Inhibition of the chemokine (C-C motif) ligand 2/chemokine (C-C motif) receptor 2 pathway attenuates hyperglycaemia and inflammation in a mouse model of hepatic steatosis and lipoatrophy

scientific article published on 10 March 2009

Inhibition of the chemokine (C-C motif) ligand 2/chemokine (C-C motif) receptor 2 pathway attenuates hyperglycaemia and inflammation in a mouse model of hepatic steatosis and lipoatrophy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00125-009-1309-8
P698PubMed publication ID19277603
P5875ResearchGate publication ID24192705

P50authorSoo Jin YangQ42706459
P2093author name stringH B IglayReger
H C Kadouh
P F Bodary
P2860cites workInflammation and insulin resistanceQ22241893
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistanceQ24617743
Obesity is associated with macrophage accumulation in adipose tissueQ27860976
Free fatty acids and insulin resistanceQ28287167
MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesityQ29614283
Adipocytokines: mediators linking adipose tissue, inflammation and immunityQ29619393
CCR2 modulates inflammatory and metabolic effects of high-fat feedingQ29622869
Blockade of CCR2 ameliorates progressive fibrosis in kidney.Q35102859
Nonalcoholic steatohepatitis: Summary of an AASLD Single Topic ConferenceQ35115696
Life without white fat: a transgenic mouseQ35210661
Adipose tissue, adipokines, and inflammationQ36114223
The fatty liver and insulin resistanceQ36126652
Molecular mechanisms of lipid-induced insulin resistance in muscle, liver and vasculature.Q36283799
Non-alcoholic fatty liver disease and the metabolic syndrome: an updateQ37054351
Generalized lipodystrophy, congenital and acquired (lipoatrophy).Q41092401
Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factorsQ41208203
Chemokines as risk factors for type 2 diabetes: results from the MONICA/KORA Augsburg study, 1984-2002.Q43489113
The relation of markers of inflammation to the development of glucose disorders in the elderly: the Cardiovascular Health StudyQ43748961
Role of CCR2 in macrophage migration into the liver during acetaminophen-induced hepatotoxicity in the mouseQ43974826
The prevalence of nonalcoholic steatohepatitis is greater in morbidly obese men compared to womenQ44067750
Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteinsQ44181135
Monocyte chemoattractant protein-1 and CCR2 interactions are required for IFN-alpha/beta-induced inflammatory responses and antiviral defense in liverQ45232017
Inhibition of CCR2 ameliorates insulin resistance and hepatic steatosis in db/db mice.Q46345972
Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitisQ46455735
Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liverQ46818626
Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parametersQ46988914
The significance of tumor necrosis factor-alpha in newly diagnosed type 2 diabetic patients by transient intensive insulin treatmentQ51141324
Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesityQ51467955
Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjectsQ53533679
Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue.Q53556065
A unique role of monocyte chemoattractant protein 1 among chemokines in adipose tissue of obese subjectsQ53847918
Lipoatrophy, lipodystrophy, and insulin resistanceQ54041787
Effects of female sex hormones on mitochondria: possible role in acute fatty liver of pregnancyQ72491890
Mechanism of insulin resistance in A-ZIP/F-1 fatless miceQ73561042
CCR2 signaling contributes to ischemia-reperfusion injury in kidneyQ79091407
Inhibition of MCP-1/CCR2 pathway ameliorates the development of diabetic nephropathyQ80613413
Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2Q83161496
P433issue5
P921main subjecthyperglycemiaQ271993
steatosisQ1365091
P304page(s)972-981
P577publication date2009-03-10
P1433published inDiabetologiaQ5270140
P1476titleInhibition of the chemokine (C-C motif) ligand 2/chemokine (C-C motif) receptor 2 pathway attenuates hyperglycaemia and inflammation in a mouse model of hepatic steatosis and lipoatrophy
P478volume52

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