B-cell agonists up-regulate AID and APOBEC3G deaminases, which induce IgA and IgG class antibodies and anti-viral function

scientific article published in March 2012

B-cell agonists up-regulate AID and APOBEC3G deaminases, which induce IgA and IgG class antibodies and anti-viral function is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1365-2567.2011.03524.X
P932PMC publication ID3311043
P698PubMed publication ID22044427
P5875ResearchGate publication ID51762175

P2093author name stringThomas Lehner
Kaboutar Babaahmady
Thomas Seidl
Trevor Whittall
P2860cites workCD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tractQ22242965
Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tractQ22242981
Phosphorylation meets ubiquitination: the control of NF-[kappa]B activityQ27860643
DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retrovirusesQ28182624
AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversificationQ28208979
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzymeQ29547201
Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infectionQ29619124
Innate and adaptive immune correlates of vaccine and adjuvant-induced control of mucosal transmission of SIV in macaquesQ34006329
Mechanism and control of class-switch recombinationQ34500935
The regulation of IgA class switching.Q34708215
Mechanism and regulation of class switch recombinationQ34764888
Editing at the crossroad of innate and adaptive immunityQ36046696
The biochemistry of somatic hypermutationQ37096080
The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelementsQ37096085
Defining APOBEC3 expression patterns in human tissues and hematopoietic cell subsetsQ37333883
Mucosal immunization in macaques upregulates the innate APOBEC 3G anti-viral factor in CD4(+) memory T cells.Q37347854
HIV-1 evades virus-specific IgG2 and IgA responses by targeting systemic and intestinal B cells via long-range intercellular conduitsQ37444317
Exosome release by primary B cells.Q37524069
B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencersQ38348243
High level expression of the anti-retroviral protein APOBEC3G is induced by influenza A virus but does not confer antiviral activityQ39860276
Exosomes packaging APOBEC3G confer human immunodeficiency virus resistance to recipient cellsQ39920895
Induction of exosome release in primary B cells stimulated via CD40 and the IL-4 receptorQ39975624
B cell activation regulates exosomal HLA productionQ39990041
Evolution of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases.Q45117058
Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells.Q51993308
Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm ExchangeQ55178105
S epsilon S mu and S epsilon S gamma switch circles in human nasal mucosa following ex vivo allergen challenge: evidence for direct as well as sequential class switch recombinationQ79074387
Stimulation of cell surface CCR5 and CD40 molecules by their ligands or by HSP70 up-regulates APOBEC3G expression in CD4(+) T cells and dendritic cellsQ79609733
P433issue3
P921main subjectantibodyQ79460
P304page(s)207-215
P577publication date2012-03-01
P1433published inImmunologyQ15754984
P1476titleB-cell agonists up-regulate AID and APOBEC3G deaminases, which induce IgA and IgG class antibodies and anti-viral function
P478volume135

Reverse relations

cites work (P2860)
Q64086097AID modulates carcinogenesis network via DNA demethylation in bladder urothelial cell carcinoma
Q36263411APOBEC3 Proteins in Viral Immunity.
Q36592764Activation-induced Cytidine Deaminase in B Cell Immunity and Cancers.
Q52677761Defective activation of the MAPK/ERK pathway, leading to PARP1 and DNMT1 dysregulation, is a common defect in IgA nephropathy and Henoch-Schönlein purpura.
Q34328961Direct phenotypical and functional dysregulation of primary human B cells by human immunodeficiency virus (HIV) type 1 in vitro.
Q36261556Interleukin-21 Drives Proliferation and Differentiation of Porcine Memory B Cells into Antibody Secreting Cells.
Q90598776Molecular analysis of γ1, γ3, and α class switch recombination junctions in APOBEC3-deficient mice using high-throughput sequencing
Q48281909Professor Thomas Lehner: archetypal translational scientist
Q60046078Restriction Factors: From Intrinsic Viral Restriction to Shaping Cellular Immunity Against HIV-1
Q27305204The role of innate APOBEC3G and adaptive AID immune responses in HLA-HIV/SIV immunized SHIV infected macaques
Q46232387Transcellular communication at the immunological synapse: a vesicular traffic-mediated mutual exchange