Abasic translesion synthesis by DNA polymerase beta violates the "A-rule". Novel types of nucleotide incorporation by human DNA polymerase beta at an abasic lesion in different sequence contexts

scientific article published in January 1997

Abasic translesion synthesis by DNA polymerase beta violates the "A-rule". Novel types of nucleotide incorporation by human DNA polymerase beta at an abasic lesion in different sequence contexts is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.272.4.2559
P698PubMed publication ID8999973
P5875ResearchGate publication ID14208388

P50authorRamon EritjaQ42621686
P2093author name stringWilson SH
Goodman MF
Tocco G
Efrati E
P2860cites workStructures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTPQ27729369
Crystal structures of human DNA polymerase beta complexed with DNA: implications for catalytic mechanism, processivity, and fidelityQ27733467
Deoxycytidyl transferase activity of yeast REV1 proteinQ27931173
DNA repair synthesis during base excision repair in vitro is catalyzed by DNA polymerase epsilon and is influenced by DNA polymerases alpha and delta in Saccharomyces cerevisiaeQ27937651
DNA Repair EnzymesQ28264799
Expression of human DNA polymerase beta in Escherichia coli and characterization of the recombinant enzymeQ28294819
Comparison between DNA melting thermodynamics and DNA polymerase fidelityQ33642760
An N -Glycosidase from Escherichia coli That Releases Free Uracil from DNA Containing Deaminated Cytosine ResiduesQ34052545
Frameshift mutations and the genetic code. This paper is dedicated to Professor Theodosius Dobzhansky on the occasion of his 66th birthdayQ34229913
An abasic site in DNA. Solution conformation determined by proton NMR and molecular mechanics calculations.Q34712938
Comparison of nucleotide interactions in water, proteins, and vacuum: model for DNA polymerase fidelityQ35594093
Substitution of mucAB or rumAB for umuDC alters the relative frequencies of the two classes of mutations induced by a site-specific T-T cyclobutane dimer and the efficiency of translesion DNA synthesisQ35606437
Specificity of the mutator caused by deletion of the yeast structural gene (APN1) for the major apurinic endonucleaseQ35686019
Mutation frequency and spectrum resulting from a single abasic site in a single-stranded vectorQ35837992
Novel non-templated nucleotide addition reactions catalyzed by procaryotic and eucaryotic DNA polymerasesQ36070698
Carcinogen-induced frameshift mutagenesis in repetitive sequencesQ36832702
Eukaryotic DNA polymerasesQ37285272
Infidelity of DNA synthesis associated with bypass of apurinic sitesQ37601868
The 'A rule' of mutagen specificity: a consequence of DNA polymerase bypass of non-instructional lesions?Q37713424
Frameshift mutation: determinants of specificityQ37794682
Mutation induced by DNA damage: a many protein affairQ37892175
An abasic site analogue activates a c-Ha-ras gene by a point mutation at modified and adjacent positionsQ40533907
Biochemical basis of DNA replication fidelityQ40903454
Requirement of mammalian DNA polymerase-beta in base-excision repair.Q41239890
Coding properties of a unique apurinic/apyrimidinic site replicated in mammalian cellsQ41453765
Mutagenesis by apurinic sites in normal and ataxia telangiectasia human lymphoblastoid cellsQ41647461
Gel kinetic analysis of DNA polymerase fidelity in the presence of proofreading using bacteriophage T4 DNA polymeraseQ46607481
Low molecular weight deoxyribonucleic acid polymerase from rabbit bone marrowQ47375870
Novel Mutagenic Properties of Abasic Sites inSaccharomyces cerevisiaeQ54606410
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)2559-2569
P577publication date1997-01-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleAbasic translesion synthesis by DNA polymerase beta violates the "A-rule". Novel types of nucleotide incorporation by human DNA polymerase beta at an abasic lesion in different sequence contexts
P478volume272

Reverse relations

cites work (P2860)
Q41666500"Action-at-a-distance" mutagenesis. 8-oxo-7, 8-dihydro-2'-deoxyguanosine causes base substitution errors at neighboring template sites when copied by DNA polymerase beta.
Q34712058A 5', 8-cyclo-2'-deoxypurine lesion induces trinucleotide repeat deletion via a unique lesion bypass by DNA polymerase β
Q37646895A DNA polymerase beta mutant from colon cancer cells induces mutations
Q41973778A mechanism of nucleotide misincorporation during transcription due to template-strand misalignment
Q28570436A role for DNA polymerase beta in mutagenic UV lesion bypass
Q28485434A transposon-derived DNA polymerase from Entamoeba histolytica displays intrinsic strand displacement, processivity and lesion bypass
Q77631492Alkylation-induced frameshift mutagenesis during in vitro DNA synthesis by DNA polymerases alpha and beta
Q27677160Amino Acid Templating Mechanisms in Selection of Nucleotides Opposite Abasic Sites by a Family A DNA Polymerase
Q38026112Biological and therapeutic relevance of nonreplicative DNA polymerases to cancer
Q35977207Bypass of a 5',8-cyclopurine-2'-deoxynucleoside by DNA polymerase β during DNA replication and base excision repair leads to nucleotide misinsertions and DNA strand breaks
Q37461336Chemistry and biology of DNA containing 1,N(2)-deoxyguanosine adducts of the alpha,beta-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxynonenal
Q33777689Cytosine unstacking and strand slippage at an insertion-deletion mutation sequence in an overhang-containing DNA duplex
Q27657443DNA Polymerase   Substrate Specificity: SIDE CHAIN MODULATION OF THE"A-RULE"
Q41430585DNA expansions generated by human Polμ on iterative sequences.
Q34375816DNA lesion bypass polymerases open up.
Q35278258DNA pol λ's extraordinary ability to stabilize misaligned DNA.
Q34603989DNA polymerase fidelity: from genetics toward a biochemical understanding
Q43518631DNA polymerase mutagenic bypass and proofreading of endogenous DNA lesions.
Q36470344DNA polymerase β gap-filling translesion DNA synthesis
Q35038055DNA polymerases provide a canon of strategies for translesion synthesis past oxidatively generated lesions
Q46002898DNA replication and postreplication mismatch repair in cell-free extracts from cultured human neuroblastoma and fibroblast cells.
Q34616458Dissecting the fidelity of bacteriophage RB69 DNA polymerase: site-specific modulation of fidelity by polymerase accessory proteins
Q24613748Effect of a monofunctional phenanthriplatin-DNA adduct on RNA polymerase II transcriptional fidelity and translesion synthesis
Q43816434Efficiency and accuracy of SOS-induced DNA polymerases replicating benzo[a]pyrene-7,8-diol 9,10-epoxide A and G adducts
Q24604149Error-prone bypass of certain DNA lesions by the human DNA polymerase kappa
Q52672715Error-prone replication bypass of the imidazole ring-opened formamidopyrimidine deoxyguanosine adduct.
Q34958722Error-prone translesion synthesis past DNA-peptide cross-links conjugated to the major groove of DNA via C5 of thymidine
Q33994529Escherichia coli DNA polymerase IV mutator activity: genetic requirements and mutational specificity
Q73214162Evidence that error-prone DNA repair converts dibenzo[a,l]pyrene-induced depurinating lesions into mutations: formation, clonal proliferation and regression of initiated cells carrying H-ras oncogene mutations in early preneoplasia
Q27015719Exploiting the nucleotide substrate specificity of repair DNA polymerases to develop novel anticancer agents
Q45345090Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene
Q46320742Fidelity of Escherichia coli DNA polymerase III holoenzyme. The effects of beta, gamma complex processivity proteins and epsilon proofreading exonuclease on nucleotide misincorporation efficiencies
Q44049947Fidelity of Escherichia coli DNA polymerase IV. Preferential generation of small deletion mutations by dNTP-stabilized misalignment
Q37454368Frameshift deletion by Sulfolobus solfataricus P2 DNA polymerase Dpo4 T239W is selective for purines and involves normal conformational change followed by slow phosphodiester bond formation
Q35748265Frameshift mutagenesis: the roles of primer-template misalignment and the nonhomologous end-joining pathway in Saccharomyces cerevisiae.
Q35588912Genetic evidence that both dNTP-stabilized and strand slippage mechanisms may dictate DNA polymerase errors within mononucleotide microsatellites
Q28264035Genetic instability in budding and fission yeast-sources and mechanisms
Q36627910Genome-wide analysis of the specificity and mechanisms of replication infidelity driven by imbalanced dNTP pools.
Q27666061Human DNA Polymerase   Mutations Allowing Efficient Abasic Site Bypass
Q24670499Human DNA polymerase kappa uses template-primer misalignment as a novel means for extending mispaired termini and for generating single-base deletions
Q34055705Human base excision repair creates a bias toward -1 frameshift mutations
Q36814219Human polymerase kappa uses a template-slippage deletion mechanism, but can realign the slipped strands to favour base substitution mutations over deletions
Q38271789Implications of acetaldehyde-derived DNA adducts for understanding alcohol-related carcinogenesis.
Q38421370In vitro gap-directed translesion DNA synthesis of an abasic site involving human DNA polymerases epsilon, lambda, and beta
Q27650887Insertion of dNTPs Opposite the 1, N 2 -Propanodeoxyguanosine Adduct by Sulfolobus solfataricus P2 DNA Polymerase IV † ‡
Q37629795Insights into the conformation of aminofluorene-deoxyguanine adduct in a DNA polymerase active site.
Q34385155Lesion bypass DNA polymerases replicate across non-DNA segments
Q54516425Lesion bypass by human DNA polymerase mu reveals a template-dependent, sequence-independent nucleotidyl transferase activity.
Q43937118Low fidelity DNA synthesis by a y family DNA polymerase due to misalignment in the active site.
Q36740110Low-fidelity DNA synthesis by human DNA polymerase theta.
Q89870636Machine learning of reverse transcription signatures of variegated polymerases allows mapping and discrimination of methylated purines in limited transcriptomes
Q74754533Mammalian base excision repair and DNA polymerase beta
Q37216959Mechanism and dynamics of translesion DNA synthesis catalyzed by the Escherichia coli Klenow fragment
Q34609166Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools
Q35888841Metal-induced DNA translocation leads to DNA polymerase conformational activation
Q37158531Multifactor dimensionality reduction analysis identifies specific nucleotide patterns promoting genetic polymorphisms
Q40913159Multiple mutations in a shuttle vector modified by ultraviolet irradiation, (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, and aflatoxin B(1) have different properties than single mutations and may be genera
Q35842713Multiple solutions to inefficient lesion bypass by T7 DNA polymerase.
Q47876213Mutagenic potential of nitrogen mustard-induced formamidopyrimidine DNA adduct: Contribution of the non-canonical α-anomer.
Q35044983Mutagenic potentials of damaged nucleic acids produced by reactive oxygen/nitrogen species: approaches using synthetic oligonucleotides and nucleotides: survey and summary
Q41824083Mutagenic spectra arising from replication bypass of the 2,6-diamino-4-hydroxy-N(5)-methyl formamidopyrimidine adduct in primate cells.
Q34919969Mutator phenotypes due to DNA replication infidelity.
Q34243740N-terminal domains of human DNA polymerase lambda promote primer realignment during translesion DNA synthesis.
Q35013048New structural and mechanistic insight into the A-rule and the instructional and non-instructional behavior of DNA photoproducts and other lesions
Q40405554Overexpression of human DNA polymerase mu (Pol mu) in a Burkitt's lymphoma cell line affects the somatic hypermutation rate
Q92809345Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene via the Crosstalk between DNA Polymerase β and a de novo DNA Methyltransferase
Q34020161Quantitative measurement of translesion replication in human cells: evidence for bypass of abasic sites by a replicative DNA polymerase
Q35241107Real-time surface plasmon resonance study of biomolecular interactions between polymerase and bulky mutagenic DNA lesions
Q77895441Relationship between DNA methylation and mutational patterns induced by a sequence selective minor groove methylating agent
Q42266829Replication of an oxidized abasic site in Escherichia coli by a dNTP-stabilized misalignment mechanism that reads upstream and downstream nucleotides
Q30746296Replication of damaged DNA in mammalian cells: new solutions to an old problem
Q73555611Replication of template-primers containing propanodeoxyguanosine by DNA polymerase beta. Induction of base pair substitution and frameshift mutations by template slippage and deoxynucleoside triphosphate stabilization
Q27660600Replication through an abasic DNA lesion: structural basis for adenine selectivity
Q77322177Resolving a fidelity paradox: why Escherichia coli DNA polymerase II makes more base substitution errors in AT- compared with GC-rich DNA
Q33371451Serial analysis of mutation spectra (SAMS): a new approach for the determination of mutation spectra of site-specific DNA damage and their sequence dependence
Q43022010Sloppy bypass of an abasic lesion catalyzed by a Y-family DNA polymerase
Q35132473Streisinger revisited: DNA synthesis errors mediated by substrate misalignments
Q35221498Structural and kinetic analysis of nucleoside triphosphate incorporation opposite an abasic site by human translesion DNA polymerase η.
Q34006347Structural design of a eukaryotic DNA repair polymerase: DNA polymerase beta.
Q74232718Structural insights into DNA polymerase beta fidelity: hold tight if you want it right
Q27758682Structures of apurinic and apyrimidinic sites in duplex DNAs
Q43630601Synthesis and properties of oligonucleotides containing 8-bromo-2'-deoxyguanosine
Q48212896The A-Rule and Deletion Formation During Abasic and Oxidized Abasic Site Bypass by DNA Polymerase θ.
Q28756561The N-clasp of human DNA polymerase kappa promotes blockage or error-free bypass of adenine- or guanine-benzo[a]pyrenyl lesions
Q27667302The Y-Family DNA Polymerase Dpo4 Uses a Template Slippage Mechanism To Create Single-Base Deletions
Q43548141The effect of DNA structure on the catalytic efficiency and fidelity of human DNA polymerase beta on templates with platinum-DNA adducts
Q44569160The essential C family DnaE polymerase is error-prone and efficient at lesion bypass
Q24630867The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases
Q53653976The frameshift infidelity of human DNA polymerase lambda. Implications for function.
Q35618148The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair
Q77231587The mutagenesis proteins UmuD' and UmuC prevent lethal frameshifts while increasing base substitution mutations
Q42676720The mutational specificity of the Dbh lesion bypass polymerase and its implications
Q28259282The structural basis of XRCC1-mediated DNA repair
Q46375749To slip or skip, visualizing frameshift mutation dynamics for error-prone DNA polymerases
Q36210704Translesion DNA polymerases and cancer
Q43619478Translesion DNA synthesis catalyzed by human pol eta and pol kappa across 1,N6-ethenodeoxyadenosine.
Q37952001Translesion DNA synthesis in the context of cancer research
Q42637992Translesion DNA synthesis-assisted non-homologous end-joining of complex double-strand breaks prevents loss of DNA sequences in mammalian cells
Q39095399Translesional synthesis on DNA templates containing the 2'-deoxyribonolactone lesion.
Q34003939UmuD(2) inhibits a non-covalent step during DinB-mediated template slippage on homopolymeric nucleotide runs.
Q41869549Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity

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