| scholarly article | Q13442814 |
| P356 | DOI | 10.1038/6675 |
| P698 | PubMed publication ID | 10074942 |
| P50 | author | Thierry Fischmann | Q67982013 |
| P2093 | author name string | Narula SK | |
| Weber PC | |||
| Hruza A | |||
| Reichert P | |||
| Lunn CA | |||
| Lundell DJ | |||
| Niu XD | |||
| Fossetta JD | |||
| Prongay AJ | |||
| Dolphin E | |||
| P433 | issue | 3 | |
| P304 | page(s) | 233-242 | |
| P577 | publication date | 1999-03-01 | |
| P1433 | published in | Nature structural biology | Q26842658 |
| P1476 | title | Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation | |
| P478 | volume | 6 |
| Q47097540 | 1,6-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors. |
| Q28576068 | A bridging interaction allows calmodulin to activate NO synthase through a bi-modal mechanism |
| Q44771684 | A conserved Val to Ile switch near the heme pocket of animal and bacterial nitric-oxide synthases helps determine their distinct catalytic profiles |
| Q34159837 | A conserved flavin-shielding residue regulates NO synthase electron transfer and nicotinamide coenzyme specificity |
| Q43874033 | A conserved tryptophan 457 modulates the kinetics and extent of N-hydroxy-L-arginine oxidation by inducible nitric-oxide synthase |
| Q43508469 | A kinetic simulation model that describes catalysis and regulation in nitric-oxide synthase. |
| Q37338939 | A professional and personal odyssey |
| Q43568673 | A proximal tryptophan in NO synthase controls activity by a novel mechanism |
| Q44592824 | A tetrahydrobiopterin radical forms and then becomes reduced during Nomega-hydroxyarginine oxidation by nitric-oxide synthase |
| Q36345737 | ADPKD: molecular characterization and quest for treatment |
| Q47842585 | Activation of peroxynitrite by inducible nitric-oxide synthase: a direct source of nitrative stress. |
| Q43887767 | Agmatine oxidation by copper amine oxidase |
| Q27621434 | Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry |
| Q43849849 | Amphibian peptides that inhibit neuronal nitric oxide synthase. Isolation of lesuerin from the skin secretion of the Australian Stony Creek frog Litoria lesueuri |
| Q38908260 | An analysis of horseradish peroxidase enzyme for effluent treatment |
| Q27652490 | Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase |
| Q35836392 | Arg375 tunes tetrahydrobiopterin functions and modulates catalysis by inducible nitric oxide synthase |
| Q52579752 | Aromatic residues and neighboring Arg414 in the (6R)-5,6,7, 8-tetrahydro-L-biopterin binding site of full-length neuronal nitric-oxide synthase are crucial in catalysis and heme reduction with NADPH. |
| Q40703445 | Assembly and activation of heme-deficient neuronal NO synthase with various porphyrins |
| Q92496300 | Association of endothelial nitric oxide synthase (NOS3) gene polymorphisms with primary open-angle glaucoma in a Saudi cohort |
| Q40262562 | Badger macrophages fail to produce nitric oxide, a key anti-mycobacterial effector molecule |
| Q36191972 | Biophysical limits of protein-ligand binding |
| Q38087503 | CO, NO and O2 as Vibrational Probes of Heme Protein Interactions |
| Q43590662 | Calmodulin activates intersubunit electron transfer in the neuronal nitric-oxide synthase dimer |
| Q44476772 | Characterization of Drosophila nitric oxide synthase: a biochemical study. |
| Q58972110 | Characterization of Recombinant Human Endothelial Nitric-oxide Synthase Purified from the YeastPichia pastoris |
| Q47934524 | Chimeric Enzymes of Cytochrome P450 Oxidoreductase and Neuronal Nitric-oxide Synthase Reductase Domain Reveal Structural and Functional Differences |
| Q28485658 | Cloning, expression, and characterization of a nitric oxide synthase protein from Deinococcus radiodurans |
| Q41812699 | Cobalamin in inflammation III - glutathionylcobalamin and methylcobalamin/adenosylcobalamin coenzymes: the sword in the stone? How cobalamin may directly regulate the nitric oxide synthases |
| Q90468974 | Combined effects of cigarette smoking, alcohol drinking and eNOS Glu298Asp polymorphism on blood pressure in Chinese male hypertensive subjects |
| Q44490984 | Competition and binding of arginine, imidazole, and aminoguanidine to endothelial nitric oxide synthase: aminoguanidine is a poor model for substrate, intermediate, and arginine analog inhibitor binding |
| Q36840543 | Conformationally restricted dipeptide amides as potent and selective neuronal nitric oxide synthase inhibitors |
| Q28574134 | Contrasting effects of N5-substituted tetrahydrobiopterin derivatives on phenylalanine hydroxylase, dihydropteridine reductase and nitric oxide synthase |
| Q43823329 | Critical role of the neuronal nitric-oxide synthase heme proximal side residue, Arg418, in catalysis and electron transfer |
| Q78239774 | Crucial role of Lys(423) in the electron transfer of neuronal nitric-oxide synthase |
| Q27640111 | Crystal structure of SANOS, a bacterial nitric oxide synthase oxygenase protein from Staphylococcus aureus |
| Q27633641 | Crystal structure of the FAD/NADPH-binding domain of rat neuronal nitric-oxide synthase. Comparisons with NADPH-cytochrome P450 oxidoreductase |
| Q27640093 | Crystal structures of cyanide complexes of P450cam and the oxygenase domain of inducible nitric oxide synthase-structural models of the short-lived oxygen complexes |
| Q27619063 | Crystal structures of zinc-free and -bound heme domain of human inducible nitric-oxide synthase. Implications for dimer stability and comparison with endothelial nitric-oxide synthase |
| Q39999567 | Deciphering the binding of caveolin-1 to client protein endothelial nitric-oxide synthase (eNOS): scaffolding subdomain identification, interaction modeling, and biological significance |
| Q80488403 | Design of benzene-1,2-diamines as selective inducible nitric oxide synthase inhibitors: a combined de novo design and docking analysis |
| Q37372675 | Design of selective neuronal nitric oxide synthase inhibitors for the prevention and treatment of neurodegenerative diseases |
| Q35865533 | Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair. |
| Q34067176 | Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain. |
| Q44318695 | Differential effects of mutations in human endothelial nitric oxide synthase at residues Tyr-357 and Arg-365 on L-arginine hydroxylation and GN-hydroxy-L-arginine oxidation |
| Q74114991 | Discovery and development of neuronal nitric oxide synthase inhibitors |
| Q37147032 | Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping. |
| Q42162235 | Dissociation and unfolding of inducible nitric oxide synthase oxygenase domain identifies structural role of tetrahydrobiopterin in modulating the heme environment |
| Q44016910 | Distinct dimer interaction and regulation in nitric-oxide synthase types I, II, and III. |
| Q44504070 | Distinct influence of N-terminal elements on neuronal nitric-oxide synthase structure and catalysis |
| Q44640441 | Dynamic regulation of the inducible nitric-oxide synthase by NO: comparison with the endothelial isoform. |
| Q34818959 | Electron supply and catalytic oxidation of nitrogen by cytochrome P450 and nitric oxide synthase |
| Q44368327 | Electron transfer is activated by calmodulin in the flavin domain of human neuronal nitric oxide synthase |
| Q39722526 | Elucidating nitric oxide synthase domain interactions by molecular dynamics |
| Q40485897 | Endogenous methylarginines modulate superoxide as well as nitric oxide generation from neuronal nitric-oxide synthase: differences in the effects of monomethyl- and dimethylarginines in the presence and absence of tetrahydrobiopterin |
| Q30351081 | Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation. |
| Q30278654 | Endothelial nitric oxide synthase in the microcirculation |
| Q34197487 | Endothelial nitric oxide synthase is regulated by ERK phosphorylation at Ser602. |
| Q36221405 | Enzyme Tunnels and Gates As Relevant Targets in Drug Design. |
| Q89869387 | Evolutionary Relationships Between Low Potential Ferredoxin and Flavodoxin Electron Carriers |
| Q27665170 | Exploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine Derivatives |
| Q41229363 | Exploring second coordination sphere effects in nitric oxide synthase |
| Q42085127 | Fourier transform infrared spectroscopy study of ligand photodissociation and migration in inducible nitric oxide synthase |
| Q37995087 | Fragment informatics and computational fragment-based drug design: an overview and update |
| Q47564586 | Genetic variation in human drug-related genes. |
| Q34396417 | Heme enzyme structure and function |
| Q36026278 | Hydroxyethylene isosteres of selective neuronal nitric oxide synthase inhibitors |
| Q39884769 | Identification of iNOS inhibitors using InteraX. |
| Q27631560 | Implications for isoform-selective inhibitor design derived from the binding mode of bulky isothioureas to the heme domain of endothelial nitric-oxide synthase |
| Q58734218 | Importance of Val567 on heme environment and substrate recognition of neuronal nitric oxide synthase |
| Q40720920 | Inducible nitric oxide synthase (NOS2) expressed in septic patients is nitrated on selected tyrosine residues: implications for enzymic activity. |
| Q40276985 | Inhibition of MEK/ERK1/2 signalling alters endothelial nitric oxide synthase activity in an agonist-dependent manner |
| Q73604406 | Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine |
| Q30327608 | Insight into protein structure and protein-ligand recognition by Fourier transform infrared spectroscopy. |
| Q57990988 | Insights into the structural determinants for selective inhibition of nitric oxide synthase isoforms |
| Q43988591 | Interaction of 5-methyltetrahydrofolate and tetrahydrobiopterin on endothelial function |
| Q40815078 | Involvement of the perferryl complex of nitric oxide synthase in the catalysis of secondary free radical formation |
| Q35180269 | Is survival possible without arachidonate metabolites in the brain during systemic infection? |
| Q42560699 | Kinetics of CO Recombination to the Heme in Geobacillus Stearothermophilus Nitric Oxide Synthase |
| Q28345236 | Kinetics of CO binding to the haem domain of murine inducible nitric oxide synthase: differential effects of haem domain ligands |
| Q40932895 | L-arginine binding to nitric-oxide synthase. The role of H-bonds to the nonreactive guanidinium nitrogens |
| Q27627674 | Mapping the active site polarity in structures of endothelial nitric oxide synthase heme domain complexed with isothioureas |
| Q33905282 | Mass spectroscopy and molecular modeling predict endothelial nitric oxide synthase dimer collapse by hydrogen peroxide through zinc tetrathiolate metal-binding site disruption |
| Q34241528 | Mechanism of Nitric Oxide Synthase Regulation: Electron Transfer and Interdomain Interactions. |
| Q44460134 | Mechanistic studies on the intramolecular one-electron transfer between the two flavins in the human neuronal nitric-oxide synthase and inducible nitric-oxide synthase flavin domains |
| Q27649995 | Minimal Pharmacophoric Elements and Fragment Hopping, an Approach Directed at Molecular Diversity and Isozyme Selectivity. Design of Selective Neuronal Nitric Oxide Synthase Inhibitors |
| Q35961100 | Models and mechanisms of O-O bond activation by cytochrome P450. A critical assessment of the potential role of multiple active intermediates in oxidative catalysis |
| Q30275542 | Modulating Vascular Hemodynamics With an Alpha Globin Mimetic Peptide (HbαX). |
| Q54487636 | Molecular basis for hyperactivity in tryptophan 409 mutants of neuronal NO synthase. |
| Q38839293 | Molecular docking analysis of UniProtKB nitrate reductase enzyme with known natural flavonoids |
| Q36728270 | Molecular docking studies of quercetin and its analogues against human inducible nitric oxide synthase |
| Q50848558 | Molecular modeling and simulation of the human eNOS reductase domain, an enzyme involved in the release of vascular nitric oxide. |
| Q30741770 | Mutation of the five conserved histidines in the endothelial nitric-oxide synthase hemoprotein domain. No evidence for a non-heme metal requirement for catalysis |
| Q30537968 | NADPH-cytochrome P450 oxidoreductase: prototypic member of the diflavin reductase family |
| Q24646635 | NO formation by a catalytically self-sufficient bacterial nitric oxide synthase from Sorangium cellulosum |
| Q42907578 | NO synthase isoforms specifically modify peroxynitrite reactivity. |
| Q43806621 | Nitric oxide (NO) traffic in endothelial NO synthase. Evidence for a new NO binding site dependent on tetrahydrobiopterin? |
| Q96614438 | Nitric oxide and the brain. Part 2: Effects following neonatal brain injury-friend or foe? |
| Q39021613 | Nitric oxide synthase and structure-based inhibitor design |
| Q28365347 | Nitric oxide synthase is induced in sporulation of Physarum polycephalum |
| Q34449706 | Nitric oxide synthases activation and inhibition by metallacarborane-cluster-based isoform-specific affectors |
| Q28207668 | Nitric oxide synthases: structure, function and inhibition |
| Q38353623 | Nitric-oxide synthase (NOS) reductase domain models suggest a new control element in endothelial NOS that attenuates calmodulin-dependent activity |
| Q40352723 | Nitric-oxide synthase output state. Design and properties of nitric-oxide synthase oxygenase/FMN domain constructs |
| Q35087382 | Novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase |
| Q44057943 | Novel substrates for nitric oxide synthases |
| Q91887422 | Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold |
| Q34048405 | Oriented single-crystal nuclear resonance vibrational spectroscopy of [Fe(TPP)(MI)(NO)]: quantitative assessment of the trans effect of NO. |
| Q33775518 | Peroxynitrite induces destruction of the tetrahydrobiopterin and heme in endothelial nitric oxide synthase: transition from reversible to irreversible enzyme inhibition |
| Q34217803 | Pharmacogenetic association of NOS3 variants with cardiovascular disease in patients with hypertension: the GenHAT study |
| Q41874577 | Physarum nitric oxide synthases: genomic structures and enzymology of recombinant proteins |
| Q24796301 | Proinflammatory role of inducible nitric oxide synthase in acute hyperoxic lung injury |
| Q37061605 | Protein functional surfaces: global shape matching and local spatial alignments of ligand binding sites |
| Q27621322 | Proton delivery in NO reduction by fungal nitric-oxide reductase. Cryogenic crystallography, spectroscopy, and kinetics of ferric-NO complexes of wild-type and mutant enzymes |
| Q46679093 | Proximal effects in the modulation of nitric oxide synthase reactivity: a QM-MM study |
| Q78659392 | Quantitation of expressed message for inducible nitric oxide synthase |
| Q43717031 | Rapid calmodulin-dependent interdomain electron transfer in neuronal nitric-oxide synthase measured by pulse radiolysis. |
| Q31446994 | Rapid kinetic studies link tetrahydrobiopterin radical formation to heme-dioxy reduction and arginine hydroxylation in inducible nitric-oxide synthase. |
| Q46198845 | Re and (99m)Tc organometallic complexes containing pendant l-arginine derivatives as potential probes of inducible nitric oxide synthase |
| Q37190166 | Reaction of Mycobacterium tuberculosis cytochrome P450 enzymes with nitric oxide |
| Q31448893 | Reconstitution of pterin-free inducible nitric-oxide synthase |
| Q34115975 | Recruitment of governing elements for electron transfer in the nitric oxide synthase family |
| Q40615821 | Redox properties of human endothelial nitric-oxide synthase oxygenase and reductase domains purified from yeast expression system |
| Q46280869 | Redox-Dependent Calpain Signaling in Airway and Pulmonary Vascular Remodeling in COPD. |
| Q37431868 | Regulation of interdomain interactions by calmodulin in inducible nitric-oxide synthase |
| Q37521248 | Regulation of multimers via truncated isoforms: a novel mechanism to control nitric-oxide signaling. |
| Q46899973 | Regulation of the monomer-dimer equilibrium in inducible nitric-oxide synthase by nitric oxide. |
| Q43572177 | Relationship between the G894T polymorphism (Glu298Asp variant) in endothelial nitric oxide synthase and nitric oxide-mediated endothelial function in human atherosclerosis |
| Q27700074 | Ribosome. The complete structure of the 55S mammalian mitochondrial ribosome |
| Q87088527 | Role of Nitric Oxide and Hydrogen Sulfide in the Vasodilator Effect of Ursolic Acid and Uvaol from Black Cherry Prunus serotina Fruits |
| Q28344263 | Role of nitric oxide synthase in the light-induced development of sporangiophores in Phycomyces blakesleeanus |
| Q73333549 | Roles of the heme proximal side residues tryptophan409 and tryptophan421 of neuronal nitric oxide synthase in the electron transfer reaction |
| Q28363098 | Selective inhibition of human inducible nitric oxide synthase by S-alkyl-L-isothiocitrulline-containing dipeptides |
| Q55475480 | Selective inhibition of nitric oxide synthase type I by clonidine, an anti-hypertensive drug. |
| Q89575368 | Solid-Phase Synthesis of Substrate-Based Dipeptides and Heterocyclic Pseudo-dipeptides as Potential NO Synthase Inhibitors |
| Q40382185 | Src-mediated phosphorylation regulates subcellular distribution and activity of human inducible nitric oxide synthase. |
| Q24655182 | Stabilization and characterization of a heme-oxy reaction intermediate in inducible nitric-oxide synthase |
| Q44619462 | Structural Elements Contribute to the Calcium/Calmodulin Dependence on Enzyme Activation in Human Endothelial Nitric-oxide Synthase |
| Q33830350 | Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain |
| Q27642934 | Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase |
| Q42146949 | Structural basis for isoform-selective inhibition in nitric oxide synthase |
| Q44945441 | Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase. |
| Q27635239 | Structural basis for pterin antagonism in nitric-oxide synthase. Development of novel 4-oxo-pteridine antagonists of (6R)-5,6,7,8-tetrahydrobiopterin |
| Q27641955 | Structural basis for the specificity of the nitric-oxide synthase inhibitors W1400 and Nomega-propyl-L-Arg for the inducible and neuronal isoforms |
| Q27641968 | Structural characterization and kinetics of nitric-oxide synthase inhibition by novel N5-(iminoalkyl)- and N5-(iminoalkenyl)-ornithines |
| Q27644394 | Structure-Based Design and Synthesis of N ω -Nitro- l -Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural Water |
| Q41969697 | Structures of human constitutive nitric oxide synthases |
| Q37645554 | Structures of nitric oxide synthase isoforms complexed with the inhibitor AR-R17477 suggest a rational basis for specificity and inhibitor design |
| Q34024333 | Structures of redox enzymes |
| Q53631801 | Suppression of inducible nitric oxide synthase by 10-23 DNAzymes in murine macrophage. |
| Q34094541 | Surface charges and regulation of FMN to heme electron transfer in nitric-oxide synthase |
| Q37873087 | Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease |
| Q28396739 | Telmisartan protects 5/6 Nx rats against renal injury by enhancing nNOS-derived NO generation via regulation of PPARγ signaling |
| Q33687812 | Tetrahydrobiopterin in cardiovascular health and disease |
| Q38084634 | Tetrahydrobiopterin in nitric oxide synthase. |
| Q57219640 | The C termini of constitutive nitric-oxide synthases control electron flow through the flavin and heme domains and affect modulation by calmodulin |
| Q57219760 | The C terminus of mouse macrophage inducible nitric-oxide synthase attenuates electron flow through the flavin domain |
| Q27684931 | The Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme–Inhibitor Interactions in Nitric Oxide Synthases |
| Q34007426 | The N-terminal portion of autoinhibitory element modulates human endothelial nitric-oxide synthase activity through coordinated controls of phosphorylation at Thr495 and Ser1177. |
| Q33848398 | The autoinhibitory control element and calmodulin conspire to provide physiological modulation of endothelial and neuronal nitric oxide synthase activity |
| Q49346285 | The dichotomous role of H2S in cancer cell biology? Déjà vu all over again |
| Q90575937 | The polymorphism G894 T of endothelial nitric oxide synthase (eNOS) gene is associated with susceptibility to essential hypertension (EH) in Morocco |
| Q43011251 | The return of the Scarlet Pimpernel: cobalamin in inflammation II - cobalamins can both selectively promote all three nitric oxide synthases (NOS), particularly iNOS and eNOS, and, as needed, selectively inhibit iNOS and nNOS. |
| Q57217019 | The role of a conserved serine residue within hydrogen bonding distance of FAD in redox properties and the modulation of catalysis by Ca2+/calmodulin of constitutive nitric-oxide synthases |
| Q73123245 | The role of tetrahydrobiopterin in the activation of oxygen by nitric-oxide synthase |
| Q46104207 | The tetrahydrobiopterin radical interacting with high- and low-spin heme in neuronal nitric oxide synthase - A new indicator of the extent of NOS coupling. |
| Q27649209 | The tuberculosis prodrug isoniazid bound to activating peroxidases |
| Q37156500 | Thermodynamic characterization of five key kinetic parameters that define neuronal nitric oxide synthase catalysis. |
| Q44912900 | Three different oxygen-induced radical species in endothelial nitric-oxide synthase oxygenase domain under regulation by L-arginine and tetrahydrobiopterin |
| Q78239730 | Tryptophan 409 controls the activity of neuronal nitric-oxide synthase by regulating nitric oxide feedback inhibition |
| Q37242994 | Two synthetic peptides corresponding to the proximal heme-binding domain and CD1 domain of human endothelial nitric-oxide synthase inhibit the oxygenase activity by interacting with CaM |
| Q37290864 | Tyrosine phosphorylation of neuronal nitric oxide synthase (nNOS) during hypoxia in the cerebral cortex of newborn piglets: the role of nitric oxide |
| Q64058332 | Use of Computational Biochemistry for Elucidating Molecular Mechanisms of Nitric Oxide Synthase |
| Q40228889 | Use of a murine cell line for identification of human nitric oxide synthase inhibitors |
| Q64108583 | Vasodilation Elicited by Isoxsuprine, Identified by High-Throughput Virtual Screening of Compound Libraries, Involves Activation of the NO/cGMP and H₂S/K Pathways and Blockade of α₁-Adrenoceptors and Calcium Channels |
| Q24617202 | Vitamins C and E: beneficial effects from a mechanistic perspective |
| Q47430827 | Withapubesides A-D: natural inducible nitric oxide synthase (iNOS) inhibitors from Physalis pubescens |
| Q30364031 | Zinc-binding cysteines: diverse functions and structural motifs. |
| Q73522374 | [Transition metals and nitric oxide production in human endothelial cells] |
| Q35889758 | eNOS activation and NO function: structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity |
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