Inhibition of p53 after acute myocardial infarction: reduction of apoptosis is counteracted by disturbed scar formation and cardiac rupture

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Inhibition of p53 after acute myocardial infarction: reduction of apoptosis is counteracted by disturbed scar formation and cardiac rupture is …
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scholarly articleQ13442814

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P356DOI10.1016/J.YJMCC.2010.11.006
P698PubMed publication ID21074539

P50authorThomas BraunQ40760364
Ursula Müller-WerdanQ87347446
P2093author name stringYing Zhang
Henning Ebelt
Jia Xu
Katharina Köhler
Di Lu
Michael Buerke
Axel Schlitt
Karl Werdan
P2860cites workDirected expression of dominant-negative p73 enables proliferation of cardiomyocytes in miceQ24314598
The homeobox gene Lbx1 specifies a subpopulation of cardiac neural crest necessary for normal heart developmentQ28512425
Left ventricular remodeling after myocardial infarction: pathophysiology and therapyQ33951649
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Ventricular remodeling after infarction and the extracellular collagen matrix: when is enough enough?Q35219500
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MMP induction and inhibition in myocardial infarctionQ35636511
The mitochondrial death pathway and cardiac myocyte apoptosisQ35946473
Healing after myocardial infarctionQ36071600
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p53 and the hypoxia-induced apoptosis of cultured neonatal rat cardiac myocytesQ37368100
Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarctionQ37527656
The expanding universe of p53 targetsQ37602507
TNFalpha in atherosclerosis, myocardial ischemia/reperfusion and heart failureQ37771751
Pifithrin-alpha protects against doxorubicin-induced apoptosis and acute cardiotoxicity in miceQ40591772
Optimized, highly efficient transfer of foreign genes into newborn mouse hearts in vivo.Q40626245
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapyQ40929887
Targeted deletion or pharmacological inhibition of MMP-2 prevents cardiac rupture after myocardial infarction in miceQ41051040
Targeted deletion of MMP-2 attenuates early LV rupture and late remodeling after experimental myocardial infarctionQ43687688
Transforming growth factor beta inhibition increases mortality and left ventricular dilatation after myocardial infarctionQ44528242
Expression of mutant p193 and p53 permits cardiomyocyte cell cycle reentry after myocardial infarction in transgenic miceQ44734667
Ischemia-reperfusion injury activates early extracellular matrix processing and expression of endostatin in the heart with differential effects of temperatureQ46102686
Anti-inflammatory effect of oxytocin in rat myocardial infarctionQ48378125
Pifithrin-alpha attenuates p53-mediated apoptosis and improves cardiac function in response to myocardial ischemia/reperfusion in aged rats.Q50474028
Divergent siblings: E2F2 and E2F4 but not E2F1 and E2F3 induce DNA synthesis in cardiomyocytes without activation of apoptosis.Q51539361
Role of collagen in acute myocardial infarct expansion.Q54285193
Depressed expression of MuRF1 and MAFbx in areas remote of recent myocardial infarction: a mechanism contributing to myocardial remodeling?Q54713072
Antioxidants attenuate myocyte apoptosis in the remote non-infarcted myocardium following large myocardial infarctionQ73573648
Progressively developed myocardial apoptotic cell death during late phase of reperfusionQ74166178
Survey of studies examining mammalian cardiomyocyte DNA synthesisQ74791661
Cellular cardiomyoplasty: improvement of left ventricular function correlates with the release of cardioactive cytokinesQ80264618
Targeted deletion of p53 prevents cardiac rupture after myocardial infarction in miceQ82807256
P433issue3
P921main subjectmyocardial infarctionQ12152
acute myocardial infarctionQ18558122
P304page(s)471-478
P577publication date2010-11-11
P1433published inJournal of Molecular and Cellular CardiologyQ2061932
P1476titleInhibition of p53 after acute myocardial infarction: reduction of apoptosis is counteracted by disturbed scar formation and cardiac rupture
P478volume50