Structure of the HERG K+ channel S5P extracellular linker: role of an amphipathic alpha-helix in C-type inactivation

scientific article published on 5 August 2003

Structure of the HERG K+ channel S5P extracellular linker: role of an amphipathic alpha-helix in C-type inactivation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M212824200
P698PubMed publication ID12902341

P50authorTerence J CampbellQ58231955
Jamie VandenbergQ42353728
Margaret SundeQ46732256
P2093author name stringAsne Bauskin
Allan M Torres
Philip W Kuchel
Samuel N Breit
Paul F Alewood
David J Smith
Catherine E Clarke
Paramjit S Bansal
Jane A Bursill
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A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndromeQ24316980
The inward rectification mechanism of the HERG cardiac potassium channelQ24320034
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Transfer of rapid inactivation and sensitivity to the class III antiarrhythmic drug E-4031 from HERG to M-eag channelsQ47786553
Molecular determinants of dofetilide block of HERG K+ channelsQ48945449
Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel.Q50761875
Structures of the M2 channel-lining segments from nicotinic acetylcholine and NMDA receptors by NMR spectroscopyQ27617929
Crystal structure and mechanism of a calcium-gated potassium channelQ27639064
Crystal structure of the potassium channel KirBac1.1 in the closed stateQ27641201
Torsion angle dynamics for NMR structure calculation with the new program DYANAQ27860808
Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutionsQ27860828
MOLMOL: a program for display and analysis of macromolecular structuresQ27860873
The program XEASY for computer-supported NMR spectral analysis of biological macromoleculesQ27860993
Potassium channel structuresQ28218200
The chemical shift index: a fast and simple method for the assignment of protein secondary structure through NMR spectroscopyQ28293625
State-dependent barium block of wild-type and inactivation-deficient HERG channels in Xenopus oocytesQ28344460
A structural basis for drug-induced long QT syndromeQ28344808
Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperatureQ28379324
A two-dimensional nuclear Overhauser enhancement (2D NOE) experiment for the elucidation of complete proton-proton cross-relaxation networks in biological macromoleculesQ29616473
Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteinsQ29616474
Intrinsic helical propensities and stable secondary structure in a membrane-bound fragment (S4) of the shaker potassium channelQ30583519
Stability of membrane proteins: relevance for the selection of appropriate methods for high-resolution structure determinationsQ32065676
The moving parts of voltage-gated ion channelsQ33671684
An ERG channel inhibitor from the scorpion Buthus eupeusQ33929814
The long QT syndromes: genetic basis and clinical implicationsQ33970623
The potential for QT prolongation and proarrhythmia by non-antiarrhythmic drugs: clinical and regulatory implications. Report on a policy conference of the European Society of CardiologyQ33989507
Potassium channels: from scorpion venoms to high-resolution structureQ34117953
Effects of outer mouth mutations on hERG channel function: a comparison with similar mutations in the Shaker channelQ34170649
Molecular and cellular mechanisms of cardiac arrhythmiasQ34175373
HERG K+ channels: friend and foe.Q34243160
I(Kr): the hERG channelQ34245075
Inhibition of HERG channels stably expressed in a mammalian cell line by the antianginal agent perhexiline maleateQ35028771
Fast inactivation causes rectification of the IKr channelQ36411776
Extracellular sodium interacts with the HERG channel at an outer pore siteQ36436477
Structural and functional role of the extracellular s5-p linker in the HERG potassium channelQ36436566
Mapping the binding site of a human ether-a-go-go-related gene-specific peptide toxin (ErgTx) to the channel's outer vestibuleQ40657689
Time course and voltage dependence of expressed HERG current compared with native "rapid" delayed rectifier K current during the cardiac ventricular action potentialQ40997568
Allosteric effects of mutations in the extracellular S5-P loop on the gating and ion permeation properties of the hERG potassium channelQ44867990
P433issue43
P407language of work or nameEnglishQ1860
P304page(s)42136-42148
P577publication date2003-08-05
P1433published inJournal of Biological ChemistryQ867727
P1476titleStructure of the HERG K+ channel S5P extracellular linker: role of an amphipathic alpha-helix in C-type inactivation
P478volume278

Reverse relations

cites work (P2860)
Q33155692A KCNE2 mutation in a patient with cardiac arrhythmia induced by auditory stimuli and serum electrolyte imbalance
Q28481507A molecular switch driving inactivation in the cardiac K+ channel HERG
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Q37580457Delayed rectifier K(+) currents and cardiac repolarization.
Q45783631Differential effects of the β-adrenoceptor blockers carvedilol and metoprolol on SQT1- and SQT2-mutant channels
Q44913448Dynamic conformational changes of extracellular S5-P linkers in the hERG channel
Q82927163Effect of S5P alpha-helix charge mutants on inactivation of hERG K+ channels
Q47414764Functional interaction between extracellular sodium, potassium and inactivation gating in HERG channels
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Q37464835Gating the pore of potassium leak channels
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Q24299208Insight into the molecular interaction between the cyclic nucleotide-binding homology domain and the eag domain of the hERG channel
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Q35794534Mechanism of block of the hERG K+ channel by the scorpion toxin CnErg1
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