Immunomodulatory drug costimulates T cells via the B7-CD28 pathway

scientific article published on 25 September 2003

Immunomodulatory drug costimulates T cells via the B7-CD28 pathway is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1182/BLOOD-2003-02-0361
P698PubMed publication ID14512311
P5875ResearchGate publication ID5810512

P50authorKenneth C. AndersonQ28421846
Paul G. RichardsonQ87712102
Nikhil V MunshiQ89228014
Teru HideshimaQ114455520
Dharminder ChauhanQ117224711
Constantine S MitsiadesQ117224720
Laurence P CatleyQ117224725
Nicholas S MitsiadesQ117224764
Reshma ShringarpureQ117224785
P2093author name stringRichard LeBlanc
Renate Burger
Puneet Cheema
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)1787-1790
P577publication date2003-09-25
P1433published inBloodQ885070
P1476titleImmunomodulatory drug costimulates T cells via the B7-CD28 pathway
P478volume103

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cites work (P2860)
Q33421680A phase I dose-escalation study of lenalidomide in combination with gemcitabine in patients with advanced pancreatic cancer
Q35848744A randomized phase 2 study of lenalidomide therapy for patients with relapsed or relapsed and refractory multiple myeloma
Q36822868A review of lenalidomide in combination with dexamethasone for the treatment of multiple myeloma
Q39045586Adoptive immunotherapy for the treatment of glioblastoma: progress and possibilities
Q40429629Antimyeloma activity of two novel N-substituted and tetraflourinated thalidomide analogs
Q41818550Are the immuno-stimulatory properties of Lenalidomide extinguished by co-administration of Dexamethasone?
Q21285161Biological activity of lenalidomide and its underlying therapeutic effects in multiple myeloma
Q41728843CC-122 immunomodulatory effects in refractory patients with diffuse large B-cell lymphoma
Q35828826CD28-mediated regulation of multiple myeloma cell proliferation and survival
Q36546548CD4⁺ T cells play a crucial role for lenalidomide in vivo anti-tumor activity in murine multiple myeloma
Q38062038Can we change the disease biology of multiple myeloma?
Q38779858Carfilzomib alters the HLA-presented peptidome of myeloma cells and impairs presentation of peptides with aromatic C-termini.
Q37983913Chemokine-dependent B cell-T cell interactions in chronic lymphocytic leukemia and multiple myeloma - targets for therapeutic intervention?
Q37902948Chronic lymphocytic leukemia: an update on biology and treatment.
Q35322473Clarithromycin overcomes resistance to lenalidomide and dexamethasone in multiple myeloma
Q36252792Clinical and Immune Effects of Lenalidomide in Combination with Gemcitabine in Patients with Advanced Pancreatic Cancer
Q35784505Clinical and pharmacodynamic analysis of pomalidomide dosing strategies in myeloma: impact of immune activation and cereblon targets
Q38530066Clinical utility and patient consideration in the use of lenalidomide for multiple myeloma in Chinese patients
Q38155039Coinhibitory molecule PD-1 as a potential target for the immunotherapy of multiple myeloma
Q37764870Cost-effectiveness of lenalidomide in multiple myeloma.
Q36376450Current therapeutic uses of lenalidomide in multiple myeloma
Q38110935Dendritic cells in myelodysplastic syndromes: from pathogenesis to immunotherapy.
Q28066890Development of Novel Immunotherapies for Multiple Myeloma
Q36304004Drug insight: thalidomide as a treatment for multiple myeloma
Q37773257Drug-mediated and cellular immunotherapy in multiple myeloma
Q41877240Dysfunctional T regulatory cells in multiple myeloma
Q28241744Early experience with novel immunomodulators for cancer treatment
Q92722336Elevated eosinophil level predicted long time to next treatment in relapsed or refractory myeloma patients treated with lenalidomide
Q30353154Emerging drugs for chronic lymphocytic leukaemia.
Q44599389Enhanced cross-priming of naive CD8+ T cells by dendritic cells treated by the IMiDs® immunomodulatory compounds lenalidomide and pomalidomide
Q24685895Enhancement of ligand-dependent activation of human natural killer T cells by lenalidomide: therapeutic implications
Q37142367Epigenetic induction of adaptive immune response in multiple myeloma: sequential azacitidine and lenalidomide generate cancer testis antigen-specific cellular immunity
Q35592305Expanding role of lenalidomide in hematologic malignancies
Q36154837Expansion of polyfunctional HIV-specific T cells upon stimulation with mRNA electroporated dendritic cells in the presence of immunomodulatory drugs
Q89726615Expression, mutation, and methylation of cereblon-pathway genes at pre- and post-lenalidomide treatment in multiple myeloma
Q34257912Generation of antitumor invariant natural killer T cell lines in multiple myeloma and promotion of their functions via lenalidomide: a strategy for immunotherapy.
Q35033514Higher doses of lenalidomide are associated with unacceptable toxicity including life-threatening tumor flare in patients with chronic lymphocytic leukemia
Q26865561Immune reconstitution in chronic lymphocytic leukemia
Q36904977Immunodeficiency and immunotherapy in multiple myeloma
Q92407035Immunomodulation with pomalidomide at early lymphocyte recovery after induction chemotherapy in newly diagnosed AML and high-risk MDS
Q54204985Immunomodulatory Drugs Exert Anti-Leukemia Effects in Acute Myeloid Leukemia by Direct and Immunostimulatory Activities.
Q39138108Immunomodulatory Drugs in Multiple Myeloma: Mechanisms of Action and Clinical Experience
Q90835733Immunomodulatory drugs activate NK cells via both Zap-70 and cereblon-dependent pathways
Q27001318Immunomodulatory drugs and active immunotherapy for chronic lymphocytic leukemia
Q34325722Immunomodulatory drugs in multiple myeloma
Q37991783Immunomodulatory drugs in multiple myeloma: from molecular mechanisms of action to clinical practice
Q40053620Immunomodulatory drugs stimulate natural killer-cell function, alter cytokine production by dendritic cells, and inhibit angiogenesis enhancing the anti-tumour activity of rituximab in vivo
Q34369823Immunomodulatory effects of lenalidomide and pomalidomide on interaction of tumor and bone marrow accessory cells in multiple myeloma
Q54213159Impact of lenalidomide maintenance on the immune environment of multiple myeloma patients with low tumor burden after autologous stem cell transplantation.
Q37945305Intrinsic modulation of lymphocyte function by stromal cell network: advance in therapeutic targeting of cancer
Q51709036Lenalidomide Induces Interleukin-21 Production by T Cells and Enhances IL21-Mediated Cytotoxicity in Chronic Lymphocytic Leukemia B Cells.
Q37275289Lenalidomide Polarizes Th1-specific Anti-tumor Immune Response and Expands XBP1 Antigen-Specific Central Memory CD3(+)CD8(+) T cells against Various Solid Tumors
Q34009041Lenalidomide as initial therapy of elderly patients with chronic lymphocytic leukemia
Q33903133Lenalidomide enhances anti-myeloma cellular immunity
Q39654887Lenalidomide enhances antibody-dependent cellular cytotoxicity of solid tumor cells in vitro: influence of host immune and tumor markers
Q39798588Lenalidomide enhances antitumor functions of chimeric antigen receptor modified T cells.
Q37012554Lenalidomide enhances myeloma-specific T-cell responses in vivo and in vitro
Q38829322Lenalidomide enhances the function of chimeric antigen receptor T cells against the epidermal growth factor receptor variant III by enhancing immune synapses
Q36090011Lenalidomide enhances the protective effect of a therapeutic vaccine and reverses immune suppression in mice bearing established lymphomas
Q30249007Lenalidomide for the treatment of B-cell lymphoma
Q33403183Lenalidomide for the treatment of relapsed and refractory multiple myeloma.
Q38010055Lenalidomide in solid tumors
Q36125070Lenalidomide in the treatment of chronic lymphocytic leukemia.
Q37626685Lenalidomide inhibits lymphangiogenesis in preclinical models of mantle cell lymphoma
Q35844148Lenalidomide inhibits the malignant clone and up-regulates the SPARC gene mapping to the commonly deleted region in 5q- syndrome patients
Q34137016Lenalidomide inhibits the proliferation of CLL cells via a cereblon/p21(WAF1/Cip1)-dependent mechanism independent of functional p53
Q47112048Lenalidomide overcomes the immunosuppression of regulatory CD8+CD28- T-cells
Q38758162Lenalidomide use in myelodysplastic syndromes: Insights into the biologic mechanisms and clinical applications
Q52577558Lenalidomide versus lenalidomide + dexamethasone prolonged treatment after second-line lenalidomide + dexamethasone induction in multiple myeloma.
Q36806619Lenalidomide-induced immunomodulation in multiple myeloma: impact on vaccines and antitumor responses
Q37334965Lenalidomide-induced upregulation of CD80 on tumor cells correlates with T-cell activation, the rapid onset of a cytokine release syndrome and leukemic cell clearance in chronic lymphocytic leukemia
Q37791617Lenalidomide: a synthetic compound with an evolving role in cancer management
Q36731534Lenalidomide: immunomodulatory, antiangiogenic, and clinical activity in solid tumors
Q30235355Management of lower-risk myelodysplastic syndromes without del5q: current approach and future trends
Q37734280Mechanism of action of immunomodulatory agents in multiple myeloma
Q24605861Mechanism of action of immunomodulatory drugs (IMiDS) in multiple myeloma
Q21198872Mechanism of action of lenalidomide in hematological malignancies
Q35171777Mechanism of immunomodulatory drugs' action in the treatment of multiple myeloma
Q38551337Mechanisms of Action of Lenalidomide in B-Cell Non-Hodgkin Lymphoma
Q90505125Microfluidic assembly of hydrogel-based immunogenic tumor spheroids for evaluation of anticancer therapies and biomarker release
Q36498784Model of translational cancer research in multiple myeloma
Q39570166Molecular action of lenalidomide in lymphocytes and hematologic malignancies
Q38035044Molecular mechanisms of effectiveness of novel therapies in multiple myeloma
Q40473651Molecular mechanisms whereby immunomodulatory drugs activate natural killer cells: clinical application.
Q37815266Multiple myeloma: biology of the disease
Q37340304Myeloma-specific multiple peptides able to generate cytotoxic T lymphocytes: a potential therapeutic application in multiple myeloma and other plasma cell disorders
Q37691759Novel agents for B-cell non-Hodgkin lymphoma: science and the promise
Q37822742Novel agents to improve outcome of allogeneic transplantation for patients with multiple myeloma.
Q35558057Novel and emerging targeted-based cancer therapy agents and methods
Q38069614Novel immunomodulatory compounds in multiple myeloma
Q26770391Novel immunotherapeutic approaches for the treatment of acute leukemia (myeloid and lymphoblastic)
Q38164818Novel investigational agents for the treatment of scleroderma
Q36871990Novel therapeutic targets in mantle cell lymphoma
Q34636002Novel therapies for metastatic renal cell carcinoma: efforts to expand beyond the VEGF/mTOR signaling paradigm
Q33429608Phase I clinical trial of lenalidomide in combination with 5-fluorouracil, leucovorin, and oxaliplatin in patients with advanced cancer
Q34666866Phase I trial of lenalidomide in pediatric patients with recurrent, refractory, or progressive primary CNS tumors: Pediatric Brain Tumor Consortium study PBTC-018.
Q33436535Phase I-II study of lenalidomide and alemtuzumab in refractory chronic lymphocytic leukemia (CLL): effects on T cells and immune checkpoints
Q36998210Preclinical studies of novel targeted therapies
Q36274133Preferential enhancement of older human T cell cytokine generation, chemotaxis, proliferation and survival by lenalidomide
Q38462720Prognostic indicators of lenalidomide for multiple myeloma: consensus and controversy
Q43250303Prognostically significant cytotoxic T cell clones are stimulated after thalidomide therapy in patients with multiple myeloma
Q33398019Salvage treatment with lenalidomide and dexamethasone in relapsed/refractory mantle cell lymphoma: clinical results and effects on microenvironment and neo-angiogenic biomarkers
Q38006901T-regulatory cells: key players in tumor immune escape and angiogenesis
Q37431609Targeted therapies in multiple myeloma
Q38853857Targeting Intrinsic and Extrinsic Vulnerabilities for the Treatment of Multiple Myeloma
Q36965455Thalidomide and lenalidomide as new therapeutics for the treatment of chronic lymphocytic leukemia
Q34775475Thalidomide and lenalidomide: Mechanism-based potential drug combinations
Q80406975Thalidomide for rheumatic disease: the best of both worlds?
Q39600474Thalidomide has anti-inflammatory properties in neonatal immune cells
Q38074017Thalidomide-analogue biology: immunological, molecular and epigenetic targets in cancer therapy.
Q36612543The emerging role of lenalidomide in the management of lymphoid malignancies
Q44824886The evolution of thalidomide and its IMiD derivatives as anticancer agents
Q36739807The evolving role of lenalidomide in the treatment of hematologic malignancies
Q99211979The immunomodulatory drugs lenalidomide and pomalidomide enhance the potency of AMG 701 in multiple myeloma preclinical models
Q38749362The safety of pomalidomide for the treatment of multiple myeloma
Q35097319The use of novel agents in the treatment of relapsed and refractory multiple myeloma
Q36613990Therapeutic use of immunomodulatory drugs in the treatment of multiple myeloma
Q37958036Treating chronic lymphocytic leukemia with thalidomide and lenalidomide
Q38791007Treatment of Multiple Myeloma in a Heart Transplant Recipient
Q37176044Treatment of plasma cell dyscrasias with lenalidomide
Q42737828Trial Watch: Lenalidomide-based immunochemotherapy
Q34253548Update on immunomodulatory drugs (IMiDs) in hematologic and solid malignancies
Q40382947p53-related protein kinase confers poor prognosis and represents a novel therapeutic target in multiple myeloma

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