Crucial role for T cell-intrinsic IL-18R-MyD88 signaling in cognate immune response to intracellular parasite infection

scientific article published on 12 September 2017

Crucial role for T cell-intrinsic IL-18R-MyD88 signaling in cognate immune response to intracellular parasite infection is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.7554/ELIFE.30883
P932PMC publication ID5629024
P698PubMed publication ID28895840

P50authorAna Carolina OliveiraQ95825083
Fábio B CantoQ106265435
Helder I. NakayaQ42614737
Bernardo Sgarbi ReisQ51731843
Maria BellioQ56449330
P2093author name stringAlessandra Granato
Alberto Nóbrega
Bruno Maia Santos
Carlos-Henrique Dantas Barbosa
João Francisco Gomes-Neto
Rita Fucs
P2860cites workIL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiationQ24649009
IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cellsQ24652221
Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction programQ24673216
Issues in T-helper 1 development--resolved and unresolvedQ28592990
Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cellsQ29618163
Analysis of microarray data using Z score transformationQ30787499
Deconvolution of blood microarray data identifies cellular activation patterns in systemic lupus erythematosusQ33476822
Tumor necrosis factor alpha-mediated toxic shock in Trypanosoma cruzi-infected interleukin 10-deficient miceQ33597343
T cell-intrinsic role of IL-6 signaling in primary and memory responsesQ33715213
Impaired innate immunity in Tlr4(-/-) mice but preserved CD8+ T cell responses against Trypanosoma cruzi in Tlr4-, Tlr2-, Tlr9- or Myd88-deficient miceQ33818765
Interleukin 33: a switch-hitting cytokineQ33987547
Interleukin-18 regulates both Th1 and Th2 responsesQ34178165
The interleukin-1 family: back to the futureQ34391415
Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruziQ35147723
Pivotal Role of Interleukin-12 and Interferon-γ Axis in Controlling Tissue Parasitism and Inflammation in the Heart and Central Nervous System during Trypanosoma cruzi InfectionQ35750253
The Immune Response to Trypanosoma cruzi: Role of Toll-Like Receptors and Perspectives for Vaccine DevelopmentQ35838023
Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in miceQ36362141
T cell expression of MyD88 is required for resistance to Toxoplasma gondiiQ36499083
Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cellsQ36553535
MyD88 intrinsically regulates CD4 T-cell responsesQ37099777
Interleukin-18-related genes are induced during the contraction phase but do not play major roles in regulating the dynamics or function of the T-cell response to Listeria monocytogenes infectionQ37191434
CD4+ T cell expression of MyD88 is essential for normal resolution of Chlamydia muridarum genital tract infectionQ37228267
Critical regulation of early Th17 cell differentiation by interleukin-1 signalingQ37250727
Toll-like receptor and inflammasome signals converge to amplify the innate bactericidal capacity of T helper 1 cells.Q37651368
Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88.Q37700302
A role for IL-18 in protective immunity against Mycobacterium tuberculosisQ38659442
Rapid quantitation of Trypanosoma cruzi in host tissue by real-time PCR.Q38957765
Interleukin-12 but not interleukin-18 is required for immunity to Trypanosoma cruzi in miceQ39030716
Signaling through the adaptor molecule MyD88 in CD4+ T cells is required to overcome suppression by regulatory T cellsQ41155531
Defective NK Cell Activity and Th1 Response in IL-18–Deficient MiceQ43595287
Role of IFN-gamma in Th1 differentiation: IFN-gamma regulates IL-18R alpha expression by preventing the negative effects of IL-4 and by inducing/maintaining IL-12 receptor beta 2 expressionQ45173040
IGIF Does Not Drive Th1 Development but Synergizes with IL-12 for Interferon-γ Production and Activates IRAK and NFκBQ45933733
Expression of functional TLR4 confers proinflammatory responsiveness to Trypanosoma cruzi glycoinositolphospholipids and higher resistance to infection with T. cruziQ51822633
MyD88-dependent pathway in T cells directly modulates the expansion of colitogenic CD4+ T cells in chronic colitisQ51965841
Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88.Q53905520
Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cellsQ53968562
Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infectionQ58845195
Genetically Resistant Mice Lacking MyD88-Adapter Protein Display a High Susceptibility to Leishmania major Infection Associated with a Polarized Th2 ResponseQ59312651
Genetically resistant mice lacking IL-18 gene develop Th1 response and control cutaneous Leishmania major infectionQ73812253
Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in miceQ74817301
Interleukin 18-independent engagement of interleukin 18 receptor-alpha is required for autoimmune inflammationQ80102514
The contribution of transcription factor IRF1 to the interferon-gamma-interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cellsQ80146459
P407language of work or nameEnglishQ1860
P921main subjectInterleukin 18 receptor 1Q21120642
P577publication date2017-09-12
P1433published ineLifeQ2000008
P1476titleCrucial role for T cell-intrinsic IL-18R-MyD88 signaling in cognate immune response to intracellular parasite infection
P478volume6

Reverse relations

cites work (P2860)
Q58609021Bystander T Cells: A Balancing Act of Friends and Foes
Q89725115Emerging Roles for Interleukin-18 in the Gastrointestinal Tumor Microenvironment
Q64116658Intracellular Pathogens: Host Immunity and Microbial Persistence Strategies
Q64897365NLRP3 Inflammasome Participates in Host Response to Neospora caninum Infection.
Q94502896São Paulo School of Advanced Sciences on Vaccines: an overview

Search more.