Matrix-specific protein kinase A signaling regulates p21-activated kinase activation by flow in endothelial cells

scientific article

Matrix-specific protein kinase A signaling regulates p21-activated kinase activation by flow in endothelial cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1161/CIRCRESAHA.109.210286
P932PMC publication ID2862370
P698PubMed publication ID20224042
P5875ResearchGate publication ID41910375

P2093author name stringA Wayne Orr
Arif Yurdagul
Jonette M Green
Krishna A Jhaveri
Martin Alexander Schwartz
Steven Daniel Funk
P2860cites workCentral Roles of α 5 β 1 Integrin and Fibronectin in Vascular Development in Mouse Embryos and Embryoid BodiesQ61960709
Expression of PKA inhibitor (PKI) gene abolishes cAMP-mediated protection to endothelial barrier dysfunctionQ64381271
Norepinephrine and iloprost improve barrier function of human endothelial cell monolayers: role of cAMPQ67690110
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Differential activation of NF-kappa B in human aortic endothelial cells conditioned to specific flow environmentsQ73644615
Shear-induced tyrosine phosphorylation in endothelial cells requires Rac1-dependent production of ROSQ77312785
Use of pseudosubstrate affinity to measure active protein kinase AQ79911977
Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathwayQ24290228
The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C familyQ24292365
Regulation of the p21-activated kinase (PAK) by a human Gbeta -like WD-repeat protein, hPIP1Q24628972
Atherosclerosis — An Inflammatory DiseaseQ26776972
VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherinQ28116308
NF-kappaB: pivotal mediator or innocent bystander in atherogenesis?Q28346544
Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignmentQ28348367
Biology of the p21-activated kinasesQ29616035
A dominant-negative p65 PAK peptide inhibits angiogenesis.Q30165500
p21-activated kinase regulates endothelial permeability through modulation of contractility.Q30434340
The subendothelial extracellular matrix modulates NF-kappaB activation by flow: a potential role in atherosclerosisQ30436462
The subendothelial extracellular matrix modulates JNK activation by flowQ30438150
Mechanotransduction in vascular physiology and atherogenesisQ30439086
p21-activated kinase signaling regulates oxidant-dependent NF-kappa B activation by flow.Q30439404
Matrix-specific suppression of integrin activation in shear stress signaling.Q30441401
Blocking p21-activated kinase reduces lipopolysaccharide-induced acute lung injury by preventing polymorphonuclear leukocyte infiltrationQ30441773
Matrix-specific p21-activated kinase activation regulates vascular permeability in atherogenesis.Q30442993
Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression.Q30453215
Endothelial dysfunction, hemodynamic forces, and atherogenesisQ33949677
Shear stress selectively upregulates intercellular adhesion molecule-1 expression in cultured human vascular endothelial cellsQ34229735
Identification and characterization of cell-substratum adhesion receptors on cultured human endothelial cellsQ34575208
G protein-coupled receptors sense fluid shear stress in endothelial cellsQ35108277
Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cellsQ35372931
Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56delta subunitQ35669844
PDE4 inhibition: a novel approach for the treatment of inflammatory bowel diseaseQ35847126
The genetics of Pak.Q35872596
Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activationQ35987707
Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectinQ36235530
Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin.Q36322054
Localized alpha4 integrin phosphorylation directs shear stress-induced endothelial cell alignmentQ37160157
Mechanical control of cAMP signaling through integrins is mediated by the heterotrimeric Galphas proteinQ37337029
The integrin-binding protein Nischarin regulates cell migration by inhibiting PAK.Q39959463
Novel mode of action of iloprost: in vitro down-regulation of endothelial cell adhesion moleculesQ40799605
Iloprost and salvage of a free flapQ41075622
Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinaseQ42797515
A role for Gab1/SHP2 in thrombin activation of PAK1: gene transfer of kinase-dead PAK1 inhibits injury-induced restenosisQ42926016
PKA inhibits RhoA activation: a protection mechanism against endothelial barrier dysfunctionQ43712800
Shear stress stimulates phosphorylation of eNOS at Ser(635) by a protein kinase A-dependent mechanismQ44182985
Fluid flow rapidly activates G proteins in human endothelial cells. Involvement of G proteins in mechanochemical signal transductionQ44337534
p21-Activated Kinase 2 in Neutrophils Can Be Regulated by Phosphorylation at Multiple Sites and by a Variety of Protein PhosphatasesQ44590788
Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease.Q46150192
Elevated cyclic AMP inhibits NF-kappaB-mediated transcription in human monocytic cells and endothelial cells.Q46262655
Localized cdc42 activation, detected using a novel assay, mediates microtubule organizing center positioning in endothelial cells in response to fluid shear stress.Q46499640
cGMP-dependent protein kinase phosphorylates p21-activated kinase (Pak) 1, inhibiting Pak/Nck binding and stimulating Pak/vasodilator-stimulated phosphoprotein associationQ46954347
P433issue8
P921main subjectendotheliumQ111140
P304page(s)1394-1403
P577publication date2010-03-11
P1433published inCirculation ResearchQ2599020
P1476titleMatrix-specific protein kinase A signaling regulates p21-activated kinase activation by flow in endothelial cells
P478volume106

Reverse relations

cites work (P2860)
Q36498382Activation of integrin α5 mediated by flow requires its translocation to membrane lipid rafts in vascular endothelial cells
Q28394043Altered nitric oxide production mediates matrix-specific PAK2 and NF-κB activation by flow
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Q38926872Blood Brothers: Hemodynamics and Cell-Matrix Interactions in Endothelial Function
Q33947972Carcinoma matrix controls resistance to cisplatin through talin regulation of NF-kB
Q34159834Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives
Q57786787Endothelial FN (Fibronectin) Deposition by α5β1 Integrins Drives Atherogenic Inflammation
Q38630594Endothelial fluid shear stress sensing in vascular health and disease.
Q41881743Endothelial nuclear factor-κB-dependent regulation of arteriogenesis and branching
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