| scholarly article | Q13442814 |
| P50 | author | Jason K Kim | Q92180750 |
| Gerald I. Shulman | Q52509909 | ||
| Barbara Kahn | Q60572402 | ||
| P2093 | author name string | Benjamin G Neel | |
| Janice M Zabolotny | |||
| Hyo-Jeong Kim | |||
| Young-Bum Kim | |||
| Fawaz G Haj | |||
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| Disruption of IRS-2 causes type 2 diabetes in mice | Q24316112 | ||
| Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice | Q24552910 | ||
| Cloning of a cDNA for a major human protein-tyrosine-phosphatase | Q24558722 | ||
| Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance | Q28363155 | ||
| Dynamics of protein-tyrosine phosphatases in rat adipocytes | Q28568792 | ||
| The transmembrane protein-tyrosine phosphatase LAR modulates signaling by multiple receptor tyrosine kinases | Q28569180 | ||
| Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport | Q28570514 | ||
| Mechanism for differential effect of protein-tyrosine phosphatase 1B on Akt versus mitogen-activated protein kinase in 3T3-L1 adipocytes | Q28572663 | ||
| Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene | Q29618933 | ||
| Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes | Q33853693 | ||
| Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus | Q33904740 | ||
| Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats | Q33906333 | ||
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| Skeletal muscle protein tyrosine phosphatase activity and tyrosine phosphatase 1B protein content are associated with insulin action and resistance | Q34132983 | ||
| Increased abundance of the receptor-type protein-tyrosine phosphatase LAR accounts for the elevated insulin receptor dephosphorylating activity in adipose tissue of obese human subjects | Q34224154 | ||
| Protein tyrosine phosphatase 1B interacts with the activated insulin receptor | Q34399346 | ||
| Coordinated action of protein tyrosine phosphatases in insulin signal transduction | Q34539371 | ||
| Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis | Q35146388 | ||
| The muscle creatine kinase gene is regulated by multiple upstream elements, including a muscle-specific enhancer | Q36779266 | ||
| A variation in 3' UTR of hPTP1B increases specific gene expression and associates with insulin resistance | Q37361629 | ||
| Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes | Q37370197 | ||
| Antisense protein tyrosine phosphatase 1B reverses activation of p38 mitogen-activated protein kinase in liver of ob/ob mice | Q38356534 | ||
| Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice | Q38359290 | ||
| Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis | Q38363967 | ||
| Marked impairment of protein tyrosine phosphatase 1B activity in adipose tissue of obese subjects with and without type 2 diabetes mellitus | Q40936141 | ||
| Suppression of insulin receptor activation by overexpression of the protein-tyrosine phosphatase LAR in hepatoma cells | Q41343402 | ||
| Insulin receptor signaling is augmented by antisense inhibition of the protein tyrosine phosphatase LAR. | Q41370376 | ||
| Deficient LAR expression decreases basal forebrain cholinergic neuronal size and hippocampal cholinergic innervation | Q42434826 | ||
| In vivo adenoviral delivery of recombinant human protein kinase C-zeta stimulates glucose transport activity in rat skeletal muscle | Q42475612 | ||
| Overexpression of protein-tyrosine phosphatase-1B in adipocytes inhibits insulin-stimulated phosphoinositide 3-kinase activity without altering glucose transport or Akt/Protein kinase B activation | Q42486150 | ||
| Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (zeta/lambda) activities | Q42507824 | ||
| Altered basal and insulin-stimulated phosphotyrosine phosphatase (PTPase) activity in skeletal muscle from NIDDM patients compared with control subjects | Q42526384 | ||
| Insulin resistance with enhanced insulin signaling in high-salt diet-fed rats | Q43541259 | ||
| Rosiglitazone, insulin treatment, and fasting correct defective activation of protein kinase C-zeta/lambda by insulin in vastus lateralis muscles and adipocytes of diabetic rats | Q43543575 | ||
| Depot-specific variation in protein-tyrosine phosphatase activities in human omental and subcutaneous adipose tissue: a potential contribution to differential insulin sensitivity | Q43819880 | ||
| A P387L variant in protein tyrosine phosphatase-1B (PTP-1B) is associated with type 2 diabetes and impaired serine phosphorylation of PTP-1B in vitro | Q43833524 | ||
| Impaired insulin signaling in the liver of transgenic rats with low circulating growth hormone levels | Q43851263 | ||
| Insulin resistance, defective insulin receptor substrate 2-associated phosphatidylinositol-3' kinase activation, and impaired atypical protein kinase C (zeta/lambda) activation in myotubes from obese patients with impaired glucose tolerance | Q43935436 | ||
| Fatty acid infusion selectively impairs insulin action on Akt1 and protein kinase C lambda /zeta but not on glycogen synthase kinase-3. | Q44049215 | ||
| High-salt diet enhances insulin signaling and induces insulin resistance in Dahl salt-sensitive rats | Q44053708 | ||
| Association of SH2-containing inositol phosphatase 2 with the insulin resistance of diabetic db/db mice | Q44080983 | ||
| Skeletal muscle insulin resistance in obesity-associated type 2 diabetes in monkeys is linked to a defect in insulin activation of protein kinase C-zeta/lambda/iota | Q44155495 | ||
| Reduction of protein-tyrosine phosphatase-1B increases insulin signaling in FAO hepatoma cells | Q44263764 | ||
| Defective activation of atypical protein kinase C zeta and lambda by insulin and phosphatidylinositol-3,4,5-(PO4)(3) in skeletal muscle of rats following high-fat feeding and streptozotocin-induced diabetes | Q44315354 | ||
| Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: amelioration by rosiglitazone and exercise | Q44527036 | ||
| Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: reversal with weight reduction | Q44527038 | ||
| An improved method for prenatal diagnosis of genetic diseases by analysis of amplified DNA sequences. Application to hemophilia A. | Q45889244 | ||
| Improved sensitivity to insulin in obese subjects following weight loss is accompanied by reduced protein-tyrosine phosphatases in adipose tissue | Q47301714 | ||
| Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases | Q48021665 | ||
| Transgenic mice deficient in the LAR protein-tyrosine phosphatase exhibit profound defects in glucose homeostasis. | Q51571073 | ||
| Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle. | Q54095661 | ||
| Enhanced insulin-stimulated activation of phosphatidylinositol 3-kinase in the liver of high-fat-fed rats. | Q54108239 | ||
| Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats. | Q54150649 | ||
| Effect of aging on insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of rats. | Q54154719 | ||
| Increased abundance of specific skeletal muscle protein-tyrosine phosphatases in a genetic model of insulin-resistant obesity and diabetes mellitus | Q54163802 | ||
| Modulation of insulin signal transduction by eutopic overexpression of the receptor-type protein-tyrosine phosphatase LAR | Q55920896 | ||
| P433 | issue | 23 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | insulin resistance | Q1053470 |
| preproinsulin | Q7240673 | ||
| overexpression | Q61643320 | ||
| P304 | page(s) | 24844-24851 | |
| P577 | publication date | 2004-03-18 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action | |
| P478 | volume | 279 |
| Q40084177 | Action mechanism of bis(allixinato)oxovanadium(IV) as a novel potent insulin-mimetic complex: regulation of GLUT4 translocation and FoxO1 transcription factor |
| Q45154660 | Alterations in insulin receptor signalling in the rat epitrochlearis muscle upon cessation of voluntary exercise |
| Q57652579 | Altered glucose homeostasis in mice lacking the receptor protein tyrosine phosphatase sigmaThis paper is one of a selection of papers published in this Special issue, entitled Second Messengers and Phosphoproteins—12th International Conference |
| Q39326170 | Astragalus polysaccharide improves palmitate-induced insulin resistance by inhibiting PTP1B and NF-κB in C2C12 myotubes. |
| Q42516714 | Basal activation of p70S6K results in adipose-specific insulin resistance in protein-tyrosine phosphatase 1B -/- mice. |
| Q42146973 | Berberine Moderates Glucose and Lipid Metabolism through Multipathway Mechanism |
| Q37088346 | Binge drinking induces whole-body insulin resistance by impairing hypothalamic insulin action |
| Q53628990 | Cardiac overexpression of catalase rescues cardiac contractile dysfunction induced by insulin resistance: Role of oxidative stress, protein carbonyl formation and insulin sensitivity. |
| Q37729162 | Chronic ethanol consumption up-regulates protein-tyrosine phosphatase-1B (PTP1B) expression in rat skeletal muscle |
| Q46794494 | Discovery of a novel competitive inhibitor of PTP1B by high-throughput screening |
| Q30010287 | Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling |
| Q42135596 | Dual role of interleukin-6 in regulating insulin sensitivity in murine skeletal muscle |
| Q35004422 | Effect of Hypericum perforatum L. extract on insulin resistance and lipid metabolic disorder in high-fat-diet induced obese mice |
| Q51359048 | Effect of a novel proteoglycan PTP1B inhibitor from Ganoderma lucidum on the amelioration of hyperglycaemia and dyslipidaemia in db/db mice. |
| Q41129993 | Enhanced insulin signaling in density-enhanced phosphatase-1 (DEP-1) knockout mice |
| Q51560394 | Fucosterol activates the insulin signaling pathway in insulin resistant HepG2 cells via inhibiting PTP1B. |
| Q34388740 | Functional significance of the LAR receptor protein tyrosine phosphatase family in development and diseases |
| Q51582804 | Gene expression profile of human skeletal muscle and adipose tissue of Chinese Han patients with type 2 diabetes mellitus. |
| Q37102835 | HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms |
| Q84008571 | Hepatic PTP1B Deficiency: The Promise of a Treatment for Metabolic Syndrome? |
| Q36315662 | Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B. |
| Q42489541 | Improved glucose-stimulated insulin secretion by intra-islet inhibition of protein-tyrosine phosphatase 1B expression in rats fed a high-fat diet |
| Q36452535 | Insulin resistance and improvements in signal transduction |
| Q48187499 | Insulin resistance from binge drinking: it's all in your head |
| Q60228037 | Isolation of Protein Tyrosine Phosphatase 1B Inhibitory Constituents from the Sclerotia of Polyporus umbellatus Fries |
| Q38350989 | Leptin receptor 170 kDa (OB-R170) protein expression is reduced in obese human skeletal muscle: a potential mechanism of leptin resistance. |
| Q38310764 | Leptin signaling in skeletal muscle after bed rest in healthy humans |
| Q37105304 | Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress |
| Q45256105 | Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice |
| Q35890756 | Marine Bromophenol Derivative 3,4-Dibromo-5-(2-bromo-3,4-dihydroxy-6-isopropoxymethyl benzyl)benzene-1,2-diol Protects Hepatocytes from Lipid-Induced Cell Damage and Insulin Resistance via PTP1B Inhibition |
| Q34031701 | Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training |
| Q42484209 | Metallothionein alleviates cardiac contractile dysfunction induced by insulin resistance: role of Akt phosphorylation, PTB1B, PPARgamma and c-Jun. |
| Q33893897 | Molecular mechanism of insulin resistance in obesity and type 2 diabetes |
| Q37578545 | Molecular mechanisms involved in obesity-associated insulin resistance: therapeutical approach. |
| Q38661391 | Molecular physiopathology of obesity-related diseases: multi-organ integration by GRK2. |
| Q42656002 | Negative regulation of MAP kinase signaling in Drosophila by Ptp61F/PTP1B. |
| Q39594207 | New emerging role of protein-tyrosine phosphatase 1B in the regulation of glycogen metabolism in basal and TNF-α-induced insulin-resistant conditions in an immortalised muscle cell line isolated from mice. |
| Q46287259 | Oligonol promotes glucose uptake by modulating the insulin signaling pathway in insulin-resistant HepG2 cells via inhibiting protein tyrosine phosphatase 1B. |
| Q37992232 | PTP1B and TCPTP--nonredundant phosphatases in insulin signaling and glucose homeostasis |
| Q39717309 | Palmitate enhances protein tyrosine phosphatase 1B (PTP1B) gene expression at transcriptional level in C2C12 skeletal muscle cells |
| Q46306508 | Perturbed skeletal muscle insulin signaling in the adult female intrauterine growth-restricted rat. |
| Q39652158 | Prep1 Controls Insulin Glucoregulatory Function in Liver by Transcriptional Targeting of SHP1 Tyrosine Phosphatase |
| Q54968713 | Protein Tyrosine Phosphatase 1B Inhibition and Glucose Uptake Potentials of Mulberrofuran G, Albanol B, and Kuwanon G from Root Bark of Morus alba L. in Insulin-Resistant HepG2 Cells: An In Vitro and In Silico Study. |
| Q36713273 | Protein tyrosine phosphatase function: the substrate perspective |
| Q39736345 | Protein tyrosine phosphatase-1B (PTP-1B) knockdown improves palmitate-induced insulin resistance in C2C12 skeletal muscle cells. |
| Q36662772 | Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo |
| Q35118726 | Protein-tyrosine phosphatase 1B substrates and metabolic regulation |
| Q40177903 | Protein-tyrosine phosphatase 1B-deficient myocytes show increased insulin sensitivity and protection against tumor necrosis factor-alpha-induced insulin resistance |
| Q51352796 | Prunin is a highly potent flavonoid from Prunus davidiana stems that inhibits protein tyrosine phosphatase 1B and stimulates glucose uptake in insulin-resistant HepG2 cells. |
| Q37575422 | ROCK1 isoform-specific deletion reveals a role for diet-induced insulin resistance |
| Q38546045 | Recent progress in studies on the health benefits of pyrroloquinoline quinone. |
| Q33815738 | Regulation of brown fat adipogenesis by protein tyrosine phosphatase 1B |
| Q35035098 | Retracted: Protein Tyrosine Phosphatase 1B and Insulin Resistance: Role of Endoplasmic Reticulum Stress/Reactive Oxygen Species/Nuclear Factor Kappa B Axis |
| Q38937256 | Rosiglitazone, a PPARγ agonist, ameliorates palmitate-induced insulin resistance and apoptosis in skeletal muscle cells. |
| Q53060635 | Safranal, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves glucose tolerance in diabetic KK-Ay mice. |
| Q48057385 | Severe energy deficit upregulates leptin receptors, leptin signaling, and PTP1B in human skeletal muscle |
| Q35976750 | Skeletal muscle protein tyrosine phosphatase 1B regulates insulin sensitivity in African Americans |
| Q42427575 | Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice |
| Q50891541 | Steered Molecular Dynamics for Investigating the Interactions Between Insulin Receptor Tyrosine Kinase (IRK) and Variants of Protein Tyrosine Phosphatase 1B (PTP1B). |
| Q37326060 | T cell protein tyrosine phosphatase (TCPTP) deficiency in muscle does not alter insulin signalling and glucose homeostasis in mice |
| Q90546431 | The Emerging Roles of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 in Skeletal Muscle Redox Signaling and Metabolism |
| Q91994816 | The Role of Protein Tyrosine Phosphatase (PTP)-1B in Cardiovascular Disease and Its Interplay with Insulin Resistance |
| Q64377894 | The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis |
| Q28074241 | The metal face of protein tyrosine phosphatase 1B |
| Q37805797 | Tissue specificity on insulin action and resistance: past to recent mechanisms. |
| Q92039059 | Vanadium: Risks and possible benefits in the light of a comprehensive overview of its pharmacotoxicological mechanisms and multi-applications with a summary of further research trends |
| Q34117513 | Ventromedial hypothalamus-specific Ptpn1 deletion exacerbates diet-induced obesity in female mice |
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