Nuclear transport of Wilms' tumour protein Wt1 involves importins α and β.

scientific article published in March 2012

Nuclear transport of Wilms' tumour protein Wt1 involves importins α and β. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1159/000337603
P698PubMed publication ID22415091

P50authorCharlotte JacobiQ56956127
P2093author name stringHolger Scholz
Karin M Kirschner
Reinhard Depping
Susann G Schindler
P2860cites workMechanisms of Receptor-Mediated Nuclear Import and Nuclear ExportQ22065647
NF-{kappa}B is transported into the nucleus by importin {alpha}3 and importin {alpha}4Q24293000
SUMO-1 modification of the Wilms' tumor suppressor WT1Q24310548
High affinity binding sites for the Wilms' tumour suppressor protein WT1Q24314245
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Molecular basis for the recognition of a nonclassical nuclear localization signal by importin betaQ27640251
CRM1 is an export receptor for leucine-rich nuclear export signalsQ27860453
Nuclear targeting sequences--a consensus?Q27860997
WT1 proteins: functions in growth and differentiationQ28191433
Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locusQ28236741
Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumpingQ28236877
The Wilms' tumour protein (WT1) shuttles between nucleus and cytoplasm and is present in functional polysomesQ28505624
Coronary vessel development requires activation of the TrkB neurotrophin receptor by the Wilms' tumor transcription factor Wt1.Q28507412
WT-1 is required for early kidney developmentQ28512266
The Wilms' tumor gene Wt1 is required for normal development of the retinaQ28590668
A short amino acid sequence able to specify nuclear locationQ29547781
Transport into and out of the nucleusQ29615611
RanBP3 contains an unusual nuclear localization signal that is imported preferentially by importin-alpha3.Q30304464
The Wilms' tumor 1 (WT1) gene (+KTS isoform) functions with a CTE to enhance translation from an unspliced RNA with a retained intronQ30440624
Truncated WT1 mutants alter the subnuclear localization of the wild-type proteinQ33635997
A polypeptide domain that specifies migration of nucleoplasmin into the nucleusQ34056435
Recognition of nuclear targeting signals by Karyopherin-β proteinsQ34367559
Protein export from the nucleusQ34384095
Classical nuclear localization signals: definition, function, and interaction with importin alphaQ34591163
Molecular basis for modulation of biological function by alternate splicing of the Wilms' tumor suppressor proteinQ35351671
Nucleocytoplasmic transport: taking an inventoryQ35541034
Transcriptional regulation by WT1 in development.Q36229114
Wilms' tumour: connecting tumorigenesis and organ development in the kidneyQ36234726
Karyopherin flexibility in nucleocytoplasmic transportQ36432992
Regulation of nuclear import and export of negative cofactor 2Q37152866
RNA binding by the Wilms tumor suppressor zinc finger proteins.Q37426489
Alternative splicing and genomic structure of the Wilms tumor gene WT1Q37611742
Wilms' tumour protein Wt1 stimulates transcription of the gene encoding vascular endothelial cadherinQ39660484
Actin: a novel interaction partner of WT1 influencing its cell dynamic propertiesQ39766194
Cellular oxygen sensing: Importins and exportins are mediators of intracellular localisation of prolyl-4-hydroxylases PHD1 and PHD2.Q39820969
The Wilms tumor suppressor Wt1 promotes cell adhesion through transcriptional activation of the alpha4integrin geneQ40241736
In vivo analysis of importin alpha proteins reveals cellular proliferation inhibition and substrate specificityQ40418394
The genetics of Wilms' tumor--a case of disrupted developmentQ40614052
The Wilms’ tumour suppressor protein, WT1, undergoes CRM1‐independent nucleocytoplasmic shuttlingQ40620494
The genomic organization and expression of the WT1 geneQ41120172
Regulation of transcription factor localization: fine-tuning of gene expressionQ41147395
Identification of nuclear localization signals within the zinc fingers of the WT1 tumor suppressor gene productQ41168599
Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicingQ41347006
Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndromeQ41660674
Transcriptional repression mediated by the WT1 Wilms tumor gene productQ41661461
Facilitated nuclear transport of histone H1 and other small nucleophilic proteinsQ41740214
Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin.Q42945812
Nuclear translocation of hypoxia-inducible factors (HIFs): involvement of the classical importin alpha/beta pathwayQ45345074
An RNA recognition motif in Wilms' tumour protein (WT1) revealed by structural modelling.Q48066073
WT1 is a tumor-associated antigen in colon cancer that can be recognized by in vitro stimulated cytotoxic T cells.Q51038817
The Wilms tumor suppressor gene wt1 is required for development of the spleen.Q52174780
Adenoviral E1A protein nuclear import is preferentially mediated by importin alpha3 in vitro.Q52961038
P433issue1-2
P304page(s)223-232
P577publication date2012-03-01
P1433published inCellular Physiology and BiochemistryQ2229420
P1476titleNuclear transport of Wilms' tumour protein Wt1 involves importins α and β.
P478volume29

Reverse relations

cites work (P2860)
Q33847590Classification of a frameshift/extended and a stop mutation in WT1 as gain-of-function mutations that activate cell cycle genes and promote Wilms tumour cell proliferation
Q59813350Controlling the Gatekeeper: Therapeutic Targeting of Nuclear Transport
Q37467831Design of an Optimized Wilms' Tumor 1 (WT1) mRNA Construct for Enhanced WT1 Expression and Improved Immunogenicity In Vitro and In Vivo
Q35511186Diversification of importin-α isoforms in cellular trafficking and disease states
Q33583177Identification of importin α 7 specific transport cargoes using a proteomic screening approach
Q38391328Nuclear-cytoplasmatic shuttling of proteins in control of cellular oxygen sensing
Q27689878Structural basis for the selective nuclear import of the C2H2 zinc-finger protein Snail by importin β
Q35955008Targeting nuclear transporters in cancer: Diagnostic, prognostic and therapeutic potential.
Q92783038The FGF, TGFβ and WNT axis Modulate Self-renewal of Human SIX2+ Urine Derived Renal Progenitor Cells
Q48141400The conserved basic residues and the charged amino acid residues at the α-helix of the zinc finger motif regulate the nuclear transport activity of triple C2H2 zinc finger proteins.
Q52563089The presence of human mesenchymal stem cells of renal origin in amniotic fluid increases with gestational time.

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