Enhanced 7-ethyl-10-hydroxycamptothecin (SN-38) lethality by methylselenocysteine is associated with Chk2 phosphorylation at threonine-68 and down-regulation of Cdc6 expression

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Enhanced 7-ethyl-10-hydroxycamptothecin (SN-38) lethality by methylselenocysteine is associated with Chk2 phosphorylation at threonine-68 and down-regulation of Cdc6 expression is …
instance of (P31):
scholarly articleQ13442814
retracted paperQ45182324

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P356DOI10.1124/MOL.66.1.153
P698PubMed publication ID15213307
P5875ResearchGate publication ID8495555

P2093author name stringFarukh A Durrani
Shousong Cao
Youcef M Rustum
Rami G Azrak
Cheryl Frank
Zhan-Rong Li
Ming-Biao Yin
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Human replication protein Cdc6 is selectively cleaved by caspase 3 during apoptosisQ40714032
Antisense inhibition of Chk2/hCds1 expression attenuates DNA damage-induced S and G2 checkpoints and enhances apoptotic activity in HEK-293 cellsQ40780586
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Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group.Q42528232
On the nature of selenium toxicity and carcinostatic activityQ43981962
Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosisQ44509795
Drosophila Chk2 is required for DNA damage-mediated cell cycle arrest and apoptosisQ47072850
P433issue1
P304page(s)153-160
P577publication date2004-07-01
P1433published inMolecular PharmacologyQ1943386
P1476titleEnhanced 7-ethyl-10-hydroxycamptothecin (SN-38) lethality by methylselenocysteine is associated with Chk2 phosphorylation at threonine-68 and down-regulation of Cdc6 expression
P478volume66

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cites work (P2860)
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Q46978068Norcantharidin inhibits DNA replication and induces apoptosis with the cleavage of initiation protein Cdc6 in HL-60 cells
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