Krüppel-like factors 4 and 5: unity in diversity

scientific article published on December 2009

Krüppel-like factors 4 and 5: unity in diversity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2174/138920209789503932
P932PMC publication ID2817890
P698PubMed publication ID20514221
P5875ResearchGate publication ID44641295

P2093author name stringInderpreet Sur
P2860cites workLoss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomachQ81640280
Proteasomal degradation of the KLF5 transcription factor through a ubiquitin-independent pathwayQ24298274
Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrestQ24311735
Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferationQ24535046
A gene encoding an intestinal-enriched member of the Krüppel-like factor family expressed in intestinal epithelial cellsQ24548693
Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoterQ24548907
Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domainQ24648562
Intestinal-enriched Krüppel-like factor (Krüppel-like factor 5) is a positive regulator of cellular proliferationQ24653635
Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation functionQ24680901
Sp1- and Krüppel-like transcription factorsQ24804528
Kruppel-like factor 5 is an important mediator for lipopolysaccharide-induced proinflammatory response in intestinal epithelial cellsQ25255397
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factorsQ27860937
Induction of pluripotent stem cells from adult human fibroblasts by defined factorsQ27860967
Klf4 is a transcription factor required for establishing the barrier function of the skinQ28115084
Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancerQ28155828
KLF5 is frequently deleted and down-regulated but rarely mutated in prostate cancerQ28186820
A possible tumor suppressor role of the KLF5 transcription factor in human breast cancerQ28202820
Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodelingQ28213257
Human Krüppel-like factor5/KLF5: synergy with NF-kappaB/Rel factors and expression in human skin and hair folliclesQ28214365
Krüppel-like transcription factors: a functional familyQ28251191
Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiationQ28264507
Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cellsQ28276911
Krüppel-like factor 4 (gut-enriched Krüppel-like factor) inhibits cell proliferation by blocking G1/S progression of the cell cycleQ28366322
Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5Q28578164
Intestinal tumor progression is associated with altered function of KLF5Q28579165
Complement 3 activates the KLF5 gene in rat vascular smooth muscle cellsQ28580634
Induction of p53 by GKLF is essential for inhibition of proliferation of vascular smooth muscle cellsQ28581855
Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesisQ28592219
Klf4 and corticosteroids activate an overlapping set of transcriptional targets to accelerate in utero epidermal barrier acquisitionQ28593494
Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cellsQ28595100
PIAS1 mediates TGFbeta-induced SM alpha-actin gene expression through inhibition of KLF4 function-expression by protein sumoylationQ30427433
Oxidized phospholipids induce phenotypic switching of vascular smooth muscle cells in vivo and in vitroQ30444292
15-deoxy-Delta12,14 prostaglandin J2 up-regulates Kruppel-like factor 4 expression independently of peroxisome proliferator-activated receptor gamma by activating the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signQ30858775
Destabilization of Krüppel-like factor 4 protein in response to serum stimulation involves the ubiquitin-proteasome pathwayQ33227192
Gut-enriched Krüppel-like factor represses cyclin D1 promoter activity through Sp1 motifQ33617171
The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon.Q34128767
Ectopic expression of Kruppel like factor 4 (Klf4) accelerates formation of the epidermal permeability barrierQ34195392
Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancerQ34290018
Capturing and profiling adult hair follicle stem cells.Q34306293
Krüppel-like factor 5 mediates the transforming activity of oncogenic H-RasQ34312909
Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasiaQ34338550
Drastic down-regulation of Krüppel-like factor 4 expression is critical in human gastric cancer development and progressionQ34408251
Krüppel-like factor 4 prevents centrosome amplification following gamma-irradiation-induced DNA damageQ34408376
Kruppel-like factor 4 is a mediator of proinflammatory signaling in macrophagesQ34451870
The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogeneQ34462232
KLF4 and KLF5 regulate proliferation, apoptosis and invasion in esophageal cancer cellsQ34477034
Loss of Krüppel-like factor 4 expression contributes to Sp1 overexpression and human gastric cancer development and progressionQ34579406
Genetic and functional differences between multipotent neural and pluripotent embryonic stem cellsQ34582314
Krüppel-like factor 5 mediates cellular transformation during oncogenic KRAS-induced intestinal tumorigenesisQ34585656
KLF4 regulates the expression of interleukin-10 in RAW264.7 macrophagesQ34667354
The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiationQ34673600
Krüppel-like factor 4 regulates B cell number and activation-induced B cell proliferationQ34689980
Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation.Q34696116
Krüppel-like factor 4 is involved in functional differentiation of testicular Sertoli cells.Q34744650
KLF4 is a FOXO target gene that suppresses B cell proliferationQ34765687
Identification of candidate Klf4 target genes reveals the molecular basis of the diverse regulatory roles of Klf4 in the mouse corneaQ34777725
Generation of human-induced pluripotent stem cellsQ34792230
A two-step mechanism for stem cell activation during hair regenerationQ34939606
All-trans retinoic acid inhibits proliferation of intestinal epithelial cells by inhibiting expression of the gene encoding Kruppel-like factor 5Q35080121
Induction of KLF4 in response to heat stressQ35239578
KLF4 suppresses transformation of pre-B cells by ABL oncogenesQ35615876
Lysophosphatidic acid facilitates proliferation of colon cancer cells via induction of Krüppel-like factor 5.Q36023622
Promoter region-specific histone incorporation by the novel histone chaperone ANP32B and DNA-binding factor KLF5.Q36421370
Kruppel-like factor 4 induces p27Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cellsQ36787443
Roles of Krüpel-like factor 4 in normal homeostasis, cancer and stem cellsQ37158208
Acetylation of KLF5 alters the assembly of p15 transcription factors in transforming growth factor-beta-mediated induction in epithelial cellsQ37258607
Regulation of Kruppel-like factor 4, 9, and 13 genes and the steroidogenic genes LDLR, StAR, and CYP11A in ovarian granulosa cellsQ37354408
Early genetic mechanisms underlying the inhibitory effects of endostatin and fumagillin on human endothelial cellsQ37389156
Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseasesQ37486142
KLF5 enhances SREBP-1 action in androgen-dependent induction of fatty acid synthase in prostate cancer cells.Q38287719
Tcf3 governs stem cell features and represses cell fate determination in skinQ38308903
Krüppel-like factor 4 (KLF4/GKLF) is a target of bone morphogenetic proteins and transforming growth factor beta 1 in the regulation of vascular smooth muscle cell phenotype.Q38358459
KLF4 suppresses estrogen-dependent breast cancer growth by inhibiting the transcriptional activity of ERalphaQ39841606
Pro-proliferative factor KLF5 becomes anti-proliferative in epithelial homeostasis upon signaling-mediated modificationQ39908760
SUMOylation regulates nuclear localization of Krüppel-like factor 5.Q39941426
Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9.Q39962828
Kruppel-like factor 5 is required for perinatal lung morphogenesis and functionQ39965475
SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-deltaQ39979150
KLF5 promotes cell proliferation and tumorigenesis through gene regulation and the TSU-Pr1 human bladder cancer cell lineQ40368983
Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells.Q40453525
Nuclear localization of KLF4 is associated with an aggressive phenotype in early-stage breast cancerQ40564116
Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the Krüppel-like factors KLF4 and KLF2.Q42039558
Developmental expression of the mouse gene coding for the Krüppel-like transcription factor KLF5.Q42486688
Epidermal and craniofacial defects in mice overexpressing Klf5 in the basal layer of the epidermisQ42499811
Overexpression of Kruppel-like factor 5 in esophageal epithelia in vivo leads to increased proliferation in basal but not suprabasal cellsQ42510390
Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cellsQ42807434
Haploinsufficiency of Krüppel-like factor 5 rescues the tumor-initiating effect of the Apc(Min) mutation in the intestineQ43105441
Embryonic stem cell markers expression in cancers.Q43717864
STAT1 is required for IFN-gamma-mediated gut-enriched Krüppel-like factor expressionQ44222263
Identification of aberrantly methylated genes in association with adult T-cell leukemiaQ45040822
Krüppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs.Q51947004
A core Klf circuitry regulates self-renewal of embryonic stem cells.Q51964604
Krüppel, a gene whose activity is required early in the zygotic genome for normal embryonic segmentation.Q52520643
Lgr5 marks cycling, yet long-lived, hair follicle stem cells.Q53447869
Angiotensin II and tumor necrosis factor-alpha upregulate survivin and Kruppel-like factor 5 in smooth muscle cells: Potential relevance to vein graft hyperplasia.Q53605623
Expression of KLF5 is a prognostic factor for disease-free survival and overall survival in patients with breast cancer.Q54605682
Chromosomal gains and losses indicate oncogene and tumor suppressor gene candidates in salivary gland tumorsQ58316537
Regulation of angiotensin II-Induced Krüppel-like factor 5 expression in vascular smooth muscle cellsQ79174967
Expression of Krüppel-like factor 5 in human gastric carcinomasQ80593487
P433issue8
P304page(s)594-603
P577publication date2009-12-01
P1433published inCurrent GenomicsQ5195047
P1476titleKrüppel-like factors 4 and 5: unity in diversity
P478volume10

Reverse relations

cites work (P2860)
Q35840453Analysis of uterine gene expression in interleukin-15 knockout mice reveals uterine natural killer cells do not play a major role in decidualization and associated angiogenesis
Q42733015Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi.
Q33924309Krüppel mediates the selective rebalancing of ion channel expression.
Q42014389The transcription factor Krüppel homolog 1 is linked to the juvenile hormone-dependent maturation of sexual behavior in the male moth, Agrotis ipsilon

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