A safety study of a B-class CpG ODN in Sprague-Dawley rats

scientific article published on 29 April 2011

A safety study of a B-class CpG ODN in Sprague-Dawley rats is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/JAT.1683
P698PubMed publication ID21538408

P2093author name stringBo Li
Li Liu
Liying Wang
Chunyan He
Jianning Sun
Xiaomeng Liu
Yongli Yu
Lianzhong Shen
Yinzeng Li
P2860cites workLymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administrationQ38345478
Activation of APCs through CD40 or Toll-like receptor 9 overcomes tolerance and precipitates autoimmune diseaseQ38363544
Stimulatory effects of CpG oligodeoxynucleotide on dendritic cell-based immunotherapy of colon cancer in CEA/HLA-A2 transgenic miceQ39912017
CpG immunomer DNA enhances antisense protein kinase A RIalpha inhibition of multidrug-resistant colon carcinoma growth in nude mice: molecular basis for combinatorial therapyQ40382325
Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cellsQ40382473
CpG increases vaccine antigen-specific cell-mediated immunity when administered with hepatitis B vaccine in HIV infection.Q42422809
Dendritic cells pulsed with hepatitis C virus NS3 protein induce immune responses and protection from infection with recombinant vaccinia virus expressing NS3.Q42997168
Extensive necrosis of visceral melanoma metastases after immunotherapyQ43111380
Synthetic CpG oligodeoxynucleotides accelerate the development of lupus nephritis during preactive phase in NZB x NZWF1 miceQ44687455
Protection of mice against Brucella abortus 544 challenge by vaccination with recombinant OMP28 adjuvanted with CpG oligonucleotidesQ45251770
Co-administration of polyphosphazenes with CpG oligodeoxynucleotides strongly enhances immune responses in mice immunized with Hepatitis B virus surface antigenQ45262603
A CpG oligodeoxynucleotide acts as a potent adjuvant for inactivated rabies virus vaccineQ45396680
CpG-C ISS-ODN activation of blood-derived B cells from healthy and chronic immunodeficiency virus-infected macaquesQ45420331
Immunostimulatory DNA sequences influence the course of adjuvant arthritisQ46321005
CpG oligonucleotide, host defense peptide and polyphosphazene act synergistically, inducing long-lasting, balanced immune responses in cattleQ47841368
New malaria vaccine candidates based on the Plasmodium vivax Merozoite Surface Protein-1 and the TLR-5 agonist Salmonella Typhimurium FliC flagellin.Q47878245
Intranasal administration of peptide antigens of HIV with mucosal adjuvant CpG ODN coentrapped in microparticles enhances the mucosal and systemic immune responses.Q51765392
Use of A-type CpG oligodeoxynucleotides as an adjuvant in allergen-specific immunotherapy in humans: a phase I/IIa clinical trial.Q51813678
In vivo and in vitro effect of killed Propionibacterium acnes and its purified soluble polysaccharide on mouse bone marrow stem cells and dendritic cell differentiation.Q54642746
Maternal treatment with a high dose of CpG ODN during gestation alters fetal craniofacial and distal limb development in C57BL/6 miceQ23917440
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Short- and long-term changes in gene expression mediated by the activation of TLR9Q33695664
Immunostimulatory CpG oligonucleotides: Effect on gene expression and utility as vaccine adjuvantsQ33698106
Impaired monocyte maturation in response to CpG oligodeoxynucleotide is related to viral RNA levels in human immunodeficiency virus disease and is at least partially mediated by deficiencies in alpha/beta interferon responsiveness and productionQ33707350
CpG motifs in bacterial DNA and their immune effectsQ34542287
Evaluation of the humoral and cellular immune response to different antigens of Corynebacterium pseudotuberculosis in Canindé goats and their potential protection against caseous lymphadenitis.Q34596263
Therapeutic potential of Toll-like receptor 9 activationQ36501229
Coencapsulation of CpG oligodeoxynucleotides with recombinant Leishmania major stress-inducible protein 1 in liposome enhances immune response and protection against leishmaniasis in immunized BALB/c miceQ36539044
Induction of protective immunity by vaccination against Chlamydia trachomatis using the major outer membrane protein adjuvanted with CpG oligodeoxynucleotide coupled to the nontoxic B subunit of cholera toxinQ36593534
Legionella lipoprotein activates toll-like receptor 2 and induces cytokine production and expression of costimulatory molecules in peritoneal macrophagesQ37411194
Activation of human B cells by the agonist CD40 antibody CP-870,893 and augmentation with simultaneous toll-like receptor 9 stimulationQ37422374
A critical role of CpG motifs in a murine peritonitis model by their binding to highly expressed toll-like receptor-9 on liver NKT cellsQ38308732
Stimulation via Toll-like receptor 9 reduces Cryptococcus neoformans-induced pulmonary inflammation in an IL-12-dependent mannerQ38333159
Rat plasmacytoid dendritic cells are an abundant subset of MHC class II+ CD4+CD11b-OX62- and type I IFN-producing cells that exhibit selective expression of Toll-like receptors 7 and 9 and strong responsiveness to CpG.Q38340284
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)60-71
P577publication date2011-04-29
P1433published inJournal of Applied ToxicologyQ3186896
P1476titleA safety study of a B-class CpG ODN in Sprague-Dawley rats
P478volume32

Reverse relations

cites work (P2860)
Q27025290Epithelial toll-like receptor 9 signaling in colorectal inflammation and cancer: clinico-pathogenic aspects
Q42011532Initial preclinical safety of non-replicating human endogenous retrovirus envelope protein-coated baculovirus vector-based vaccines against human papillomavirus

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