Oxidative stress induces apoptosis in embryonic cortical neurons.

scientific article published in January 1994

Oxidative stress induces apoptosis in embryonic cortical neurons. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1046/J.1471-4159.1994.62010376.X
P698PubMed publication ID7903353

P2093author name stringJ M Baraban
R R Ratan
T H Murphy
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectapoptotic processQ14599311
P304page(s)376-379
P577publication date1994-01-01
P1433published inJournal of NeurochemistryQ6295643
P1476titleOxidative stress induces apoptosis in embryonic cortical neurons
P478volume62

Reverse relations

cites work (P2860)
Q34891485A chemical compound commonly used to inhibit PKR, {8-(imidazol-4-ylmethylene)-6H-azolidino[5,4-g] benzothiazol-7-one}, protects neurons by inhibiting cyclin-dependent kinase
Q34127473A comparison of the different animal models of fetal alcohol spectrum disorders and their use in studying complex behaviors
Q46445779A detailed analysis of hydrogen peroxide-induced cell death in primary neuronal culture
Q44611070A novel potent radical scavenger, 8-(4-fluorophenyl)-2-((2E)-3-phenyl-2-propenoyl)-1,2,3,4-tetrahydropyrazolo[5,1-c] [1,2,4]triazine (FR210575), prevents neuronal cell death in cultured primary neurons and attenuates brain injury after focal ischemi
Q40437117A potential role for apoptosis in neurodegeneration and Alzheimer's disease
Q41096149A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion.
Q41514691A selective phenelzine analogue inhibitor of histone demethylase LSD1.
Q36640055ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo
Q40631378Activation of stimulatory heterotrimeric G proteins increases glutathione and protects neuronal cells against oxidative stress
Q36602241Akt attenuates apoptotic death through phosphorylation of H2A under hydrogen peroxide-induced oxidative stress in PC12 cells and hippocampal neurons
Q39183725Alteration of isocitrate dehydrogenase following acute ischemic injury as a means to improve cellular energetic status in neuroadaptation
Q49090171Alterations in glutathione and amino acid concentrations after hypoxia-ischemia in the immature rat brain
Q46193397Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells
Q34076971Androgens selectively protect against apoptosis in hippocampal neurones
Q48696062Anoxia regulates gene expression in the central nervous system of Drosophila melanogaster
Q35568827Antiapoptotic and Pronecrotic Actions of Neurotrophins
Q72030737Antioxidants, but not cAMP or high K+;, prevent arachidonic acid toxicity on neuronal cultures
Q33895536Apoptosis induced by chelation of intracellular zinc is associated with depletion of cellular reduced glutathione level in rat hepatocytes
Q42082553Apoptosis of retrogradely degenerating neurons occurs in association with the accumulation of perikaryal mitochondria and oxidative damage to the nucleus
Q89848961Apoptotic Inducement of Neuronal Cells by Aluminium Chloride and the Neuroprotective Effect of Eugenol in Wistar Rats
Q40480393Apoptotic death in an in vitro model of neuronal oxidative stress
Q48788958Apoptotic death in cerebral hemisphere cells is density dependent and modulated by transient oxygen and glucose deprivation
Q37220935Apoptotic neuronal death following cerebral ischaemia
Q35765360Apoptotic-like changes in Lewy-body-associated disorders and normal aging in substantia nigral neurons
Q48736931Ascorbate availability and neurodegeneration in amyotrophic lateral sclerosis
Q35166582Ascorbate compartmentalization in the CNS.
Q44078799Biochemical and molecular basis of thimerosal-induced apoptosis in T cells: a major role of mitochondrial pathway
Q33857922Biochemical responses and mitochondrial mediated activation of apoptosis on long-term effect of aspartame in rat brain
Q40935579Bioluminescence in scale-worm photosomes: the photoprotein polynoidin is specific for the detection of superoxide radicals
Q88180460Brain tissue oxygen regulation in awake and anesthetized neonates
Q38479273Butylated hydroxyanisole inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis and GSH depletion
Q73270367Butyric acid and pivaloyloxymethyl butyrate, AN-9, a novel butyric acid derivative, induce apoptosis in HL-60 cells
Q73098621CV-2619 protects cultured astrocytes against reperfusion injury via nerve growth factor production
Q34435342Carboxyfullerenes as neuroprotective agents.
Q41861340Cell and Context-Dependent Effects of the Heat Shock Protein DNAJB6 on Neuronal Survival.
Q36684406Cell death induced by β-amyloid 1–40 in MES 23.5 hybrid clone: the role of nitric oxide and NMDA-gated channel activation leading to apoptosis
Q44266729Cell permeable ROS scavengers, Tiron and Tempol, rescue PC12 cell death caused by pyrogallol or hypoxia/reoxygenation
Q41030810Cellular mechanisms of resistance to chronic oxidative stress
Q73864815Changes in mitochondrial membrane potential during oxidative stress-induced apoptosis in PC12 cells
Q48792928Characterization of hydrogen peroxide toxicity in cultured rat forebrain neurons.
Q35218435Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons
Q35078485Congenital malformations in offspring of diabetic mothers--animal and human studies
Q49144509Control of neurotransmission, behaviour and development, by photo-dynamic manipulation of tissue redox state of brain targets
Q34182570Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway
Q38355236Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress
Q78115680Cupric nitrilotriacetate-induced apoptosis in HL-60 cells association with lipid peroxidation, release of cytochrome C from mitochondria, and activation of caspase-3
Q33896920Cyclopentenone eicosanoids as mediators of neurodegeneration: a pathogenic mechanism of oxidative stress-mediated and cyclooxygenase-mediated neurotoxicity
Q33896926Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration
Q40221101Cystine/glutamate exchange modulates glutathione supply for neuroprotection from oxidative stress and cell proliferation.
Q73726152Decreased phosphorylation levels of TrkB neurotrophin receptor in the spinal cords from patients with amyotrophic lateral sclerosis
Q41692462Decreased susceptibility to lipid peroxidation of Goto-Kakizaki rats: relationship to mitochondrial antioxidant capacity.
Q27480811Dengue virus replication in human hepatoma cells activates NF-kappaB which in turn induces apoptotic cell death
Q49204906Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration
Q39663514Dichloromethane fraction fromGardenia jasminoides: DNA topoisomerase 1 inhibition and oral cancer cell death induction
Q48534216Differential compartmentalization of brain ascorbate and glutathione between neurons and glia
Q46116585Differential sensitivity of naïve and subsets of memory CD4+ and CD8+ T cells to hydrogen peroxide-induced apoptosis
Q40987762Direct evidence for glutathione as mediator of apoptosis in neuronal cells
Q62473026Distribution and kainate-mediated induction of the DNA mismatch repair protein MSH2 in rat brain
Q48197249Diverse stimuli induce calpain overexpression and apoptosis in C6 glioma cells
Q48221102Effect of hyperoxia on cortical neuronal nuclear function and programmed cell death mechanisms
Q28369284Enalapril and moexipril protect from free radical-induced neuronal damage in vitro and reduce ischemic brain injury in mice and rats
Q28276049Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate
Q61795861Ferroptosis in Neurons and Cancer Cells Is Similar But Differentially Regulated by Histone Deacetylase Inhibitors
Q34032093Ferroptosis: an iron-dependent form of nonapoptotic cell death
Q49150355Free radical production and changes in superoxide dismutases associated with hypoxia/reoxygenation-induced apoptosis of embryonic rat forebrain neurons in culture
Q41732106GABAergic deafferentation hypothesis of brain aging and Alzheimer's disease revisited
Q73185480Generation of free radicals during lipid hydroperoxide-triggered apoptosis in PC12h cells
Q48253405Generation of reactive oxygen species, release of L-glutamate and activation of caspases are required for oxygen-induced apoptosis of embryonic hippocampal neurons in culture.
Q57042709Glutamate potentiates the toxicity of mutant Cu/Zn-superoxide dismutase in motor neurons by postsynaptic calcium-dependent mechanisms
Q90330268Histological Study on the Protective Role of Ascorbic Acid on Cadmium Induced Cerebral Cortical Neurotoxicity in Adult Male Albino Rats
Q42155982Histone Deacetylase Inhibitors and Mithramycin A Impact a Similar Neuroprotective Pathway at a Crossroad between Cancer and Neurodegeneration.
Q34923735Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway
Q27480387Human isolates of dengue type 1 virus induce apoptosis in mouse neuroblastoma cells
Q48786900Hydrogen peroxide-induced neurotoxicity in cultured cortical cells grown in serum-free and serum-containing media
Q36034427Hydroxamate-based histone deacetylase inhibitors can protect neurons from oxidative stress via a histone deacetylase-independent catalase-like mechanism
Q34383455Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition
Q37236104Hypoxia-ischemia and retinal ganglion cell damage
Q40480511Hypoxic-ischemic Encephalopathy: Therapeutic Approaches Against Microvascular Injury, and Role of Neutrophils, PAF, and Free Radicals
Q26853254Idebenone and neuroprotection: antioxidant, pro-oxidant, or electron carrier?
Q43843408Identification and functional analysis of the rat caspase-3 gene promoter
Q35758331Identification of a Maleimide-Based Glycogen Synthase Kinase-3 (GSK-3) Inhibitor, BIP-135, that Prolongs the Median Survival Time of Δ7 SMA KO Mouse Model of Spinal Muscular Atrophy.
Q40918106In the neuronal cell line SH-SY5Y, oxidative stress-induced free radical overproduction causes cell death without any participation of intracellular Ca(2+) increase.
Q44069255In vitro model of oxidative stress in cortical neurons
Q44115018In vitro neurotoxicity of methylisothiazolinone, a commonly used industrial and household biocide, proceeds via a zinc and extracellular signal-regulated kinase mitogen-activated protein kinase-dependent pathway.
Q41063368In vitro toxicity of sodium nitroprusside to human endothelial ECV304 cells
Q35044065Inducing the cell cycle arrest and apoptosis of oral KB carcinoma cells by hydroxychavicol: roles of glutathione and reactive oxygen species
Q48335687Induction of apoptosis in the CNS during development by the combination of hyperoxia and inhibition of glutathione synthesis
Q40744342Induction of cytochrome c-mediated apoptosis by amyloid beta 25-35 requires functional mitochondria
Q36237214Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity
Q85172509Inhibition of Axonal Transport Caused by tert-Butyl Hydroperoxide in Cultured Mouse Dorsal Root Ganglion Neurons
Q37189377Inhibition of cystine uptake disrupts the growth of primary brain tumors
Q73194915Inhibition of glutathione depletion by retinoic acid and tocopherol protects cultured neurons from staurosporine-induced oxidative stress and apoptosis
Q48681337Inhibition of heat shock-induced apoptosis by peppermint oil in astrocytes
Q48213185Inhibitory effect of the neuroprotective agent idebenone on arachidonic acid metabolism in astrocytes
Q43774300Intracellular generation of free radicals and modifications of detoxifying enzymes in cultured neurons from the developing rat forebrain in response to transient hypoxia
Q28540311Investigating migration inhibition and apoptotic effects of Fomitopsis pinicola chloroform extract on human colorectal cancer SW-480 cells
Q40767102Juniper oil inhibits the heat shock-induced apoptosis via preventing the caspase-3 activation in human astrocytes CCF-STTG1 cells
Q36913914Lipoxygenase: an emerging target for stroke therapy
Q48290878Mechanisms of NO neurotoxicity.
Q48723929Mechanisms of cell death induced by the mitochondrial toxin 3-nitropropionic acid: acute excitotoxic necrosis and delayed apoptosis
Q48630156Mechanisms of reduced striatal NMDA excitotoxicity in type I nitric oxide synthase knock-out mice
Q37029655Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration
Q41039539Mitochondrial biogenesis and neural differentiation of human iPSC is modulated by idebenone in a developmental stage-dependent manner.
Q41001065Mitochondrial impairment as an early event in the process of apoptosis induced by glutathione depletion in neuronal cells: relevance to Parkinson's disease
Q36302067Molecular and cellular mechanisms of neuronal cell death in HIV dementia
Q41707592Molecular regulation of neuronal apoptosis
Q52029587N-Acetylcysteine delays age-associated memory impairment in mice: role in synaptic mitochondria.
Q57182391N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with PGE to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice
Q73398026N-methyl-D-aspartate receptor blockade enhances neuronal apoptosis induced by serum deprivation
Q73258586NMDA and glutamate evoke excitotoxicity at distinct cellular locations in rat cortical neurons in vitro
Q37050584NMDA receptor-dependent glutamate excitotoxicity in human embryonic stem cell-derived neurons
Q57454215Neuregulin1 Attenuates HO-Induced Reductions in EAAC1 Protein Levels and Reduces HO-Induced Oxidative Stress
Q48427213Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: A perspective on the contributions of apoptosis and necrosis
Q74293271Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death
Q40312201Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis
Q24810086Neuroprotection by Brazilian Green Propolis against In vitro and In vivo Ischemic Neuronal Damage
Q36254536Neuroprotective action of cycloheximide involves induction of bcl-2 and antioxidant pathways
Q82561841Neuroprotective effects of Salidroside and its analogue tyrosol galactoside against focal cerebral ischemia in vivo and H2O2-induced neurotoxicity in vitro
Q33828029Neuroprotective effects of estradiol in mesencephalic dopaminergic neurons
Q37548366Neuroprotective potential of Indigofera oblongifolia leaf methanolic extract against lead acetate-induced neurotoxicity
Q35081723Neuroprotective strategies against calpain-mediated neurodegeneration
Q44418164Neurotrophic factor effects on oxidative stress-induced neuronal death
Q48290890Nitric oxide in neurodegeneration
Q50621480Novel compounds that enhance Agrobacterium-mediated plant transformation by mitigating oxidative stress.
Q33390906Novel multi-modal strategies to promote brain and spinal cord injury recovery
Q33966953Novel role of vitamin k in preventing oxidative injury to developing oligodendrocytes and neurons.
Q48417893Occipital cortex ablation in adult rat causes retrograde neuronal death in the lateral geniculate nucleus that resembles apoptosis
Q73457845Oxidative stress and Ca2+ influx upregulate calpain and induce apoptosis in PC12 cells
Q36874783Oxidized low density lipoprotein caused CNS neuron cell death
Q42466138Oxygen toxicity induces apoptosis in neuronal cells.
Q73091695Pathophysiology of perinatal brain damage
Q40958763Peroxynitrite induces haem oxygenase-1 in vascular endothelial cells: a link to apoptosis.
Q36508125Phosphatidylcholine-specific phospholipase C regulates glutamate-induced nerve cell death.
Q38560204Phytoconstituents as apoptosis inducing agents: strategy to combat cancer
Q28567261Poly(ADP-ribose) polymerase-1 protects neurons against apoptosis induced by oxidative stress
Q48829072Postnatal retinal ganglion cells in vitro: protection against reactive oxygen species (ROS)-induced axonal degeneration by cocultured astrocytes
Q33662463Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies
Q37812676Potential of cystamine and cysteamine in the treatment of neurodegenerative diseases
Q52208882Programmed cell death and Bcl-2 protection in very low oxygen.
Q36992563Prolyl 4-hydroxylase activity-responsive transcription factors: from hydroxylation to gene expression and neuroprotection
Q28376328Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, [...]
Q35850108Protective effect of 20-HETE inhibition in a model of oxygen-glucose deprivation in hippocampal slice cultures.
Q45953668Protective effect of salidroside against H2O2-induced cell apoptosis in primary culture of rat hippocampal neurons.
Q40603703Protective effect of shenqi-wan against H2O2-induced apoptosis in hippocampal neuronal cells
Q40672851Protective effects of Wuyaoshunqisan against H2O2-induced apoptosis on hippocampal cell line HiB5.
Q36959335Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection
Q48455614Purification of a multipotent antideath activity from bovine liver and its identification as arginase: nitric oxide-independent inhibition of neuronal apoptosis.
Q33182373Puromycin aminonucleoside induces apoptosis and increases HNE in cultured glomerular epithelial cells(1).
Q39757671Quantum dots enhance Cu2+ -induced hepatic L02 cells toxicity
Q34361149Recent advances in human perinatal white matter injury
Q45302345Reduced Expression of Foxp1 as a Contributing Factor in Huntington's Disease
Q46116462Reduced mitochondrial manganese-superoxide dismutase activity exacerbates glutamate toxicity in cultured mouse cortical neurons
Q41144827Reducing sugars trigger oxidative modification and apoptosis in pancreatic beta-cells by provoking oxidative stress through the glycation reaction
Q57417820Regulation of adenylyl cyclase in LTP
Q35993899Regulation of neuronal Bcl2 protein expression and calcium homeostasis by transforming growth factor type beta confers wide-ranging protection on rat hippocampal neurons
Q36275021Requirement for cGMP in nerve cell death caused by glutathione depletion
Q46125827Response of postmitotic neurons to X-irradiation: implications for the role of DNA damage in neuronal apoptosis.
Q74545802Riboflavin-mediated axonal degeneration of postnatal retinal ganglion cells in vitro is related to the formation of free radicals
Q55478492Role of glutathione metabolism in the glutamate-induced programmed cell death of neuronal-like PC12 cells.
Q84356912Role of reactive oxygen species in triptolide-induced apoptosis of renal tubular cells and renal injury in rats
Q34673148Searching for disease modifiers-PKC activation and HDAC inhibition - a dual drug approach to Alzheimer's disease that decreases Abeta production while blocking oxidative stress
Q24312134Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways
Q48769445Slowly triggered excitotoxicity occurs by necrosis in cortical cultures
Q41008524Sodium fluoride causes oxidative stress and apoptosis in the mouse liver
Q42440875Sp1 and Sp3 Are Oxidative Stress-Inducible, Antideath Transcription Factors in Cortical Neurons
Q35031658Spatial, temporal, and quantitative manipulation of intracellular hydrogen peroxide in cultured cells
Q45955357Stereoselective HDAC inhibition from cysteine-derived zinc-binding groups.
Q46058932Studies of benzamide- and thiol-based histone deacetylase inhibitors in models of oxidative-stress-induced neuronal death: identification of some HDAC3-selective inhibitors
Q47710423Survival of cultured neurons from amyloid precursor protein knock-out mice against Alzheimer's amyloid-beta toxicity and oxidative stress.
Q77632361Synaptosomal susceptibility on global ischaemia caused by cardiac arrest correlated with early and late times after recirculation in rats
Q40916468Synthesis of novel orthoalkylaminophenol derivatives as potent neuroprotective agents in vitro.
Q35219534T-helper1/T-helper2 cytokine imbalance in the iris of patients with glaucoma
Q34806557The mitochondrial permeability transition pore regulates nitric oxide-mediated apoptosis of neurons induced by target deprivation
Q79760117The putative neuroprotective role of dopamine agonists in Parkinson's disease
Q45296306The role of apoptosis in neurodegenerative diseases
Q74589707The role of calcium in apoptosis
Q36236221Thiol agents and Bcl-2 identify an alphavirus-induced apoptotic pathway that requires activation of the transcription factor NF-kappa B.
Q33881855Tissue transglutaminase: a possible role in neurodegenerative diseases
Q36241237Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activation
Q46060121Trolox and 6,7-dinitroquinoxaline-2,3-dione prevent necrosis but not apoptosis in cultured neurons subjected to oxygen deprivation
Q36550693Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA
Q43137780Tyrosine phosphorylation of apoptotic proteins during hyperoxia in mitochondria of the cerebral cortex of newborn piglets
Q43887806Ultrastructure of Purkinje cell perikarya and their dendritic processes in the rat cerebellar cortex in experimental encephalopathy induced by chronic application of valproate
Q44785865Ursodeoxycholic acid protects against secondary biliary cirrhosis in rats by preventing mitochondrial oxidative stress.
Q27028225Vitreous mediators in retinal hypoxic diseases
Q44268136WR-2721 (amifostine, ethyol) prevents motor and morphological changes induced by neonatal X-irradiation
Q48640047YVAD protect post-natal retinal ganglion cells against axotomy-induced but not free radical-induced axonal degeneration in vitro
Q43545777beta-Amyloid protein induces the formation of purine dimers in cellular DNA.
Q36515603c-Fos Protects Neurons Through a Noncanonical Mechanism Involving HDAC3 Interaction: Identification of a 21-Amino Acid Fragment with Neuroprotective Activity

Search more.