Spiradoline, a kappa opioid receptor agonist, produces tonic- and use-dependent block of sodium channels expressed in Xenopus oocytes

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Spiradoline, a kappa opioid receptor agonist, produces tonic- and use-dependent block of sodium channels expressed in Xenopus oocytes is …
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scholarly articleQ13442814

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P356DOI10.1016/S0306-3623(01)00079-9
P698PubMed publication ID11483291

P50authorAlan GoldinQ42884134
P2093author name stringPugsley MK
Yu EJ
P2860cites workA quantitative description of membrane current and its application to conduction and excitation in nerveQ22337072
Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channelQ28186859
Cardiac sodium channels (hH1) are intrinsically more sensitive to block by lidocaine than are skeletal muscle (mu 1) channelsQ28379079
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Kinetic effects of quaternary lidocaine block of cardiac sodium channels: a gating current studyQ36411498
Blockade of current through single calcium channels by Cd2+, Mg2+, and Ca2+. Voltage and concentration dependence of calcium entry into the poreQ36433881
Sodium channel inactivation is altered by substitution of voltage sensor positive chargesQ36435941
A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivationQ37301303
A neutral amino acid change in segment IIS4 dramatically alters the gating properties of the voltage-dependent sodium channelQ37665790
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Antiarrhythmic agents: the modulated receptor mechanism of action of sodium and calcium channel-blocking drugsQ40110329
Structure and function of voltage-dependent sodium channels: comparison of brain II and cardiac isoformsQ40935493
Two human paramyotonia congenita mutations have opposite effects on lidocaine block of Na+ channels expressed in a mammalian cell lineQ41161442
Quantitative analysis of effects of kappa-opioid agonists on postischemic hippocampal CA1 neuronal necrosis in gerbilsQ41336024
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On the molecular nature of the lidocaine receptor of cardiac Na+ channels. Modification of block by alterations in the alpha-subunit III-IV interdomainQ41679802
Primary structure and expression of a sodium channel characteristic of denervated and immature rat skeletal muscleQ41745813
Cardiovascular actions of the κ‐agonist, U‐50,488H, in the absence and presence of opioid receptor blockadeQ42028208
Molecular determinants of state-dependent block of Na+ channels by local anestheticsQ42284240
Functional analysis of the rat I sodium channel in xenopus oocytes.Q42545515
Stereoselective block of cardiac sodium channels by bupivacaine in guinea pig ventricular myocytesQ42677849
PD117302: a selective agonist for the kappa-opioid receptorQ42849304
Effects of bisaramil, a novel class I antiarrhythmic agent, on heart, skeletal muscle and brain Na+ channelsQ43489970
An electrophysiological basis for the antiarrhythmic actions of the kappa-opioid receptor agonist U-50,488H.Q44335415
Effects of drugs interacting with opioid receptors during normal perfusion or ischemia and reperfusion in the isolated rat heart--an attempt to identify cardiac opioid receptor subtype(s) involved in arrhythmogenesisQ44336625
Beneficial effects of the kappa opioid receptor agonist U-50488H in experimental acute brain and spinal cord injuryQ44342356
Highly selective kappa opioid analgesics. Synthesis and structure-activity relationships of novel N-[(2-aminocyclohexyl)aryl]acetamide and N-[(2-aminocyclohexyl)aryloxy]acetamide derivativesQ44342759
Protection from cerebral ischemia by U-50,488E, a specific kappa opioid analgesic agentQ44346283
Class III antiarrhythmic effects of zatebradine. Time-, state-, use-, and voltage-dependent block of hKv1.5 channelsQ46817303
Preparation of RNA for injection into Xenopus oocytesQ48588746
Lidocaine blockade of continuously and transiently accessible sites in cardiac sodium channels*1Q51717818
Antiarrhythmic effects of U-50,488H in rats subject to coronary artery occlusionQ68084734
Sodium channel-blocking properties of spiradoline, a kappa receptor agonist, are responsible for its antiarrhythmic action in the ratQ77738084
P433issue6
P921main subjectopioidQ427523
P304page(s)417-427
P577publication date2000-06-01
P1433published inGeneral PharmacologyQ27710984
P1476titleSpiradoline, a kappa opioid receptor agonist, produces tonic- and use-dependent block of sodium channels expressed in Xenopus oocytes
P478volume34

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cites work (P2860)
Q34212344A review of the properties of spiradoline: a potent and selective kappa-opioid receptor agonist.
Q36638349Insight into the Mode of Action of Haedoxan A from Phryma leptostachya

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