Tat protein induces human immunodeficiency virus type 1 (HIV-1) coreceptors and promotes infection with both macrophage-tropic and T-lymphotropic HIV-1 strains

scientific article

Tat protein induces human immunodeficiency virus type 1 (HIV-1) coreceptors and promotes infection with both macrophage-tropic and T-lymphotropic HIV-1 strains is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.72.11.8952-8960.1998
P932PMC publication ID110312
P698PubMed publication ID9765440

P50authorJoseph SodroskiQ64524473
P2093author name stringL Huang
A B Pardee
W Hofmann
I Bosch
P2860cites workHIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled ReceptorQ22242268
Identification of a major co-receptor for primary isolates of HIV-1Q22251282
The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequenceQ24561727
Human immunodeficiency virus type 1 Tat upregulates interleukin-2 secretion in activated T cellsQ24649124
The expression of the interleukin 6 gene is induced by the human immunodeficiency virus 1 TAT proteinQ24680024
Tat protein induces self-perpetuating permissivity for productive HIV-1 infectionQ24683211
A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactorsQ28118386
HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic regionQ28252310
HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of diseaseQ28267375
The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolatesQ28282895
HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structureQ28283258
HIV-1-Tat protein promotes chemotaxis and invasive behavior by monocytesQ28286968
Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell lineQ28291464
CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1Q28646859
Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor geneQ29614892
Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDSQ59057787
What can stochastic resonance do?Q59061953
Immune Hyperactivation of HIV-1-Infected T Cells Mediated by Tat and the CD28 PathwayQ63351477
Pleiotropic effects of immobilized versus soluble recombinant HIV-1 Tat protein on CD3-mediated activation, induction of apoptosis, and HIV-1 long terminal repeat transactivation in purified CD4+ T lymphocytesQ71396779
Lipopolysaccharide (LPS) down-regulates CD4 expression in primary human macrophages through induction of endogenous tumour necrosis factor (TNF) and IL-1βQ71808694
Evidence for the differential expression of the functional alpha-melanocyte-stimulating hormone receptor MC-1 on human monocytesQ73271324
Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infectionQ29614956
HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5Q29616094
Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1.Q29622903
CCR5 expression correlates with susceptibility of maturing monocytes to human immunodeficiency virus type 1 infectionQ33782193
Bioassay for trans-activation using purified human immunodeficiency virus tat-encoded protein: trans-activation requires mRNA synthesisQ33834125
HIV-1 replication is controlled at the level of T cell activation and proviral integrationQ33919765
Reciprocal modulations between p53 and Tat of human immunodeficiency virus type 1Q34226294
The role of CCR5 and CCR2 polymorphisms in HIV-1 transmission and disease progressionQ34442744
A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus type 1 strains.Q35868457
CXCR4 expression during lymphopoiesis: implications for human immunodeficiency virus type 1 infection of the thymusQ35892412
Endocytosis and targeting of exogenous HIV-1 Tat proteinQ35926764
The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytesQ36028490
Identification of an Arg-Gly-Asp (RGD) cell adhesion site in human immunodeficiency virus type 1 transactivation protein, tatQ36223757
CD4 down-regulation by nef alleles isolated from human immunodeficiency virus type 1-infected individualsQ36363328
Chemoattractants attract HIV researchersQ36367072
Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes.Q36367109
Bacterial lipopolysaccharide rapidly inhibits expression of C-C chemokine receptors in human monocytesQ36376839
CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitroQ36377185
Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivationQ36639380
Vpu-induced degradation of CD4: requirement for specific amino acid residues in the cytoplasmic domain of CD4.Q36655137
Effects of the human immunodeficiency virus type 1 Tat protein on the expression of inflammatory cytokinesQ36687077
Rapid complementation assays measuring replicative potential of human immunodeficiency virus type 1 envelope glycoprotein mutantsQ36806278
Differential regulation of HIV-1 fusion cofactor expression by CD28 costimulation of CD4+ T cellsQ38933102
Co-receptors for HIV-1 entryQ39265878
Macrophage-tropic HIV: critical for AIDS pathogenesis?Q39273394
Utilization of chemokine receptors, orphan receptors, and herpesvirus-encoded receptors by diverse human and simian immunodeficiency virusesQ39413069
Macrophage tropism: fact or fiction?Q39489497
Viral latency in HIV disease.Q40456335
Tat and the HIV-1 promoterQ40835492
An autocrine loop of HIV type-1 Tat protein responsible for the improved survival/proliferation capacity of permanently Tat-transfected cells and required for optimal HIV-1 LTR transactivating activityQ41278999
Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120.Q41335848
Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat proteinQ41349382
Interleukin 10 increases CCR5 expression and HIV infection in human monocytesQ41779916
The role of a mutant CCR5 allele in HIV-1 transmission and disease progression.Q43521980
HIV-1 envelope glycoprotein gp120 down-regulates CD4 expression in primary human macrophages through induction of endogenous tumour necrosis factor-alphaQ44030691
Modulation of surface antigens of a human monocyte cell line, U937, during incubation with T lymphocyte-conditioned medium: detection of T4 antigen and its presence on normal blood monocytesQ44145033
Loss of circulating T4+ monocytes in patients infected with HTLV-III.Q44248235
HIV-1-Tat modulates the function of monocytes and alters their interactions with microvessel endothelial cells. A mechanism of HIV pathogenesisQ44498807
Evidence that T cell activation is required for HIV-1 entry in CD4+ lymphocytes.Q44968448
The human immunodeficiency virus type-1 Tat protein upregulates Bcl-2 gene expression in Jurkat T-cell lines and primary peripheral blood mononuclear cellsQ45788521
Activation of monocytes by HIV-Tat treatment is mediated by cytokine expression.Q52192468
Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural GeneQ56591978
P433issue11
P921main subjectHuman T-lymphotropic virus 1Q1280388
P1104number of pages9
P304page(s)8952-8960
P577publication date1998-11-01
P1433published inJournal of VirologyQ1251128
P1476titleTat protein induces human immunodeficiency virus type 1 (HIV-1) coreceptors and promotes infection with both macrophage-tropic and T-lymphotropic HIV-1 strains
P478volume72

Reverse relations

cites work (P2860)
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