M channel enhancers and physiological M channel block

scientific article published on 12 December 2011

M channel enhancers and physiological M channel block is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1113/JPHYSIOL.2011.223404
P932PMC publication ID3381311
P698PubMed publication ID22155935
P5875ResearchGate publication ID51866134

P50authorNikita GamperQ41275613
John LinleyQ56422314
P2093author name stringLouisa Pettinger
Dongyang Huang
P2860cites workKCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafnessQ22008780
KvLQT1, a voltage-gated potassium channel responsible for human cardiac arrhythmiasQ24313536
A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndromeQ24318498
A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newbornsQ24319094
A potassium channel mutation in neonatal human epilepsyQ24320244
Mutations in the hminK gene cause long QT syndrome and suppress IKs functionQ24323571
A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy familyQ28115034
Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabineQ28141610
Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channelsQ28144303
Calmodulin is an auxiliary subunit of KCNQ2/3 potassium channelsQ28511803
The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl- channelsQ30493890
Structural requirements for differential sensitivity of KCNQ K+ channels to modulation by Ca2+/calmodulinQ33911083
Pathways modulating neural KCNQ/M (Kv7) potassium channelsQ34464180
Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockersQ34698238
Oxidative modification of M-type K(+) channels as a mechanism of cytoprotective neuronal silencingQ35102221
The therapeutic potential of neuronal KCNQ channel modulatorsQ35593939
Rapidly inducible changes in phosphatidylinositol 4,5-bisphosphate levels influence multiple regulatory functions of the lipid in intact living cellsQ36118986
Phosphoinositide lipid second messengers: new paradigms for calcium channel modulationQ36205130
Calmodulin mediates Ca2+-dependent modulation of M-type K+ channelsQ36447189
Target-specific PIP(2) signalling: how might it work?Q36782546
Regulation of neural KCNQ channels: signalling pathways, structural motifs and functional implicationsQ37073174
Understanding inflammatory pain: ion channels contributing to acute and chronic nociceptionQ37693805
Transcriptional control of KCNQ channel genes and the regulation of neuronal excitabilityQ39647545
MrgD activation inhibits KCNQ/M-currents and contributes to enhanced neuronal excitability.Q40144001
Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutantsQ40145551
Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channelsQ40228821
Some new insights into the molecular mechanisms of pain perceptionQ40238651
Transcriptional repression of the M channel subunit Kv7.2 in chronic nerve injuryQ42119342
Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine.Q43683699
Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5-bisphosphate synthesisQ44092262
The anticonvulsant retigabine attenuates nociceptive behaviours in rat models of persistent and neuropathic painQ44297459
PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currentsQ44386912
Effect of the KCNQ potassium channel opener retigabine on single KCNQ2/3 channels expressed in CHO cellsQ44408542
KCNQ/M currents in sensory neurons: significance for pain therapy.Q44540560
The new anticonvulsant retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gateQ45232112
The use of Chinese hamster ovary (CHO) cells in the study of ion channelsQ46464395
Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine.Q46497180
Regulation of Kv7 (KCNQ) K+ channel open probability by phosphatidylinositol 4,5-bisphosphate.Q46776132
Regulation of neuronal M-channel gating in an isoform-specific manner: functional interplay between calmodulin and syntaxin 1A.Q48663756
Inhibition of M current in sensory neurons by exogenous proteases: a signaling pathway mediating inflammatory nociception.Q51785375
HCN2 Ion Channels Play a Central Role in Inflammatory and Neuropathic PainQ58791990
Intracellular calcium directly inhibits potassium M channels in excised membrane patches from rat sympathetic neuronsQ70901383
The therapeutic potential of neuronal K V 7 (KCNQ) channel modulators: an updateQ81077718
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)793-807
P577publication date2011-12-12
P1433published inJournal of PhysiologyQ7743612
P1476titleM channel enhancers and physiological M channel block
P478volume590

Reverse relations

cites work (P2860)
Q93126054Activation of Kv7 Potassium Channels Inhibits Intracellular Ca2+ Increases Triggered By TRPV1-Mediated Pain-Inducing Stimuli in F11 Immortalized Sensory Neurons
Q35670568Activation of peripheral KCNQ channels relieves gout pain
Q60678441Amplified Cold Transduction in Native Nociceptors by M-Channel Inhibition
Q35719617Amyloid-β(25-35) Modulates the Expression of GirK and KCNQ Channel Genes in the Hippocampus.
Q54229916Cholinergic signalling-regulated KV7.5 currents are expressed in colonic ICC-IM but not ICC-MP.
Q36534135Contribution of near-threshold currents to intrinsic oscillatory activity in rat medial entorhinal cortex layer II stellate cells
Q34585723Control of somatic membrane potential in nociceptive neurons and its implications for peripheral nociceptive transmission.
Q35098568Functional and molecular evidence for Kv7 channel subtypes in human detrusor from patients with and without bladder outflow obstruction
Q48112896Intracellular zinc activates KCNQ channels by reducing their dependence on phosphatidylinositol 4,5-bisphosphate
Q48580114KV 7/M channels as targets for lipopolysaccharide-induced inflammatory neuronal hyperexcitability
Q36895771KV7 channels contribute to paracrine, but not metabolic or ischemic, regulation of coronary vascular reactivity in swine
Q38628600M-type K(+) channels in peripheral nociceptive pathways.
Q97420308Modulation of KV7 Channel Deactivation by PI(4,5)P2
Q34631956Muscarinic depolarization of layer II neurons of the parasubiculum
Q92165160Neuropathic pain and Kv7 voltage-gated potassium channels: The potential role of Kv7 activators in the treatment of neuropathic pain
Q36884049Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels
Q92750613Platelet-derived growth factor activates nociceptive neurons by inhibiting M-current and contributes to inflammatory pain
Q37362041Potassium channels in peripheral pain pathways: expression, function and therapeutic potential
Q30519202Reactive oxygen species are second messengers of neurokinin signaling in peripheral sensory neurons
Q90658343Redox Regulation of Ion Channels and Receptors in Pulmonary Hypertension
Q35068102Redox and nitric oxide-mediated regulation of sensory neuron ion channel function
Q36770811Redox regulation of ion channels in the pulmonary circulation
Q27308025Redox-Dependent Modulation of T-Type Ca(2+) Channels in Sensory Neurons Contributes to Acute Anti-Nociceptive Effect of Substance P
Q36634324Retigabine holds KV7 channels open and stabilizes the resting potential
Q35298167The M-current contributes to high threshold membrane potential oscillations in a cell type-specific way in the pedunculopontine nucleus of mice
Q42061272The Role of Kv7/M Potassium Channels in Controlling Ectopic Firing in Nociceptors
Q36675813The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)-benzamid displays anticonvulsant potential.
Q64275891The paracetamol metabolite N-acetylp-benzoquinone imine reduces excitability in first- and second-order neurons of the pain pathway through actions on KV7 channels
Q36876339Triple cysteine module within M-type K+ channels mediates reciprocal channel modulation by nitric oxide and reactive oxygen species
Q55191250Zinc pyrithione activates K+ channels and hyperpolarizes the membrane of rat pulmonary artery smooth muscle cells.
Q48221664β-Secretase BACE1 regulates hippocampal and reconstituted M-currents in a β-subunit-like fashion.

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