Competition and binding of arginine, imidazole, and aminoguanidine to endothelial nitric oxide synthase: aminoguanidine is a poor model for substrate, intermediate, and arginine analog inhibitor binding

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Competition and binding of arginine, imidazole, and aminoguanidine to endothelial nitric oxide synthase: aminoguanidine is a poor model for substrate, intermediate, and arginine analog inhibitor binding is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S1089-8603(02)00118-0
P698PubMed publication ID12826063

P50authorPavel MartásekQ42546185
P2093author name stringSusan M E Smith
John C Salerno
Satoshi Katsumoto
P2860cites workIsolation of nitric oxide synthetase, a calmodulin-requiring enzymeQ24299059
Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservationQ27617498
The structure of nitric oxide synthase oxygenase domain and inhibitor complexesQ27745924
Structure of nitric oxide synthase oxygenase dimer with pterin and substrateQ27748968
Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal centerQ27766420
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factorQ28299224
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholineQ29547539
Nitric oxide synthases: Roles, tolls, and controlsQ29618629
Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxideQ29619956
Mutation of Glu-361 in human endothelial nitric-oxide synthase selectively abolishes L-arginine binding without perturbing the behavior of heme and other redox centersQ34046008
Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoproteinQ37587741
Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cellsQ37628594
Electron paramagnetic resonance spectroscopy of the heme domain of inducible nitric oxide synthase: binding of ligands at the arginine site induces changes in the heme ligation geometryQ38356425
Characterization of bovine endothelial nitric oxide synthase expressed in E. coli.Q38361671
Nitric oxide: a physiologic messenger moleculeQ40394921
Characterization by electron paramagnetic resonance of the interactions of L-arginine and L-thiocitrulline with the heme cofactor region of nitric oxide synthaseQ41270361
Optical difference spectrophotometry as a probe of rat brain nitric oxide synthase heme-substrate interactionQ41526294
Titration of low K(d) binding sites: binding of arginine analogs to nitric oxide synthasesQ43757040
Spatial relationship between L-arginine and heme binding sites of endothelial nitric-oxide synthaseQ50189774
Mutagenesis of acidic residues in the oxygenase domain of inducible nitric-oxide synthase identifies a glutamate involved in arginine binding.Q54567377
Substrate binding-induced changes in the EPR spectra of the ferrous nitric oxide complexes of neuronal nitric oxide synthaseQ73664568
Substrate and substrate analog binding to endothelial nitric oxide synthase: electron paramagnetic resonance as an isoform-specific probe of the binding mode of substrate analogsQ73718084
P433issue3
P921main subjectendotheliumQ111140
P304page(s)149-154
P577publication date2003-05-01
P1433published inNitric OxideQ7041392
P1476titleCompetition and binding of arginine, imidazole, and aminoguanidine to endothelial nitric oxide synthase: aminoguanidine is a poor model for substrate, intermediate, and arginine analog inhibitor binding
P478volume8

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Q88105642Inhibition of Inducible Nitric Oxide Synthase Attenuates Deficits in Synaptic Plasticity and Brain Functions Following Traumatic Brain Injurycites workP2860

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