Ribosome. The complete structure of the 55S mammalian mitochondrial ribosome

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Ribosome. The complete structure of the 55S mammalian mitochondrial ribosome is …
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scholarly articleQ13442814

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P356DOI10.1126/SCIENCE.AAA3872
P3181OpenCitations bibliographic resource ID652900
P698PubMed publication ID25837512

P50authorRuedi AebersoldQ7377799
Nenad BanQ11252748
Basil J. GreberQ38362078
Philipp BieriQ57637508
Alexander LeitnerQ58808618
Daniel BoehringerQ90083639
P2093author name stringMarc Leibundgut
P2860cites workThe small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins presentQ24291056
Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunitQ24291321
New developments in aminoglycoside therapy and ototoxicityQ24599985
Structures of the bacterial ribosome in classical and hybrid states of tRNA bindingQ24635922
Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosomeQ24647686
PHENIX: a comprehensive Python-based system for macromolecular structure solutionQ24654617
Improved methods for building protein models in electron density maps and the location of errors in these modelsQ26776980
Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservationQ27617498
Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibioticsQ27627265
Crystal structure of the ribosome at 5.5 A resolutionQ27630949
Recognition of cognate transfer RNA by the 30S ribosomal subunitQ27631606
Structural basis for aminoglycoside inhibition of bacterial ribosome recyclingQ27646911
The structure of the eukaryotic ribosome at 3.0 Å resolutionQ27675638
Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM.Q27677990
Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycinQ27681169
Regulation of the Mammalian Elongation Cycle by Subunit Rolling: A Eukaryotic-Specific Ribosome RearrangementQ27684558
Inference of macromolecular assemblies from crystalline stateQ27860457
Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensionsQ27860532
Protein structure prediction on the Web: a case study using the Phyre serverQ27860664
UCSF Chimera--a visualization system for exploratory research and analysisQ27860666
Towards automated crystallographic structure refinement with phenix.refineQ27860678
EMAN: semiautomated software for high-resolution single-particle reconstructionsQ27860772
Structures of the bacterial ribosome at 3.5 A resolutionQ27860848
Accurate determination of local defocus and specimen tilt in electron microscopyQ27861008
Features and development of CootQ27861079
The novel component Kgd4 recruits the E3 subunit to the mitochondrial α-ketoglutarate dehydrogenase.Q27935604
Structure of the large ribosomal subunit from human mitochondria.Q28116177
A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteinsQ28190849
A new face on apoptosis: death-associated protein 3 and PDCD9 are mitochondrial ribosomal proteinsQ28204709
On the origin of mitosing cellsQ28215435
Identification of phosphorylation sites in mammalian mitochondrial ribosomal protein DAP3Q28266280
Distinctive features of the 5'-terminal sequences of the human mitochondrial mRNAsQ28280119
STAND, a class of P-loop NTPases including animal and plant regulators of programmed cell death: multiple, complex domain architectures, unusual phyletic patterns, and evolution by horizontal gene transferQ28283391
A new system for naming ribosomal proteinsQ28307640
Optimal determination of particle orientation, absolute hand, and contrast loss in single-particle electron cryomicroscopyQ29547579
RELION: implementation of a Bayesian approach to cryo-EM structure determinationQ29547673
Prevention of overfitting in cryo-EM structure determinationQ29614287
Interaction of antibiotics with functional sites in 16S ribosomal RNAQ29616813
Evolutionary relationships and structural mechanisms of AAA+ proteinsQ29617454
The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sitesQ29618224
Interactive electron-density map interpretation: from INTER to O.Q31133209
RPG: the Ribosomal Protein Gene databaseQ34284566
Defective mitochondrial translation caused by a ribosomal protein (MRPS16) mutationQ34362062
Mutation in mitochondrial ribosomal protein MRPS22 leads to Cornelia de Lange-like phenotype, brain abnormalities and hypertrophic cardiomyopathyQ34694743
Mitochondria "fuel" breast cancer metabolism: fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cellsQ36556326
The effect of mutated mitochondrial ribosomal proteins S16 and S22 on the assembly of the small and large ribosomal subunits in human mitochondria.Q36840250
Crystallographic model quality at a glanceQ37118694
Antenatal mitochondrial disease caused by mitochondrial ribosomal protein (MRPS22) mutationQ37120989
Pentatricopeptide repeats: modular blocks for building RNA-binding proteinsQ37381218
Human diseases with impaired mitochondrial protein synthesisQ37894888
Mitochondrial disorders as windows into an ancient organelleQ38059778
Lack of secondary structure characterizes the 5' ends of mammalian mitochondrial mRNAs.Q38292355
Structure of the Mammalian Mitochondrial Ribosome Reveals an Expanded Functional Role for Its Component ProteinsQ41628956
Visualization of the hybrid state of tRNA binding promoted by spontaneous ratcheting of the ribosomeQ41914975
Mitochondrial ribosomal RNA mutation associated with both antibiotic–induced and non–syndromic deafnessQ46157086
The disulfide relay of the intermembrane space oxidizes the ribosomal subunit mrp10 on its transit into the mitochondrial matrix.Q53077102
P433issue6232
P407language of work or nameEnglishQ1860
P921main subjectmitochondrionQ39572
P304page(s)303-8
P577publication date2015-04-17
P1433published inScienceQ192864
P1476titleRibosome. The complete structure of the 55S mammalian mitochondrial ribosome
P478volume348

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cites work (P2860)
Q89831567A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways
Q57898569A Ribosome Without RNA
Q58090255A cross-linking/mass spectrometry workflow based on MS-cleavable cross-linkers and the MeroX software for studying protein structures and protein-protein interactions
Q40846256Aim-less translation: loss of Saccharomyces cerevisiae mitochondrial translation initiation factor mIF3/Aim23 leads to unbalanced protein synthesis.
Q91808403An Update on Mitochondrial Ribosome Biology: The Plant Mitoribosome in the Spotlight
Q36376828An innovative strategy to clone positive modifier genes of defects caused by mtDNA mutations: MRPS18C as suppressor gene of m.3946G>A mutation in MT-ND1 gene
Q100558739Analysis of translating mitoribosome reveals functional characteristics of translation in mitochondria of fungi
Q38640567Biallelic Mutations in MRPS34 Lead to Instability of the Small Mitoribosomal Subunit and Leigh Syndrome
Q92126848Biological Functions and Molecular Mechanisms of Antibiotic Tigecycline in the Treatment of Cancers
Q30400101Blind testing cross-linking/mass spectrometry under the auspices of the 11th critical assessment of methods of protein structure prediction (CASP11)
Q91712822CR6-interacting factor-1 contributes to osteoclastogenesis by inducing receptor activator of nuclear factor κB ligand after radiation
Q38824435Cancer metabolism: a therapeutic perspective
Q64105438Challenges and opportunities in cryo-EM single-particle analysis
Q51105004Chemical Crosslinking in Intact Mitochondria.
Q41430322Co-Activation of PKC-δ by CRIF1 Modulates Oxidative Stress in Bone Marrow Multipotent Mesenchymal Stromal Cells after Irradiation by Phosphorylating NRF2 Ser40.
Q98784800Complete chemical structures of human mitochondrial tRNAs
Q47250308Could a Proto-Ribosome Emerge Spontaneously in the Prebiotic World?
Q46525686Cross-Linking Mass Spectrometry: An Emerging Technology for Interactomics and Structural Biology.
Q58105967Cross-linking mass spectrometry: methods and applications in structural, molecular and systems biology
Q91595621Cryo-EM structure of the RNA-rich plant mitochondrial ribosome
Q30824910Cryo-EM structure of the large subunit of the spinach chloroplast ribosome
Q41872322Cryo-EM structure of the spinach chloroplast ribosome reveals the location of plastid-specific ribosomal proteins and extensions.
Q39177991Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii
Q89583429Cryo-EM study of an archaeal 30S initiation complex gives insights into evolution of translation initiation
Q37651572Differential Tandem Mass Spectrometry-Based Cross-Linker: A New Approach for High Confidence in Identifying Protein Cross-Linking.
Q38380171Dinosaur: A Refined Open-Source Peptide MS Feature Detector
Q33669774Disentangling constraints using viability evolution principles in integrative modeling of macromolecular assemblies
Q55359327Dissecting ribosomal particles throughout the kingdoms of life using advanced hybrid mass spectrometry methods.
Q96303236Distinct pre-initiation steps in human mitochondrial translation
Q88511229Effects of the 1- N-(4-Amino-2 S-hydroxybutyryl) and 6'- N-(2-Hydroxyethyl) Substituents on Ribosomal Selectivity, Cochleotoxicity, and Antibacterial Activity in the Sisomicin Class of Aminoglycoside Antibiotics
Q103000578Elongational stalling activates mitoribosome-associated quality control
Q93239084Evolution of Structural Biology through the Lens of Mass Spectrometry
Q92426145Fidelity of translation initiation is required for coordinated respiratory complex assembly
Q90597438Functionally critical residues in the aminoglycoside resistance-associated methyltransferase RmtC play distinct roles in 30S substrate recognition
Q37576614Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis.
Q36076892High Sensitivity Crosslink Detection Coupled With Integrative Structure Modeling in the Mass Spec Studio
Q35946692High throughput gene complementation screening permits identification of a mammalian mitochondrial protein synthesis (ρ(-)) mutant.
Q40368301High-fidelity mass analysis unveils heterogeneity in intact ribosomal particles
Q59125461How to fold and protect mitochondrial ribosomal RNA with fewer guanines
Q57469418Human GTPBP10 is required for mitoribosome maturation
Q38635117Human mitochondrial ribosomes can switch structural tRNAs - but when and why?
Q37379696Human mitochondrial ribosomes can switch their structural RNA composition.
Q70200234Identification of the Toxoplasma gondii mitochondrial ribosome, and characterisation of a protein essential for mitochondrial translation.
Q36358001Idiosyncratic recognition of UUG/UUA codons by modified nucleoside 5-taurinomethyluridine, τm5U present at 'wobble' position in anticodon loop of tRNALeu: A molecular modeling approach
Q64117187Import of Non-Coding RNAs into Human Mitochondria: A Critical Review and Emerging Approaches
Q38624841Integrating mitochondrial translation into the cellular context
Q49997170Kinetics and Mechanism of Mammalian Mitochondrial Ribosome Assembly
Q42777998Lactate-mediated mitoribosomal defects impair mitochondrial oxidative phosphorylation and promote hepatoma cell invasiveness
Q36540988Linezolid Trough Concentrations Correlate with Mitochondrial Toxicity-Related Adverse Events in the Treatment of Chronic Extensively Drug-Resistant Tuberculosis.
Q27312752Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice
Q36575916Mechanisms of Resistance to Aminoglycoside Antibiotics: Overview and Perspectives
Q28117404Mitochondrial 16S rRNA Is Methylated by tRNA Methyltransferase TRMT61B in All Vertebrates
Q89449580Mitochondrial DNA transcription and translation: clinical syndromes
Q92155153Mitochondrial Gene Expression and Beyond-Novel Aspects of Cellular Physiology
Q47309962Mitochondrial Genome Engineering: The Revolution May Not Be CRISPR-Ized
Q38742965Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein
Q47974129Mitochondrial diseases: the contribution of organelle stress responses to pathology
Q39264654Mitochondrial ribosomes in cancer
Q61443763Mitochondrial stress response triggered by defects in protein synthesis quality control
Q64964896Mitochondrial transcription and translation: overview.
Q41991215Mitoriboscins: Mitochondrial-based therapeutics targeting cancer stem cells (CSCs), bacteria and pathogenic yeast
Q47767405MrpL35, a mitospecific component of mitoribosomes, plays a key role in cytochrome c oxidase assembly
Q88679874Mt-rps3 is an ancient gene which provides insight into the evolution of fungal mitochondrial genomes
Q33710845Multifunctional Mitochondrial AAA Proteases
Q58708208Mutant MRPS5 affects mitoribosomal accuracy and confers stress-related behavioral alterations
Q52642650Mutations in the mitochondrial ribosomal protein MRPS22 lead to primary ovarian insufficiency.
Q39185393Non-coding RNAs: the dark side of nuclear-mitochondrial communication
Q57055330Pathways to balance mitochondrial translation and protein import
Q45957328PharmGKB summary: very important pharmacogene information for MT-RNR1.
Q28598105ProXL (Protein Cross-Linking Database): A Platform for Analysis, Visualization, and Sharing of Protein Cross-Linking Mass Spectrometry Data
Q48503596Protein Tertiary Structure by Crosslinking/Mass Spectrometry
Q35810086R3D-2-MSA: the RNA 3D structure-to-multiple sequence alignment server
Q57818170Rapid Isolation of the Mitoribosome from HEK Cells
Q39174983Regulation of Mammalian Mitochondrial Gene Expression: Recent Advances
Q58557235Regulation of mitochondrion-associated cytosolic ribosomes by mammalian mitochondrial ribonuclease T2 (RNASET2)
Q52359075Revising the structural diversity of ribosomal proteins across the three domains of life.
Q47827613Ribosomes are optimized for autocatalytic production
Q37688294S18 family of mitochondrial ribosomal proteins: evolutionary history and Gly132 polymorphism in colon carcinoma
Q37211023SLIRP stabilizes LRPPRC via an RRM-PPR protein interface
Q90970857Small is big in Arabidopsis mitochondrial ribosome
Q64880231Structural Patching Fosters Divergence of Mitochondrial Ribosomes.
Q53541286Structural biology. Mitoribosome oddities.
Q64068262Structural insights into unique features of the human mitochondrial ribosome recycling
Q61807051Structure of Human Mitochondrial Translation Initiation Factor 3 Bound to the Small Ribosomal Subunit
Q37473069Structure of the 70S ribosome from human pathogen Staphylococcus aureus.
Q52333960Structure of the chloroplast ribosome with chl-RRF and hibernation-promoting factor.
Q98184138Structures of the human mitochondrial ribosome bound to EF-G1 reveal distinct features of mitochondrial translation elongation
Q47823744Structures of the human mitochondrial ribosome in native states of assembly.
Q28817084Surface Accessibility and Dynamics of Macromolecular Assemblies Probed by Covalent Labeling Mass Spectrometry and Integrative Modeling
Q36588897Targeted cross-linking-mass spectrometry determines vicinal interactomes within heterogeneous RNP complexes
Q90163279Targeting the Human 80S Ribosome in Cancer: From Structure to Function and Drug Design for Innovative Adjuvant Therapeutic Strategies
Q40950781The DEAD-box helicase Mss116 plays distinct roles in mitochondrial ribogenesis and mRNA-specific translation
Q38801478The Evolving Contribution of Mass Spectrometry to Integrative Structural Biology
Q64249400The Origin and Evolution of Release Factors: Implications for Translation Termination, Ribosome Rescue, and Quality Control Pathways
Q47213873The complete structure of the chloroplast 70S ribosome in complex with translation factor pY.
Q28080243The diverse and expanding role of mass spectrometry in structural and molecular biology
Q42205867The human RNA-binding protein RBFA promotes the maturation of the mitochondrial ribosome
Q36161216The integrative role of cryo electron microscopy in molecular and cellular structural biology
Q47313696The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for co-existing respiratory supercomplexes.
Q39201670The mechanism of translation
Q48018317The mitochondrial epitranscriptome: the roles of RNA modifications in mitochondrial translation and human disease.
Q64982220The mitoribosome-specific protein mS38 is preferentially required for synthesis of cytochrome c oxidase subunits.
Q38895517The process of mammalian mitochondrial protein synthesis.
Q42268302The structure of the yeast mitochondrial ribosome
Q57176977The translational landscape of Arabidopsis mitochondria
Q90101132Three human aminoacyl-tRNA synthetases have distinct sub-mitochondrial localizations that are unaffected by disease-associated mutations
Q46270520Towards the Prevention of Aminoglycoside-Related Hearing Loss
Q91826462Transcription, Processing, and Decay of Mitochondrial RNA in Health and Disease
Q44722002Translational machinery of mitochondrial mRNA is promoted by physical activity in Western diet-induced obese mice
Q59065984Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM
Q37357527Unravelling biological macromolecules with cryo-electron microscopy.
Q36240931Upregulation of Mrps18a in breast cancer identified by selecting phage antibody libraries on breast tissue sections
Q64228827When a common biological role does not imply common disease outcomes: Disparate pathology linked to human mitochondrial aminoacyl-tRNA synthetases
Q90391288YBEY is an essential biogenesis factor for mitochondrial ribosomes
Q90380026ncRNAs: New Players in Mitochondrial Health and Disease?
Q60918290tRNA Translocation by the Eukaryotic 80S Ribosome and the Impact of GTP Hydrolysis
Q47894332tRNAs and proteins use the same import channel for translocation across the mitochondrial outer membrane of trypanosomes

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