Pim1 Kinase Overexpression Enhances ckit+ Cardiac Stem Cell Cardiac Repair Following Myocardial Infarction in Swine

scientific article published in December 2016

Pim1 Kinase Overexpression Enhances ckit+ Cardiac Stem Cell Cardiac Repair Following Myocardial Infarction in Swine is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.JACC.2016.09.925
P932PMC publication ID5223744
P698PubMed publication ID27908351

P50authorKonstantinos E HatzistergosQ43204018
P2093author name stringBo Wang
Adam Williams
Joshua M Hare
Mark A Sussman
Vasileios Karantalis
Wayne Balkan
Shathiyah Kulandavelu
Sadia Mohsin
Samuel Golpanian
Luiza Bagno
Ariel Wolf
Azorides Morales
Frederic McCall
Aaron Kupin
Aaron Rosenfeld
Julia Fritsch
Justin Grenet
Viky Y Loescher
P2860cites workEnhancement of myocardial regeneration through genetic engineering of cardiac progenitor cells expressing Pim-1 kinaseQ24646472
Role of cardiac stem cells in cardiac pathophysiology: a paradigm shift in human myocardial biologyQ26858965
CADUCEUS, SCIPIO, ALCADIA: Cell therapy trials using cardiac-derived cells for patients with post myocardial infarction LV dysfunction, still evolvingQ28660773
Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trialQ29620043
RETRACTED: Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trialQ29620044
Adult cardiac stem cells are multipotent and support myocardial regenerationQ29620122
Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiationQ30523741
Rapid and sensitive detection of enhanced green fluorescent protein expression in paraffin sections by confocal laser scanning microscopyQ30871849
Assessment and optimization of cell engraftment after transplantation into the heartQ33680007
Mitochondrial integrity: preservation through Akt/Pim-1 kinase signaling in the cardiomyocyteQ33791025
Pim-1 kinase protects mitochondrial integrity in cardiomyocytes.Q33828487
c-kit+ cells minimally contribute cardiomyocytes to the heartQ34021586
Human cardiac progenitor cells engineered with Pim-I kinase enhance myocardial repair.Q34290791
Stem cell niches in the adult mouse heartQ34657903
Pim-1: a serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis.Q35004096
Safety of intracoronary infusion of 20 million C-kit positive human cardiac stem cells in pigsQ35532877
Functional Effect of Pim1 Depends upon Intracellular Localization in Human Cardiac Progenitor Cells.Q35662315
HIF-1alpha induced-VEGF overexpression in bone marrow stem cells protects cardiomyocytes against ischemiaQ36016430
Cell-based therapy for prevention and reversal of myocardial remodelingQ36176132
cKit+ cardiac progenitors of neural crest originQ36207283
Synergistic Effects of Combined Cell Therapy for Chronic Ischemic CardiomyopathyQ36236436
Increased mitotic rate coincident with transient telomere lengthening resulting from pim-1 overexpression in cardiac progenitor cells.Q36342079
Comparison of allogeneic vs autologous bone marrow–derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trialQ36603453
Enhanced effect of combining human cardiac stem cells and bone marrow mesenchymal stem cells to reduce infarct size and to restore cardiac function after myocardial infarctionQ36630155
The advancing field of cell-based therapy: insights and lessons from clinical trials.Q37328786
Myocardial infarction and intramyocardial injection models in swineQ37606101
Rejuvenation of human cardiac progenitor cells with Pim-1 kinaseQ37723749
Pim-1 kinase inhibits pathological injury by promoting cardioprotective signaling.Q37831454
Swine as models in biomedical research and toxicology testingQ37858258
Aging and regeneration in vertebratesQ38186825
Cardiac MRI: a central prognostic tool in myocardial fibrosisQ38263089
Rebuilding the Damaged Heart: Mesenchymal Stem Cells, Cell-Based Therapy, and Engineered Heart Tissue.Q38874116
Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis.Q40907792
Intrinsic hypoxia sensitivity of the cytomegalovirus promoter.Q41216385
Adult c-kit(pos) cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair.Q42250849
Pim-1 regulates cardiomyocyte survival downstream of Akt.Q46022665
Effect of exercise on left ventricular mechanical efficiency in conscious dogsQ72893605
Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted heartsQ73791469
Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvementQ83043116
The effect of age on the efficacy of human mesenchymal stem cell transplantation after a myocardial infarctionQ84490295
P4510describes a project that usesImageJQ1659584
P433issue22
P407language of work or nameEnglishQ1860
P921main subjectmyocardial infarctionQ12152
overexpressionQ61643320
P304page(s)2454-2464
P577publication date2016-12-01
P1433published inJournal of the American College of CardiologyQ2984355
P1476titlePim1 Kinase Overexpression Enhances ckit+ Cardiac Stem Cell Cardiac Repair Following Myocardial Infarction in Swine
P478volume68

Reverse relations

cites work (P2860)
Q91695940Adult human cardiac stem cell supplementation effectively increases contractile function and maturation in human engineered cardiac tissues
Q64912607Age-Appropriateness of Porcine Models Used for Cell Transplantation.
Q89142435Age-Related Impaired Efficacy of Bone Marrow Cell Therapy for Myocardial Infarction Reflects a Decrease in B Lymphocytes
Q89433765Can We Engineer a Human Cardiac Patch for Therapy?
Q57165494Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence
Q64964326Cardiac interstitial tetraploid cells can escape replicative senescence in rodents but not large mammals.
Q90082403Cardiac regenerative therapy: Many paths to repair
Q47951585Cardiomyocyte Regeneration: A Consensus Statement
Q38669503Chasing c-Kit through the heart: Taking a broader view
Q39265109Concurrent Isolation of 3 Distinct Cardiac Stem Cell Populations From a Single Human Heart Biopsy
Q92447152Dose-dependent improvement of cardiac function in a swine model of acute myocardial infarction after intracoronary administration of allogeneic heart-derived cells
Q47890976Emerging Therapies for Congestive Heart Failure
Q46294258Empowering human cardiac progenitor cells by P2Y14 nucleotide receptor overexpression
Q92092817Enhanced cardiac repair by telomerase reverse transcriptase over-expression in human cardiac mesenchymal stromal cells
Q57176904Enhancement Strategies for Cardiac Regenerative Cell Therapy: Focus on Adult Stem Cells
Q57162894Future directions for therapeutic strategies in post-ischaemic vascularization: a position paper from European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology
Q88884604Mesenchymal Stem Cell-Based Therapy for Cardiovascular Disease: Progress and Challenges
Q36316502PIM1-minicircle as a therapeutic treatment for myocardial infarction.
Q91787891Pharmacological inhibition of mTOR attenuates replicative cell senescence and improves cellular function via regulating the STAT3-PIM1 axis in human cardiac progenitor cells
Q88219970Preclinical Studies of Stem Cell Therapy for Heart Disease
Q57396450Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction
Q93025200Safety profiling of genetically engineered Pim-1 kinase overexpression for oncogenicity risk in human c-kit+ cardiac interstitial cells
Q52729630Translational cardiac stem cell therapy: advancing from first-generation to next-generation cell types.

Search more.