Pivotal role of interleukin-12 and interferon-gamma axis in controlling tissue parasitism and inflammation in the heart and central nervous system during Trypanosoma cruzi infection

scientific article published on November 2001

Pivotal role of interleukin-12 and interferon-gamma axis in controlling tissue parasitism and inflammation in the heart and central nervous system during Trypanosoma cruzi infection is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0002-9440(10)63019-2
P932PMC publication ID3277321
P698PubMed publication ID11696433
P5875ResearchGate publication ID11658839

P2093author name stringL Q Vieira
C D Rocha
J Lannes-Vieira
N M Silva
R T Gazzinelli
V Michailowsky
P2860cites workTrypanosoma cruzi meningoencephalitis in HIV-infected patientsQ33546054
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Nitric oxide is involved in control of Trypanosoma cruzi-induced parasitemia and directly kills the parasite in vitroQ34546031
Tumor necrosis factor alpha mediates resistance to Trypanosoma cruzi infection in mice by inducing nitric oxide production in infected gamma interferon-activated macrophagesQ35457307
Regulation of Trypanosoma cruzi infection in mice by gamma interferon and interleukin 10: role of NK cellsQ35462159
Interleukin-12 mediates resistance to Trypanosoma cruzi in mice and is produced by murine macrophages in response to live trypomastigotesQ35494931
Modulation of chagasic cardiomyopathy by interleukin-4: dissociation between inflammation and tissue parasitismQ35746981
Depletion of T-cell subpopulations results in exacerbation of myocarditis and parasitism in experimental Chagas' diseaseQ35779913
Genetic characterization of Trypanosoma cruzi directly from tissues of patients with chronic Chagas disease: differential distribution of genetic types into diverse organsQ35810210
Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsetsQ36355870
T cell genetic background determines default T helper phenotype development in vitroQ36364428
Genetics of murine resistance to Trypanosoma cruzi.Q36435831
Genetic control of responses to Trypanosoma cruzi in mice: multiple genes influencing parasitemia and survivalQ36441021
Chagas' disease: CD5 B-cell-dependent Th2 pathology?Q36671183
The indeterminate form of human chronic Chagas' disease A clinical epidemiological reviewQ38215235
Correlation between Trypanosoma cruzi parasitism and myocardial inflammatory infiltrate in human chronic chagasic myocarditis: Light microscopy and immunohistochemical findingsQ39067405
Trypanosoma cruzi induces strong IL-12 and IL-18 gene expression in vivo: correlation with interferon-gamma (IFN-gamma) productionQ39248577
Stage-dependent role of nitric oxide in control of Trypanosoma cruzi infectionQ39419338
Interleukin-12 enhances in vivo parasiticidal effect of benznidazole during acute experimental infection with a naturally drug-resistant strain of Trypanosoma cruziQ39559044
Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in gamma interferon receptor or inducible nitric oxide synthaseQ39570411
Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformansQ39573339
Cardiac involvement is a constant finding in acute Chagas' disease: a clinical, parasitological and histopathological studyQ40649314
Pathology of patients with Chagas' disease and acquired immunodeficiency syndrome.Q40735125
Impaired interleukin 12 production in human immunodeficiency virus-infected patientsQ41478389
The microbicidal activity of interferon-gamma-treated macrophages against Trypanosoma cruzi involves an L-arginine-dependent, nitrogen oxide-mediated mechanism inhibitable by interleukin-10 and transforming growth factor-betaQ41600919
Immunological control of Trypanosoma cruzi infection and pathogenesis of Chagas' disease.Q41617474
Anti-CD4 abrogates rejection and reestablishes long-term tolerance to syngeneic newborn hearts grafted in mice chronically infected with Trypanosoma cruziQ41823109
Influence of Trypanosoma cruzi strain on the pathogenesis of chronic myocardiopathy in miceQ43772956
Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruziQ44684713
Reactivation of Chagas' disease in a human immunodeficiency virus-infected patient leading to severe heart disease with a late positive direct microscopic examination of the blood.Q45752490
Trypanosoma cruzi: IL-10, TNF, IFN-gamma, and IL-12 regulate innate and acquired immunity to infection.Q52522603
CHRONIC AND PROGRESSIVE MYOCARDITIS AND MYOSITIS IN C3H MICE INFECTED WITH TRYPANOSOMA CRUZI.Q52630738
Endogenous IFN-gamma is required for resistance to acute Trypanosoma cruzi infection in mice.Q54296214
Chagas' disease: Trypanosoma cruzi vs. the host immune systemQ57842381
Chagas' disease encephalitis: intense CD8+ lymphocytic infiltrate is restricted to the acute phase, but is not related to the presence of Trypanosoma cruzi antigensQ58842381
Differential tissue distribution of diverse clones of Trypanosoma cruzi in infected miceQ58842411
Myocardial parasite persistence in chronic chagasic patientsQ58842412
An in situ quantitative immunohistochemical study of cytokines and IL-2R+ in chronic human chagasic myocarditis: correlation with the presence of myocardial Trypanosoma cruzi antigensQ58843149
IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruziQ58843169
PCR detection of Trypanosoma cruzi DNA in oesophageal tissues of patients with chronic digestive Chagas' diseaseQ58843303
Chagasic meningoencephalitis with detection of Trypanosoma cruzi in the cerebrospinal fluid of an immunodepressed patientQ58843842
Amplification of a Trypanosoma cruzi DNA sequence from inflammatory lesions in human chagasic cardiomyopathyQ58844325
Depletion of CD8+ T cells increases susceptibility and reverses vaccine-induced immunity in mice infected with Trypanosoma cruziQ58845221
Kinetics of cytokine gene expression in experimental chagasic cardiomyopathy: tissue parasitism and endogenous IFN-gamma as important determinants of chemokine mRNA expression during infection with Trypanosoma cruziQ58846768
Impaired production of lymphokines and immune (gamma) interferon in the acquired immunodeficiency syndromeQ70468096
The mechanisms of Trypanosoma cruzi invasion of mammalian cellsQ70899913
HIV infection suppresses type 1 lymphokine and IL-12 responses to Toxoplasma gondii but fails to inhibit the synthesis of other parasite-induced monokinesQ71961117
Cutting edge: IL-12 is required for the maintenance of IFN-gamma production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondiiQ73948679
Interleukin-4 and interferon-gamma: the quintessence of a mutual antagonistic relationshipQ77579665
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectnervous systemQ9404
Trypanosoma cruziQ150162
P304page(s)1723-1733
P577publication date2001-11-01
P1433published inThe American Journal of PathologyQ4744259
P1476titlePivotal role of interleukin-12 and interferon-gamma axis in controlling tissue parasitism and inflammation in the heart and central nervous system during Trypanosoma cruzi infection
P478volume159

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