Resistant mice lacking interleukin-12 become susceptible to Trypanosoma cruzi infection but fail to mount a T helper type 2 response

scientific article published in February 2003

Resistant mice lacking interleukin-12 become susceptible to Trypanosoma cruzi infection but fail to mount a T helper type 2 response is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1046/J.1365-2567.2003.01571.X
P932PMC publication ID1782876
P698PubMed publication ID12562332
P5875ResearchGate publication ID10922329

P2093author name stringAna Paula Galvão Da Silva
Ises De Almeida Abrahamsohn
Jacqueline F Jacysyn
P2860cites workNovel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12Q24290619
Interleukin-12 stimulation of lymphoproliferative responses in Trypanosoma cruzi infectionQ28365242
Effects of interleukin-4 deprivation and treatment on resistance to Trypanosoma cruziQ34003863
Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosisQ34431001
Nitric oxide is involved in control of Trypanosoma cruzi-induced parasitemia and directly kills the parasite in vitroQ34546031
Tumor necrosis factor alpha mediates resistance to Trypanosoma cruzi infection in mice by inducing nitric oxide production in infected gamma interferon-activated macrophagesQ35457307
Interleukin-12 mediates resistance to Trypanosoma cruzi in mice and is produced by murine macrophages in response to live trypomastigotesQ35494931
Interleukin-12-mediated resistance to Trypanosoma cruzi is dependent on tumor necrosis factor alpha and gamma interferon.Q35501871
Pivotal role of interleukin-12 and interferon-gamma axis in controlling tissue parasitism and inflammation in the heart and central nervous system during Trypanosoma cruzi infectionQ35750253
Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonistQ36260899
Stage-dependent role of nitric oxide in control of Trypanosoma cruzi infectionQ39419338
Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in gamma interferon receptor or inducible nitric oxide synthaseQ39570411
Trypanosoma cruzi infection in tumor necrosis factor receptor p55-deficient miceQ39571751
Regulation of nitric oxide synthesis in infectious and autoimmune diseasesQ40517670
Mechanism and regulation of immunoglobulin isotype switching.Q40850235
The microbicidal activity of interferon-gamma-treated macrophages against Trypanosoma cruzi involves an L-arginine-dependent, nitrogen oxide-mediated mechanism inhibitable by interleukin-10 and transforming growth factor-betaQ41600919
Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-gamma in murine macrophagesQ41640032
Synergism between tumor necrosis factor-alpha and interferon-gamma on macrophage activation for the killing of intracellular Trypanosoma cruzi through a nitric oxide-dependent mechanismQ41641701
Trypanosoma cruzi: maintenance of parasite-specific T cell responses in lymph nodes during the acute phase of the infectionQ41746672
Modulation induced by estradiol in the acute phase of Trypanosoma cruzi infection in miceQ43695103
Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruziQ44684713
In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) settingQ45069275
Influence of female gonadal hormones on the parasitemia of female Calomys callosus infected with the "Y" strain of Trypanosoma cruziQ50904202
Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response.Q52520769
Trypanosoma cruzi: IL-10, TNF, IFN-gamma, and IL-12 regulate innate and acquired immunity to infection.Q52522603
Macrophages from IL-12p40-deficient mice have a bias toward the M2 activation profile.Q52937076
NF-kappa B2 is required for optimal CD40-induced IL-12 production but dispensable for Th1 cell Differentiation.Q53973062
IL-12-independent IFN-gamma production by T cells in experimental Chagas' disease is mediated by IL-18.Q53994536
Endogenous IFN-gamma is required for resistance to acute Trypanosoma cruzi infection in mice.Q54296214
Prostaglandins mediate suppression of lymphocyte proliferation and cytokine synthesis in acute Trypanosoma cruzi infectionQ58842426
Antigen-specific Il-4- and IL-10-secreting CD4+ lymphocytes increase in vivo susceptibility to Trypanosoma cruzi infectionQ58843389
Cytokine and nitric oxide regulation of the immunosuppression in Trypanosoma cruzi infectionQ58843603
IgG subclasses responsible for immune clearance in mice infected with Trypanosoma cruziQ58845286
Kinetics of cytokine gene expression in experimental chagasic cardiomyopathy: tissue parasitism and endogenous IFN-gamma as important determinants of chemokine mRNA expression during infection with Trypanosoma cruziQ58846768
Leishmania sp: comparative study with Toxoplasma gondii and Trypanosoma cruzi in their ability to initialize IL-12 and IFN-gamma synthesisQ58846788
Interleukin-12: a cytokine at the interface of inflammation and immunityQ77355814
P433issue2
P921main subjectTrypanosoma cruziQ150162
P304page(s)230-237
P577publication date2003-02-01
P1433published inImmunologyQ15754984
P1476titleResistant mice lacking interleukin-12 become susceptible to Trypanosoma cruzi infection but fail to mount a T helper type 2 response
P478volume108

Reverse relations

cites work (P2860)
Q33760119A synthetic peptide from Trypanosoma cruzi mucin-like associated surface protein as candidate for a vaccine against Chagas disease
Q59800419Arginase-1 Is Responsible for IL-13-Mediated Susceptibility to Trypanosoma cruzi Infection
Q27319499Bradykinin B2 Receptors of dendritic cells, acting as sensors of kinins proteolytically released by Trypanosoma cruzi, are critical for the development of protective type-1 responses
Q37310959Chagas' disease: an update on immune mechanisms and therapeutic strategies
Q37582794Combined vaccine regimen based on parenteral priming with a DNA vaccine and administration of an oral booster consisting of a recombinant Salmonella enterica serovar Typhimurium vaccine strain for immunization against infection with human-derived en
Q38927945Epstein-Barr virus-induced gene 3 suppresses T helper type 1, type 17 and type 2 immune responses after Trypanosoma cruzi infection and inhibits parasite replication by interfering with alternative macrophage activation
Q37754742Gene expression patterns and susceptibility to allergic responses.
Q37426304Host and bacterial factors affecting induction of immune responses to flagellin expressed by attenuated Salmonella vaccine strains
Q33282864Modulation of CD4(+) T cell-dependent specific cytotoxic CD8(+) T cells differentiation and proliferation by the timing of increase in the pathogen load
Q33483331NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection
Q35758872The Anti-Trypanosoma cruzi activity of posaconazole in a murine model of acute Chagas' disease is less dependent on gamma interferon than that of benznidazole
Q58705710The Unsolved Jigsaw Puzzle of the Immune Response in Chagas Disease
Q35126647The use of a heterogeneously controlled mouse population reveals a significant correlation of acute phase parasitemia with mortality in Chagas disease.
Q46009587Trypanosoma cruzi: dehydroepiandrosterone (DHEA) and immune response during the chronic phase of the experimental Chagas' disease.

Search more.