Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling

scientific article published on 05 September 2016

Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NCB3405
P8608Fatcat IDrelease_y3focymdorgbxcbq5ccqn4ihyy
P932PMC publication ID5301150
P698PubMed publication ID27595237

P50authorRobert S. Langer, Jr.Q669597
Martin A SchwartzQ57237220
George BaillieQ73827461
Brian G CoonQ96021784
P2093author name stringDaniel G Anderson
Madhusudhan Budatha
Sanguk Yun
Ryan T Cameron
James E Dahlman
P2860cites workIdentification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesionsQ24651203
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ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regionsQ28145238
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The subendothelial extracellular matrix modulates NF-kappaB activation by flow: a potential role in atherosclerosisQ30436462
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Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasomeQ41574826
Temporal gradient in shear but not steady shear stress induces PDGF-A and MCP-1 expression in endothelial cells: role of NO, NF kappa B, and egr-1.Q41644604
Plasma fibronectin deficiency impedes atherosclerosis progression and fibrous cap formationQ42254716
Regulation of cyclic AMP in rat pulmonary microvascular endothelial cells by rolipram-sensitive cyclic AMP phosphodiesterase (PDE4).Q43981329
Deletion of the alternatively spliced fibronectin EIIIA domain in mice reduces atherosclerosisQ44771606
Vascular endothelial cell cyclic nucleotide phosphodiesterases and regulated cell migration: implications in angiogenesisQ45099474
Integrin beta cytoplasmic domains differentially bind to cytoskeletal proteins.Q46376510
NADPH oxidase 4 mediates upregulation of type 4 phosphodiesterases in human endothelial cells.Q46870640
Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasisQ48963900
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cAMP phosphodiesterase inhibitors increases nitric oxide production by modulating dimethylarginine dimethylaminohydrolases.Q54384259
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Immunohistochemical detection of fibronectin in early and advanced atherosclerosisQ72046894
Neutrophils from MMP-9- or neutrophil elastase-deficient mice show no defect in transendothelial migration under flow in vitroQ78058089
Use of pseudosubstrate affinity to measure active protein kinase AQ79911977
Matrix-specific suppression of integrin activation in shear stress signaling.Q30441401
Matrix-specific p21-activated kinase activation regulates vascular permeability in atherogenesis.Q30442993
Plasma fibronectin promotes thrombus growth and stability in injured arteriolesQ30477630
Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formationQ30492193
Lipid-like materials for low-dose, in vivo gene silencingQ33583399
Localization of atherosclerosis: role of hemodynamicsQ33752374
Extracellular matrix, inflammation, and the angiogenic responseQ33795730
α5β1 integrin signaling mediates oxidized low-density lipoprotein-induced inflammation and early atherosclerosisQ33896730
Extracellular matrix regulation of inflammation in the healthy and injured spinal cordQ33906928
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Hemodynamics and atherosclerosis. Insights and perspectives gained from studies of human arteries.Q34164190
Shear stress selectively upregulates intercellular adhesion molecule-1 expression in cultured human vascular endothelial cellsQ34229735
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In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weightQ34393539
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Prostaglandin E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human MacrophagesQ35612957
Nuclear factor-kappa B interacts functionally with the platelet-derived growth factor B-chain shear-stress response element in vascular endothelial cells exposed to fluid shear stress.Q35753630
Regulation of angiogenesis in vivo by ligation of integrin alpha5beta1 with the central cell-binding domain of fibronectinQ35810000
The role of hyaluronan and the extracellular matrix in islet inflammation and immune regulationQ36204847
Low-grade chronic inflammation in regions of the normal mouse arterial intima predisposed to atherosclerosisQ36228893
Endothelial extracellular matrix: biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilizationQ36321628
Absence of regulated splicing of fibronectin EDA exon reduces atherosclerosis in mice.Q36606722
Carotid bifurcation atherosclerosis. Quantitative correlation of plaque localization with flow velocity profiles and wall shear stressQ36618016
Cardioprotective prostacyclin signaling in vascular smooth muscleQ36681705
Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery DiseaseQ36827659
Shear stress induces synthetic-to-contractile phenotypic modulation in smooth muscle cells via peroxisome proliferator-activated receptor alpha/delta activations by prostacyclin released by sheared endothelial cellsQ37170052
Immune and inflammatory mechanisms of atherosclerosis (*)Q37325024
Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases.Q37401396
Partial carotid ligation is a model of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosisQ37406316
Inflammation in atherosclerosis: transition from theory to practiceQ37672113
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The role of basement membranes in vascular developmentQ37934355
Compartmentalisation of second messenger signalling pathwaysQ38208922
P4510describes a project that usesImageJQ1659584
P433issue10
P921main subjectinflammationQ101991
endotheliumQ111140
P304page(s)1043-1053
P577publication date2016-09-05
P1433published inNature Cell BiologyQ1574111
P1476titleInteraction between integrin α5 and PDE4D regulates endothelial inflammatory signalling
P478volume18

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Q91929786β1 integrin is a sensor of blood flow direction

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