Pre-existing immunity to adenovirus does not prevent tumor regression following intratumoral administration of a vector expressing IL-12 but inhibits virus dissemination

scientific article published in October 1997

Pre-existing immunity to adenovirus does not prevent tumor regression following intratumoral administration of a vector expressing IL-12 but inhibits virus dissemination is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1033780095
P356DOI10.1038/SJ.GT.3300508
P698PubMed publication ID9415313
P5875ResearchGate publication ID13815566

P50authorJonathan L BramsonQ45367604
P2093author name stringGauldie J
Graham FL
Hitt M
P433issue10
P921main subjectAdenoviridaeQ193447
vector-borne diseaseQ2083837
P304page(s)1069-1076
P577publication date1997-10-01
P1433published inGene TherapyQ15763095
P1476titlePre-existing immunity to adenovirus does not prevent tumor regression following intratumoral administration of a vector expressing IL-12 but inhibits virus dissemination
P478volume4

Reverse relations

cites work (P2860)
Q64377893"Man's best friend": a new model system for cancer therapeutics?
Q64377412A phase I trial of adenovector-mediated delivery of interleukin-2 (AdIL-2) in high-risk localized prostate cancer
Q40580007A phase I/II trial of rAd/p53 (SCH 58500) gene replacement in recurrent ovarian cancer
Q45859665Adenovector-mediated gene delivery of interleukin-2 in metastatic breast cancer and melanoma: results of a phase 1 clinical trial
Q33565630Adenoviral vector immunity: its implications and circumvention strategies
Q33744876Adenovirus vectors for gene delivery
Q45876450Adenovirus-mediated transfer of p53 and p16(INK4a) results in pancreatic cancer regression in vitro and in vivo
Q43785744Adenovirus-mediated wt-p16 reintroduction induces cell cycle arrest or apoptosis in pancreatic cancer
Q64905542An Oncolytic Adenovirus Vector Expressing p14 FAST Protein Induces Widespread Syncytium Formation and Reduces Tumor Growth Rate In Vivo.
Q54573260Anti-angiogenic effects of interleukin-12 delivered by a novel hyperthermia induced gene construct.
Q45856841Baculoviruses exhibit restricted cell type specificity in rat brain: a comparison of baculovirus- and adenovirus-mediated intracerebral gene transfer in vivo
Q38772887Breast cancer gene therapy using an adenovirus encoding human IL-2 under control of mammaglobin promoter/enhancer sequences.
Q36616672Characterisation of systemic dissemination of nonreplicating adenoviral vectors from tumours in local gene delivery
Q34759406Characterization of the adaptive and innate immune response to intravenous oncolytic reovirus (Dearing type 3) during a phase I clinical trial
Q45747425Complete cure of established murine hepatocellular carcinoma is achievable by repeated injections of retroviruses carrying the herpes simplex virus thymidine kinase gene
Q34585554Current strategies and future directions for eluding adenoviral vector immunity
Q37099738Effect of preexisting immunity on oncolytic adenovirus vector INGN 007 antitumor efficacy in immunocompetent and immunosuppressed Syrian hamsters
Q45883442Effective gene therapy for medullary thyroid carcinoma using recombinant adenovirus inducing tumor-specific expression of interleukin-12.
Q45867755Effective repeat administration with adenovirus vectors to the muscle
Q44305187Enabling topical immunization via microporation: a novel method for pain-free and needle-free delivery of adenovirus-based vaccines
Q45865369Enhanced local delivery with reduced systemic toxicity: delivery, delivery, and delivery.
Q45873183Enhancement of radiotherapy by hyperthermia-regulated gene therapy
Q39591041Expression of an antigenic adenovirus epitope in a group B coxsackievirus
Q37393759Expression of the fusogenic p14 FAST protein from a replication-defective adenovirus vector does not provide a therapeutic benefit in an immunocompetent mouse model of cancer.
Q44012459Gene therapy for prostate cancer delivered by ovine adenovirus and mediated by purine nucleoside phosphorylase and fludarabine in mouse models
Q45880329Heat-inducible TNF-alpha gene therapy combined with hyperthermia using magnetic nanoparticles as a novel tumor-targeted therapy
Q36065620Human endostatin gene transfer, either naked or with liposome, has the same inhibitory effect on growth of mouse liver tumor cells in vivo
Q64379641Immunotherapy of established tumors in mice by intratumoral injection of an adenovirus vector harboring the human IL-2 cDNA: induction of CD8(+) T-cell immunity and NK activity
Q33604559Induction of CD8 T cells by vaccination with recombinant adenovirus expressing human papillomavirus type 16 E5 gene reduces tumor growth
Q47277616Input virion proteins: cryptic targets of antivector immune responses in preimmunized subjects
Q35800342Intratumoral delivery of CD154 homolog (Ad-ISF35) induces tumor regression: analysis of vector biodistribution, persistence and gene expression
Q44192084Large nontransplanted hepatocellular carcinoma in woodchucks: treatment with adenovirus-mediated delivery of interleukin 12/B7.1 genes
Q37310677Mesenchymal stem cells expressing TRAIL lead to tumour growth inhibition in an experimental lung cancer model
Q34269646Molecular therapeutics of liver disease
Q44808014On the role of CD4+ T cells in the CD8+ T-cell response elicited by recombinant adenovirus vaccines
Q34329548Oncolytic viruses as therapeutic agents
Q33817933Ovine adenovirus vectors overcome preexisting humoral immunity against human adenoviruses in vivo
Q37452136Persistence of transgene expression influences CD8+ T-cell expansion and maintenance following immunization with recombinant adenovirus
Q24799710Pharmacogenetic heterogeneity of transgene expression in muscle and tumours
Q33713048Pre-existing immunity and passive immunity to adenovirus 5 prevents toxicity caused by an oncolytic adenovirus vector in the Syrian hamster model
Q40519641Preclinical evaluation of a prostate-targeted gene-directed enzyme prodrug therapy delivered by ovine atadenovirus
Q56980888Recombinant Adenovirus Vaccines Can Successfully Elicit CD8+ T Cell Immunity under Conditions of Extreme Leukopenia
Q34361466Regulatable and cell-type specific transgene expression in glial cells: prospects for gene therapy for neurological disorders
Q36086213Replication-Competent Controlled Herpes Simplex Virus
Q56980983Super-activated interferon-regulatory factors can enhance plasmid immunization
Q40510406The human SCGB2A2 (mammaglobin-1) promoter/enhancer in a helper-dependent adenovirus vector directs high levels of transgene expression in mammary carcinoma cells but not in normal nonmammary cells
Q33857121The potential of gene therapy in the treatment of hepatocellular carcinoma
Q40587839Thyroid cancer immuno-therapy with retroviral and adenoviral vectors expressing granulocyte macrophage colony stimulating factor and interleukin-12 in a rat model

Search more.