Continuous low-dose chemotherapy plus inhibition of cyclooxygenase-2 as an antiangiogenic therapy of glioblastoma multiforme

scientific article published on 28 September 2004

Continuous low-dose chemotherapy plus inhibition of cyclooxygenase-2 as an antiangiogenic therapy of glioblastoma multiforme is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00432-004-0620-5
P698PubMed publication ID15565458

P50authorJochen TuettenbergQ39904320
P2093author name stringFrederik Wenz
Peter Vajkoczy
Rainer Grobholz
Tobias Korn
Ralf Erber
P2860cites workContinuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicityQ24561642
Tumor angiogenesis: therapeutic implicationsQ27860595
Non steroidal anti-inflammatory drugs and COX-2 inhibitors as anti-cancer therapeutics: hypes, hopes and realityQ28166312
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogeneQ28202069
Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancerQ28376841
Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteriaQ29616614
Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal Brain Tumor GroupQ30584392
Multicenter phase II trial of temozolomide in patients with glioblastoma multiforme at first relapseQ30647642
Thromboxane A2 is a mediator of cyclooxygenase-2-dependent endothelial migration and angiogenesisQ33178917
Phase I trial of temozolomide using an extended continuous oral schedule.Q33503863
Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiationQ33868831
Antiangiogenic therapy in brain tumor modelsQ33938969
Redefining the target: chemotherapeutics as antiangiogenicsQ34142103
Antiangiogenic scheduling of lower dose cancer chemotherapy.Q34427979
Therapeutic potential of selective cyclooxygenase-2 inhibitors in the management of tumor angiogenesisQ35148959
Neuro-Oncology Working Group 01 trial of nimustine plus teniposide versus nimustine plus cytarabine chemotherapy in addition to involved-field radiotherapy in the first-line treatment of malignant gliomaQ35208736
Inhibition of angiogenesis by non-toxic doses of temozolomideQ35213979
Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: roles of the nuclear factor of activated T cells and cyclooxygenase 2Q36369190
A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapseQ36621800
Antiangiogenic potential of camptothecin and topotecanQ39518724
Combination of a selective cyclooxygenase-2 inhibitor with epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 and protein kinase A antisense causes cooperative antitumor and antiangiogenic effect.Q40657509
Inhibition of tumor growth, angiogenesis, and microcirculation by the novel Flk-1 inhibitor SU5416 as assessed by intravital multi-fluorescence videomicroscopyQ40753323
Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawalQ40848490
Angiogenesis in malignant gliomasQ40961541
Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healingQ41705080
SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors.Q41756065
NSAIDs inhibit alpha V beta 3 integrin-mediated and Cdc42/Rac-dependent endothelial-cell spreading, migration and angiogenesis.Q43726776
Low-dose chemotherapy combined with an antiangiogenic drug reduces human glioma growth in vivo.Q43770323
Differences in therapeutic indexes of combination metronomic chemotherapy and an anti-VEGFR-2 antibody in multidrug-resistant human breast cancer xenograftsQ43860650
Fatal allergic vasculitis associated with celecoxibQ43919660
Cyclooxygenase-2 expression in endometrial cancer: correlation with microvessel count and expression of vascular endothelial growth factor and thymidine phosphorylaseQ43961971
SU6668 inhibits Flk-1/KDR and PDGFRbeta in vivo, resulting in rapid apoptosis of tumor vasculature and tumor regression in miceQ43972645
Placental growth factor is a survival factor for tumor endothelial cells and macrophagesQ43998967
Prognostic significance of cyclooxygenase-2 pathway and angiogenesis in head and neck squamous cell carcinomaQ44115238
Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs.Q44235692
COX-2 inhibitors and cancer therapeutics: potential roles for inhibitors of COX-2 in combination with cytotoxic therapy: reports from a symposium held in conjunction with the Radiation Therapy Oncology Group June 2001 MeetingQ44539559
Immunolocalization of basic fibroblast growth factor to the microvasculature of human brain tumorsQ45308366
Inhibition of growth of C6 glioma cells in vivo by expression of antisense vascular endothelial growth factor sequence.Q45875779
Patterns of cyclooxygenase-1 and -2 expression in human gliomas in vivoQ48114757
Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trialsQ48286137
Inhibition of glioma angiogenesis and growth in vivo by systemic treatment with a monoclonal antibody against vascular endothelial growth factor receptor-2.Q48789795
Antitumor effects in mice of low-dose (metronomic) cyclophosphamide administered continuously through the drinking water.Q53970403
Microvessel density is a prognostic indicator for patients with astroglial brain tumors.Q55479921
Computerized tomographic and pathologic studies of the untreated, quiescent, and recurrent glioblastoma multiformeQ55489464
Antiangiogenic agents potentiate cytotoxic cancer therapies against primary and metastatic diseaseQ67900636
Inhibition of angiogenesis by the antineoplastic agents mitoxantrone and bisantreneQ68977946
Preclinical studies of the combination of angiogenic inhibitors with cytotoxic agentsQ73441683
Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitorsQ73574321
Cyclooxygenase-2 inhibitor induces apoptosis and enhances cytotoxicity of various anticancer agents in non-small cell lung cancer cell linesQ73803470
Correlation between neovascularisation and neuroendocrine differentiation in prostatic carcinomaQ73840540
Antiproliferative, antiangiogenic and proapoptotic activity of h-R3: A humanized anti-EGFR antibodyQ74802802
Continuous low-dose anti-angiogenic/ metronomic chemotherapy: from the research laboratory into the oncology clinicQ77683561
P433issue1
P921main subjectglioblastomaQ282142
angiogenesis inhibitorQ574834
chemotherapyQ974135
P304page(s)31-40
P577publication date2004-09-28
P1433published inJournal of Cancer Research and Clinical OncologyQ2081599
P1476titleContinuous low-dose chemotherapy plus inhibition of cyclooxygenase-2 as an antiangiogenic therapy of glioblastoma multiforme
P478volume131

Reverse relations

cites work (P2860)
Q38409615Additive antiangiogenesis effect of ginsenoside Rg3 with low-dose metronomic temozolomide on rat glioma cells both in vivo and in vitro
Q37504362Angiogenesis as a therapeutic target in malignant gliomas
Q42732588Antiangiogenesis in recurrent glioblastoma: proof of principle
Q37533652Antiangiogenic strategies for treatment of malignant gliomas
Q38157034Antiangiogenic therapy for high-grade gliomas: current concepts and limitations
Q43197450Bevacizumab and dose-intense temozolomide in recurrent high-grade glioma.
Q64994045Biomarkers for glioblastoma multiforme: status quo.
Q35027024Canadian recommendations for the treatment of recurrent or progressive glioblastoma multiforme
Q43072513Continuous low-dose temozolomide and celecoxib in recurrent glioblastoma
Q38662901Critical Care Management of Cerebral Edema in Brain Tumors
Q46817843Cyclooxygenase-2 (Cox-2) expression and angiogenesis in glioblastoma
Q38969912Cyclooxygenase-2 in glioblastoma multiforme
Q36779651Emerging treatments and gene expression profiling in high-risk medulloblastoma
Q38943301Enhanced immunosuppression by therapy-exposed glioblastoma multiforme tumor cells
Q34127138Experimental approaches for the treatment of malignant gliomas
Q48794947Expression of cyclooxygenase-2 and epidermal growth factor receptor in primary and recurrent glioblastoma multiforme
Q33543830Far-distant metastases along the CSF pathway of glioblastoma multiforme during continuous low-dose chemotherapy with temozolomide and celecoxib
Q37575528Insights into pharmacotherapy of malignant glioma in adults
Q35895174Lessons from anti-vascular endothelial growth factor and anti-vascular endothelial growth factor receptor trials in patients with glioblastoma.
Q64071354Metronomic Chemotherapy: A Systematic Review of the Literature and Clinical Experience
Q38087885Metronomic chemotherapy for cancer treatment: a decade of clinical studies
Q40867629Metronomic chemotherapy with daily low-dose temozolomide and celecoxib in elderly patients with newly diagnosed glioblastoma multiforme: a retrospective analysis
Q43196861Metronomic treatment of malignant glioma xenografts with irinotecan (CPT-11) inhibits angiogenesis and tumor growth
Q33644407Molecularly targeted therapies for malignant glioma: rationale for combinatorial strategies
Q36409038Multi-functional polymeric nanoparticles for tumour-targeted drug delivery
Q36200166Novel advances in drug delivery to brain cancer
Q46362575Phase 2 trial of temozolomide using protracted low-dose and whole-brain radiotherapy for nonsmall cell lung cancer and breast cancer patients with brain metastases.
Q30441458Phase II study of metronomic chemotherapy for recurrent malignant gliomas in adults.
Q35008766Phase II study of metronomic chemotherapy with bevacizumab for recurrent glioblastoma after progression on bevacizumab therapy
Q33388306Phase II trial of low-dose continuous (metronomic) treatment of temozolomide for recurrent glioblastoma
Q47110281Postoperative extracranial metastasis from glioblastoma: a case report and review of the literature
Q33384898Randomized phase II trial of chemoradiotherapy followed by either dose-dense or metronomic temozolomide for newly diagnosed glioblastoma
Q37400645Rechallenge with temozolomide in patients with recurrent gliomas
Q46092458Recurrence pattern in glioblastoma multiforme patients treated with anti-angiogenic chemotherapy.
Q39218093Sulindac sulfide inhibits sarcoendoplasmic reticulum Ca2+ ATPase, induces endoplasmic reticulum stress response, and exerts toxicity in glioma cells: relevant similarities to and important differences from celecoxib
Q35177942Temozolomide and radiotherapy versus radiotherapy alone in high grade gliomas: a very long term comparative study and literature review
Q37995906Temozolomide dosing regimens for glioma patients
Q37078957The emerging role of anti-angiogenic therapy for malignant glioma
Q39489252The nonsteroidal anti-inflammatory drug celecoxib suppresses the growth and induces apoptosis of human glioblastoma cells via the NF-κB pathway
Q26825502The role of NF-κB in the pathogenesis of glioma
Q42116284The use of Cox-2 and PPARγ signaling in anti-cancer therapies
Q37708428Treatment of recurrent diffuse intrinsic pontine glioma: the MD Anderson Cancer Center experience
Q35922107Use of Selective Cyclooxygenase-2 Inhibitors, Other Analgesics, and Risk of Glioma

Search more.