p21-Activated Kinase 2 in Neutrophils Can Be Regulated by Phosphorylation at Multiple Sites and by a Variety of Protein Phosphatases

scientific article published on October 1, 2003

p21-Activated Kinase 2 in Neutrophils Can Be Regulated by Phosphorylation at Multiple Sites and by a Variety of Protein Phosphatases is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.171.7.3785
P953full work available at URLhttps://journals.aai.org/jimmunol/article-pdf/171/7/3785/1174673/3785.pdf
https://www.jimmunol.org/content/jimmunol/171/7/3785.full.pdf
P698PubMed publication ID14500679
P5875ResearchGate publication ID9087570

P50authorThomas E. Van DykeQ55029890
P2093author name stringQian Zhan
Qingyuan Ge
Taisuke Ohira
John A. Badwey
P2860cites workIdentification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A.Q48316651
A novel protein phosphatase that dephosphorylates and regulates Ca2+/calmodulin-dependent protein kinase II.Q48556747
Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activityQ67534468
Calyculin A and okadaic acid: inhibitors of protein phosphatase activityQ69337324
An improved procedure for identifying and quantitating protein phosphatases in mammalian tissuesQ69353149
The serine phosphatases PP1 and PP2A associate with and activate the actin-binding protein cofilin in human T lymphocytesQ73228101
Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2Q73386407
Interaction between Nef and phosphatidylinositol-3-kinase leads to activation of p21-activated kinase and increased production of HIVQ74094927
The Caenorhabditis elegans sex-determining protein FEM-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosisQ24291692
The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C familyQ24292365
Interaction between PAK and nck: a template for Nck targets and role of PAK autophosphorylationQ24554208
The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activityQ28118693
Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activationQ28119004
Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cellsQ28198049
Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1Q28219213
A brain serine/threonine protein kinase activated by Cdc42 and Rac1Q28249559
Identification of a mouse p21Cdc42/Rac activated kinaseQ28289355
Regulation of human leukocyte p21-activated kinases through G protein--coupled receptorsQ28293826
Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1Q28609687
Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPasesQ29618793
A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNKQ30448354
Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinasesQ30777797
Antagonists of calcium fluxes and calmodulin block activation of the p21-activated protein kinases in neutrophilsQ31839261
Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosisQ33716955
Neutrophils stimulated with a variety of chemoattractants exhibit rapid activation of p21-activated kinases (Paks): separate signals are required for activation and inactivation of paksQ33781697
Emerging functions of p21-activated kinases in human cancer cellsQ34972819
p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblastsQ36256616
Signals from the Ras, Rac, and Rho GTPases converge on the Pak protein kinase in Rat-1 fibroblastsQ39444795
p21-activated kinase 1 plays a critical role in cellular activation by Nef.Q39451991
Conformational switch and role of phosphorylation in PAK activationQ39460505
A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1.Q39631120
Chemoattractant Receptors on Phagocytic CellsQ40081105
HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signalsQ40770875
Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1.Q40884279
Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activationQ41269491
Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activityQ41700861
Cell adhesion regulates the interaction between Nck and p21-activated kinaseQ42830748
NADH oxidase from guinea pig polymorphonuclear leukocytesQ43504915
Phosphorylation of the activation loop of gamma p21-activated kinase (gamma-Pak) and related kinases (MSTs) in normal and stressed neutrophilsQ43600960
Activation of the neutrophil nicotinamide adenine dinucleotide phosphate oxidase by galectin-1.Q43950683
The renaturable 69- and 63-kDa protein kinases that undergo rapid activation in chemoattractant-stimulated guinea pig neutrophils are p21-activated kinasesQ46193756
Different molecular mechanisms for Rho family GTPase-dependent, Ca2+-independent contraction of smooth muscle.Q46820326
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectimmunologyQ101929
phosphorylationQ242736
P304page(s)3785-3793
P577publication date2003-10-01
P1433published inJournal of ImmunologyQ3521441
P1476titlep21-activated kinase 2 in neutrophils can be regulated by phosphorylation at multiple sites and by a variety of protein phosphatases
p21-Activated Kinase 2 in Neutrophils Can Be Regulated by Phosphorylation at Multiple Sites and by a Variety of Protein Phosphatases
P478volume171

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cites work (P2860)
Q37058519A tale of two Paks
Q28394043Altered nitric oxide production mediates matrix-specific PAK2 and NF-κB activation by flow
Q30441773Blocking p21-activated kinase reduces lipopolysaccharide-induced acute lung injury by preventing polymorphonuclear leukocyte infiltration
Q33588830Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity
Q36846653Down-regulation of p21-activated serine/threonine kinase 1 is involved in loss of mesencephalic dopamine neurons
Q39788159ER-localized bestrophin 1 activates Ca2+-dependent ion channels TMEM16A and SK4 possibly by acting as a counterion channel.
Q24307422Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST
Q30432582Matrix-specific protein kinase A signaling regulates p21-activated kinase activation by flow in endothelial cells
Q40028273Negative regulation of caspase 3-cleaved PAK2 activity by protein phosphatase 1.
Q28285920P21-activated kinase-2 is a critical mediator of transforming growth factor-β-induced hepatoma cell migration
Q35952627PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation
Q28272877PAK as a therapeutic target in gastric cancer
Q28582141PAK is regulated by PI3K, PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway
Q37494233PAK signaling in oncogenesis.
Q34518030Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites
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Q36119589Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP
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