Interaction between trypsinogen isoforms in genetically determined pancreatitis: mutation E79K in cationic trypsin (PRSS1) causes increased transactivation of anionic trypsinogen (PRSS2).

scientific article published in January 2004

Interaction between trypsinogen isoforms in genetically determined pancreatitis: mutation E79K in cationic trypsin (PRSS1) causes increased transactivation of anionic trypsinogen (PRSS2). is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/HUMU.10285
P698PubMed publication ID14695529

P50authorMiklós Sahin-TóthQ38318675
P2093author name stringNiels Teich
Miklós Tóth
Volker Keim
Jian-Min Chen
Helmut Witzigmann
Joachim Mössner
Claude Férec
Cédric Le Maréchal
Karel Caca
Zoltán Kukor
P2860cites workChronic pancreatitis associated with an activation peptide mutation that facilitates trypsin activationQ74127323
Identification of a novel pancreatitis-associated missense mutation, R116C, in the human cationic trypsinogen gene (PRSS1)Q77171994
Clinical characterization of patients with hereditary pancreatitis and mutations in the cationic trypsinogen geneQ77385500
Determination of the relative contribution of three genes-the cystic fibrosis transmembrane conductance regulator gene, the cationic trypsinogen gene, and the pancreatic secretory trypsin inhibitor gene-to the etiology of idiopathic chronic pancreatQ77894569
Human anionic trypsinogen: properties of autocatalytic activation and degradation and implications in pancreatic diseasesQ24300351
Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen geneQ24311652
Mutational analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene in hereditary and sporadic chronic pancreatitisQ24681604
Discrimination of three mutational events that result in a disruption of the R122 primary autolysis site of the human cationic trypsinogen (PRSS1) by denaturing high performance liquid chromatographyQ24795679
Cathepsin B cleavage of the trypsinogen activation peptideQ24797108
A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitisQ28138105
SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitisQ28138406
Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitisQ28145585
Mutational screening of the cationic trypsinogen gene in a large cohort of subjects with idiopathic chronic pancreatitisQ28205812
Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitisQ28250483
Novel cationic trypsinogen (PRSS1) N29T and R122C mutations cause autosomal dominant hereditary pancreatitisQ28344965
A new polymorphism for the RI22H mutation in hereditary pancreatitisQ28345956
Mutations of the cationic trypsinogen in hereditary pancreatitisQ34472573
Trypsinogen variants in pancreatic juice of healthy volunteers, chronic alcoholics, and patients with pancreatitis and cancer of the pancreasQ34476170
Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitisQ40735691
Human cationic trypsinogen. Role of Asn-21 in zymogen activation and implications in hereditary pancreatitisQ41734787
Analysis of progress curves by simulations generated by numerical integrationQ42835646
A CGC>CAT gene conversion-like event resulting in the R122H mutation in the cationic trypsinogen gene and its implication in the genotyping of pancreatitisQ42976586
Comparative in vitro studies on native and recombinant human cationic trypsins. Cathepsin B is a possible pathological activator of trypsinogen in pancreatitis.Q43581652
Hereditary pancreatitis caused by a novel PRSS1 mutation (Arg-122 --> Cys) that alters autoactivation and autodegradation of cationic trypsinogenQ43806616
Human cationic trypsinogen. Arg(117) is the reactive site of an inhibitory surface loop that controls spontaneous zymogen activation.Q43826802
R116C mutation of cationic trypsinogen in a Turkish family with recurrent pancreatitis illustrates genetic microheterogeneity of hereditary pancreatitisQ43884492
Presence of cathepsin B in the human pancreatic secretory pathway and its role in trypsinogen activation during hereditary pancreatitisQ43946815
"Loss of function" mutations in the cationic trypsinogen gene (PRSS1) may act as a protective factor against pancreatitisQ44452899
Two human trypsinogens. Purification, molecular properties, and N-terminal sequencesQ44455238
Evolution of trypsinogen activation peptidesQ44495545
Affinity purification of recombinant trypsinogen using immobilized ecotin.Q46011088
Gain-of-function mutations associated with hereditary pancreatitis enhance autoactivation of human cationic trypsinogenQ46911281
Analysis of numerical methods for computer simulation of kinetic processes: development of KINSIM--a flexible, portable system.Q52706984
Human pancreatic secretory trypsin inhibitorQ68237081
Effects of chronic alcohol abuse on exocrine pancreatic secretion in manQ70044313
An exceptional genealogy for hereditary chronic pancreatitisQ71214968
Exclusion of anionic trypsinogen and mesotrypsinogen involvement in hereditary pancreatitis without cationic trypsinogen gene mutationsQ73025220
Early events in acute pancreatitisQ73075153
P433issue1
P304page(s)22-31
P577publication date2004-01-01
P1433published inHuman MutationQ5937269
P1476titleInteraction between trypsinogen isoforms in genetically determined pancreatitis: mutation E79K in cationic trypsin (PRSS1) causes increased transactivation of anionic trypsinogen (PRSS2)
P478volume23

Reverse relations

cites work (P2860)
Q35011363A Thai family with hereditary pancreatitis and increased cancer risk due to a mutation in PRSS1 gene
Q30000783A conservative assessment of the major genetic causes of idiopathic chronic pancreatitis: data from a comprehensive analysis of PRSS1, SPINK1, CTRC and CFTR genes in 253 young French patients
Q24675973Biochemical models of hereditary pancreatitis
Q45309271Chronic parotitis: not another SPINKosis
Q54593532Detection of a large genomic deletion in the pancreatic secretory trypsin inhibitor (SPINK1) gene.
Q51796788Functional analysis of pancreatitis-associated missense mutations in the pancreatic secretory trypsin inhibitor (SPINK1) gene.
Q37363563Gene conversion between functional trypsinogen genes PRSS1 and PRSS2 associated with chronic pancreatitis in a six-year-old girl
Q37208470Genetic aspects of tropical calcific pancreatitis
Q35162016Genetic risk for alcoholic chronic pancreatitis
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Q35534772Protein surface charge of trypsinogen changes its activation pattern
Q37255493The guinea pig pancreas secretes a single trypsinogen isoform, which is defective in autoactivation.
Q24620760Uncertainties in the classification of human cationic trypsinogen (PRSS1) variants as hereditary pancreatitis-associated mutations
Q81285595[Clinical implications of genetic risk factors of chronic pancreatitis]
Q81160733[Genetic testing for acute or chronic pancreatitis]

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