Ursodeoxycholic acid protects against secondary biliary cirrhosis in rats by preventing mitochondrial oxidative stress.

scientific article published in March 2004

Ursodeoxycholic acid protects against secondary biliary cirrhosis in rats by preventing mitochondrial oxidative stress. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/HEP.20101
P698PubMed publication ID14999689
P5875ResearchGate publication ID5359280

P50authorJulian CarreteroQ42890318
Javier PeredaQ56241139
Gaetano ServiddioQ57339752
Jose VinaQ72143204
P2093author name stringJuan Sastre
Giuseppe Poli
Federico V Pallardó
Gianluigi Vendemiale
Consuelo Borras
Juan Cutrin
P2860cites workA multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis. UDCA-PBC Study GroupQ28243457
Ursodeoxycholic acid protects hepatocytes against oxidative injury via induction of antioxidantsQ28373006
Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species productionQ28379482
Bile acid-induced rat hepatocyte apoptosis is inhibited by antioxidants and blockers of the mitochondrial permeability transitionQ32075959
Primary biliary cirrhosis: an orchestrated immune response against epithelial cellsQ33916633
Studies on the regulation of glutathione level in rat liverQ34203084
Hormone-mediated down-regulation of hepatic glutathione synthesis in the ratQ34225743
Ursodeoxycholic acid 'mechanisms of action and clinical use in hepatobiliary disorders'.Q34330984
A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbationQ37383640
Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocaseQ38559578
Reaction of formiminoglutamate with liver glutamate dehydrogenaseQ40144427
The effect of ursodeoxycholic acid therapy on liver fibrosis progression in primary biliary cirrhosisQ40737262
Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosisQ40883127
Inhibition of apoptosis by antioxidants in the human HL-60 leukemia cell lineQ41293446
Generation of hydroperoxides in isolated rat hepatocytes and hepatic mitochondria exposed to hydrophobic bile acidsQ41668171
Reactive oxygen species affect mitochondrial electron transport complex I activity through oxidative cardiolipin damageQ42519929
Interferon/antioxidant combination therapy for chronic hepatitis C--a controlled pilot trialQ42995489
Effect of ursodeoxycholic acid on methionine adenosyltransferase activity and hepatic glutathione metabolism in ratsQ43006361
Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liverQ43601206
Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytesQ43933924
Mitochondrial oxidative stress and CD95 ligand: a dual mechanism for hepatocyte apoptosis in chronic alcoholism.Q43974839
Antioxidant defenses in the bile duct-ligated ratQ46424638
Oxidative stress induces apoptosis in embryonic cortical neurons.Q48226359
Ursodeoxycholate reduces hepatotoxicity of bile salts in primary human hepatocytes.Q50878460
Analysis of the membrane potential of rat- and mouse-liver mitochondria by flow cytometry and possible applications.Q54085818
10-N nonyl-acridine orange: a fluorescent probe which stains mitochondria independently of their energetic state.Q54491447
Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinomaQ62727088
Molecular aspects of membrane stabilization by ursodeoxycholate [see comment]Q70457384
Modulation of matrix Ca2+ content by the ADP/ATP carrier in brown adipose tissue mitochondria. Influence of membrane lipid compositionQ71483200
Primary biliary cirrhosisQ71742524
A fast kinetic method for assessing mitochondrial membrane potential in isolated hepatocytes with rhodamine 123 and flow cytometryQ72048392
Protective effect of S-adenosyl-l-methionine on liver damage induced by biliary obstruction in rats: a histological, ultrastructural and biochemical approachQ72812628
Vitamin E reduces oxidant injury to mitochondria and the hepatotoxicity of taurochenodeoxycholic acid in the ratQ74036220
Evidence for accelerated generation of hydroxyl radicals in experimental obstructive jaundice of ratsQ74545781
Cholestasis confers resistance to the rat liver mitochondrial permeability transitionQ77164927
Effect of oxypurinol, a xanthine oxidase inhibitor, on hepatic injury in the bile duct-ligated ratQ77199438
Oxidative damage to mitochondrial DNA and glutathione oxidation in apoptosis: studies in vivo and in vitroQ77774290
P433issue3
P407language of work or nameEnglishQ1860
P1104number of pages10
P304page(s)711-720
P577publication date2004-03-01
P1433published inHepatologyQ15724398
P1476titleUrsodeoxycholic acid protects against secondary biliary cirrhosis in rats by preventing mitochondrial oxidative stress
P478volume39

Reverse relations

cites work (P2860)
Q36172470A growing burden: the pathogenesis, investigation and management of non-alcoholic fatty liver disease
Q36116022Advances in pharmacotherapy for primary biliary cirrhosis
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Q37157813Bile-acid-induced cell injury and protection
Q41095627Chemical chaperone, TUDCA unlike PBA, mitigates protein aggregation efficiently and resists ER and non-ER stress induced HepG2 cell death
Q47145626Curcumin enhances liver SIRT3 expression in the rat model of cirrhosis.
Q34634218Decreasing mitochondrial fission prevents cholestatic liver injury
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Q33213710Effects of total glucosides of peony on immunological hepatic fibrosis in rats
Q79537490Erdosteine treatment attenuates oxidative stress and fibrosis in experimental biliary obstruction
Q41823793Hepatic fibrosis in biliary-obstructed rats is prevented by Ginkgo biloba treatment
Q53622503Is ursodeoxycholic acid crucial for ischemia/reperfusion-induced ovarian injury in rat ovary?
Q35010560Liver fibrosis caused by choledocholith to regress after biliary drainage
Q53122729Liver-specific p38α deficiency causes reduced cell growth and cytokinesis failure during chronic biliary cirrhosis in mice.
Q46005599Many faces of mitochondrial uncoupling during age: damage or defense?
Q37158649Melatonin ameliorates experimental hepatic fibrosis induced by carbon tetrachloride in rats
Q53137606Melatonin attenuates oxidative stress, liver damage and hepatocyte apoptosis after bile-duct ligation in rats.
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Q37863137Mitochondrial dysfunction in nonalcoholic steatohepatitis
Q35730907Oral solubilized ursodeoxycholic acid therapy in amyotrophic lateral sclerosis: a randomized cross-over trial
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Q87561627Oxidative stress and antioxidant status in patients with autoimmune liver diseases
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Q36316956Pathophysiological basis for antioxidant therapy in chronic liver disease
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Q37413654Protection against hepatocyte mitochondrial dysfunction delays fibrosis progression in mice
Q44814235Protective effect of Urtica dioica on liver damage induced by biliary obstruction in rats
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Q83868802[Liver apoptosis]

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