beta-hydroxybutyrate replaces glucose in cultured neurons.Q46003859
NMDA receptor activation by HIV-Tat protein is clade dependentQ46237608
HIV-1 transactivator of transcription protein induces mitochondrial hyperpolarization and synaptic stress leading to apoptosis.Q46391202
Cocaine-mediated enhancement of Tat toxicity in rat hippocampal cell cultures: the role of oxidative stress and D1 dopamine receptorQ46873640
The ketogenic diet increases mitochondrial uncoupling protein levels and activityQ47866548
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectketone bodiesQ746183
neurotoxicityQ3338704
P304page(s)382-391
P577publication date2012-05-17
P1433published inJournal of NeurochemistryQ6295643
P1476titleKetone bodies protection against HIV-1 Tat-induced neurotoxicity
P478volume122

Reverse relations

cites work (P2860)
Q369841675α-reduced progestogens ameliorate mood-related behavioral pathology, neurotoxicity, and microgliosis associated with exposure to HIV-1 Tat.
Q34131740Atg7 deficiency impairs host defense against Klebsiella pneumoniae by impacting bacterial clearance, survival and inflammatory responses in mice
Q92797381BK channels regulate extracellular Tat-mediated HIV-1 LTR transactivation
Q96350898Conditional expression of HIV-1 Tat in the mouse alters the onset and progression of tonic, inflammatory, and neuropathic hypersensitivity in a sex-dependent manner
Q35215063Creatine protects against mitochondrial dysfunction associated with HIV-1 Tat-induced neuronal injury
Q38716297DNA Repair Interacts with Autophagy To Regulate Inflammatory Responses to Pulmonary Hyperoxia
Q43598814HIV-1 Tat C modulates expression of miRNA-101 to suppress VE-cadherin in human brain microvascular endothelial cells.
Q92548566HIV-1 Tat-Induced Astrocytic Extracellular Vesicle miR-7 Impairs Synaptic Architecture
Q92158622HIV-1 infection alters energy metabolism in the brain: Contributions to HIV-associated neurocognitive disorders
Q45824470Ketone-Based Metabolic Therapy: Is Increased NAD+ a Primary Mechanism?
Q35440147MSM ameliorates HIV-1 Tat induced neuronal oxidative stress via rebalance of the glutathione cycle
Q38101560Neuronal toxicity in HIV CNS disease
Q24293525PACAP27 is protective against tat-induced neurotoxicity
Q40422651Release of calcium from endolysosomes increases calcium influx through N-type calcium channels: Evidence for acidic store-operated calcium entry in neurons
Q27025573Role of neurotrophic factor alterations in the neurodegenerative process in HIV associated neurocognitive disorders
Q52654834Scaling Synapses in the Presence of HIV.
Q49787444TGF-β2-induced EMT is dampened by inhibition of autophagy and TNF-α treatment

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