Single-channel analysis of KCNQ K+ channels reveals the mechanism of augmentation by a cysteine-modifying reagent.

scientific article

Single-channel analysis of KCNQ K+ channels reveals the mechanism of augmentation by a cysteine-modifying reagent. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.0882-04.2004
P932PMC publication ID6729199
P698PubMed publication ID15175377

P50authorNikita GamperQ41275613
P2093author name stringYang Li
Mark S Shapiro
P2860cites workKCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channelQ22008501
KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafnessQ22008780
A constitutively open potassium channel formed by KCNQ1 and KCNE3Q22011154
Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversityQ22254006
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Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channelQ24318271
A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndromeQ24318498
A carboxy-terminal domain determines the subunit specificity of KCNQ K+ channel assemblyQ24534565
Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cellsQ74344711
Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesionQ27939824
The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells tranfected with human KCNQ2/3 subunitsQ28138343
Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channelsQ28144303
KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currentsQ28144661
Reconstitution of muscarinic modulation of the KCNQ2/KCNQ3 K(+) channels that underlie the neuronal M currentQ28145290
International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channelsQ28189496
The identification and characterization of a noncontinuous calmodulin-binding site in noninactivating voltage-dependent KCNQ potassium channelsQ28198311
K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium currentQ28295470
Calmodulin is an auxiliary subunit of KCNQ2/3 potassium channelsQ28511803
Imaging actin and dynamin recruitment during invagination of single clathrin-coated pitsQ29620473
A real-time view of life within 100 nm of the plasma membraneQ31890399
KCNQ potassium channels: physiology, pathophysiology, and pharmacologyQ34305841
Genes and mutations in idiopathic epilepsyQ34386799
Emerging structure of the nicotinic acetylcholine receptorsQ34522883
Secretory granules are recaptured largely intact after stimulated exocytosis in cultured endocrine cells.Q34763388
Calmodulin mediates Ca2+-dependent modulation of M-type K+ channelsQ36447189
Bradykinin excites rat sympathetic neurons by inhibition of M current through a mechanism involving B2 receptors and G alpha q/11.Q38299056
M-channel gating and simulationQ40147110
Total internal reflection fluorescenceQ40181869
Activation of KCNQ5 channels stably expressed in HEK293 cells by BMS-204352.Q40745093
KCNQ4 channel activation by BMS-204352 and retigabineQ40802799
Mechanisms underlying modulation of neuronal KCNQ2/KCNQ3 potassium channels by extracellular protonsQ41939192
M channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain.Q42513993
Antibodies and a cysteine-modifying reagent show correspondence of M current in neurons to KCNQ2 and KCNQ3 K+ channelsQ43263581
Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine.Q43683699
Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5-bisphosphate synthesisQ44092262
Molecular correlates of the M-current in cultured rat hippocampal neuronsQ44161111
Subunit-specific modulation of KCNQ potassium channels by Src tyrosine kinase.Q44270181
PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currentsQ44386912
Effect of the KCNQ potassium channel opener retigabine on single KCNQ2/3 channels expressed in CHO cellsQ44408542
(S)-N-[1-(3-morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide: an orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraineQ44507857
Direct activation of the epithelial Na(+) channel by phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate produced by phosphoinositide 3-OH kinaseQ47930919
Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdineQ48473252
C-terminal interaction of KCNQ2 and KCNQ3 K+ channelsQ48831806
Interdomain interactions underlying activation of cyclic nucleotide-gated channels.Q52527323
Inhibition of the muscarinic receptor-activated K+ current by N-ethylmaleimide in rabbit heartQ67988107
Modulation of Ca2+ channels by PTX-sensitive G-proteins is blocked by N-ethylmaleimide in rat sympathetic neuronsQ71657344
Total internal reflection fluorescence microscopy in cell biologyQ73096752
Blocker protection in the pore of a voltage-gated K+ channel and its structural implicationsQ73412357
Properties of single M-type KCNQ2/KCNQ3 potassium channels expressed in mammalian cellsQ74120884
P433issue22
P407language of work or nameEnglishQ1860
P304page(s)5079-5090
P577publication date2004-06-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleSingle-channel analysis of KCNQ K+ channels reveals the mechanism of augmentation by a cysteine-modifying reagent
P478volume24

Reverse relations

cites work (P2860)
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Q37402286Affinity for phosphatidylinositol 4,5-bisphosphate determines muscarinic agonist sensitivity of Kv7 K+ channels
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Q54229916Cholinergic signalling-regulated KV7.5 currents are expressed in colonic ICC-IM but not ICC-MP.
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Q33933223The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus
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Q36548403The Sensorless Pore Module of Voltage-gated K+ Channel Family 7 Embodies the Target Site for the Anticonvulsant Retigabine
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Q40145551Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants
Q48221664β-Secretase BACE1 regulates hippocampal and reconstituted M-currents in a β-subunit-like fashion.

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