Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations

scientific article

Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00401-013-1093-X
P698PubMed publication ID23404370

P50authorOtmar WiestlerQ97949
Roland EilsQ30004000
Stefan M. PfisterQ39183179
Andreas von DeimlingQ40381084
Christel Herold-MendeQ40381807
Ralf KetterQ42289550
Felix SahmQ42774262
Rosario M. PiroQ51075539
Stefan PuschQ51075545
Christian KoelscheQ57614644
Simon Matthias MayQ58210269
David T. W. JonesQ58388511
P. Andrew FutrealQ63232438
David CapperQ63366395
Nathalia GieseQ87716518
Christian MawrinQ87844654
Marcel KoolQ90637389
David E ReussQ98294091
Leonille SchweizerQ99412181
Christian HagenlocherQ114726957
P2093author name stringPatrick S Tarpey
Philip J Stephens
Thomas Santarius
V Peter Collins
Christian Hartmann
Rainer König
Ruth Wellenreuther
Natalie Jäger
Jürgen Kraus
Doris Lenartz
Albert Becker
Jochen Meyer
Jana Mucha
Phillipp Kickingereder
P2860cites workA physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathwayQ21735927
Mammalian Krüppel-Like Factors in Health and DiseasesQ24612560
Dissecting the genomic complexity underlying medulloblastomaQ24621907
Fast and accurate short read alignment with Burrows-Wheeler transformQ24653853
The structure of the Klf4 DNA-binding domain links to self-renewal and macrophage differentiationQ27666639
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factorsQ27860937
The Sequence Alignment/Map format and SAMtoolsQ27860966
Combinatorial control of the bradykinin B2 receptor promoter by p53, CREB, KLF-4, and CBP: implications for terminal nephron differentiationQ28582825
ANNOVAR: functional annotation of genetic variants from high-throughput sequencing dataQ29547161
Secretory meningiomas: a benign subgroup causing life-threatening complicationsQ33574558
Sequence-specific error profile of Illumina sequencersQ34185285
KLF4, p21 and context-dependent opposing forces in cancerQ34478868
Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathwaysQ35641254
Merlin expression in secretory meningiomas: evidence of an NF2-independent pathogenesis? Immunohistochemical studyQ36919876
The seventh ring: exploring TRAF7 functions.Q37959350
Discovery of Ca2+-relevant and differentiation-associated genes downregulated in esophageal squamous cell carcinoma using cDNA microarrayQ38347517
KLF4 suppresses estrogen-dependent breast cancer growth by inhibiting the transcriptional activity of ERalphaQ39841606
Improving SNP discovery by base alignment qualityQ41909573
Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutationsQ42548316
TRAF7 protein promotes Lys-29-linked polyubiquitination of IkappaB kinase (IKKgamma)/NF-kappaB essential modulator (NEMO) and p65/RelA protein and represses NF-kappaB activationQ42773665
PCR- and restriction endonuclease-based detection of IDH1 mutationsQ43278566
NF2 mutations in secretory and other rare variants of meningiomasQ48585454
Web-based primer design for single nucleotide polymorphism analysisQ49010083
Female predominance in meningiomas can not be explained by differences in progesterone, estrogen, or androgen receptor expression.Q51804977
Significant reduction in brain swelling by administration of nonpeptide kinin B2 receptor antagonist LF 16-0687Ms after controlled cortical impact injury in rats.Q52972353
Secretory meningioma: clinical, histologic, and immunohistochemical findings in 31 cases.Q55067015
Evidence for the complete inactivation of the NF2 gene in the majority of sporadic meningiomasQ58862180
P433issue3
P304page(s)351-358
P577publication date2013-02-12
P1433published inActa NeuropathologicaQ343168
P1476titleSecretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations
P478volume125

Reverse relations

cites work (P2860)
Q42445998AKT1E17K mutations cluster with meningothelial and transitional meningiomas and can be detected by SFRP1 immunohistochemistry
Q36942228ARID1A and TERT promoter mutations in dedifferentiated meningioma
Q45997283Adenomatoid tumors of the male and female genital tract are defined by TRAF7 mutations that drive aberrant NF-kB pathway activation.
Q47208014Advances in meningioma genetics: novel therapeutic opportunities
Q57163869An overview of meningiomas
Q43084857Angiomatous meningiomas have a distinct genetic profile with multiple chromosomal polysomies including polysomy of chromosome 5.
Q39290955BAP1 mutations in high-grade meningioma: implications for patient care
Q40682213Brain Invasion in Meningiomas: Incidence and Correlations with Clinical Variables and Prognosis
Q58491122Brain Tumours
Q92446819Case-Based Review: meningioma
Q38810583Classification of human meningiomas: lights, shadows, and future perspectives
Q47578132Clinical features, surgical management, and prognostic factors of secretory meningiomas: a single-center case series of 149 patients.
Q53117505Clinical impact of targeted amplicon sequencing for meningioma as a practical clinical-sequencing system.
Q48355463Clinicopathological and molecular characteristics of pediatric meningiomas
Q98158606Comparative clinical and genomic analysis of neurofibromatosis type 2-associated cranial and spinal meningiomas
Q64927814Comparative genomic analysis of driver mutations in matched primary and recurrent meningiomas.
Q36807618Copy number variation analysis identifies novel CAKUT candidate genes in children with a solitary functioning kidney.
Q89795838DNA methylation analysis for the treatment of meningiomas
Q38743450DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis
Q38680767Diagnostic Challenges in Meningioma
Q48109121Diffuse midline skull base meningiomas: identification of a rare and aggressive subgroup of meningiomas
Q38823997EANO guidelines for the diagnosis and treatment of meningiomas
Q58798211Emerging Medical Treatments for Meningioma in the Molecular Era
Q55456657Epithelial differentiation with microlumen formation in meningioma: diagnostic utility of NHERF1/EBP50 immunohistochemistry.
Q36483721Exome sequencing on malignant meningiomas identified mutations in neurofibromatosis type 2 (NF2) and meningioma 1 (MN1) genes.
Q50664835Frequent AKT1E17K mutations in skull base meningiomas are associated with mTOR and ERK1/2 activation and reduced time to tumor recurrence.
Q57191736Genetic Alterations of TRAF Proteins in Human Cancers
Q38953562Genetic landscape of meningioma
Q35072568Genetic profiling by single-nucleotide polymorphism-based array analysis defines three distinct subtypes of orbital meningioma
Q35793582Genetic/molecular alterations of meningiomas and the signaling pathways targeted
Q48030508Genomic analysis reveals frequent TRAF7 mutations in intraneural perineuriomas.
Q46129842Germline and somatic BAP1 mutations in high-grade rhabdoid meningiomas
Q48857394High incidence of activating TERT promoter mutations in meningiomas undergoing malignant progression
Q93133413Identification of KIF11 As a Novel Target in Meningioma
Q90468370Identification of PD-L2, B7-H3 and CTLA-4 immune checkpoint proteins in genetic subtypes of meningioma
Q35741539Increased expression of the immune modulatory molecule PD-L1 (CD274) in anaplastic meningioma
Q93018924Intraventricular meningiomas frequently harbor NF2 mutations but lack common genetic alterations in TRAF7, AKT1, SMO, KLF4, PIK3CA, and TERT
Q52764536KLF4 is a tumor suppressor in anaplastic meningioma stem-like cells and human meningiomas.
Q36472473KLF4 regulates adult lung tumor-initiating cells and represses K-Ras-mediated lung cancer
Q38572601Malignant progression to anaplastic meningioma: Neuropathology, molecular pathology, and experimental models
Q51075492Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein.
Q26741529Meningioma Genomics: Diagnostic, Prognostic, and Therapeutic Applications
Q90021888Meningiomas Display a Specific Immunoexpression Pattern in a Rostrocaudal Gradient: An Analysis of 366 Patients
Q97519828Meningiomas: An Overview of the Landscape of Copy Number Alterations in Samples from an Admixed Population
Q91879154Mismatch repair deficiency in high-grade meningioma: a rare but recurrent event associated with dramatic immune activation and clinical response to PD-1 blockade
Q33729693Molecular Testing of Brain Tumor
Q38633637Molecular Transition of an Adult Low-Grade Brain Tumor to an Atypical Teratoid/Rhabdoid Tumor Over a Time-Course of 14 Years
Q92817234Molecular characteristics of meningiomas
Q92353488Molecular characterization of localized pleural mesothelioma
Q38125031Molecular neuro-oncology in clinical practice: a new horizon
Q92264924Molecular pathology of tumors of the central nervous system
Q99616661Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma
Q88917856Multiplatform profiling of meningioma provides molecular insight and prioritization of drug targets for rational clinical trial design
Q92810911Mutation Status and Epithelial Differentiation Stratify Recurrence Risk in Chordoid Meningioma-A Multicenter Study with High Prognostic Relevance
Q36785144Oncogenic PI3K mutations are as common as AKT1 and SMO mutations in meningioma
Q37645016Overexpression of KLF4 promotes cell senescence through microRNA-203-survivin-p21 pathway
Q34682187PET Imaging in Patients with Meningioma - Report of the RANO/PET Group.
Q35943650Pathology and molecular genetics of meningioma: recent advances
Q100457833Peritumoral Brain Edema and Surgical Outcome in Secretory Meningiomas: a matched cohort analysis
Q94592174Phenotypic spectrum and transcriptomic profile associated with germline variants in TRAF7
Q92862814Recent Advances in Meningioma Immunogenetics
Q37420954Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas
Q53971614SMO mutant olfactory groove meningiomas-the next in line for targeted therapy.
Q96772861Scalp invasion by atypical or anaplastic meningioma is a risk factor for development of systemic metastasis
Q39725060Secretory Meningiomas: Increased Prevalence of Seizures Secondary to Edema Formation in a Rare Histologic Subtype.
Q88778968Selective vulnerability of the primitive meningeal layer to prenatal Smo activation for skull base meningothelial meningioma formation
Q99357798Sensitivity of human meningioma cells to the cyclin-dependent kinase inhibitor, TG02
Q36849156TERT Promoter Mutations and Risk of Recurrence in Meningioma
Q38997320The Emerging Role of TRAF7 in Tumor Development
Q38565718The Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor
Q39091307The new WHO 2016 classification of brain tumors-what neurosurgeons need to know
Q103826154The spatial phenotype of genotypically distinct meningiomas demonstrate potential implications of the embryology of the meninges
Q91107708Towards Molecular Classification of Meningioma: Evolving Treatment and Diagnostic Paradigms
Q27853347Transcriptomic analysis of aggressive meningiomas identifies PTTG1 and LEPR as prognostic biomarkers independent of WHO grade
Q50217988Tumors of the inner ear and adjacent structures
Q64928290Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42.

Search more.