The in vitro effects of dehydroepiandrosterone on human osteoarthritic chondrocytes

scientific article published in August 2003

The in vitro effects of dehydroepiandrosterone on human osteoarthritic chondrocytes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S1063-4584(03)00094-3
P698PubMed publication ID12880581

P2093author name stringJ S Park
S C Park
S H Lee
H J Kim
M C Lee
S C Seong
H Jo
M Y Jung
E M Kim
P2860cites workHyposecretion of the adrenal androgen dehydroepiandrosterone sulfate and its relation to clinical variables in inflammatory arthritisQ24796769
Conversion of dehydroepiandrosterone to downstream steroid hormones in macrophagesQ28369687
Fundamental pathways in osteoarthritis: an overviewQ33753621
Evidence for metalloproteinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilageQ33848759
The role of the chondrocyte in osteoarthritisQ34051076
Sex hormone adjuvant therapy in rheumatoid arthritisQ34085910
Role of glucose-6-phosphate dehydrogenase inhibition in the antiproliferative effects of dehydroepiandrosterone on human breast cancer cellsQ34418162
Changes in type of collagen synthesized as clones of chick chondrocytes grow and eventually lose division capacityQ35002602
Dehydroepiandrosterone protects mice from endotoxin toxicity and reduces tumor necrosis factor productionQ36757909
Selective activation of the mitogen-activated protein kinase subgroups c-Jun NH2 terminal kinase and p38 by IL-1 and TNF in human articular chondrocytesQ37361642
Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid jointsQ37369629
Physiological importance of dehydroepiandrosteroneQ40623250
Oxythiamine and dehydroepiandrosterone induce a G1 phase cycle arrest in Ehrlich's tumor cells through inhibition of the pentose cycleQ40800971
The relationship of natural androgens to coronary heart disease in males: a reviewQ41131386
Dehydroepiandrosterone and diseases of agingQ41190774
The effects of hyaluronan on matrix metalloproteinase-3 (MMP-3), interleukin-1beta(IL-1beta), and tissue inhibitor of metalloproteinase-1 (TIMP-1) gene expression during the development of osteoarthritisQ41648917
Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymesQ41866734
Extracts of human articular cartilage contain an inhibitor of tissue metalloproteinases.Q42139543
Effects of non-steroidal antiinflammatory drugs and dexamethasone on the activity and expression of matrix metalloproteinase-1, matrix metalloproteinase-3 and tissue inhibitor of metalloproteinases-1 by bovine articular chondrocytesQ43684417
The interleukin-1 receptor in normal and osteoarthritic human articular chondrocytes. Identification as the type I receptor and analysis of binding kinetics and biologic functionQ43852783
The indole method for determination of DNA: Conditions for maximal sensitivityQ44318401
Reduction in the incidence and severity of collagen-induced arthritis in DBA/1 mice, using exogenous dehydroepiandrosteroneQ44811943
Expression of a stable articular cartilage phenotype without evidence of hypertrophy by adult human articular chondrocytes in vitroQ47988998
Comparison of cell proliferation and toxicity assays using two cationic liposomes.Q50770431
Culture and growth characteristics of chondrocytes encapsulated in alginate beads.Q50891012
Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue.Q50907649
A study of serum androgen and cortisol levels in female patients with rheumatoid arthritis. Correlation with disease activity.Q50990513
Effect of genetic background on the therapeutic effects of dehydroepiandrosterone (DHEA) in diabetes-obesity mutants and in aged normal mice.Q54485223
Peroxisome Proliferator-activated Receptor α Activation Modulates Cellular Redox Status, Represses Nuclear Factor-κB Signaling, and Reduces Inflammatory Cytokine Production in AgingQ59944212
Independent regulation of collagen types by chondrocytes during the loss of differentiated function in cultureQ67427730
Imbalance between the mechanisms of activation and inhibition of metalloproteases in the early lesions of experimental osteoarthritisQ68482348
Culture and differentiation of chondrocytes entrapped in alginate gelsQ70610871
Direct evidence for active metalloproteinases mediating matrix degradation in interleukin 1-stimulated human articular cartilageQ70713946
Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase-1 expressionQ71548098
Reexpression of cartilage-specific genes by dedifferentiated human articular chondrocytes cultured in alginate beadsQ72401047
Role of interleukin-1, tumor necrosis factor alpha, and interleukin-6 in cartilage proteoglycan metabolism and destruction. Effect of in situ blocking in murine antigen- and zymosan-induced arthritisQ72526685
Effects of dehydroepiandrosterone on proliferation of human aortic smooth muscle cellsQ73167972
Modulation of immune dysfunction during murine leukaemia retrovirus infection of old mice by dehydroepiandrosterone sulphate (DHEAS)Q73347803
Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3Q73678522
Effects of dehydroepiandrosterone on collagen and collagenase gene expression by skin fibroblasts in cultureQ73784633
Matrix metalloproteinase-1, -3, -13 and aggrecanase-1 and -2 are differentially expressed in experimental osteoarthritisQ73812383
Cytokine dysregulation and increased oxidation is prevented by dehydroepiandrosterone in mice infected with murine leukemia retrovirusQ73948080
Androstenediol and dehydroepiandrosterone protect mice against lethal bacterial infections and lipopolysaccharide toxicityQ77403884
Anabolic and catabolic gene expression pattern analysis in normal versus osteoarthritic cartilage using complementary DNA-array technologyQ77406828
Nuclear factor kappaB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1beta-stimulated synovial fibroblastsQ77539470
Modulation of the synthesis and activation of matrix metalloproteinases in IL-1-treated chondrocytes by antirheumatic drugsQ78027414
P433issue8
P921main subjectosteoarthritisQ62736
P304page(s)585-594
P577publication date2003-08-01
P1433published inOsteoarthritis and CartilageQ7107605
P1476titleThe in vitro effects of dehydroepiandrosterone on human osteoarthritic chondrocytes
P478volume11

Reverse relations

cites work (P2860)
Q44117274Anti-arthritic effects of crocin in interleukin-1β-treated articular chondrocytes and cartilage in a rabbit osteoarthritic model
Q36640418Apigenin Regulates Interleukin-1β-Induced Production of Matrix Metalloproteinase Both in the Knee Joint of Rat and in Primary Cultured Articular Chondrocytes
Q37559563Betulin suppressed interleukin-1β-induced gene expression, secretion and proteolytic activity of matrix metalloproteinase in cultured articular chondrocytes and production of matrix metalloproteinase in the knee joint of rat
Q36015710Chondroprotective Effects of Wogonin in Experimental Models of Osteoarthritis in vitro and in vivo
Q35959470Decreasing cartilage damage in a rat model of osteoarthritis by intra-articular injection of deoxycholic acid
Q82587533Effect of dehydroepiandrosterone on aggrecanase expression in articular cartilage in a rabbit model of osteoarthritis
Q79222791Effect of dehydroepiandrosterone on cartilage and synovium of knee joints with osteoarthritis in rabbits
Q37689511Effect of oleanolic acid on the activity, secretion and gene expression of matrix metalloproteinase-3 in articular chondrocytes in vitro and the production of matrix metalloproteinase-3 in vivo
Q50967031Effects of Platelet-Rich Plasma With Concomitant Use of a Corticosteroid on Tenocytes From Degenerative Rotator Cuff Tears in Interleukin 1β-Induced Tendinopathic Conditions.
Q51629280Effects of a chitosan scaffold containing TGF-beta1 encapsulated chitosan microspheres on in vitro chondrocyte culture.
Q36627632Effects of prunetin on the proteolytic activity, secretion and gene expression of MMP-3 in vitro and production of MMP-3 in vivo
Q59335372Inhibition of the Expression of Matrix Metalloproteinases in Articular Chondrocytes by Resveratrol through Affecting Nuclear Factor-Kappa B Signaling Pathway
Q51757280Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial.
Q33765076Luteolin Inhibits the Activity, Secretion and Gene Expression of MMP-3 in Cultured Articular Chondrocytes and Production of MMP-3 in the Rat Knee
Q53556082Production of sex steroid hormones from DHEA in articular chondrocyte of rats.
Q28581700Protective Effects of Berberine in an Experimental Rat Osteoarthritis Model
Q34610146Protective effects of biochanin A on articular cartilage: in vitro and in vivo studies
Q40897064Serum dehydroepiandrosterone sulfate and osteoarthritis in older people: the Pro.V.A. study
Q37412497Suppression of aggrecanase: a novel protective mechanism of dehydroepiandrosterone in osteoarthritis?
Q35728563The disease-modifying effect of dehydroepiandrosterone in different stages of experimentally induced osteoarthritis: a histomorphometric study
Q36204519Therapeutic Effect of Chenodeoxycholic Acid in an Experimental Rabbit Model of Osteoarthritis
Q37244895Treatment with SiMiaoFang, an anti-arthritis chinese herbal formula, inhibits cartilage matrix degradation in osteoarthritis rat model

Search more.