KLF4 suppresses estrogen-dependent breast cancer growth by inhibiting the transcriptional activity of ERalpha

scientific article published on 8 June 2009

KLF4 suppresses estrogen-dependent breast cancer growth by inhibiting the transcriptional activity of ERalpha is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/ONC.2009.151
P698PubMed publication ID19503094

P2093author name stringJ Yanagisawa
Y Nakajima
K Kimura
S Kawasaki
A Murayama
I Ito
K Akaogi
S-h Oie
P2860cites workIdentification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrestQ24311735
Epigenetic control of rDNA loci in response to intracellular energy statusQ24313528
A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cellsQ24322959
Transcriptional profiling of Krüppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiationQ24648756
The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoterQ24653488
Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damageQ24655032
The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifenQ27766417
The nuclear receptor superfamily: the second decadeQ27860725
A signature motif in transcriptional co-activators mediates binding to nuclear receptorsQ27860938
Klf4 is a transcription factor required for establishing the barrier function of the skinQ28115084
Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancerQ28155828
Combinatorial control of gene expression by nuclear receptors and coregulatorsQ28209095
Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodelingQ28213257
X chromosomal abnormalities in basal-like human breast cancerQ28296876
Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesisQ28592219
Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cellsQ28592799
Klf4 and corticosteroids activate an overlapping set of transcriptional targets to accelerate in utero epidermal barrier acquisitionQ28593494
Genes that mediate breast cancer metastasis to lungQ29547479
The human estrogen receptor has two independent nonacidic transcriptional activation functionsQ29617089
Stromal gene expression predicts clinical outcome in breast cancerQ33330931
Gut-enriched Krüppel-like factor represses cyclin D1 promoter activity through Sp1 motifQ33617171
An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survivalQ33939753
Requirement of Krüppel-like factor 4 in preventing entry into mitosis following DNA damageQ34092984
Down-regulation of gut-enriched Kruppel-like factor expression in esophageal cancerQ34159812
Ectopic expression of Kruppel like factor 4 (Klf4) accelerates formation of the epidermal permeability barrierQ34195392
The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogeneQ34462232
Activation of the human pregnancy-specific glycoprotein PSG-5 promoter by KLF4 and Sp1.Q34505246
Roles of Krüpel-like factor 4 in normal homeostasis, cancer and stem cellsQ37158208
Discovery of Ca2+-relevant and differentiation-associated genes downregulated in esophageal squamous cell carcinoma using cDNA microarrayQ38347517
Turning off estrogen receptor beta-mediated transcription requires estrogen-dependent receptor proteolysis.Q39125264
The role of oestrogens and progestagens in the epidemiology and prevention of breast cancerQ39626911
Characterization of the structure and regulation of the murine gene encoding gut-enriched Krüppel-like factor (Krüppel-like factor 4).Q39729656
SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-deltaQ39979150
Human mucin 1 oncoprotein represses transcription of the p53 tumor suppressor geneQ40169562
Estrogen receptor-alpha binds p53 tumor suppressor protein directly and represses its functionQ40318351
Nuclear localization of KLF4 is associated with an aggressive phenotype in early-stage breast cancerQ40564116
Estradiol stabilizes p53 protein in breast cancer cell line, MCF-7.Q40652110
Gut-enriched Krüppel-like factor regulates colonic cell growth through APC/beta-catenin pathwayQ40696363
Role of gut-enriched Krüppel-like factor in colonic cell growth and differentiationQ40852596
Estrogens, progestogens, normal breast cell proliferation, and breast cancer riskQ40862149
Redox-sensitive vascular smooth muscle cell proliferation is mediated by GKLF and Id3 in vitro and in vivoQ44043409
p21-induced cycle arrest in G1 protects cells from apoptosis induced by UV-irradiation or RNA polymerase II blockageQ47735165
Genetic reclassification of histologic grade delineates new clinical subtypes of breast cancer.Q51929705
The tumor suppressor p53 is a negative regulator of estrogen receptor signaling pathwaysQ73821163
p53 regulates Cdc2 independently of inhibitory phosphorylation to reinforce radiation-induced G2 arrest in human cellsQ77138780
P433issue32
P407language of work or nameEnglishQ1860
P304page(s)2894-2902
P577publication date2009-06-08
P1433published inOncogeneQ1568657
P1476titleKLF4 suppresses estrogen-dependent breast cancer growth by inhibiting the transcriptional activity of ERalpha
P478volume28

Reverse relations

cites work (P2860)
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