Intra-articular treatment of inflammatory arthritis with microsphere formulations of methotrexate: pharmacokinetics and efficacy determination in antigen-induced arthritic rabbits

scientific article published on 6 March 2009

Intra-articular treatment of inflammatory arthritis with microsphere formulations of methotrexate: pharmacokinetics and efficacy determination in antigen-induced arthritic rabbits is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00011-009-0009-7
P698PubMed publication ID19266262

P50authorHelen M. BurtQ105069912
P2093author name stringDavid A Hart
Paul T Salo
Linda S Liang
P2860cites workAnti-inflammatory mechanisms of methotrexate in rheumatoid arthritisQ24674760
Intra-articular depot formulation principles: role in the management of postoperative pain and arthritic disorders.Q37096677
The production of arthritis in rabbits by an immunological reaction to fibrin.Q40646345
Intrarticular methotrexate in the therapy of rheumatoid arthritisQ41319475
Prolonged anti-inflammatory action of DL-lactide/glycolide copolymer nanospheres containing betamethasone sodium phosphate for an intra-articular delivery system in antigen-induced arthritic rabbitQ44008085
Intra-articular injection therapy in patient with rheumatoid arthritisQ44317034
Intra-articular treatment of arthritis with microsphere formulations of paclitaxel: biocompatibility and efficacy determinations in rabbitsQ45022246
Pharmacokinetic study of methotrexate following intra-articular injection of methotrexate loaded poly(L-lactic acid) microspheres in rabbitsQ46461592
Development and histologic characterizations of an animal model of antigen-induced arthritis of the juvenile rabbit temporomandibular jointQ46694835
Biodistribution and clearance of intra-articular liposomes in a large animal model using a radiographic markerQ46890416
Transynovial exchange of small molecules in normal human subjectsQ47873107
Methotrexate loaded poly(L-lactic acid) microspheres for intra-articular delivery of methotrexate to the joint.Q51706069
Vegfb gene knockout mice display reduced pathology and synovial angiogenesis in both antigen-induced and collagen-induced models of arthritisQ57693311
A comparative study by morphometry of the microvasculature in normal and rheumatoid synoviumQ67771296
Chronic arthritis in rabbitsQ68032202
The antigen induced arthritis model: the relevance of the method of induction to its use as a model of human diseaseQ69551617
Retention and distribution of liposome-entrapped [3H]methotrexate injected into normal or arthritic rabbit jointsQ69928501
A single intra-articular injection of liposomally conjugated methotrexate suppresses joint inflammation in rat antigen-induced arthritisQ71408255
Methotrexate pharmacokinetics after intraarticular injection in patients with rheumatoid arthritisQ72073092
Treatment of antigen-induced arthritis in rabbits with liposome-entrapped methotrexate injected intra-articularlyQ72217344
Amelioration of rat antigen-induced arthritis by liposomally conjugated methotrexate is accompanied by down-regulation of cytokine mRNA expressionQ73782485
The suppression of rat collagen-induced arthritis and inhibition of macrophage derived mediator release by liposomal methotrexate formulationsQ73905139
Early inflammatory arthritis in the rabbit: the influence of intraarticular and systemic corticosteroids on mRNA levels in connective tissues of the kneeQ79373038
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectmethotrexateQ422232
microsphereQ1759020
P304page(s)445-456
P577publication date2009-03-06
P1433published inInflammation ResearchQ1819367
P1476titleIntra-articular treatment of inflammatory arthritis with microsphere formulations of methotrexate: pharmacokinetics and efficacy determination in antigen-induced arthritic rabbits
P478volume58

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cites work (P2860)
Q83425344Antigen-induced arthritis in rabbits: a comparative study between high-resolution ultrasound and contrast-enhanced ultrasound and pathologic findings
Q36758384Novel hyaluronic acid-methotrexate conjugate suppresses joint inflammation in the rat knee: efficacy and safety evaluation in two rat arthritis models
Q51012284Therapeutic effect of methotrexate encapsulated in cationic liposomes (EndoMTX) in comparison to free methotrexate in an antigen-induced arthritis study in vivo.

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