Targeting β1-integrin inhibits vascular leakage in endotoxemia

article published in the Proceedings of the National Academy of Sciences of the United States of America

Targeting β1-integrin inhibits vascular leakage in endotoxemia is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1073/PNAS.1722317115
P932PMC publication ID6048499
P698PubMed publication ID29941602

P50authorJohanna IvaskaQ21263411
Guillaume JacquemetQ56457272
Martina LercheQ88335153
P2093author name stringPipsa Saharinen
Ilkka Miinalainen
Elina A Kiss
Eero Mervaala
Lauri Eklund
Camilo Guzmán
Laura Hakanpaa
P2860cites workBroken barriers: a new take on sepsis pathogenesis.Q43492938
Effective treatment of mouse sepsis with an inhibitory antibody targeting integrin αvβ5.Q43682098
Regulation of angiopoietin expression by bacterial lipopolysaccharide.Q46725976
Integrin β1 controls VE-cadherin localization and blood vessel stabilityQ48218297
Central Roles of α 5 β 1 Integrin and Fibronectin in Vascular Development in Mouse Embryos and Embryoid BodiesQ61960709
Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesisQ24313372
Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humansQ25255098
Cell adhesion: integrating cytoskeletal dynamics and cellular tensionQ29618066
Cell-autonomous requirement for beta1 integrin in endothelial cell adhesion, migration and survival during angiogenesis in miceQ30484500
Tie1 controls angiopoietin function in vascular remodeling and inflammationQ30805233
α5β1 integrin signaling mediates oxidized low-density lipoprotein-induced inflammation and early atherosclerosisQ33896730
Angiopoietin-2 is critical for cytokine-induced vascular leakageQ34935131
Endothelial destabilization by angiopoietin-2 via integrin β1 activation.Q35047913
Integrin-dependent and -independent functions of astrocytic fibronectin in retinal angiogenesis.Q35224567
Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanismQ35227393
Absence of integrin αvβ3 enhances vascular leak in mice by inhibiting endothelial cortical actin formationQ35683028
Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasisQ35842980
Integrin dynamics and matrix assembly: tensin-dependent translocation of alpha(5)beta(1) integrins promotes early fibronectin fibrillogenesisQ36326968
Activation of integrin α5 mediated by flow requires its translocation to membrane lipid rafts in vascular endothelial cellsQ36498382
Robo4-dependent Slit signaling stabilizes the vasculature during pathologic angiogenesis and cytokine stormQ36520971
Evolving functions of endothelial cells in inflammationQ36950913
Relating conformation to function in integrin α5β1.Q37086651
Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activationQ37217491
The development of experimental autoimmune encephalomyelitis in the mouse requires alpha4-integrin but not alpha4beta7-integrinQ37388211
Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signallingQ37634928
Regulation of the endothelial barrier function: a filum granum of cellular forces, Rho-GTPase signaling and microenvironment.Q38196358
New insights in the control of vascular permeability: vascular endothelial-cadherin and other playersQ38376480
AMPK negatively regulates tensin-dependent integrin activity.Q38712389
Why have clinical trials in sepsis failed?Q39242451
Interleukin receptor activates a MYD88-ARNO-ARF6 cascade to disrupt vascular stability.Q39246542
Distinct recycling of active and inactive β1 integrinsQ39417083
Angiopoietin-2 mediates thrombin-induced monocyte adhesion and endothelial permeabilityQ39724484
Amelioration of sepsis by TIE2 activation-induced vascular protection.Q39835320
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 InternationalQ24082749
P6216copyright statuscopyrightedQ50423863
P433issue28
P407language of work or nameEnglishQ1860
P921main subjectendotoxemiaQ5832599
P304page(s)E6467-E6476
P577publication date2018-06-25
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleTargeting β1-integrin inhibits vascular leakage in endotoxemia
P478volume115

Reverse relations

cites work (P2860)
Q59794392Q59794392
Q90156184Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS
Q91868242Dengue Virus Infection Activates Interleukin-1β to Induce Tissue Injury and Vascular Leakage
Q98159739Enzymatic Synthesis of Chondroitin Sulfate E to Attenuate Bacteria Lipopolysaccharide-Induced Organ Damage
Q90179453Extensive Changes in Transcriptomic "Fingerprints" and Immunological Cells in the Large Organs of Patients Dying of Acute Septic Shock and Multiple Organ Failure Caused by Neisseria meningitidis
Q64053576Fibronectin inhibitor pUR4 attenuates tumor necrosis factor α-induced endothelial hyperpermeability by modulating β1 integrin activation
Q90108542Fluctuation-Based Super-Resolution Traction Force Microscopy
Q90854188Integrin trafficking in cells and tissues
Q64948476Mast Cell Protease 7 Promotes Angiogenesis by Degradation of Integrin Subunits.
Q92163068Role of Angiopoietin-2 in Vascular Physiology and Pathophysiology
Q90675140The effects of sepsis on endothelium and clinical implications
Q111271260The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling
Q92923522Vascular Endothelium in Neonatal Sepsis: Basic Mechanisms and Translational Opportunities

Search more.