| scholarly article | Q13442814 |
| P356 | DOI | 10.1021/BI015794O |
| P698 | PubMed publication ID | 11851430 |
| P50 | author | Colin L. Masters | Q1108510 |
| Konrad Beyreuther | Q1781934 | ||
| P2093 | author name string | Gottfried Baier | |
| Markus Vogel | |||
| Andreas Weidemann | |||
| Simone Eggert | |||
| Geneviève Evin | |||
| Krzysztof Paliga | |||
| Friedrich B M Reinhard | |||
| P2860 | cites work | Purification and cloning of amyloid precursor protein beta-secretase from human brain | Q22010914 |
| P433 | issue | 8 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | Alzheimer's disease | Q11081 |
| transmembrane protein | Q424204 | ||
| P304 | page(s) | 2825-2835 | |
| P577 | publication date | 2002-02-01 | |
| P1433 | published in | Biochemistry | Q764876 |
| P1476 | title | A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing | |
| P478 | volume | 41 |
| Q24301848 | A comparative analysis of the aggregation behavior of amyloid-β peptide variants |
| Q37083598 | A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis |
| Q33661653 | A new molecular explanation for age-related neurodegeneration: the Tyr682 residue of amyloid precursor protein |
| Q42474112 | A novel mechanism of thyroid hormone-dependent negative regulation by thyroid hormone receptor, nuclear receptor corepressor (NCoR), and GAGA-binding factor on the rat cD44 promoter. |
| Q36674481 | A two decade contribution of molecular cell biology to the centennial of Alzheimer's disease: are we progressing toward therapy? |
| Q48138450 | APLP1 is endoproteolytically cleaved by γ-secretase without previous ectodomain shedding |
| Q30501193 | APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant |
| Q40640846 | APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer's disease mutations |
| Q37902514 | APP physiological and pathophysiological functions: insights from animal models. |
| Q27694738 | APP processing in Alzheimer's disease |
| Q40387366 | APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation |
| Q33572654 | Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif |
| Q50335595 | Abeta upregulates and colocalizes with LGI3 in cultured rat astrocytes |
| Q44460129 | Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain. |
| Q28569661 | Affinity pulldown of γ-secretase and associated proteins from human and rat brain |
| Q35032054 | Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases |
| Q34467478 | Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ. |
| Q34976291 | Alzheimer's disease: beta-Amyloid protein and tau. |
| Q36092947 | Amyloid Precursor Protein (APP) Metabolites APP Intracellular Fragment (AICD), Aβ42, and Tau in Nuclear Roles. |
| Q44548877 | Amyloid beta protein precursor is phosphorylated by JNK-1 independent of, yet facilitated by, JNK-interacting protein (JIP)-1. |
| Q40077211 | Amyloid beta-protein precursor juxtamembrane domain regulates specificity of gamma-secretase-dependent cleavages |
| Q37427458 | Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors |
| Q53531096 | Amyloid precursor protein intracellular domain modulates cellular calcium homeostasis and ATP content. |
| Q41822677 | Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs |
| Q35809939 | An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1. |
| Q37755129 | Aspects of beta-amyloid as a biomarker for Alzheimer's disease |
| Q48260033 | Aβ1-15/16 as a potential diagnostic marker in neurodegenerative diseases |
| Q64077439 | BACE-1 and γ-Secretase as Therapeutic Targets for Alzheimer's Disease |
| Q24312009 | Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage |
| Q38016898 | Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease |
| Q34750587 | Biogenesis and metabolism of Alzheimer's disease Abeta amyloid peptides |
| Q38122497 | Biological function of Presenilin and its role in AD pathogenesis |
| Q37869935 | Biology and pathophysiology of the amyloid precursor protein |
| Q51468621 | Blocking the cleavage at midportion between gamma- and epsilon-sites remarkably suppresses the generation of amyloid beta-protein. |
| Q34988301 | Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease |
| Q35906413 | Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments. |
| Q26859108 | Cellular mechanisms of γ-secretase substrate selection, processing and toxicity |
| Q37855869 | Computational insights into the development of novel therapeutic strategies for Alzheimer's disease |
| Q28081678 | Current and future implications of basic and translational research on amyloid-β peptide production and removal pathways |
| Q94361807 | Cycle on Wheels: Is APP Key to the AppBp1 Pathway? |
| Q53383098 | Defects of immune regulation in the presenilin-1 mutant knockin mouse. |
| Q48268085 | Diffuse amyloid deposition, but not plaque number, is reduced in amyloid precursor protein/presenilin 1 double-transgenic mice by pathway lesions |
| Q40086364 | Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA. |
| Q35498267 | Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations |
| Q52331406 | Dysfunctional γ-Secretase in Familial Alzheimer's Disease. |
| Q42573332 | Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate |
| Q36998748 | Efficacy of SPI-1865, a novel gamma-secretase modulator, in multiple rodent models |
| Q39457919 | Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta |
| Q46688640 | Eosinophilic differentiation is promoted by blockage of Notch signaling with a gamma-secretase inhibitor |
| Q51808780 | Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase. |
| Q34535890 | Evidence from solid-state NMR for nonhelical conformations in the transmembrane domain of the amyloid precursor protein |
| Q35222114 | Expression of the Notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas |
| Q41663079 | G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation. |
| Q37394529 | Gamma-secretase catalyzes sequential cleavages of the AbetaPP transmembrane domain. |
| Q34810184 | Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling |
| Q38559613 | Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site |
| Q28207449 | Generation of the β-Amyloid Peptide and the Amyloid Precursor Protein C-terminal Fragment γ Are Potentiated by FE65L1 |
| Q36089357 | Genetic and molecular aspects of Alzheimer's disease shed light on new mechanisms of transcriptional regulation. |
| Q44822089 | Growth factor receptor-bound protein 2 interaction with the tyrosine-phosphorylated tail of amyloid beta precursor protein is mediated by its Src homology 2 domain. |
| Q33276402 | GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42. |
| Q37010838 | Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations |
| Q39041998 | Hypoxia/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease |
| Q40684851 | Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation |
| Q33207923 | Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein. |
| Q55467810 | Immunohistochemical and biochemical analyses of LGI3 in monkey brain: LGI3 accumulates in aged monkey brains. |
| Q46785611 | In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc |
| Q37431194 | Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production |
| Q33243260 | Inhibition of gamma-secretase as a therapeutic intervention for Alzheimer's disease: prospects, limitations and strategies |
| Q40183194 | Insulysin cleaves the APP cytoplasmic fragment at multiple sites. |
| Q37195010 | Interactions between APP secretases and inflammatory mediators |
| Q37155734 | Intramembrane proteolysis |
| Q37876486 | Intramembrane proteolysis in regulated protein trafficking |
| Q39944020 | Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation |
| Q35057311 | Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides |
| Q40472233 | Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase. |
| Q92932113 | Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase |
| Q34712076 | Mechanism of intramembrane cleavage of alcadeins by γ-secretase |
| Q35145029 | Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo |
| Q48881691 | Mitochondrial Proteome Changes Correlating with β-Amyloid Accumulation |
| Q34427848 | Model Hirano bodies protect against tau-independent and tau-dependent cell death initiated by the amyloid precursor protein intracellular domain |
| Q38014896 | Modulating metals as a therapeutic strategy for Alzheimer's disease |
| Q44722885 | Modulation of amyloid precursor protein cleavage by cellular sphingolipids |
| Q34856213 | Molecular determinants and thermodynamics of the amyloid precursor protein transmembrane domain implicated in Alzheimer's disease. |
| Q38288083 | Molecular mechanism of the intramembrane cleavage of the β-carboxyl terminal fragment of amyloid precursor protein by γ-secretase |
| Q36408857 | Molecular rationale for the pharmacological treatment of Alzheimer's disease. |
| Q34352043 | Mutation Analysis of the Presenilin 1 N-terminal Domain Reveals a Broad Spectrum of γ-Secretase Activity toward Amyloid Precursor Protein and Other Substrates |
| Q47155049 | Mutational re-modeling of di-aspartyl intramembrane proteases: uncoupling physiologically-relevant activities from those associated with Alzheimer's disease |
| Q40686455 | Mutations at the P1' position of Notch1 decrease intracellular domain stability rather than cleavage by gamma-secretase. |
| Q37408544 | Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer's Disease |
| Q34575001 | PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2. |
| Q38983436 | Pen-2 is essential for γ-secretase complex stability and trafficking but partially dispensable for endoproteolysis |
| Q46595840 | Phosphoinositides suppress gamma-secretase in both the detergent-soluble and -insoluble states |
| Q35079442 | Physiologic and pathologic events mediated by intramembranous and juxtamembranous proteolysis |
| Q37987144 | Physiological functions of APP family proteins |
| Q27001550 | Platelets and Alzheimer's disease: Potential of APP as a biomarker |
| Q37804913 | Possible roles of amyloid intracellular domain of amyloid precursor protein |
| Q51837859 | Potential Link between Amyloid β-Protein 42 and C-terminal Fragment γ 49–99 of β-Amyloid Precursor Protein |
| Q53280053 | Presenilin 1 and cadherins: stabilization of cell-cell adhesion and proteolysis-dependent regulation of transcription. |
| Q40718061 | Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch |
| Q36109130 | Presenilin function and gamma-secretase activity |
| Q35172682 | Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex |
| Q34030951 | Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production |
| Q33751915 | Presenilins and the gamma-secretase: still a complex problem |
| Q39659066 | Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1. |
| Q36300032 | Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease |
| Q36419261 | Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases |
| Q28254104 | Proteolytic processing of Alzheimer's β-amyloid precursor protein |
| Q40524598 | Proteolytic processing of amyloid-beta precursor protein by secretases does not require cell surface transport |
| Q44642575 | Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets |
| Q33299077 | Proteomic analysis of the amyloid precursor protein fragment C99: expression in yeast |
| Q27014952 | Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage |
| Q40375910 | RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo. |
| Q35166518 | RIPped out by presenilin-dependent gamma-secretase |
| Q49310065 | Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease |
| Q48259334 | Regulated proteolytic processing of LRP6 results in release of its intracellular domain |
| Q37225056 | Regulation of amyloid beta-protein precursor by phosphorylation and protein interactions |
| Q44976555 | Secretion of long Abeta-related peptides processed at epsilon-cleavage site is dependent on the alpha-secretase pre-cutting |
| Q44287879 | Selecting cells with different Alzheimer's disease gamma-secretase activity using FACS. Differential effect on presenilin exon 9 gamma- and epsilon-cleavage |
| Q42208784 | Shedding of APP limits its synaptogenic activity and cell adhesion properties. |
| Q28131750 | Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide |
| Q24535750 | Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation |
| Q46529505 | Statin treatment and a disease-specific pattern of beta-amyloid peptides in Alzheimer's disease |
| Q27023904 | Structural biology of presenilin 1 complexes |
| Q92739032 | Structure and Function of the γ-Secretase Complex |
| Q37342295 | Structure and mechanism of intramembrane protease |
| Q27652388 | Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2 |
| Q34382868 | Structure, mechanism and inhibition of gamma-secretase and presenilin-like proteases |
| Q37073568 | Substrate specificity of gamma-secretase and other intramembrane proteases |
| Q39807867 | TMP21 transmembrane domain regulates gamma-secretase cleavage |
| Q52840245 | The Aβ-clearance protein transthyretin, like neprilysin, is epigenetically regulated by the amyloid precursor protein intracellular domain. |
| Q37150804 | The E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells |
| Q36248813 | The GxxxG motif in the transmembrane domain of AbetaPP plays an essential role in the interaction of CTF beta with the gamma-secretase complex and the formation of amyloid-beta |
| Q37047842 | The amyloid cascade: the old and the new. |
| Q24680465 | The amyloid precursor protein: beyond amyloid |
| Q24540102 | The amyloid-beta precursor protein: integrating structure with biological function |
| Q51810919 | The cytoplasmic sequence of E-cadherin promotes non-amyloidogenic degradation of A beta precursors. |
| Q31029600 | The human amyloid-beta precursor protein770 mutation V717F generates peptides longer than amyloid-beta-(40-42) and flocculent amyloid aggregates. |
| Q38365416 | The human β-amyloid precursor protein: biomolecular and epigenetic aspects |
| Q36000134 | The mechanism of γ-Secretase dysfunction in familial Alzheimer disease |
| Q34586360 | The pathogenic aβ43 is enriched in familial and sporadic Alzheimer disease |
| Q37961985 | The physiology of the β-amyloid precursor protein intracellular domain AICD. |
| Q36582358 | The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid |
| Q37643736 | The structure and function of Alzheimer's gamma secretase enzyme complex. |
| Q44231100 | The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted |
| Q38090514 | The very many faces of presenilins and the γ-secretase complex. |
| Q34677532 | The γ-secretase complex: from structure to function |
| Q39695174 | Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis |
| Q27002018 | Toward the structure of presenilin/γ-secretase and presenilin homologs |
| Q28265871 | Trafficking and proteolytic processing of APP |
| Q47592174 | Trafficking in Alzheimer's Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin. |
| Q42005373 | Transmembrane Substrate Determinants for γ-Secretase Processing of APP CTFβ. |
| Q46593582 | Transmembrane domain 9 of presenilin determines the dynamic conformation of the catalytic site of gamma-secretase |
| Q37691942 | Troubleshooting methods for APP processing in vitro |
| Q34854001 | Turnover of amyloid precursor protein family members determines their nuclear signaling capability |
| Q39285976 | Unlocking truths of γ-secretase in Alzheimer's disease: what is the translational potential? |
| Q35093148 | Upregulation of PGC-1α expression by Alzheimer's disease-associated pathway: presenilin 1/amyloid precursor protein (APP)/intracellular domain of APP |
| Q38253642 | Use of Caenorhabditis elegans as a model to study Alzheimer's disease and other neurodegenerative diseases |
| Q33977500 | What is the role of amyloid precursor protein dimerization? |
| Q24676480 | When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease |
| Q53276850 | Wild-type presenilin 1 protects against Alzheimer disease mutation-induced amyloid pathology. |
| Q33762857 | beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins. |
| Q40374588 | gamma-Cleavage is dependent on zeta-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain |
| Q33545253 | gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranes |
| Q39418271 | siRNA against presenilin 1 (PS1) down regulates amyloid β42 production in IMR-32 cells. |
| Q35871906 | γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP). |
| Q38076426 | γ-Secretase-Dependent Proteolysis of Transmembrane Domain of Amyloid Precursor Protein: Successive Tri- and Tetrapeptide Release in Amyloid β-Protein Production |
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