Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells.

scientific article

Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.168.12.5997
P698PubMed publication ID12055206
P5875ResearchGate publication ID11318991

P50authorAlan SherQ88390533
Ruslan MedzhitovQ517459
P2093author name stringDragana Jankovic
Julio Aliberti
Eric Y Denkers
Soumaya Bennouna
Charles A Scanga
Florence Tilloy
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectToxoplasma gondiiQ131003
dendritic cellQ506253
P304page(s)5997-6001
P577publication date2002-06-01
P1433published inJournal of ImmunologyQ3521441
P1476titleCutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells.
P478volume168

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cites work (P2860)
Q3745119012/15-lipoxygenase-dependent myeloid production of interleukin-12 is essential for resistance to chronic toxoplasmosis
Q35147460A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses
Q33530781A simple method to detect Toxoplasma gondii-specific cytotoxic T cells in vivo
Q33591077A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3.
Q40097769Activation of ERK Signaling via TLR11 Induces IL-12p40 Production in Peritoneal Macrophages Challenged by Neospora caninum
Q37173798Activation requirements and responses to TLR ligands in human CD4+ T cells: comparison of two T cell isolation techniques
Q26771957Advances in T Helper 17 Cell Biology: Pathogenic Role and Potential Therapy in Multiple Sclerosis
Q37056732Advances in the use of genetically engineered parasites to study immunity to Toxoplasma gondii
Q97568152An Important Role for CD4+ T Cells in Adaptive Immunity to Toxoplasma gondii in Mice Lacking the Transcription Factor Batf3
Q38247207Apicomplexan infections in the gut.
Q35920573Attenuated Toxoplasma gondii Stimulates Immunity to Pancreatic Cancer by Manipulation of Myeloid Cell Populations
Q33893517B cell TLRs and induction of immunoglobulin class-switch DNA recombination
Q37719443Bacterial infections in Myd88-deficient mice
Q35143581Border maneuvers: deployment of mucosal immune defenses against Toxoplasma gondii
Q98177694C5aR1 Activation Drives Early IFN-γ Production to Control Experimental Toxoplasma gondii Infection
Q35209897CD8α(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites
Q35018100CXCR3-dependent CD4⁺ T cells are required to activate inflammatory monocytes for defense against intestinal infection
Q44908648Candidate gene analysis of ocular toxoplasmosis in Brazil: evidence for a role for toll-like receptor 9 (TLR9).
Q37030426Caspase-11 Modulates Inflammation and Attenuates Toxoplasma gondii Pathogenesis
Q91028898Cell mediated and innate immune responses in pigs following vaccination and challenge with Toxoplasma parasites
Q37041277Cell-mediated immunity to Toxoplasma gondii develops primarily by local Th1 host immune responses in the absence of parasite replication
Q34565532Characterization analysis and polymorphism detection of the porcine Myd88 gene
Q80350100Chronic pneumonia despite adaptive immune response to Mycobacterium bovis BCG in MyD88-deficient mice
Q52367196Clonorchis sinensis adult-derived proteins elicit Th2 immune responses by regulating dendritic cells via mannose receptor.
Q36553712Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice
Q33606893Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence
Q38215371Complex immune cell interplay in the gamma interferon response during Toxoplasma gondii infection
Q37743170Congenital toxoplasmosis: candidate host immune genes relevant for vertical transmission and pathogenesis
Q38293610Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and -9.
Q35630534Controlling the Toll road to dendritic cell polarization
Q37248577Cooperation of TLR12 and TLR11 in the IRF8-dependent IL-12 response to Toxoplasma gondii profilin
Q34472010Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors
Q91123087Critical role of TLR2 in triggering protective immunity with cyclophilin entrapped in oligomannose-coated liposomes against Neospora caninum infection in mice
Q33187036Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection
Q40051563Crucial role for T cell-intrinsic IL-18R-MyD88 signaling in cognate immune response to intracellular parasite infection
Q41195214Cutting Edge: Developmental Regulation of IFN-γ Production by Mouse Neutrophil Precursor Cells
Q36709991Cytokine regulation of immunopathology in toxoplasmosis
Q35178634Dendritic cells and host resistance to infection.
Q38944438Dendritic cells and parasites: from recognition and activation to immune response instruction
Q35219298Dendritic cells as inducers of antimicrobial immunity in vivo
Q41978103Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii
Q37257003Diacylglycerol kinases in immune cell function and self-tolerance
Q48890621Dissemination of Toxoplasma gondii to immunoprivileged organs and role of Toll/interleukin-1 receptor signalling for host resistance assessed by in vivo bioluminescence imaging
Q37256528Distinct roles for MyD88 and Toll-like receptor 2 during Leishmania braziliensis infection in mice
Q36710716Distinct roles for MyD88 and Toll-like receptors 2, 5, and 9 in phagocytosis of Borrelia burgdorferi and cytokine induction
Q38266457Do you see what I see: Recognition of protozoan parasites by Toll-like receptors
Q37621648Dual role for inflammasome sensors NLRP1 and NLRP3 in murine resistance to Toxoplasma gondii
Q35220267Dual role of MyD88 in rapid clearance of relapsing fever Borrelia spp
Q36029085Early response of mucosal epithelial cells during Toxoplasma gondii infection
Q34983845Evasion of innate immunity by parasitic protozoa
Q24673216Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program
Q37119134Experimental and natural infections in MyD88- and IRAK-4-deficient mice and humans
Q37700302Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88.
Q40991779Flt3 Ligand Is Essential for Survival and Protective Immune Responses during Toxoplasmosis
Q35594836From cells to signaling cascades: manipulation of innate immunity by Toxoplasma gondii
Q42623337Full-length sequence and expression analysis of a myeloid differentiation factor 88 (MyD88) in half-smooth tongue sole Cynoglossus semilaevis
Q40053470Functional analysis of a zebrafish myd88 mutant identifies key transcriptional components of the innate immune system.
Q37374974Functional aspects of Toll-like receptor/MyD88 signalling during protozoan infection: focus on Toxoplasma gondii
Q36090933Functional diversity and plasticity of human dendritic cell subsets
Q39500713Fusion of foreign T-cell epitopes and addition of TLR agonists enhance immunity against Neospora caninum profilin in cattle
Q36921649Genome-wide comparative analysis revealed significant transcriptome changes in mice after Toxoplasma gondii infection
Q50332623Graft-versus-host disease is independent of innate signaling pathways triggered by pathogens in host hematopoietic cells
Q37353312Gut commensal bacteria direct a protective immune response against Toxoplasma gondii.
Q37521754Helicobacter pylori infection targets adherens junction regulatory proteins and results in increased rates of migration in human gastric epithelial cells.
Q34941305High levels of susceptibility and T helper 2 response in MyD88-deficient mice infected with Leishmania major are interleukin-4 dependent
Q39113003Host cell signalling and leishmania mechanisms of evasion.
Q36015869Host persistence: exploitation of anti-inflammatory pathways by Toxoplasma gondii
Q36830211How important are Toll-like receptors for antimicrobial responses?
Q39686718Identification of key immune mediators regulating T helper 1 responses in swine.
Q89516778Immediate Interferon Gamma Induction Determines Murine Host Compatibility Differences between Toxoplasma gondii and Neospora caninum
Q24612341Immune response and immunopathology during toxoplasmosis
Q36685549Impact of lipoxin-mediated regulation on immune response to infectious disease
Q36396820Impaired innate immunity in mice deficient in interleukin-1 receptor-associated kinase 4 leads to defective type 1 T cell responses, B cell expansion, and enhanced susceptibility to infection with Toxoplasma gondii
Q35064310In the belly of the beast: subversion of macrophage proinflammatory signalling cascades during Toxoplasma gondii infection
Q35329145Increased disease severity of parasite-infected TLR2-/- mice is correlated with decreased central nervous system inflammation and reduced numbers of cells with alternatively activated macrophage phenotypes in a murine model of neurocysticercosis
Q35176429Induction and regulation of IL-12-dependent host resistance to Toxoplasma gondii
Q55512573Induction of Hypergammaglobulinemia and Autoantibodies by Salmonella Infection in MyD88-Deficient Mice.
Q50714975Induction of dendritic cell migration upon Toxoplasma gondii infection potentiates parasite dissemination.
Q28545027Induction of interferon-stimulated genes by IRF3 promotes replication of Toxoplasma gondii
Q34043775Inflammasomes in host response to protozoan parasites.
Q93050874Inflammatory Role of TLR-MyD88 Signaling in Multiple Sclerosis
Q56880717Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function
Q36835115Inhibition of TLR3 and TLR4 function and expression in human dendritic cells by helminth parasites
Q38181331Innate immunity to Toxoplasma gondii infection
Q37735128Innate resistance against Toxoplasma gondii: an evolutionary tale of mice, cats, and men.
Q35175437Innate responses to Toxoplasma gondii in mice and humans
Q91890897Innate, adaptive, and cell-autonomous immunity against Toxoplasma gondii infection
Q37953824Insights into inflammatory bowel disease using Toxoplasma gondii as an infectious trigger
Q35832497Interactions between NK cells and B lymphocytes
Q27011746Interferon-gamma- and perforin-mediated immune responses for resistance against Toxoplasma gondii in the brain
Q34576329Internalization and TLR-dependent type I interferon production by monocytes in response to Toxoplasma gondii
Q92564206Involvement of Toll-like receptor 2 in the cerebral immune response and behavioral changes caused by latent Toxoplasma infection in mice
Q34992629Kaposi's sarcoma-associated herpesvirus-encoded replication and transcription activator impairs innate immunity via ubiquitin-mediated degradation of myeloid differentiation factor 88
Q52994753Lack of antigen-specific Th1 response alters granuloma formation and composition in Schistosoma mansoni-infected MyD88-/- mice.
Q28082315Long-Term Relationships: the Complicated Interplay between the Host and the Developmental Stages of Toxoplasma gondii during Acute and Chronic Infections
Q36879444Macrophage migration inhibitory factor (MIF) is critical for the host resistance against Toxoplasma gondii
Q35884234Manipulation of mitogen-activated protein kinase/nuclear factor-kappaB-signaling cascades during intracellular Toxoplasma gondii infection
Q58864880Mast cells are crucial in the resistance againstToxoplasma gondiioral infection
Q40227012Microbial infection-induced expansion of effector T cells overcomes the suppressive effects of regulatory T cells via an IL-2 deprivation mechanism
Q38743095Modulation of Toll-like receptor signaling in innate immunity by natural products
Q39124518Modulation of host immune responses to Toxoplasma gondii by microRNAs.
Q34033981Modulation of innate immunity by Toxoplasma gondii virulence effectors
Q37577380Molecular markers of susceptibility to ocular toxoplasmosis, host and guest behaving badly
Q45281820Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells
Q37764125Monocytes mediate mucosal immunity to Toxoplasma gondii
Q36426058Mucosal defences against orally acquired protozoan parasites, emphasis on Toxoplasma gondii infections
Q36981000MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages.
Q28730442MyD88 associated ROS generation is crucial for Lactobacillus induced IL-12 production in macrophage
Q34491817MyD88 deficiency results in tissue-specific changes in cytokine induction and inflammation in interleukin-18-independent mice infected with Borrelia burgdorferi
Q33835188MyD88 expression is required for efficient cross-presentation of viral antigens from infected cells.
Q36594433MyD88 is crucial for the development of a protective CNS immune response to Toxoplasma gondii infection
Q40630648MyD88 is essential for clearance of Leishmania major: possible role for lipophosphoglycan and Toll‐like receptor 2 signaling
Q37062172MyD88 is necessary for neutrophil recruitment in hypersensitivity pneumonitis
Q33392688MyD88 is required for protection from lethal infection with a mouse-adapted SARS-CoV.
Q36539704MyD88 negatively controls hypergammaglobulinemia with autoantibody production during bacterial infection.
Q33714626MyD88 plays a critical T cell-intrinsic role in supporting CD8 T cell expansion during acute lymphocytic choriomeningitis virus infection
Q36371756MyD88 primes macrophages for full-scale activation by interferon-gamma yet mediates few responses to Mycobacterium tuberculosis
Q34416382MyD88 signaling is indispensable for primary influenza A virus infection but dispensable for secondary infection
Q42779098MyD88 signaling is required for efficient innate and adaptive immune responses to Paracoccidioides brasiliensis infection
Q37117674MyD88-deficient mice display a profound loss in resistance to Mycobacterium tuberculosis associated with partially impaired Th1 cytokine and nitric oxide synthase 2 expression
Q37451102MyD88-deficient mice exhibit decreased parasite-induced immune responses but reduced disease severity in a murine model of neurocysticercosis
Q34300981MyD88-dependent pathways mediate resistance to Cryptosporidium parvum infection in mice
Q36170074MyD88-dependent signals are essential for the host immune response in experimental brain abscess.
Q28087307MyD88: a central player in innate immune signaling
Q38789081Mycobacterium fortuitum induces A20 expression that impairs macrophage inflammatory responses.
Q40883190Myeloid differentiation antigen 88 deficiency impairs pathogen clearance but does not alter inflammation in Borrelia burgdorferi-infected mice
Q41532838Myeloid differentiation factor 88 is required for resistance to Neospora caninum infection
Q33814730NF-kappaB1 contributes to T cell-mediated control of Toxoplasma gondii in the CNS.
Q36141120NK cell-derived interferon-γ orchestrates cellular dynamics and the differentiation of monocytes into dendritic cells at the site of infection
Q36231107Negative regulation of cytokine and TLR signalings by SOCS and others
Q33847259Neurophysiological Changes Induced by Chronic Toxoplasma gondii Infection
Q37361936New insights into the roles of dendritic cells in intestinal immunity and tolerance
Q38120958Newly described pattern recognition receptors team up against intracellular pathogens
Q35128914Overproduction of Toxoplasma gondii cyclophilin-18 regulates host cell migration and enhances parasite dissemination in a CCR5-independent manner
Q36053611Parasite Manipulation of the Invariant Chain and the Peptide Editor H2-DM Affects Major Histocompatibility Complex Class II Antigen Presentation during Toxoplasma gondii Infection
Q36553535Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells
Q24643034Pathogen recognition and inflammatory signaling in innate immune defenses
Q35175494Pattern recognition molecules and innate immunity to parasites
Q40548422Peroxiredoxin 1 Contributes to Host Defenses against Mycobacterium tuberculosis.
Q36314019Phosphoinositide-3-kinase-dependent, MyD88-independent induction of CC-type chemokines characterizes the macrophage response to Toxoplasma gondii strains with high virulence
Q81119942Plasmacytoid dendritic cells are activated by Toxoplasma gondii to present antigen and produce cytokines
Q37919542Polymorphisms of innate immunity receptors in infection by parasites
Q27005837Protection and pathology during parasite infection: IL-10 strikes the balance
Q36404749Protective and destructive immunity in the periodontium: Part 1--innate and humoral immunity and the periodontium
Q43425324Protective immunity against Toxoplasma challenge in mice by coadministration of T. gondii antigens and Eimeria profilin-like protein as an adjuvant
Q36655907Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism.
Q26747055Recent advances in understanding apicomplexan parasites
Q39881461Recognition by Toll-like receptor 2 induces antigen-presenting cell activation and Th1 programming during infection by Neospora caninum
Q35192575Recognition of microbial infection by Toll-like receptors
Q34318100Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii
Q36403789Recruitment of Gr-1+ monocytes is essential for control of acute toxoplasmosis
Q90218937Regulation of NF-κB- and STAT1-mediated plasmacytoid dendritic cell functions by A20
Q30409386Regulation of immunopathogenesis during Plasmodium and Toxoplasma infections: more parallels than distinctions?
Q35147723Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruzi
Q37028880Role of TLRs/MyD88 in host resistance and pathogenesis during protozoan infection: lessons from malaria.
Q35884180Role of the Toll/interleukin-1 receptor signaling pathway in host resistance and pathogenesis during infection with protozoan parasites.
Q73548279Roles of glycosylphosphatidylinositols of Toxoplasma gondii. Induction of tumor necrosis factor-alpha production in macrophages
Q30275440STAT1 Signaling in Astrocytes Is Essential for Control of Infection in the Central Nervous System
Q40634602STAT1 is essential for antimicrobial effector function but dispensable for gamma interferon production during Toxoplasma gondii infection.
Q90449433Schizophrenia and bipolar disorders: The Toxoplasma connection
Q37119146Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity
Q58843220Selective maturation of dendritic cells byNippostrongylus brasiliensis-secreted proteins drives Th2 immune responses
Q28250405Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity
Q35192593Shaping the immune response to parasites: role of dendritic cells
Q35951819Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4.
Q36310946Stimulation of innate immune responses by malarial glycosylphosphatidylinositol via pattern recognition receptors.
Q36499083T cell expression of MyD88 is required for resistance to Toxoplasma gondii
Q35984329TB, or not TB: that is the question -- does TLR signaling hold the answer?
Q37040069TLR adaptor MyD88 is essential for pathogen control during oral toxoplasma gondii infection but not adaptive immunity induced by a vaccine strain of the parasite
Q36967641TLR-independent neutrophil-derived IFN-γ is important for host resistance to intracellular pathogens
Q92718987TLR11-independent inflammasome activation is critical for CD4+ T cell-derived IFN-γ production and host resistance to Toxoplasma gondii
Q39331395TLR2 signaling subpathways regulate TLR9 signaling for the effective induction of IL-12 upon stimulation by heat-killed Brucella abortus
Q58585474TNIP1 in Autoimmune Diseases: Regulation of Toll-like Receptor Signaling
Q40017083TRAF6-dependent mitogen-activated protein kinase activation differentially regulates the production of interleukin-12 by macrophages in response to Toxoplasma gondii
Q33899190TRIM21 is critical for survival of Toxoplasma gondii infection and localises to GBP-positive parasite vacuoles.
Q35884210Th2 response polarization during infection with the helminth parasite Schistosoma mansoni
Q36387165The IL-12 Response of Primary Human Dendritic Cells and Monocytes to Toxoplasma gondii Is Stimulated by Phagocytosis of Live Parasites Rather Than Host Cell Invasion.
Q37265478The adaptor molecule MyD88 directly promotes CD8 T cell responses to vaccinia virus
Q35209127The biology of IL-12: coordinating innate and adaptive immune responses
Q54453675The contribution of Toll-like receptor 2 to the innate recognition of a Leishmania infantum silent information regulator 2 protein.
Q41585090The contribution of direct TLR signaling to T cell responses.
Q54701109The development of early host response to Pseudomonas aeruginosa lung infection is critically dependent on myeloid differentiation factor 88 in mice.
Q29615457The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
Q92937037The lectin-specific activity of Toxoplasma gondii microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune priming
Q39285665The myeloid differentiation factor 88 (MyD88) is required for CD4+ T cell effector function in a murine model of inflammatory bowel disease.
Q45231915The physiological regulation of toll-like receptor expression and function in humans
Q43698054The role of MHC haplotypes H2d/H2b in mouse resistance/susceptibility to cyst formation is influenced by the lineage of infective Toxoplasma gondii strain
Q33938242The role of TLR2, TRL3, TRL4, and TRL9 signaling in the pathogenesis of autoimmune disease in a retinal autoimmunity model
Q34941214The use of germ line-mutated mice in understanding host-pathogen interactions
Q37418141Toll-like receptor initiated host defense against Toxoplasma gondii
Q24624348Toll-like receptors and B-cell receptors synergize to induce immunoglobulin class-switch DNA recombination: relevance to microbial antibody responses
Q36483521Toll-like receptors and leishmaniasis.
Q35742370Toll-like receptors and the host defense against microbial pathogens: bringing specificity to the innate-immune system
Q35078620Toll-like receptors and their role in experimental models of microbial infection
Q36422953Toll-like receptors in central nervous system glial inflammation and homeostasis
Q34510368Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential
Q36345480Toll-like receptors in ocular immunity and the immunopathogenesis of inflammatory eye disease
Q40101005Toxoplasma Co-infection Prevents Th2 Differentiation and Leads to a Helminth-Specific Th1 Response
Q38731005Toxoplasma Effectors Targeting Host Signaling and Transcription
Q36410907Toxoplasma gondii GRA7-Induced TRAF6 Activation Contributes to Host Protective Immunity
Q34150369Toxoplasma gondii cyclophilin 18 regulates the proliferation and migration of murine macrophages and spleen cells
Q37333376Toxoplasma gondii cyclophilin 18-mediated production of nitric oxide induces Bradyzoite conversion in a CCR5-dependent manner
Q35434828Toxoplasma gondii effectors are master regulators of the inflammatory response
Q80983681Toxoplasma gondii induces changes in intracellular calcium in macrophages
Q34023014Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control
Q27305548Toxoplasma gondii soluble tachyzoite antigen triggers protective mechanisms against fatal intestinal pathology in oral infection of C57BL/6 mice
Q28240755Toxoplasma gondii- derived profilin triggers human toll-like receptor 5-dependent cytokine production
Q33956789Toxoplasma gondii: 25 years and 25 major advances for the field
Q98205073Treatment of mice with S4B6 IL-2 complex prevents lethal toxoplasmosis via IL-12- and IL-18-dependent interferon-gamma production by non-CD4 immune cells
Q35884184Turning it on and off: regulation of dendritic cell function in Toxoplasma gondii infection
Q27313711UNC93B1 mediates host resistance to infection with Toxoplasma gondii
Q37056347Understanding the multiple functions of Gr-1(+) cell subpopulations during microbial infection
Q39347817Up-regulated TLR2 and TLR4 expressions in liver and spleen during acute murine T. gondii infection
Q26852870Use and abuse of dendritic cells by Toxoplasma gondii
Q34298654Use of transgenic parasites and host reporters to dissect events that promote interleukin-12 production during toxoplasmosis
Q114261762WITHDRAWN: Macrophage migration inhibitory factor (MIF) and pregnancy may impact the balance of intestinal cytokines and the development of intestinal pathology caused by Toxoplasma gondii infection

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