Inhibitory effects of anti-tumor platinum compounds on DNA, RNA and protein syntheses in mammalian cells in virtro

scientific article published in September 1970

Inhibitory effects of anti-tumor platinum compounds on DNA, RNA and protein syntheses in mammalian cells in virtro is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/IJC.2910060207
P698PubMed publication ID5479434

P2093author name stringB Rosenberg
H C Harder
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectplatinumQ880
P1104number of pages10
P304page(s)207-216
P577publication date1970-09-01
P1433published inInternational Journal of CancerQ332492
P1476titleInhibitory effects of anti-tumor platinum compounds on DNA, RNA and protein syntheses in mammalian cells in virtro
P478volume6

Reverse relations

cites work (P2860)
Q718797201,3‐Diphenylpropane‐1,3‐diamines, VI: DNA‐Interaction, Estrogen Receptor Affinity, and Cytostatic Activity of 1,3‐Diphenylpropane‐1,3‐diamine‐Pt(II) Complexes
Q67290762A Circular Dichroism Study of DNA . Platinum Complexes. Differentiation between Monofunctional. cis-Bidentate and trans-Bidentate Platinum Fixation on a Series of DNAs
Q40202099A crystalline platinum blue: its molecular structure, chemical reactivity, and possible relevance to the mode of action of antitumor platinum drugs
Q44770779A density functional reactivity theory (DFRT) based approach to understand the interaction of cisplatin analogues with protecting agents
Q39181502A platinum complex that binds non-covalently to DNA and induces cell death via a different mechanism than cisplatin
Q37905280A strategy for the development of two clinically active cisplatin analogs: CBDCA and CHIP.
Q52837598An Analysis of the Interaction of a Platinum Complex and Radiation with CHO Cells Using the Molecular Theory of Cell Survival
Q39496661Antineoplastic drugs: clinical pharmacology and therapeutic use.
Q40150996Antitumor activity of platinum complexes
Q36379523Base-pair substitution hotspots in GAG and GCG nucleotide sequences in Escherichia coli K-12 induced by cis-diamminedichloroplatinum (II).
Q41258864Bifunctional binding of cisplatin to DNA: why does cisplatin form 1,2-intrastrand cross-links with ag but not with GA?
Q33842478Binding of kinetically inert metal ions to RNA: the case of platinum(II).
Q38872477Biologically active [Pd2L4](4+) quadruply-stranded helicates: stability and cytotoxicity.
Q78237248Capillary electrophoretic study of cisplatin interaction with nucleoside monophosphates, di- and trinucleotides
Q68157850Changes in the cytoskeleton pattern of tumor cells by cisplatin in vitro
Q42463568Cis-diamminedichloroplatinum (II) ototoxicity in the guinea pig.
Q39718529Cis-diamminedichloroplatinum(II). A new antineoplastic agent derived from the group of heavy metal complexes (author's transl)
Q34196954Cis-platin ototoxicity in previously noise-exposed guinea pigs
Q50610869Cis-platinum: a new anticancer agent
Q36184105Cisplatin Targeting of Bacterial Ribosomal RNA Hairpins
Q40040349Cisplatin and siRNA interference with structure and function of Wnt-5a mRNA: design and in vitro evaluation of targeting AU-rich elements in the 3' UTR.
Q72336793Cisplatin induced nephrotoxicity and the modulating effect of glutathione ester
Q68921233Cisplatin nephrotoxicity
Q42343539Cisplatin-Induced Nephrotoxicity; Protective Supplements and Gender Differences
Q37380106Cisplatin: a review of toxicities and therapeutic applications
Q35938726Combined cis-platinum and alpha interferon therapy of advanced hepatocellular carcinoma
Q37729428Common Chemical Inductors of Replication Stress:  Focus on Cell-Based Studies
Q59096780Cross-linking of Complementary Strands of DNA in Mammalian Cells by Antitumour Platinum Compounds
Q33998355Current status of the development of trans-platinum antitumor drugs
Q72597362Cytologic observations on the effects of metallocene dichlorides on human fibroblasts cultivated in vitro
Q67020074Cytotoxicity and influence on radiation dose response curve of cis-diamminedichloroplatinum II (cis-DDP)
Q67322647DNA-platinum interactions in vitro with trans- and cis- Pt(NH3)2Cl2
Q71850691Differences in the inhibition of translation by cisplatin, transplatin, and certain related compounds
Q68877372Differential effects of cisplatin on mouse hepatic and renal mitochondrial DNA
Q41614336Differential effects of cisplatin on the expression of chimeric marker genes in CV-1 cells
Q48058684Direct measurement of interaction forces between a platinum dichloride complex and DNA molecules.
Q53884367Early morphological and chemical changes induced by cisplatin in the guinea pig organ of Corti.
Q71844106Effect of Dalton's lymphoma on the antigen presentation of murine peritoneal macrophages
Q40026912Effect of cis-platinum(II)diamminodichloride on cell division of Hyphomicrobium and Caulobacter
Q36767060Effect of cis-platinum(II)diamminodichloride on wild type and deoxyribonucleic acid repair deficient mutants of Escherichia coli
Q39977337Effect of pKM101 on cell killing and specificity of mutation induction by cis-diaminedichloroplatinum(II) in Escherichia coli K-12
Q34662725Effect of platinum and palladium salts on thymidine incorporation into DNA of rat tissues
Q44479123Effect of serum on inhibition of DNA synthesis in leukemia cells by cis- and trans-(Pt (NH3) 2C1(2)).
Q59649953Effects of cobalt (III) complexes on growth and metabolism of Escherichia coli
Q69355172Effects of cobalt (III) complexes on the endogenous metabolism of Escherichia coli
Q67947463Effects of isomeric 2-(arylmethylamino)-1,3-propanediols (AMAPs) and clinically established agents on macromolecular synthesis in P388 and MCF-7 cells
Q53520548Elasticity of cisplatin-bound DNA reveals the degree of cisplatin binding.
Q43591020Evidence for lack of mitochondrial DNA repair following cis-dichlorodiammineplatinum treatment
Q58874510Experimental cisplatin neuronopathy in rats and the effect of retinoic acid administration
Q70369960Genotoxic effects of cisplatin in somatic tissue of Drosophila melanogaster
Q24629542Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy
Q33493799Haematological toxicity of carboplatin and cisplatin combined with whole body hyperthermia in rats
Q53028113In vitro studies on genotoxicity and cytotoxicity of the anticancer drugs cisplatin and cofplaton, a caffeine-8-ether plus cisplatinum compound
Q40504348Inactivation of Tetrahymena rRNA self-splicing by cis-platin proceeds through dissociable complexes
Q77486703Induction of instability of p34(cdc2) expression by treatment with cisplatin (CDDP) in mouse teratocarcinoma F9 cells
Q45820181Influence of cis-dichlorodiammineplatinum (II) on growth of SV 40 virus in green monkey kidney cells
Q41181434Influence of cisplatin on cell-cycle progression in xenografted human head and neck carcinomas
Q47341135Inhibition by caffeine of post-replication repair in Chinese hamster cells treated with cis platinum (II) diamminedichloride: The extent of platinum binding to template DNA in relation to the size of low molecular weight nascent DNA
Q69355321Inhibition of bacterial growth and nucleic acids synthesis by planar complexes of rhodium (I)
Q70439651Inhibition of cell division by sodium chloroiridate
Q41130062Inhibitory effects of a new oral gold compound on hela cells
Q72605126Inhibitory studies of DNA, RNA and protein synthesis in Escherichia coli by platinum containing complexes
Q40048032Interaction of Pt(II) complexes with DNAs from various sources. A circular dichroism study
Q41141577Interaction of cis-diamminedichloroplatinum(II) with phi X174 DNA.
Q52996234Interaction of cis-dichlorodiammineplatinum (II) with DNA
Q40764429Interaction of platinum compounds with bacterial DNA
Q67289035Interactions between tetrahydrofolate and palladium(II) complexes
Q34663069Interactions of platinum metals and their complexes in biological systems
Q51822028Investigation of the elasticity of a cisplatin-DNA adduct via single-molecule measurements and bimodal modeling.
Q39407436Investigational drugs under study by the United States National Cancer Institute
Q44069031Mass spectrometry of cis-diamminedichloroplatinum(II) adducts with the dinucleosidemonophosphates d(ApG), d(GpG) and d(TpC) in an ion trap.
Q38310005More pronounced salt dependence and higher reactivity for platination of the hairpin r(CGCGUUGUUCGCG) compared with d(CGCGTTGTTCGCG).
Q64033408Multiplicity of metal ion binding patterns to nucleobases
Q50166948Mutagenic activity of some platinum and palladium complexes
Q66894876Mutagenic properties of CIS-Platinum(II)diammino-dichloride in Escherichia coli
Q28241326Negative control of the Myc protein by the stress-responsive kinase Pak2
Q39717597Noble Metal Complexes in Cancer Chemotherapy
Q28364232Nucleolar damage correlates with neurotoxicity induced by different platinum drugs
Q89687519Oncolytic adenovirus Ad11 enhances the chemotherapy effect of cisplatin on osteosarcoma cells by inhibiting autophagy
Q42461144Ototoxicity of cis-dichlorodiammine platinum (II) in guinea pigs
Q45111783Palladium(II) compounds with potential antitumour properties and their platinum analogues: a comparative study of the reaction of some orotic acid derivatives with DNA in vitro
Q69358010Phase I clinical trial of combined therapy with 5-FU (NSC 19893) and cis-platinum (II) diaminedichloride (NSC 119875)
Q67351775Physical studies on the binding of cis-dichlorodiamine platinum(II) to DNA and homopolynucleotides
Q50941553Platinosomes produced in synovial membrane by platinum coordination complexes
Q41582439Platinum complex-induced dysfunction of cultured renal proximal tubule cells. A comparative study of carboplatin and transplatin with cisplatin
Q67322645Platinum complexes of nucleotides
Q53728172Platinum coordination complexes in cancer chemotherapy.
Q67429352Post-replication repair of DNA in chinese hamster cells treated with CIS platinum (II) diamine dichloride. Enhancement of toxicity and chromosome damage by caffeine
Q64889081Preferential Interstrand Cross-Linking of DNA Rich in Guanine and Cytosine by cis-Dichlorodiammineplatinum(II)
Q33465444Preliminary clinical experience withcis-diamminedichloroplatinum (II) (NSC 119875, CACP)
Q34151556Preparation of organometallic ruthenium-arene-diaminotriazine complexes as binding agents to DNA.
Q38907617Quantitative analysis of Gd@C82(OH)22 and cisplatin uptake in single cells by inductively coupled plasma mass spectrometry.
Q33476310Rapid cross-linking of an RNA internal loop by the anticancer drug cisplatin
Q78045586Rapid fluorescence-based reporter-gene assays to evaluate the cytotoxicity and antitumor drug potential of platinum complexes
Q40472204Reactions of the UVRABC excision nuclease with DNA damaged by diamminedichloroplatinum(II).
Q38343385Reduced RNA synthesis levels in isolated mouse liver nuclei following reaction with [(H2O)(NH3)5Ru(II)]2+.
Q40308378Renaturation effects of cis and trans platinum II and IV compounds on calf thymus deoxyribonucleic acid
Q36458492Response of murine erythroleukemia cells to cis- and trans-diamminedichloroplatinum (II).
Q60585078Separation of platinated derivatives of nucleic acid bases on Sephadex G10
Q37523234Sequence-dependent termination of in vitro DNA synthesis by cis- and trans-diamminedichloroplatinum (II).
Q59071343Specific binding of antitumour drug cis-Pt(NH3)2Cl2 to DNA rich in guanine and cytosine
Q72110388Study of the influence of phosphate groups on the formation of adenine nucleotide - cis-dichlorodiammineplatinum (II) complexes
Q72659524Synergistic effect ofcis-dichlorodiammineplatinum and 5-aza-2′-deoxycytidine on mouse leukemic cellsin vivo andin vitro
Q35116876The Chemical and Biological Effects of cis -Dichlorodiammineplatinum (II), an Antitumor Agent, on DNA
Q41150062The Mechanism of Action of Antitumor Platinum Compounds
Q54761524The effect of cis-dichlorodiammineplatinum(II) on Escherichia coli B the role of fil, exr and hcr markers
Q39929512The effect of heavy metal chelators on the renal accumulation of platinum after cis-dichlorodiammineplatinum II administration to the rat.
Q47729811The effects of boron containing peptides on L1210 lymphoid leukemia metabolism
Q69354003The effects of platinum ethylenediamine dichloride on the template activity of DNA
Q38356787The influence of Cisplatin on the gas-phase dissociation of oligonucleotides studied by electrospray ionization tandem mass spectrometry
Q40749663The interaction of an anti-tumour platinum complex with DNA
Q50217628The mutagenic effect of cis-diamminedichloroplatinum (II) and its degradation products in the Ames microbial assay
Q26999667The path for metal complexes to a DNA target
Q27729148The primary mode of binding of cisplatin to a B-DNA dodecamer: C-G-C-G-A-A-T-T-C-G-C-G
Q39933300Timed‐Release Depot for Anticancer Agents
Q39391487Tissue expression and correlation of a panel of urinary biomarkers following cisplatin-induced kidney injury
Q42415861Toxicity of platinum (IV) salts for cells of pulmonary origin
Q34071185Unusual DNA binding modes for metal anticancer complexes
Q67313471X-ray photoelectron spectroscopy of DNA · Pt complexes Evidence of O6(Gua) · N7(Gua) chelation of DNA with cis-dichlorodiamine platinum(II)
Q41646471[1,2-Bis(2-hydroxyphenyl)ethylenediamine]dichloroplatinum(II), a new compound for the therapy of ovarian cancer. III. Detailed evaluation of the antitumor activity of the enantiomeric complexes on the human NIH:OVCAR-3 ovarian cancer cell line
Q48705400alpha-Difluoromethylornithine-induced polyamine depletion of 9L tumor cells modifies drug-induced DNA cross-link formation
Q39805147cis-Diamminedichloroplatinum (II): A Metal Complex with Significant Anticancer Activity
Q67246961cis-Dichlorodiammineplatinum(II) (NSC-119 875): preclinical toxicologic evaluation of intravenous injection in dogs, monkeys and mice

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