Endothelium-dependent vasodilatation and exercise hyperaemia in ageing humans: impact of acute ascorbic acid administration

scientific article published on 23 March 2009

Endothelium-dependent vasodilatation and exercise hyperaemia in ageing humans: impact of acute ascorbic acid administration is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1113/JPHYSIOL.2008.167320
P932PMC publication ID2689338
P698PubMed publication ID19307300
P5875ResearchGate publication ID24220631

P2093author name stringBrett S Kirby
Frank A Dinenno
Rick E Carlson
Wyatt F Voyles
William G Schrage
Carrie B Simpson
P2860cites workReductions in basal limb blood flow and vascular conductance with human ageing: role for augmented alpha-adrenergic vasoconstrictionQ28363251
L-ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterinQ31448793
Mechanical compression elicits vasodilatation in rat skeletal muscle feed arteriesQ33234662
Evidence for impaired skeletal muscle contraction-induced rapid vasodilation in aging humansQ33321836
Primary endothelial dysfunction: atherosclerosisQ33540182
Age-related reduction of NO availability and oxidative stress in humansQ33954093
Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB.Q34625472
Vasodilatory mechanisms in contracting skeletal muscleQ35819024
Blood flow to exercising limbs varies with age, gender, and training statusQ36315451
Vasodilation and vascular control in contracting muscle of the aging humanQ36447827
Exercise hyperaemia: magnitude and aspects on regulation in humansQ36886647
Regulation of muscle sympathetic nerve activity during exercise in humansQ37441046
Oxidation of ascorbic acid with superoxide anion generated by the xanthine-xanthine oxidase systemQ40314919
Endothelial dysfunction in coronary artery diseaseQ40898007
Role of endothelium in thrombosis and hemostasisQ41036404
Importance of endothelial function in chronic heart failureQ41045835
Skeletal muscle blood flow in humans and its regulation during exerciseQ41760252
Differential effects of aging on limb blood flow in humansQ43802011
Evidence for agonist-specific endothelial vasodilator dysfunction with ageing in healthy humansQ44049319
Aging and forearm postjunctional alpha-adrenergic vasoconstriction in healthy men.Q44131319
Cytochrome P450 2C9 plays an important role in the regulation of exercise-induced skeletal muscle blood flow and oxygen uptake in humansQ44267774
Failure of Systemic Hypoxia to Blunt α‐Adrenergic Vasoconstriction in the Human ForearmQ44429412
Blunted sympathetic vasoconstriction in contracting skeletal muscle of healthy humans: is nitric oxide obligatory?Q44569252
Increase in endothelial cell Ca(2+) in response to mouse cremaster muscle contractionQ44705243
Effect of acute and chronic ascorbic acid on flow-mediated dilatation with sedentary and physically active human ageingQ44750431
Local inhibition of nitric oxide and prostaglandins independently reduces forearm exercise hyperaemia in humansQ44816935
Vasodilatation is obligatory for contraction-induced hyperaemia in canine skeletal muscleQ44836772
Combined NO and PG inhibition augments alpha-adrenergic vasoconstriction in contracting human skeletal muscleQ44991344
Heterogeneous vasodilator responses of human limbs: influence of age and habitual endurance trainingQ46391041
Vascular and metabolic response to isolated small muscle mass exercise: effect of age.Q46477352
Graded sympatholytic effect of exogenous ATP on postjunctional alpha-adrenergic vasoconstriction in the human forearm: implications for vascular control in contracting muscleQ46490402
Impaired modulation of sympathetic alpha-adrenergic vasoconstriction in contracting forearm muscle of ageing men.Q46537525
Vascular and metabolic response to cycle exercise in sedentary humans: effect of age.Q46648967
Rapid dilation of arterioles with single contraction of hamster skeletal muscleQ46650383
Tetrahydrobiopterin augments endothelium-dependent dilatation in sedentary but not in habitually exercising older adultsQ46685929
Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arteriolesQ46862881
Vitamin C blocks vascular dysfunction and release of interleukin-6 induced by endothelin-1 in humans in vivoQ46983061
Immediate exercise hyperemia in humans is contraction intensity dependent: evidence for rapid vasodilation.Q47423843
Autonomic control of skeletal muscle blood flow at the onset of exercise.Q51433217
Potassium initiates vasodilatation induced by a single skeletal muscle contraction in hamster cremaster muscle.Q51798975
Age and flow-mediated dilation: a comparison of dilatory responsiveness in the brachial and popliteal arteries.Q53592292
Impaired leg vasodilation during dynamic exercise in healthy older women.Q53652766
Rapid vasodilation in response to a brief tetanic muscle contraction.Q53689519
Age-dependent changes of antioxidant activities and markers of free radical damage in human skeletal muscle.Q53705528
Combined inhibition of nitric oxide and prostaglandins reduces human skeletal muscle blood flow during exerciseQ57024655
Inhibition of nitric oxide and prostaglandins, but not endothelial-derived hyperpolarizing factors, reduces blood flow and aerobic energy turnover in the exercising human legQ60637885
Physical activity prevents age-related impairment in nitric oxide availability in elderly athletesQ73929745
Forearm blood flow responses to handgripping after local neuromuscular blockadeQ74222057
Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy menQ74332653
EFFECT OF A BRIEF CONTRACTION OF FOREARM MUSCLES ON FOREARM BLOOD FLOWQ76681468
Effects of acetylcholine and nitric oxide on forearm blood flow at rest and after a single muscle contractionQ77648890
Ageing reduces nitric-oxide- and prostaglandin-mediated vasodilatation in exercising humansQ79396999
Electron paramagnetic spectroscopic evidence of exercise-induced free radical accumulation in human skeletal muscleQ79964072
Mechanical influences on skeletal muscle vascular tone in humans: insight into contraction-induced rapid vasodilatationQ80313691
Endothelin-1 vasoconstrictor tone increases with age in healthy men but can be reduced by regular aerobic exerciseQ80495474
P433issuePt 9
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
vasodilationQ14859627
P304page(s)1989-2003
P577publication date2009-03-23
P1433published inJournal of PhysiologyQ7743612
P1476titleEndothelium-dependent vasodilatation and exercise hyperaemia in ageing humans: impact of acute ascorbic acid administration
P478volume587

Reverse relations

cites work (P2860)
Q35859302Acute ascorbic acid ingestion increases skeletal muscle blood flow and oxygen consumption via local vasodilation during graded handgrip exercise in older adults
Q34980495Acute dietary nitrate supplementation enhances compensatory vasodilation during hypoxic exercise in older adults.
Q35876519Acute reversal of endothelial dysfunction in the elderly after antioxidant consumption
Q40160831Acute supplementation of N-acetylcysteine does not affect muscle blood flow and oxygenation characteristics during handgrip exercise.
Q42473055Advanced age protects microvascular endothelium from aberrant Ca(2+) influx and cell death induced by hydrogen peroxide
Q61446549Age and sex differences in sympathetic and hemodynamic responses to hypoxia and cold pressor test
Q51764062Age-associated impairments in contraction-induced rapid onset vasodilatation within the forearm are independent of mechanical factors.
Q83333050Ageing reduces the compensatory vasodilatation during hypoxic exercise: the role of nitric oxide
Q64911047Ageing, exercise and cardiovascular health: good and bad news.
Q37161071Aging impairs electrical conduction along endothelium of resistance arteries through enhanced Ca2+-activated K+ channel activation
Q35921753Aging is associated with altered vasodilator kinetics in dynamically contracting muscle: role of nitric oxide
Q90005528Antioxidant supplements and endurance exercise: Current evidence and mechanistic insights
Q37430894Antioxidants and aging: NMR-based evidence of improved skeletal muscle perfusion and energetics
Q37346053Ascorbate infusion increases skeletal muscle fatigue resistance in patients with chronic obstructive pulmonary disease.
Q35588695Ascorbic acid attenuates the pressor response to voluntary apnea in postmenopausal women
Q34297397Ascorbic acid does not enhance hypoxia-induced vasodilation in healthy older men.
Q36902352Ascorbic acid improves brachial artery vasodilation during progressive handgrip exercise in the elderly through a nitric oxide-mediated mechanism
Q85103251Attenuated exercise induced hyperaemia with age: mechanistic insight from passive limb movement
Q84226900Augmented skeletal muscle hyperaemia during hypoxic exercise in humans is blunted by combined inhibition of nitric oxide and vasodilating prostaglandins
Q38995845Calcium and electrical signaling in arterial endothelial tubes: New insights into cellular physiology and cardiovascular function
Q34548327Capillary endothelial cells as coordinators of skeletal muscle blood flow during active hyperemia
Q38693262Cardiovascular Adaptations to Exercise Training
Q36965782Chronic endurance exercise training offsets the age-related attenuation in contraction-induced rapid vasodilation.
Q87153080Contracting human skeletal muscle maintains the ability to blunt α1 -adrenergic vasoconstriction during KIR channel and Na(+) /K(+) -ATPase inhibition
Q37093962Contribution of nitric oxide in the contraction-induced rapid vasodilation in young and older adults
Q50439062Differential effects of age and type 2 diabetes on dynamic vs. peak response of pulmonary oxygen uptake during exercise
Q57601903Eccentric exercise slows in vivo microvascular reactivity during brief contractions in human skeletal muscle
Q35945529Effect of antioxidants on histamine receptor activation and sustained postexercise vasodilatation in humans
Q34519025Effect of vitamin C on hyperoxia-induced vasoconstriction in exercising skeletal muscle.
Q36530987Effects of aging and exercise training on skeletal muscle blood flow and resistance artery morphology
Q46730258Effects of modest hyperoxia and oral vitamin C on exercise hyperaemia and reactive hyperaemia in healthy young men.
Q37643493Evidence of a metabolic reserve in the skeletal muscle of elderly people.
Q34201108Exercise-mediated vasodilation in human obesity and metabolic syndrome: effect of acute ascorbic acid infusion.
Q48192505Folic acid ingestion improves skeletal muscle blood flow during graded handgrip and plantar flexion exercise in aged humans.
Q34153748Heterogeneous vascular responses to hypoxic forearm exercise in young and older adults
Q38629795Human cerebral blood flow control during hypoxia: focus on chronic pulmonary obstructive disease (COPD) and obstructive sleep apnea (OSA).
Q46375024Impact of Aging on Calcium Signaling and Membrane Potential in Endothelium of Resistance Arteries: A Role for Mitochondria
Q37666914Impact of polyphenol antioxidants on cycling performance and cardiovascular function
Q36086617Impaired skeletal muscle blood flow control with advancing age in humans: attenuated ATP release and local vasodilation during erythrocyte deoxygenation
Q28596757Increased ventilatory response to carbon dioxide in COPD patients following vitamin C administration
Q90015282Induced Trf2 deletion leads to aging vascular phenotype in mice associated with arterial telomere uncapping, senescence signaling, and oxidative stress
Q36320953Influence of α-adrenergic vasoconstriction on the blunted skeletal muscle contraction-induced rapid vasodilation with aging
Q45989131Keeping the juices flowing with age: vitamin C and exercise hyperaemia.
Q58091614Lack of age-specific influence on leg blood flow during incremental calf plantar-flexion exercise in men and women
Q44738481Lifelong physical activity prevents an age-related reduction in arterial and skeletal muscle nitric oxide bioavailability in humans
Q35395499Mechanisms of ATP-mediated vasodilation in humans: modest role for nitric oxide and vasodilating prostaglandins
Q37054924Mechanisms of rapid vasodilation after a brief contraction in human skeletal muscle
Q58565537Microvascular Mechanisms Limiting Skeletal Muscle Blood Flow with Advancing Age
Q37234966Microvascular function in younger adults with obesity and metabolic syndrome: role of oxidative stress
Q83842055Modulation of postjunctional α-adrenergic vasoconstriction during exercise and exogenous ATP infusions in ageing humans
Q34994570NAD(P)H oxidase-derived reactive oxygen species contribute to age-related impairments of endothelium-dependent dilation in rat soleus feed arteries
Q38130310Nitric oxide and reactive oxygen species in limb vascular function: what is the effect of physical activity?
Q34357850Nitric oxide, but not vasodilating prostaglandins, contributes to the improvement of exercise hyperemia via ascorbic acid in healthy older adults
Q26776523Nitroxide pharmaceutical development for age-related degeneration and disease
Q35217467Oral atorvastatin therapy increases nitric oxide-dependent cutaneous vasodilation in humans by decreasing ascorbate-sensitive oxidants
Q37627485Oxidative stress and COPD: the effect of oral antioxidants on skeletal muscle fatigue
Q35178663Passive leg movement and nitric oxide-mediated vascular function: the impact of age.
Q38111280Peripheral circulation
Q38890471Peripheral vascular function, oxygen delivery and utilization: the impact of oxidative stress in aging and heart failure with reduced ejection fraction
Q47855023Phosphodiesterase-5 inhibition preserves exercise-onset vasodilator kinetics when NOS activity is reduced.
Q27307929Preserved Microvascular Endothelial Function in Young, Obese Adults with Functional Loss of Nitric Oxide Signaling
Q36036504Rapid onset vasodilation with single muscle contractions in the leg: influence of age.
Q83385004Reactive oxygen species enter the tug-of-war between metabolic vasodilatation and sympathetic vasoconstriction
Q36993426Reduced muscle oxidative capacity is independent of O2 availability in elderly people
Q42376408Regulation of exercise blood flow: Role of free radicals
Q27001180Regulation of increased blood flow (hyperemia) to muscles during exercise: a hierarchy of competing physiological needs
Q38579190Regulation of skeletal muscle blood flow during exercise in ageing humans
Q46587342Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men.
Q82741723Rethinking the role of superoxide in the ageing skeletal muscle vasculature
Q83429290Retrograde flow components in the brachial artery. A new hemodynamic index
Q45904776Role of α-adrenergic vasoconstriction in regulating skeletal muscle blood flow and vascular conductance during forearm exercise in ageing humans.
Q43282892Run for your life: exercise, oxidative stress and the ageing endothelium
Q48339628Signalling of vasodilatation across an exercise transient.
Q38034464Spreading the signal for vasodilatation: implications for skeletal muscle blood flow control and the effects of ageing.
Q38849070Sympathetic nervous system activation reduces contraction-induced rapid vasodilation in the leg of humans independent of age.
Q36206593Systemic vascular function is associated with muscular power in older adults
Q36348267The impact of age on vascular smooth muscle function in humans
Q83129616The paradox of oxidative stress and exercise with advancing age
Q42921063Vasodilatory responsiveness to adenosine triphosphate in ageing humans

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