A genetic marker at the OLIG3/TNFAIP3 locus associates with methotrexate continuation in early inflammatory polyarthritis: results from the Norfolk Arthritis Register

scientific article published on 5 October 2010

A genetic marker at the OLIG3/TNFAIP3 locus associates with methotrexate continuation in early inflammatory polyarthritis: results from the Norfolk Arthritis Register is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1000411802
P356DOI10.1038/TPJ.2010.80
P698PubMed publication ID20921970

P50authorJane WorthingtonQ29998784
Anne BartonQ30348373
Wendy ThomsonQ42653464
Tracey FarragherQ47524777
Deborah P.M. SymmonsQ54100237
Paul MartinQ54165701
Stephen EyreQ55188147
P2093author name stringE Flynn
D Bunn
D Plant
P2860cites workDe-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signallingQ24299573
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide studyQ24657292
The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritisQ27860872
A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritisQ28267921
The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritisQ28306666
Effect of methotrexate on blood purine and pyrimidine levels in patients with rheumatoid arthritisQ28375106
An evaluation of the decision tree format of the American College of Rheumatology 1987 classification criteria for rheumatoid arthritis: Performance over five years in a primary care-based prospective studyQ57804956
A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritisQ33299576
STAT4: genetics, mechanisms, and implications for autoimmunityQ34804543
Methotrexate pharmacogenetics: the first step toward individualized therapy in rheumatoid arthritisQ36463121
Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibilityQ36769297
Encoding NF-kappaB temporal control in response to TNF: distinct roles for the negative regulators IkappaBalpha and A20.Q36802977
Can clinical factors at presentation be used to predict outcome of treatment with methotrexate in patients with early inflammatory polyarthritis?Q37000103
Recent advances in the genetics of RA susceptibilityQ37080741
CD226 Gly307Ser association with multiple autoimmune diseasesQ37083069
Two independent alleles at 6q23 associated with risk of rheumatoid arthritisQ37120830
Rheumatoid arthritis association at 6q23.Q37172071
Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genesQ37223270
Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23.Q37239881
Rheumatoid arthritis: a view of the current genetic landscapeQ37315484
Common variants at CD40 and other loci confer risk of rheumatoid arthritisQ37376871
Pharmacogenetics of warfarinQ37580929
Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradationQ38297721
Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes.Q40338460
Association of the 6q23 region with the rate of joint destruction in rheumatoid arthritisQ42491562
Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseasesQ43089300
Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13.Q43154311
Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs studyQ43771027
Susceptibility variants for rheumatoid arthritis in the TRAF1-C5 and 6q23 loci: a meta-analysisQ43949763
Risk genotypes in folate-dependent enzymes and their association with methotrexate-related side effects in rheumatoid arthritisQ44210170
Methotrexate in rheumatoid arthritis. Toxic effects as the major factor in limiting long-term treatmentQ46242303
A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent-onset rheumatoid arthritisQ57788757
P433issue2
P921main subjectmethotrexateQ422232
P304page(s)128-133
P577publication date2010-10-05
P1433published inThe Pharmacogenomics JournalQ10534704
P1476titleA genetic marker at the OLIG3/TNFAIP3 locus associates with methotrexate continuation in early inflammatory polyarthritis: results from the Norfolk Arthritis Register
P478volume12

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cites work (P2860)
Q99592093A20: a master regulator of arthritis
Q93035719Genetic influences on susceptibility to rheumatoid arthritis in African-Americans
Q89748484Methotrexate and its mechanisms of action in inflammatory arthritis
Q50047899Methotrexate limits inflammation through an A20-dependent cross-tolerance mechanism
Q35221741PTPN22: the archetypal non-HLA autoimmunity gene
Q58695927Whole exome sequencing in Finnish families identifies new candidate genes for osteoarthritis